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Curriculum Vitae -- Bradley B. Keller, MD
1 Updated: April 23, 2012
BIOGRAPHY and CONTACT INFORMATION
Bradley B. Keller, M.D. Birth Date: November 22, 1959
Birth Place: Ellwood City, PA
Citizenship: USA
Residence: 302 E. Muhammad Ali Blvd.
Louisville, KY 40202
Phone: 502-852-5809
Academic Office: Clinical Practice Office:
Cardiovascular Innovation Institute Pediatric Cardiology Associates, PSC
University of Louisville 601 South Floyd Street, Suite 602
302 East Muhammad Ali Blvd Louisville, KY 40202
Louisville, KY 40202 Clinical Office Phone: 502-585-4802
Academic Office Phone: 502-852-5809 Clinical Office Fax: 502-589-1368
Academic Office Fax: 502-852-1391 Practice Manager: Melanie Logsdon
Mobile Phone: 412-478-6463 502-585-2256
Email: [email protected] [email protected]
Administrative Assistant: Jeannine Barron 502-852-5809
A. Education
UNDERGRADUATE: Dates Institution and Location Degree Received Major
Sept. 1977 – May 1981 University of Pennsylvania Bachelor of Arts (1981) Biology (genetics)
Philadelphia, PA
GRADUATE: Dates Institution and Location Degree Received
Sept. 1981 – May 1985 Pennsylvania State University Doctor of Medicine (1985)
College of Medicine, Hershey, PA
POST GRADUATE: Dates Institution and Location Field of Training Program Director June 1985 – June 1988 Department of Pediatrics Pediatrics (1988) Dr. Frank Oski
The Johns Hopkins Hospital
Baltimore, MD
July 1988 – June 1991 Department of Pediatrics Pediatric Cardiology Dr. Edward B. Clark
University of Rochester School Fellowship (1991)
of Medicine, Rochester, NY
B. Academic Appointments Dates Name of Institution Rank/Title/Position
July 1988 - June 1991 University of Rochester Instructor and Fellow, Pediatrics
July 1988 - June 1992 University of Rochester Attending Pediatrician, Emergency Department
July 1991 - November 1996 University of Rochester Assistant Professor, Department of Pediatrics
October 1992 - July 1996 University of Rochester Assistant Professor, Department of Physiology
Dates Name of Institution Rank/Title/Position
May 1996 - July 1999 University of Rochester Director, Pediatric CV Disease
Specialized Center of Research
December 1996 - June 1998 University of Rochester Associate Professor, Department of Pediatrics
Curriculum Vitae -- Bradley B. Keller, MD
2 Updated: April 23, 2012
July 1998 - June 2000 University of Rochester Adjunct Associate Professor, Dept of Pediatrics
July 1998 - July 2002 University of Kentucky Jennifer Gill Associate Professor, Dept. of Pediatrics,
Chief, Division of Pediatric Cardiology
May 1999 - March 2000 University of Kentucky Medical Director, Pediatric Subspecialty Clinic
July 2001 - June 2002 University of Kentucky Associate Professor with Tenure, Dept of Pediatrics
July 2002 - June 2003 University of Kentucky Professor with Tenure, Department of Pediatrics
August 2002 – present University of Pittsburgh Professor, Department of Pediatrics (tenure)
August 2002 – June 2006 University of Pittsburgh Chief, Division of Pediatric Cardiology
August 2002 - present University of Pittsburgh Member, McGowan Institute for Regen. Medicine
August 2002 – March 2006 University of Pittsburgh Research Associate, Magee-Womens Research Instit.
March 2006 - April 2009 University of Pittsburgh Senior Investigator, Magee-Womens Research Institute
September 2003 – June 2009 University of Pittsburgh Graduate Faculty, Cell Biol. and Molecular Physiology
July 2005 – June 2006 University of Pittsburgh Director, Pediatric Card. Fellowship Training Program
July 2006 – April 2009 University of Pittsburgh Director, Pediatric Biomedical Innovative Technology
January 2007 – April 2009 University of Pittsburgh Member, Standing Committee for Tenured Faculty
Promotion and Appointment
January 2007 – April 2009 University of Pittsburgh Member, Institutional Review Board (IRB) Committee
May 2007 – present University of Pittsburgh Professor (secondary appt.), Department of
Bioengineering
June 2007 – April 2009 Children’s Hospital of Pittsburgh Member, Committee on Surgical Innovation (COSI)
July 2007 – April 2009 University of Pittsburgh Member, Technology Transfer Committee
May 2008 – present Carnegie Mellon University Adjunct Professor, Dept. of Biomedical Engineering
May 2009 - present University of Louisville Professor, Department of Pediatrics (tenure),
Division of Pediatric Cardiology
May 2009 - present University of Louisville Kosair Charities Chair in Pediatric Heart Research
May 2009 - present University of Louisville Chief, Pediatric Heart Research, Cardiovascular
Innovation Institute
July 2009 – present University of Louisville Professor (adjunct), Department of Bioengineering
June 2010 – present University of Louisville Vice Chair for Research, Department of Pediatrics
July 2010 – present University of Louisville Professor (joint), Department of Pharmacology and
Toxicology
C. Other positions and Employment including Military Service. None.
D. Board Certification and Licensure
MEDICAL LICENSURE: Licensing Board/State License Number Year National Board of Medical Examiners 308742 1986
Maryland D35795 1987
New York 174593 1988
Kentucky 34628 1999, re-activated 2009
Pennsylvania MD420075 2002
Federal Drug Enforcement Agency on request 1992, 2002
China and Tibet Autonomous Region temporary 2005, 2007, 2009, 2010
SPECIALTY CERTIFICATION: Certifying Board Certificate Number Year
Pediatrics 211796 1989, 2001
Pediatric Cardiology 211796 1991, 2001, 2007
Professional licensure and hospital privileges have never been revoked, suspended, or voluntarily reduced.
Curriculum Vitae -- Bradley B. Keller, MD
3 Updated: April 23, 2012
E. Professional Society Boards and Activities Organization Years
Rochester Community I.P.A., Inc., Cardiology Subcommittee 1996 - 1998
American Heart Association New York State Affiliate 1993 - 1998
Research Committee, Vice Chair 1994 - 1996
Chair, Grant Peer Review II 1995 - 1997
Executive Committee 1996 - 1998
American Heart Association, Genesee Board of Directors 1994 - 1998
Nominating Committee 1996 - 1998
Executive Board, Secretary 1996 - 1998
American Heart Association Mid-Atlantic Region 2003 - 2007
Research Peer Review, Cardiovascular Development and Basic Science
Co-chair, CV Development and Basic Science Review Panel 2005 - 2007
American Heart Association, National
Basic Science Research Committee Member 2009- present
Research Outcomes Taskforce 2010 -present
F. Honors and Awards Title of Award Year
Rotary International Foundation Educational Award 1979 - 1980
Magna cum laude, University of Pennsylvania 1981
Phi Beta Kappa, University of Pennsylvania 1981
University of Miami Medical Student Research Forum, First Place, Poster 1985
Fellow's Medical Student Teaching Award 1988
University of Rochester Class of 1988
World Forum Research Finalist 1993
1993 World Congress of Pediatric Cardiology and Cardiac Surgery
Chairman’s Award for Pediatric Research 2001
Department of Pediatrics, Univ. of Kentucky
Patient Satisfaction Award: Outstanding Achievement in Patient Care
Children’s Hospital of Pittsburgh top 25 physicians 2004, 2005
Children’s Hospital of Pittsburgh top 10 physicians 2006
National Patient Satisfaction Award 2007, 2008
Kosair Charities Chair in Pediatric Heart Research 2009
RESEARCH FELLOWSHIP TRAINING AWARDS NIH NHLBI NRSA
Post-Doctoral Fellowship #F32-HL07824. 07/01/1998 - 06/31/1990
Ventricular Mechanics in the Developing Chick Heart.
(E.B. Clark, sponsor, K. Sagawa, advisor).
UNIVERSITY OF ROCHESTER 07/01/1989 - 06/31/1990
Bradford Pediatric Fellow
NIH NHLBI PSA
Physician-Scientist Training Award #K11-HL02498. 07/01/1990 - 06/31/1995
Ventricular Mechanics in the Chick Embryo.
Curriculum Vitae -- Bradley B. Keller, MD
4 Updated: April 23, 2012
G. Committee Assignments and Administrative Services
DEPARTMENT, HOSPITAL, AND UNIVERSITY COMMITTEES
UNIVERSITY OF ROCHESTER
Strong Memorial Hospital Medical Records Committee 07/01/93 - 06/31/98
Policy Revision Subcommittee 07/01/96 - 06/31/98
Children's Hospital at Strong Faculty Liaison, Fundraising 07/01/94 - 06/31/98
UNIVERSITY OF KENTUCKY
Executive Committee Department of Pediatrics 07/01/98 - 07/31/02
Pediatric Clinic Management Group Department of Pediatrics 07/01/99 - 06/31/00
Children’s Services Committee Children’s Hospital 07/01/98 - 06/31/00
Business Process Improvement “A” Chandler Medical Center 07/01/99 - 07/31/02
Steering Committee Gill Heart Institute 07/01/98 - 06/31/99
Faculty Recruitment Committee Department of Biochemistry 07/01/98 - 02/01/99
Research Self-Study Committee College of Medicine 07/01/01 - 12/01/01
CHILDRENS HOSPITAL OF PITTSBURGH Division Chiefs Committee Department of Pediatrics 08/01/02 - 06/30/06
New Research Campus Design and Children's Hospital of Pittsburgh 10/01/02 - 06/30/06
Programming Committees
New CHP Hospital Design
Director, Summer Student Research Program Children's Hospital of Pittsburgh 02/01/03 - 01/31/08
Faculty Incentive Plan Committee Department of Pediatrics 04/01/03 - 06/31/04
Medical Executive Committee Children's Hospital of Pittsburgh 07/01/03 - 07/01/06
Credentialing Committee Children’s Hospital of Pittsburgh 08/01/05 - 04/30/09
Innovative Surgical Technology Committee Children’s Hospital of Pittsburgh 06/01/07 - 04/30/09
Medical Staff Bylaws Committee Children’s Hospital of Pittsburgh 12/13/07 - 04/30/09
UNIVERSITY OF PITTSBURGH Human Investigational Review Board (appointed) 01/01/07 - 04/30/09
Standing Committee for Tenured Faculty Promotion and Appointment (elected) 01/01/07 - 04/30/09
Technology Transfer Committee (appointed) 07/01/07 - 04/30/09
UNIVERSITY OF LOUISVILLE and the KOSAIR CHILDREN’S HOSPITAL
Cardiovascular Innovation Institute, Division Head Management Committee 05/01/09 - present
Dept. of Pediatrics Committee for Tenured Faculty Promotion, Appointment, and Tenure 05/01/09 - present
Dept. of Pediatrics, KCHRI Director Search Committee 07/01/09 - present
Dept. of Pediatrics, Regionalization Committee 07/01/10 - present
Dept. of Pediatrics, Operational Leadership Committee 07/10/10 - present
Dept. of Pediatrics, New Ambulatory Building Planning Committee 09/01/10 - present
Univ. of Louisville, Faculty Senate, School of Medicine Representative 09/01/09 - present
Univ. of Louisville, School of Dentistry, 5 year Chair Review Committee 01/10/10 - 06/30/10
Univ. of Louisville, Executive Vice President for Health Affairs Search Committee 07/01/10 - 07/01/11
Kosair Children’s Hospital, Outreach Committee 09/01/10 - present
Kosair Children’s Hospital , Medical Executive Committee 01/05/11- present
Kosair Children’s Hospital, Academic Excellence Committee Co-Chair 04/01/11 - present
Kosair Children’s Hospital, Physician Workforce Committee 04/01/11 - present
Curriculum Vitae -- Bradley B. Keller, MD
5 Updated: April 23, 2012
H. Journal Editorial Boards, Advisory Councils, Peer Reviewer of Manuscripts PARTICIPATION IN PEER REVIEW OF SCIENTIFIC PUBLICATIONS
American J. Physiology Anatomical Record Archives of Peds and Adol Med Basic Research Cardiology
Birth Defects Research Cardiovascular Research Circulation Research Current Opinion in Cardiol.
Developmental Dynamics Diabetes Institute for LabAnimal Res (NAS) J Biomech Engineering
J Clinical Investigation J Experimental Biology J Mol Cell Cardiology Pediatric Cardiology
Pediatrics International Pediatric Research Pediatric Transplantation Physiological Genomics
Teratology Tissue Engineering Trends in Pharmacol Science J Cardiac Failure
PARTICIPATION IN STATE, NATIONAL, AND INTERNATIONAL RESEARCH PROPOSAL PEER REVIEW Panel participant Special Emphasis Panel on Research Priorities for Special Centers of Research in Pediatric
Cardiovascular Diseases, Philadelphia, 1996.
Panel participant NIH Special Emphasis Panel to develop priorities for the NHLBI SCOR awards in Pediatric
Cardiovascular Diseases, Bethesda, 1997.
Panel participant NIH Special Emphasis Panel to review grant applications for Specialized Centers of Research
in Pediatric Cardiovascular Diseases, Bethesda, 1998.
Panel participant NIH Special Emphasis Panel to review grant applications for heart failure RFA HL-97-012.
Panel participant NIH Special Emphasis Panel on Saturation Mutagenesis and Murine Cardiovascular
Phenotyping. Denver, CO, November 1998.
Panel participant NIH Special Emphasis Panel to review Pediatric SCOR applications, NHLBI, January 2001.
Panel participant NIH NHLBI CV-A study section, Bethesda, MD, February 2001.
Panel participant NIH Special Emphasis Panel on Bioengineering Research Partnerships Bethesda, MD, April,
2001.
Panel participant American Heart Association Mid-Atlantic Study Section 6, grant review member, Bethesda,
MD April, 2004.
Session co-chairman American Heart Association Mid-Atlantic Study Section 6 grant review, Bethesda, MD,
March 2005
Panel participant NIH Special Emphasis Panel for PO1 applications on Novel Cardiovascular Genes, Bethesda,
2005
Session chairman American Heart Association Mid-Atlantic Study Section 6 grant review, Bethesda, MD,
April 2006, April 2007
Panel participant NIH Special Emphasis Panel for PO1 applications on Novel Cardiovascular Genes, Bethesda,
2006
Panel participant NIH Myocardial Ischemia and Metabolism Study Section – Ad Hoc Reviewer, Bethesda,
June 2006
Panel participant NIH Special Emphasis Panel Review: Institutional NHLBI Training Programs, Bethesda,
Nov. 2006 Baltimore, Nov. 2007, Baltimore June & Dec 2008, Standing Study Section
Member (July 1, 2009)
Panel participant NIH NHLBI IRG CDD Study Section Ad Hoc Reviewer, Bethesda, MD June & November
2007 Standing Study Section Member effective July 1, 2008 through June 2012
Curriculum Vitae -- Bradley B. Keller, MD
6 Updated: April 23, 2012
STATE, NATIONAL, AND INTERNATIONAL RESEARCH PROPOSAL PEER REVIEW (continued) Panel chair NIH Special Emphasis Panel for cardiac stem cell R01 applications, March 2008, October
2008
PARTICIPATION IN REGIONAL, NATIONAL, AND INTERNATIONAL MEETINGS Panel participant Committee on New and Emerging Models in Biomedical and Behavioral Research, National
Research Council, Washington, 1997.
Panel participant NIH Working Group on “The role of cholesterol and lipids in embryonic development and
congenital disease”, Nashville, 1998.
Panel participant Hormonal Regulation of the Growth and Function of the Neonatal Heart. 73rd Scientific
Sessions, American Heart Association, New Orleans, November, 2000.
Panel participant NIH Working Group on “Future Directions for Research Funding in Cardiac Development”,
St. Louis, June, 2000.
ORGANIZATION ROLE IN REGIONAL, NATIONAL, AND INTERNATIONAL MEETINGS Session co-chairman The World Congress on Medical Physics and Biomedical Engineering, Kyoto, JAPAN, 1991.
Session co-chairman American Physiology Society sponsored Scientific Symposium: Regulation, integration,
adaption: a species approach, San Diego,1994.
Session moderator NHLBI Weinstein Cardiac Morphogenesis and Development Meeting: Philadelphia, PA,
1996.
Session co-chairman 2nd World Congress, Pediatric Cardiology and Cardiac Surgery, Honolulu, Hawaii, 1997.
Session chairman Developmental changes in cardiac function. Muroran Institute of Technology, Japan , 1998.
Session moderator Cardiovascular Physiology and Engineering. Weinstein Cardiovascular Development
Conference, Vanderbilt University, Nashville, 1998
Session co-chairman Selection of Animal Models. 71st Scientific Sessions, American Heart Association, Dallas,
November, 1998.
Program organizer “Noonan Congenital Cardiovascular Symposium”, 10/8/99, Lexington, KY.
11 speakers, 80 participants.
Session co-chairman Featured Research: Mouse Models of Cardiac Dysfunction.72nd Scientific Sessions,
American Heart Association, Atlanta, November, 1999.
Steering committee “International Symposium on the Developing Heart”, 5/18-20/2000, Prague, Czech Republic.
40 speakers, 300 participants.
Session chairman Function and Metabolism of the Developing Heart. International Symposium on the
Developing Heart. Czech Academy of Sciences, Prague, May 2000.
Session moderator Roundtable in Comparative Developmental Physiology, Sponsored by NSF Inn on the
River, Glen Rose, TX, June 2002.
Session moderator Mechanics in Cardiac Development. 9th Weinstein Cardiovascular Development
Conference, Boston, MA, May 2003
Steering committee “2004 McGowan Institute for Regenerative Medicine Retreat” 2/23-24/2004,
Nemacolin Resort, 10 speakers, 150 participants.
Curriculum Vitae -- Bradley B. Keller, MD
7 Updated: April 23, 2012
Steering committee “2005 McGowan Institute for Regenerative Medicine Retreat” 3/6-7/2005
Nemacolin Resort, 12 speakers, 170 participants.
Program co-organizer “First Annual Symposium on Advances in Congenital Cardiovascular Care” 10/15/05
Renaissance Hotel, Pittsburgh, PA, 12 speakers, 75 participants
Session chairman Biomechanics of Cardiovascular Development. 5th World Congress of Biomechanics.
Munich, Germany, July 2006
Program Committee “Patient and Family Centered Care Workshop Series: The Innovators Conference”, 11/7/07,
Pittsburgh, PA
Session co-chairman Diastology in Congenital Heart Disease. 82nd Scientific Sessions, American Heart
Association, Orlando, November, 2009.
ACADEMIC ADVISORY ACTIVITIES May 2009 – present State of Nebraska Founding committee member, Nebraska Stem Cell
Advisory Committee “Stem Cell Research Act, LB606”
July 2009 – present University of North Texas Member, External Advisory Board, Development,
Physiology, and Genetics Academic Cluster
January 2010 –July 2010 University of Nebraska Medical Center Expanding Pediatric Cardiovascular Research
Children’s Medical Center
COMMUNITY FOUNDATIONS Medical Research Advisory Committee The Pittsburgh Foundation 04/01/03 - 04/30/09
Proposal Reviewer Pittsburgh Life Sciences Greenhouse 02/02/05 - 04/30/09
Proposal Reviewer Pittsburgh Technology Council 02/02/05 - 04/30/09
INTERNATIONAL COMMUNITY SERVICE Medical Director Touching Hearts Program in Tibet 07/01/05 – 06/01/10
This program screened school children in the Tibet Autonomous Region, PRC for congenital heart disease and then provided
cardiac catheterization, interventional closure of ASDs and PDAs in Lhasa, Tibet Autonomous Region, PRC and surgical
referral to Pediatric Heart Centers in Beijing and ChengDu, PRC. Funded by SEAPC, Oakmont, PA, via community
donations. More than 21,000 screened and 250 children successfully treated. Program operations are suspended pending
contract renewal.
I. Academic Society Memberships
Organization Year
American Academy of Pediatrics, Fellow 1992 - present
Society for Pediatric Research, Member 1994 – present
American Heart Association, National 1990 - present
Cardiovascular Disease in the Young
Basic Science 1992 – present
New York Academy of Science, Member 1996 - present
Kentucky Medical Association 1999 - present
American Physiologic Society, Member 1999 - present
American Association for the Advancement of Science, Member 1999 - present
National Marfan Society 1999 - present
International Society for Heart Research 2000 - present
International Society for Adult Congenital Heart Disease 2000 - present
Society for Southern Pediatric Research 2000 - present
Heart Failure Society of America 2000 - present
American Pediatric Society 2004 - present
American Telemedicine Association 2008 – present
Curriculum Vitae -- Bradley B. Keller, MD
8 Updated: April 23, 2012
J. Mentoring DOCTORAL THESIS COMMITTEES
Sandra Stekelenburg-de Vos 7/01 to 6/05 Hemodynamics and heart function in the venous
clipped chick embryo. Dept. of Ob/Gyn. Erasmus
Univ, the Netherlands
Thomas R. Payne 7/02 to 6/06 Differential myocardial infarct repair with muscle
derived stem cells. Dept. of Bioengineering.
University of Pittsburgh
Arielle Drummond 7/05 to 12/08 Simulation of the optimal insertion for a pediatric VAD
Dept. of Bioengineering. Carnegie Mellon University
Hsun-Hsien Chang 3/06 to 9/07 Cardiovascular magnetic resonance imaging of
paramagnetic particles to detect cardiac rejection.
Carnegie Mellon Univ.
Ti Soon Park 6/06 to 12/08 Origin and fate of human hemangioblast stem cells.
Dept. of Cell Biology and Physiology. Univ. of
Pittsburgh
Lorenzo Soletti 6/06 to 11/08 Development of a Stem Cell-Based Tissue Engineered
Vascular Graft. Dept. of Bioengineering, University of
Pittsburgh
Lauren Drowley 6/07 to 6/09 Myocardial repair using muscle derived stem cells.
Depts.of Orthopedics and Bioengineering. University
of Pittsburgh
John Stella 05/08 to 9/11 Tissue engineering approaches for pulmonary valve
surrogates. Dept. of Bioengineering, University of
Pittsburgh
Yajuan Wang 05/08 to 12/11 Decision support for ventricular mechanical assist device
. Dept. of Bioengineering. Carnegie Mellon University
Hiren Trada 07/10 to present Development of porous multiple electrode arrays
(P-MEA) to quantify and accelerate engineered tissue
maturation. Dept. of Electrical and Computer
Engineering. University of Louisville
SCHOLARLY PROJECT AND RESEARCH MENTOR COMMITTEES
Adeboyega Abdulkadir 7/06 to 6/08 Relationship between Fetal Rat Hemodynamics,
Periventricular Leukomalacia, and Chorioamnionitis
Diego Mougillansky 7/06 to 4/09 Novel Contrast Agent Approaches to Characterize
Injured Myocardium.
Evonne Krushansky 7/07 to 4/09 Wireless Detection of Abnormal Cardiac Electrical
Activity (PELEX-C)
Stephanie Downs 10/07 to 5/ 10 Improved Detection of Rural Congenital Heart Disease:
The Touching Hearts in Tibet Project
Alison Keskey 01/01/11 – present Application of Home Telemonitoring to High-Risk
Infants with Congenital Heart Disease (DIR program)
Curriculum Vitae -- Bradley B. Keller, MD
9 Updated: April 23, 2012
Junior Faculty
K. Tobita, MD 7/02 to 5/09 Biomechanics of Embryonic CV Systems
Currently: Assistant Professor, Dept. of Dev. Biol.
University of Pittsburgh, Pittsburgh, PA
C. Ralphe, M.D. 6/04 to 11/07 Maturation of Cardiomyocyte Mitochondrial Function
Currently: Assistant Professor, Dept. of Pediatrics,
Division Chief, Pediatric Cardiology, University of
Wisconsin, Madison, WS
I. Libman, MD, PhD 7/04 to 5/09 Relationship Between Type I Diabetes Mellitus,
Obesity, and Cardiovascular Risk Factors
Currently: Assistant Professor, Dept. of Pediatrics,
University of Pittsburgh, Pittsburgh, PA
T. Yanowitz, M.D. 9/04 to 11/07 Relationship between Fetal Rat Hemodynamics,
Periventricular Leukomalacia, and Chorioamnionitis
Currently: Assistant Professor, Dept. of Pediatrics,
University of Pittsburgh, Pittsburgh, PA
Post-Doctoral Residents and Fellows F. Heller, M.D. 1/92 to 3/92 Ventricular Function During Altered Contractile State
Currently: Assistant Professor, Dept. of Pediatrics,
University of Connecticut, Hartford, CT
J. Murillo-Gonzalez, M.D .9/92 to 11/92 Morphogenesis during Cardiac Looping, Universidad
Complutense, Madrid, SPAIN
Currently: Associate Professor, Dept. of Anat. and Emb,
Universidad Complutense, Madrid, SPAIN
P. Bowers, M.D. 12/92 to 6/95 Ventricular/vascular Coupling During Alterations in the
Nitric Oxide Pathway
Currently: Medical Director, Blue Cross/Blue Shield of
Connecticut, Hartford, CT
M. Yoshigi, M.D. 10/94 to 9/97 Arterial Hemodynamics in the Embryonic Circulation
(Dept. of Ped Card, Tokyo Women's Medical Col)
Currently: Assistant Professor, Dept of Pediatrics,
University of Utah, Salt Lake City, UT
M. Broekhuizen, M.D. 5/95 to 5/97 Ventricular Function Following Retinoic Acid
Treatment in the Stage 21 Chick Embryo. (Univ. Leiden,
the Netherlands)
Currently: Clinical Practice, Leiden, the Netherlands
S. Furukawa, M.D. 7/96 to 6/98 Murine Maternal/Embryonic Coupling During
Cardiovascular Development. (Medical College,
Miyazaki City, Japan)
Currently: Assistant Professor, Department of
Obstetrics and Gynecology, Miyazaki City, Japan
K. Tobita, M.D. 7/97 to 7/02 Embryonic Ventricular Mechanics Following Cardiac
Septation (Dept. of Ped Card, TWMC, Tokyo)
Currently: Assistant Professor, Dept. of Dev. Biol.,
University of Pittsburgh, Pittsburgh PA
Curriculum Vitae -- Bradley B. Keller, MD
10 Updated: April 23, 2012
Post-Doctoral Residents and Fellows (continued) E. Schroder, Ph.D. 12/97 to 8/02 Myocardial Mechanics During Cardiovascular
Development.
Currently: Assistant Professor, Dept. of Physiology,
University of Kentucky, Lexington, KY
R. Akiyama, Ph.D. 4/99 to 4/00 Numerical Analysis of Embryonic Blood Flow.
Currently: Research Assistant Professor, Dept. of
Engineering, Mururan University, Mururan, Japan
L. Jeffries, M.D. 6/99 to 7/01 Outcome Assessment in Rural Adult Congenital Heart
Disease.
Currently: Assistant Professor, Dept. of Peds., Baylor
University, Houston, TX
S. Sharma, M.D. 1/03 to 7/05 Regulation of Cardiovascular Structure and Function by
Oxygen Tension in Chick and Mouse Embryos
Currently: Pediatric Cardiology Practice, University of
Tennessee, Knoxville, TN
J. Lucitti, Ph.D. 4/03 to 8/05 Physiology and Biomechanics of the Developing
Vasculature and Ventriculo-Vascular Interactions
Currently: Research Scientist, UNC, Chapel Hill, NC
N. Momoi, M.D. 4/04 to 4/06 Rodent Models of Cardiovascular Maternal-Fetal
Coupling
Currently: Associate Professor, Dept. of Peds.,
Fukushima Medical University, Japan
M. Saaloukeh, M.D. 10/04 to 6/06 Intrauterine Effects of Maternal Caffeine Exposure on
Murine Embryonic Growth and Hemodynamics
Currently: Neonatology clinical practice
M. Manole M.D. 10 /04 to 6/06 Effect of Prerminal Gasping During Anoxic Arrest on
Cardiac Function in Immature Rats
Currently: Assistant Professor, Dept. of Emergency
Med., University of Pittsburgh, Pittsburgh, PA
E. Krushansky, M.D. 9/07 to 5/09 Wireless Detection of Abnormal Cardiac Electrical
Activity (PELEX-C)
Currently: Pediatric Cardiology Fellow, Dept. of Peds.,
Children’s Hospital of Pittsburgh, Pittsburgh, PA
K. Cross, MD 2/10 to 6/11 Comparative Effectiveness of Ultrasound-Guided
Nerve Block Versus Conscious Sedation for Pediatric
Orthopedic Injury Management
Currently: Pediatric Emergency Medicine Faculty
Dept. of Peds., University of Louisville.
R. Salimi, MD 12/10 to present Development of a Small Animal Model to Investigate
Capillary Leak via Reconstituted Microvascular
Networks
M. Peek, MD 07/11 to present Development and Validation of Home Telemedicine
Supported Anticoagulation Management
Curriculum Vitae -- Bradley B. Keller, MD
11 Updated: April 23, 2012
Post-Doctoral Residents and Fellows (continued) L Krishnan, PhD 07/11 to present Regenerative Potential of Umbilical Cord Derived
Mesenchymal Stem Cells in Pediatric Cardiovascular
Repair
Ramon Ymalay 07/11 to present VEV02100 High Resolution Imaging in Neonates
A. Le Blanc, PhD 08/11 to present Age-Related Differences in Stromal Vascular Fraction-
Assisted Coronary Microvascular Repair
Curriculum Vitae -- Bradley B. Keller, MD
12 Updated: April 23, 2012
Pre-Doctoral Students
D. Dalecki 2/89 to 5/91 Cardiac Effects of Lithotripsy and Pulsed Ultrasound
Currently: Associate Professor, Dept. of Biomed. Eng.,
University of Rochester, Rochester, NY
K. Campbell 7/90 to 9/90 Atrial Function in the Stage 16 to 24 Chick.
7/91 to 9/91 Donald Shapiro Medical Student Research Award
U of R Medical Student Research Fellowship
V. Fruci 6/90 to 9/90 Epicardial Ventricular Strains in the Stage 18 Chick
Embryo
N. Shafer 7/91 to 9/91 Morphometry of the Vitelline Arterial Tree.
7/92 to 9/92 Donald Shapiro Medical Student Research Award
U of R Medical Student Research Fellowship
D. Smith 9/91 to 12/91 Computer Image Reconstruction of the Vitelline Arterial
Tree
C. Berno 10/91 to 6/92 Ventricular Epicardial Strain Analysis in the Stage 14 to
24 Chick Embryo.
H. Sun 11/91 to 4/95 Epicardial Strain Analysis During Normal Growth and
Following Heart Rate Alterations.
J. Cartmell 7/92 to 6/93 Epicardial Strain Analysis During Alterations in Heart
Rate in the Stage 21 Chick.
J. Racy 7/92 to 9/92 Ventricular/Vascular Coupling in Response to
Isoproterenol and Supplemental Preload.
K. O'Gara 7/92 to 9/92 Embryonic Ventricular Passive Length-Tension
Relations in the Excised Embryonic Heart.
7/93 to 9/93 Ventricular/Vascular Coupling and EDRF mimetics.
C. Casillas 7/92 to 6/93 Heart Rate Reserve During Primary Cardiovascular
Morphogenesis. AHA Funded Student Fellowship
M. Preston 9/92 to 12/92 Morphometry of the Stage 9 to 13 Embryonic Heart.
N. Yip 7/93 to 9/93 Embryonic Ventricular Pressure-Volume Relations
During Changes in Heart Rate and Loading Conditions.
A. Chamis 7/93 to 9/93 3D Epicardial Strain Analysis of the Embryonic Heart.
7/94 to 9/94
Hui Li 7/93 to 5/94 Three-Dimensional Solid Geometric Modeling of the
Embryonic Heart During Cardiac Looping.
Y. Takagi 9/94 to 6/96 Accuracy Analysis of Three-Dimensional Epicardial
Strains
B. Koomer 1/95 to 6/95 Comparison of Video and Confocal Microscopic
Estimates of Embryonic Ventricular Volume.
Curriculum Vitae -- Bradley B. Keller, MD
13 Updated: April 23, 2012
Pre-Doctoral Students (continued)
J. Ettel 9/95 to 9/96 Arterial Impedance During Alterations in Cycle Length.
Epicardial Ventricular Strains Following Conotruncal
Banding.
N. Ursem 7/95 to 6/99 Quantification of Human Embryonic Blood Velocity
Profiles in Normal and High-Risk Pregnancies.
(Erasmus University, Rotterdam, the Netherlands)
K. Babbitt 7/95 to 7/97 Capacitive Nanosensors for Pressure Measurements in
the Embryonic Cardiovascular System. (RIT)
B. Zong 9/95 to 6/96 Electronic Signal Conditioning of Capacitive and
Piezoelectric Nanosensors for the Embryonic
Cardiovascular System. (RIT)
E. Schenck 9/95 to 6/96 Implantable Piezoelectric Telemetry Nanosensors for the
Embryonic Cardiovascular System. (RIT)
K. Mangold 6/96 to 8/96 Fetal Diagnosis and Therapy of Trisomy 21 With and
Without Congenital Heart Disease.
G. Neri 9/96 to 10/97 Microelectronic Design and Fabrication for Biological
Material Testing. (RIT)
E. Gilbert 6/97 to 8/97 Regional Myocardial Epicardial Strains Following Left-
Atrial Ligation in the Chick Embryo.
Currently: Pediatric Medical Practice, Philadelphia, PA
J. Tabor 6/01 to 8/01 Effect of Maternal Hypoxia on Murine Embryonic Heart
Function.
J. Nonemaker 5/03 to 8/03 Impact of Mechanical Strain of Myofiber Alignment on
Embryonic Cardiomyocytes
Currently: Clinical Research Specialist, Hartford, CT
C. Nordman 5/03 to 8/03 Relationship Between Hypoxia and Embryonic Chick
Cardiovascular Function
Currently: Chief Radiology Resident, University of
Pittsburgh PGY4
R. Barnett 6/04 to 8/04 Regulation of Vascular Material Properties by Altered
Biomechanical Load
E. Chay 6/04 to 8/04 Contribution of Pacing Stimulation to Cardiomyocyte
Maturation in Early Embryonic Engineered Cardiac
Tissue
M. Choi 9/04 to 8/05 Multimedia Presentation of Cardiovascular Research
A. Drummond 7/05 to 11/08 Simulation of the optimal insertion for a pediatric VAD
“2008 African-American Bioengineering Student of the
Year” Currently: Research Scientist, Circulite
Curriculum Vitae -- Bradley B. Keller, MD
14 Updated: April 23, 2012
Pre-Doctoral Students (continued)
Kelly Clause 7/06 to 5/10 Biomechanics of Engineered Embryonic Cardiac
Tissues (funded by NIH T32 to S. Shroff)
Currently: Doctoral Student, Dept. of BioEng,
University of Pittsburgh, Pittsburgh, PA
Katie Thompson, Marita Mann, Wendy Kho 1/07 to 6/07 CMU Senior Biomechanics Design Project: Pulsatile
Alyssa Haney, Daqian Wu Phantom for Vascular Access Training CMU
Daniel Bernier, Huiyi Li, 1/07 to 6/07 CMU Senior Biomechanics Design Project: Implantable
Rajit Patel, Sid Viswanathan Pediatric Cardiovascular Biosensor CMU
Lauren A. Paladino 6/07 to 8/07 Heart Rate, Oxygen Saturation, and Blood Pressure
Response to Exercise in Children With Congenital Heart
Disease at High Altitude in the Tibet, PRC
Yajuan Wang 9/07 to 10/08 Vascular Imaging and Flow Modeling During
Cardiovascular Cardiovascular Morphogenesis
10/08 – present Decision Support Applied to Human Heart Failure
Currently: Doctoral Student, Carnegie Mellon
University, Pittsburgh, PA
Stephanie Downs 10/07 to 2/10 Improved Detection of Rural Congenital Heart Disease:
The Touching Hearts in Tibet Project
Currently: Surgical Resident, University of Pittsburgh
School of Medicine, Pittsburgh, PA
Jennifer Stevens 06/08 to 10/08 Wireless Detection of Abnormal Cardiac Electrical
Activity (PELEX-C)
Currently: Medical Student, University of Pittsburgh
School of Medicine, Pittsburgh, PA
Onur Dur 09/07 – 07/10 Computational Fluid Dynamics and Numerical
Modeling of Embryonic, Fetal, and Pediatric Blood
Flow Relevant to Congenital Heart Disease.
Currently: Staff Engineer, Thoratec, Inc.
William J Kowalski 09/09 – present Embryonic aortic arch growth and remodeling
investigated via computational fluid dynamics.
Currently: Doctoral Student, Carnegie Mellon
University, Pittsburgh, PA
Dan Kmetz 06/10 – 08/10 3D Confocal Image Analysis of Composite Engineered
Tissues Composed of Embryonic Cardiac Cells and
Microvascular Fragments
Currently: Medical Student, University of Louisville
Alison Keskey 01/01/11 – present Application of Home Telemonitoring to High-Risk
Infants with Congenital Heart Disease
Curriculum Vitae -- Bradley B. Keller, MD
15 Updated: April 23, 2012
MEDICAL STUDENT, RESIDENT, and FELLOW EDUCATION
General Pediatric Cardiology Teaching Rounds: Medical Students, Residents, and Fellows.
Strong Memorial Hospital, Rochester, NY (avg. 2 hours per week) 1991 - 1998
University of Kentucky Children’s Hospital, Lexington, KY (avg. 2 hours per week) 1998 - 2002
Children’s Hospital of Pittsburgh, Pittsburgh, PA (avg. 2 hours per week) 2002 – 2009
Kosair Children’s Hospital, Louisville, KY (avg. 2 hrs per week) 2009 - present
Pediatric Resident Noon Conferences: “General Pediatric Cardiology Topics” (2 course hours per year) CHP 2002 - 2009
“Challenges and Opportunities: Choosing the Physician-Scientist Career Path”. Exploring Academic
and Subspecialty Careers Symposium, Ped Residents, UofL, (2 hrs/yr) 2010 - present.
Neonatology Seminar Series: Cardiovascular Development and Diseases, CHP (2 hrs/yr) 2003 - 2006
Medical School Lectures: “Genetics of Cardiovascular Disease: from Embryo to Adult” Univ. Pitt. (4 hrs/yr) 2002 - 2007
Molecular Regulation of Cardiovascular Development, Myocardial Hyperplasia and Hypertrophy.
MSCMP 2730: Mol. Mechanisms of Tissue Growth and Adaptation. Univ. Pitt. (2 hrs/yr) 2006-2007
“Origins of CHD” Department of Pediatrics – MSIII Lecture. UofL. (1 hr/yr) 2009 - present
“Challenges and New Frontiers in Pediatric Cardiology. In: “Bench to Bedside: Introduction to
Clinical and Translational Research Lecture Series”.MSII Lecture - Clinical Translational Science
Institute, UofL (1.5 hr/yr) 2010 - present
Bioengineering Lectures: “Insights from Embryos: How to Build and Mend the Heart.” Univ. of Pittsburgh. BioE 3600: Forces
That Shape Organogenesis (2 hours / yr) 2006 - 2008
“eDesign for Cardiovascular Device Applications.” Carnegie Mellon University. (1 hrs / yr) 2006-09
“Surgery for Engineers: Congenital Heart Disease.” Carnegie Mellon University. (2 hrs / yr) 2006-09
Adult Cardiology Fellow Lectures: “Origins of CHD” Louisville, KY, (1.5 hrs/yr) 2009 – present
School of Public Health and Information Sciences Lectures: “Challenges and New Frontiers in Pediatric Cardiology”.
Pre-doctoral Students, Epidemiology and Public Health. (1.5 hr/yr) 2010 - present
Research Mentorship listed under trainees and training research funding.
Curriculum Vitae -- Bradley B. Keller, MD
16 Updated: April 23, 2012
K. Abstracts and Presentations (partial listing)
1. Keller BB, Hu N, Zahka KG and Clark EB. Ventricular Pressure-Area Loops in the Stage 21 Chick Embryo.
Circulation 1987;76(4):552.
2. Keller BB, Hu N, and Clark EB. Correlation of ventricular measurements with mass and function in the stage 12 to 24
chick embryo. Ped Res 1989;25:II-26A.
3. Hu N, Keller BB, and Clark EB. Relationship of cycle length, diastolic filling and ventricular performance in the stage
21 chick. Ped Res 1989;25:II-25A.
4. Hu N, Connuck D, Keller BB, and Clark EB. Diastolic ventricular function in stage 1 to 27 chick. Ped Res
1989;25(4):II-25A.
5. Keller BB, Hu N, Serrino PJ, and Clark EB. Pressure-area loop characteristics in the stage 18, 21, and 24 chick embryo.
Circulation 1989;80(4):II-165.
6. Hu N, Connuck D, Keller BB, and Clark EB. Passive and active diastolic ventricular function in stage 12 to 27 chick
embryo. Circulation 1989;80(4):II-469.
7. Keller BB, Hu N, and Clark EB. Ventricular pressure-area loop characteristics during cardiac development in the chick
embryo. In Abstracts of the First World Congress of Biomechanics. UCSD, San Diego, 1990;I:151.
8. Taber LA, Keller BB, and Clark EB. Experimental and theoretical strains in the developing chick heart. In Abstracts of
the First World Congress of Biomechanics. UCSD, San Diego, 1990;II:234.
9. Keller BB, Hu N, and Clark EB. Ventricular filling and ejection characteristics after conotruncal banding in the chick
embryo. Circulation 1990;82(4)III-187.
10. Hu N, Keller BB, and Clark EB. Relationship of simultaneous atrial and ventricular pressures in the stage 16 to 27
chick embryo. Circulation 1990;82(4)III-491.
11. Hu N, Keller BB, Taber LA, and Clark EB. Diastolic wall modulus and ventricular stiffness in the stage 16 to 27 chick
embryo. Circulation 1990;82(4)III-605.
12. Keller BB, Hu N, and Clark EB. Embryonic ventricular mechanics during early cardiac development resembles mature
pressure-volume relations. (the World Congress on Medical Physics and Biomedical Engineering, July 1991, Kyoto,
JAPAN)
13. Keller BB, Hu N, and Clark EB. Cardiac mechanics in the developing heart during normal and accelerated ventricular
growth. Ped Res 1991;29:20A
14. Campbell KA, Keller BB, Hu N, and Clark EB. Analysis of dynamic atrial dimension and function during early cardiac
development in the chick embryo. Ped Res 1991;29:15A.
15. Hu N, Keller BB, and Clark EB. The effect of bradycardia on systolic and diastolic time intervals in the stage 16 to 27
chick embryo. Ped Res 1991;29:19A.
16. Keller BB, Tinney JP, Hu N, and Clark EB. Ventricular end-diastolic and end-systolic relations in the embryonic chick
heart. Circulation 1991;84(4)II-188.
17. Taber LA, Yang M, Keller BB, and Clark EB. A poroelastic model for the trabeculated embryonic heart. Adv. Bioeng
(presented at 1991 ASME winter annual meeting).
Curriculum Vitae -- Bradley B. Keller, MD
17 Updated: April 23, 2012
18. Keller BB, Tinney JP, Hu N, and Clark EB. Embryonic ventricular pressure-volume mechanics. Ped Res 1992;31:235A.
19. Hu N, Taber LA, Keller BB, and Clark EB. Maintenance of ventricular relaxation rate in the growth accelerated embryo
heart in stage 21 to 29 chick. Ped Res 1992;31:19A.
20. Shafer NL, Smith DS, Babineau HP, Keller BB and Clark EB. Vitelline arterial dimensions during primary
cardiovascular development. Ped Res 1992;31:23A.
21. Keller BB, Tinney JP, Hu N. Arterial elastance in the stage 16 to 21 chick embryo. Circulation 1992;86(4)I-205.
22. Hu N, Keller BB, Clark EB. Effect of chronic verapamil treatment on ventricular relaxation rate in stage 21 to 29 chick
embryo. Circulation 1992;86(4)I-843.
23. Casillas CB, Tinney JP, Clark EB, Keller BB. Heart rate reserve during cardiovascular morphogenesis. (presented at the
Annual Conference of the Society for the Advancement of Chicanos and Native Americans in Science, Albuquerque,
New Mexico)
24. Cartmell J, Taber LA, and Keller BB. Epicardial ventricular strains during tachycardia in the stage 21 chick embryo. J.
Univ Rochester Medical Center 1993;4:26.
25. Taber LA, Lin IE, and Keller. Growth and deformation during cardiac looping: Observations and hypotheses.
proceedings of the 1993 ASME Bioengineering Conference, 1993;24:111-114.
26. Taber LA, Hu N, Murillo-Gonzales J, Clark EB, and Keller BB. Residual strain in the embryonic chick heart.
proceedings of the 1993 ASME Bioengineering Conference, 1993;24:115-118.
27. Keller BB, Tinney JP, and Hu N. Ventricular/vascular coupling in the stage 16 to 21 chick embryo. Ped Res
1993;33:22A.
28. Keller BB, Heller FA, and Tinney JP. Effect of isoproterenol induced vasodilation on ventricular pressure-volume
relations in the stage 21 chick embryo. Ped Res 1993;33:248A.
29. Casillas CB, Tinney JP, Clark EB, and Keller BB. Heart rate reserve during cardiovascular morphogenesis. Ped Res
1993;33:245A.
30. Keller B, Tinney J, Hu N, and Clark E. Embryonic ventricular pressure-volume relations in the stage 16 to 21 chick
embryo. Cardiology in the Young 1993;3:2.
31. Keller B, Murillo-Gonzalez J, Aguirra M, and Taber L. Geometric measures of the stage 9 to 14 embryonic chick heart:
relevance to hypotheses of growth and deformation during cardiac looping. Cardiology in the Young 1993;3:124.
32. Bowers P, Tinney JP, and Keller BB. Nitroprusside selectively reduces preload in the stage 21 chick embryo. Circulation
1993;88:I-148.
33. Hu N, Tinney JP, and Keller BB. Atrial pressure-volume loop characteristics in the stage 24 chick embryo. Ped Res
1994;35:36A.
34. Hu N, Hansen AL, Clark EB, and Keller BB.. Atrial natriuretic peptide reduces diastolic filling in the stage 21 chick
embryo. Ped Res 1994;35:36A.
35. Taber LA, Lin IE, Hu N, Clark EB, and Keller BB. Residual stress in the developing heart. Southern Biomedical
Engineering Conference, April 1994.
36. Bowers PN, Tinney JP, and Keller BB. Embryonic ventricular response to preload reduction produced by nitric oxide or
venous hemorrhage. (poster, AHA Scientific Conference on the Molecular, Cellular, and Functional Aspects of
Cardiovascular Development, New Orleans, 3/95)
Curriculum Vitae -- Bradley B. Keller, MD
18 Updated: April 23, 2012
37. Hu N, MacLennan MJ, Yoshigi M, and Keller BB. Atrial ejection volume matches ventricular active filling volume in
the stage 16 to 27 chick embryo. Ped Res 1995;37:27A.
38. Hu N, MacLennan MJ, Tinney JP, and Keller BB. Atrial pressure-volume loop characteristics in the stage 16 to 27
chick embryo. Ped Res 1995;37:27A.
39. Yoshigi M, Hu N, and Keller BB. Flow dependence of arterial impedance in stage 24 chick embryos. Ped Res
1995;37:38A
40. Bowers PN, Tinney JP, and Keller BB. Endogenous nitric oxide from L-arginine reduces preload in stage 21 chick
embryos. Ped Res 1995;37:21A.
41. Keller BB, MacLennan MJ, Tinney JP, and Yoshigi M. In vivo assessment of murine embryonic cardiovascular
function. FASEB J 1996;10:A581.
42. Hu N and Keller BB. Left atrial ligation alters intracardiac blood flow, cardiovascular growth, and function in the chick
embryo. FASEB J 1996;10:A312.
43. Tinney JP and Keller BB. Ventricular/vascular coupling and uncoupling in the embryonic cardiovascular system.
FASEB J 1996;10:A580.
44. Yoshigi M and Keller BB. Frequency domain and time domain analysis of characteristic impedance in the embryonic
chick vasculature. FASEB J 1996;10:A564.
45. Keller BB. Pulsed-Doppler investigation of embryonic cardiovascular function: applications and limitations. Ultrasound
Obst Gyn 1996;8:A57.
46. Keller BB, Miller CE, and Tsyvian P. Force-interval relationships and mechanical restitution in developing chick and
mouse myocardium. Circulation 1996;94:I120.
47. Keller BB, Hu N, Yoshigi M, Tsyvian P, and Miller CE. Future directions in the investigation of integrated embryonic
cardiovascular physiology and mechanics. poster, 2nd World Congress, Ped Card and Cardiac Surg, Honolulu, Hawaii.
48. Yoshigi M and Keller BB: Developmental changes in wave reflection in the chick embryonic vasculature. platform talk,
2nd World Congress, Ped Card and Cardiac Surg, Honolulu, Hawaii.
49. Hu N, Smith BR, Lai CT, and Keller BB: Dependence of aortic arch morphogenesis on intra-cardiac blood flow in the
chick embryo. FASEB J 1997;11:A16.
50. Keller BB, Miller CE, Tsyvian P, Routkevich S, and Protsenko Y: Force-interval relationships in developing chick
myocardium. Effect of ryanodine and hypercalcium solutions. (poster, 33rd
International Congress of Physiological
Sciences, IUPS 1997, St. Petersburg, Russia).
51. Keller BB, Hu N, Yoshigi M, Tsyvian P, and Miller CE: Investigations in embryonic cardiovascular development: in
vivo and in vitro models. 33rd International Congress of Physiological Sciences, IUPS 1997, St. Petersburg, Russia,
July 1997.
52. Sedmera D, Rychterova V, Keller BB, and Hu N. Changes in the myoarchitecture of the left atrial-ligated heart in the
stage 34 chick embryo. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.
53. Hu N, Lai CT, McNeil EM, and Keller BB. Diastolic filling characteristics following ventricular septation in the left
atrial ligated chick. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.
54. MacLennan MJ and Keller BB. Murine embryonic umbilical arterial velocity during development and following acute
increases in heart rate. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.
Curriculum Vitae -- Bradley B. Keller, MD
19 Updated: April 23, 2012
55. Furukawa S and Keller BB. Influence of pregnancy on systemic blood pressure in the anesthetized and conscious
mouse. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.
56. Yoshigi M and Keller BB. Pulsatile vascular hemodynamics in the developing chick embryo. poster, Weinstein
Cardiovascular Development Conference, Cincinnati, June 1997.
57. Mangold KA, Keller BB, and Truesdell SC: Prenatal diagnosis of Down syndrome and its impact on the prevalence and
outcome of congenital heart disease. J Univ Rochester 1997;9:51.
58. Keller BB and MacLennan MJ. Murine embryonic umbilical arterial blood flow during development and following
acutely increased heart rate. Circulation 1997;96:I513.
59. Solovyeva O, Katsnelson L, Romanchenko T, Tsyvian P, Routkevich S, Markhasin V, and Keller BB. Mathematical
modeling of active embryonic myocardium mechanics (1998 American Biophysical Society Annual Scientific Sessions).
60. Keller BB and MacLennan MJ. Cardiovascular phenotypic analysis of targeted mouse embryos. Human Genome
Applications to Cardiovascular Diseases, San Diego, CA, March, 1998.
61. MacLennan MJ, Tinney JP, and Keller BB: In situ measurement of ventricular blood pressure in the mouse embryo.
FASEB J 1998;12:A323.
62. McNeil EM, Campbell K, Keller BB, and Hu N: Effect of increased circulating volume on diastolic filling in the stage
21 chick embryo. FASEB J 1998;12:A323.
63. Tinney JP and Keller BB: Ventricular function after chronic conotruncal banding in the chick embryo. FASEB J,
1998;12:A324.
64. Hu N, McNeil EM, Weiss KM, Baggs R, and Keller BB: Apoptosis of ventricular myocytes following left atrial ligation
in the stage 34 chick. FASEB J 1998;12:A710.
65. Furukawa S and Keller BB: Murine maternal-embryonic coupling during acute maternal hypoxia. FASEB J
1998;12:A998.
66. Tobita K and Keller BB: Average systolic myocardial stiffness is a load independent index of contractility in the
embryonic chick heart. Weinstein Cardiovascular Development Conference, Nashville, May 1998.
67. Tinney JP and Keller BB: Ventricular function after chronic conotruncal banding in the chick embryo. Weinstein
Cardiovascular Development Conference, Nashville, May 1998.
68. Furukawa S and Keller BB: Murine maternal-embryonic coupling during acute maternal hypoxia. Weinstein
Cardiovascular Development Conference, Nashville, May 1998.
69. MacLennan MJ, Tinney JP, and Keller BB: In situ measurement of ventricular blood pressure in the mouse embryo.
Weinstein Cardiovascular Development Conference, Nashville, May 1998.
70. Yoshigi M and Keller BB: Pulsatile energy expenditure in the embryonic arterial system. Third World Congress of
Biomechanics. Sapporo, JAPAN, August, 1998.
71. Keller BB: Function, biomechanics, and control of the developing cardiovascular system. The Fifth International
Symposium on Etiology and Morphogenesis of Congenital Heart Disease, Tokyo, Japan, December, 1998.
72. Smith B, Lo CW, Keller BB, and Hu N: Magnetic resonance imaging and analysis of the embryonic and fetal heart.
The Fifth International Symposium on Etiology and Morphogenesis of Congenital Heart Disease, Tokyo, Japan,
December, 1998.
Curriculum Vitae -- Bradley B. Keller, MD
20 Updated: April 23, 2012
73. Tobita K and Keller BB: Developmental change of end-systolic stress-strain relations in chick embryonic ventricle.
FASEB J 1999.
74. Schroder EA, Tsyvian PB, and Keller BB: Force-velocity relations in the developing chick myocardium. FASEB J
1999.
75. Tobita K and Keller BB: Right and left ventricular epicardial strains in normal developing chick embryonic hearts.
Weinstein Cardiovascular Development Conference, Tucson, May 1999.
76. Tobita K and Keller BB: Developmental change in ventricular contractility determined from end-systolic stress-strain
relations in the chick embryo. Weinstein Cardiovascular Development Conference, Tucson, May 1999.
77. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Force-frequency relationship in developing chick myocardium:
Effects of nickel and mibefradil. Weinstein Cardiovascular Development Conference, Tucson, May 1999.
78. Keller BB, EA, Satin J, Tsyvian PB, and Schroder EA: Sensitivity of force-interval relationships in developing chick
myocardium to Ca2+ channel blockade. 2000 Biophysical Society Meeting, New Orleans, LA.
79. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Sensitivity of force-frequency relations in developing chick
myocardium to Ca channel blockade. J Mol Cell Cardiol 2000;32:A76.
80. Schroder EA and Keller BB: Effect of temperature on force-velocity relations in stage 24 embryonic chick
myocardium. J Mol Cell Cardiol 2000;32:A77.
81. Tobita K and Keller BB: Epicardial strain patterns in normal and left heart hypoplasia embryonic chick ventricles. J
Mol Cell Cardiol 2000;32:A28.
82. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Force-frequency relations in developing chick myocardium. Exp
Clin Cardiol 2000;5:47.
83. Tobita K and Keller BB: RV and LV epicardial strain patterns in normal embryonic chick heart and following left
heart hypoplasia. Exp Clin Cardiol 2000;5:50.
84. Tobita K and Keller BB: Mechanical regulation of left ventricular development in embryonic chick ventricle.
Weinstein Cardiovascular Development Conference, St. Louis, June 2000.
85. Schroder EA and Keller BB: Effects of temperature on force-velocity relations in the developing chick myocardium.
Weinstein Cardiovascular Development Conference, St. Louis, June 2000.
86. Tobita K, Schroder EA, Tinney JP, and Keller BB: Passive biaxial ventricular pressure-strain relations during normal
development and altered loading conditions in the chick embryo. Weinstein CV Development Conference, Dallas, May
2001.
87. Tobita K, Tinney JP, and Keller BB: Assessment of embryonic mouse heart function using Doppler echocardiography
and maternal isoflurane anesthesia. Weinstein Cardiovascular Development Conference, Dallas, May 2001.
88. Sedmera D, Hu N, Keller BB, Denslow S, and Thompson RP: Label-dilution approach to study changes in cell
proliferation: a teratologist’s dream come true. Weinstein Cardiovascular Development Conference, Dallas, May 2001.
89. Keller BB, Tinney JP, and Tobita K: Cardiovascular phenotype assessment using transabdominal echocardiography
and maternal anesthesia. Poster, World Congress of Pediatric Cardiology and Cardiac Surgery, Toronto, May 2001.
90. Tobita K, Tinney JP and Keller BB: Passive biaxial ventricular wall stress-strain relations during normal and altered
load in the chick embryos. Experimental Biology, Orlando, FL 2001.
Curriculum Vitae -- Bradley B. Keller, MD
21 Updated: April 23, 2012
91. Garrison JB, Tobita K, Keller BB: Effects of cyclic stretch stimulation on embryonic ventricular cell orientation and
shape. University of Kentucky Gill Cardiovascular Research Symposium, Lexington, KY, October 2001.
92. Schroder EA, Tobita K, Tinney JP, Foldes J, and Keller BB: Microtubule involvement in the adaptation to altered
mechanical load. Biophysics Society Meeting, San Francisco, CA, February 2002.
93. Tobita K, Garrison JB, and Keller BB: Three-dimensional fiber architecture of the embryonic left ventricle during
normal development and reduced mechanical load. Weinstein Cardiovascular Development Conference, Salt Lake City,
May 2002.
94. Schroeder EA, Tobita K, Tinney JP, Foldes J, and Keller BB: Microtubule involvement in the adaptation to altered
mechanical load in developing chick myocardium. Weinstein Cardiovascular Development Conference, May 2002.
95. Poma CP, Shulimovich M, Tobita K, Keller BB, Pennisi D, and Mikawa T. Hemodynamics induce and pattern
purkinje fiber differentiation. Weinstein Cardiovascular Development Conference, Salt Lake City, May 2002.
96. Tobita K, Garrison JB, and Keller BB: Developmental change of three-dimensional fiber architecture of the
embryonic left ventricle during reduced mechanical load. Comparative Physiology Roundtable Meeting, Glenn Rose,
TX 2002.
97. Tobita K, Garrison JB, and Keller BB: Differential effects of cyclic stretch on embryonic ventricular myocyte and non-
myocyte orientation. Etiology and Morphogenesis of Congenital Cardiovascular Disease in the Post-Genomic Era: New
Takao Symposium, Tokyo, Japan, December 2002
96. Tobita K, Tinney JP, and Keller BB: Residual strain in embryonic left ventricle following normal and altered
mechanical
load in the chick embryo. Weinstein Cardiovascular Development Conference, Boston, MA, May 2003.
97. Nordman CR, Tobita K, Lucitti JL, and Keller BB: Impact of chronic hypoxia exposure on vascular impedance in
early developing chick embryo. 2003 Children's Hospital of Pittsburgh Summer Student Research Poster Session,
August 2003
98. Nonemaker JL, Tobita K, Liu LL, and Keller BB: Response of microtubule network to mechanical stretch in embryonic
ventricular cells. 2003 Children's Hospital of Pittsburgh Summer Student Research Poster Session, August 2003
99. Tobita K, Liu JL, and Keller BB: Engineered three-dimensional cardiac tissue from early embryonic chick
myocardium. Tissue Engineering Society International, 6th Annual International Conference and Exposition, Orlando,
FL, October 2003
100. Sharma S, Tobita K, Tinney JP, and Keller BB: Regulation of cardiovascular structure and function by oxygen
tension in chick embryos. 2004 American Heart Association Research Fellow Symposium, Pittsburgh, February 2004
101. Lucitti JL, Tobita K, and Keller BB: Impact of altered mechanical load on dorsal aortic impedance in the developing
chick embryo. 2004 McGowan Institute for Regenerative Medicine Planning Retreat. Nemacolin, February 2004
102. Tobita K, Liu LL, Tinney JP, and Keller BB: Engineered embryonic cardiac tissue: Initial Experience. 2004 McGowan
Institute for Regenerative Medicine Planning Retreat. Nemacolin, February 2004
103. Saaloukeh ME, Tobita K, Momoi N, Tinney JP, Keller BB: Adverse effects of caffeine on embryonic cardiac function
during early cardiac morphogenesis. Midwest Society for Pediatric Research Meeting, St. Louis, MO, 2004.
104. Tobita K, Liu LJ, Janczewski AM, Shroff SG, Keller BB: Three-dimensional engineered early embryonic cardiac tissue
(EEECT). Joint meeting of the Tissue Engineering Society International and the Europe Tissue Engineering Society,
Lausanne, Switzerland, 2004
105. Lucitti JL, Tobita K, and Keller BB: Altered mechanical load impacts arterial hemodynamics and structure during
cardiogenesis. Experimental Biology 2004. FASEB JOURNAL v.18(#4), pp. A1247-A1247. 2004.
Curriculum Vitae -- Bradley B. Keller, MD
22 Updated: April 23, 2012
106. Lucitti JL, Tobita K, Keller BB: Impact of altered mechanical load on dorsal aortic impedance during cardiovascular
morphogenesis. Weinstein Cardiovascular Development Research Meeting, Leiden, Netherlands 2004
107. Momoi N, Tobita K, Tinney JP, Saaloukeh ME, Liu JL, Elshershari H, Keller BB, Adverse effects of caffeine on
embryonic cardiac function during early cardiac morphogenesis. PAS meeting, Washington DC, 2005
108. Manole MD, Hickey RW, Momoi N, Tobita K, Tinney JP, Gabriel S, Clark R, Keller BB. Preterminal gasping is
associated with increased cardiac output and increased time till cardiac arrest in immature rats exposed to anoxia. PAS
meeting, Washington DC, 2005
109. Lucitti JL, Tobita K, and Keller BB. Impact of altered mechanical load on dorsal aortic impedance during
cardiovascular morphogenesis. 2004 Weinstein Cardiovascular Development Meeting. Leiden, the Netherlands.
110. Tobita K, Liu LJ, Janczewski AM, Shroff SG, Keller BB: Three-dimensional engineered early embryonic cardiac
tissue (EEECT). Tissue Engineering Society International 7th
Annual International Conference and Exposition and
joint meeting of the Tissue Engineering Society International and the Europe Tissue Engineering Society, Lausanne,
October, 2004.
111. Fujimoto, KL, Tobita K, Momoi N, Keller BB, Guan J, and Wagner WR : Cardiac remodeling by elastic biodegradable
cardiac patch covering the infarction area. 2005 McGowan Institute for Regenerative Medicine Planning Retreat.
Nemacolin, March 2005
112. Lucitti JL and Keller BB: Increased arterial load impacts pulse wave velocity in chick embryos. Experimental Biology
2005, San Diego, CA
113. Tobita K, Liu JL, Janczewski AM, Tinney JP, Nonemaker JM, Augustine S, Stolz DB, Shroff SG, Keller BB.
Engineered early embryonic cardiac tissue (EEECT) retains proliferative and contractile properties of developing
embryonic myocardium. Weinstein Cardiovascular Development Research Meeting, St. Petersburg, FL 2006
114. Fujimoto KL, Tobita K, Momoi N, Keller BB, Guan J, Wagner WW : Elastic, biodegradable cardiac patch induces
contractile smooth muscle bundles in sub-acute myocardial infarction, improving cardiac remodeling and function.
American Heart Association 2005 Scientific Sessions, Dallas, TX
115. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB, Peault B, Huard J. Identification of a
progenitor cell population from human skeletal muscle that is superior to committed skeletal myoblasts for cardiac cell
therapy. AHA-BCS meeting, Denver, CO, 2006.
116. Keller BB, Liu LJ, Tinney JP, Tobita K. Lessons from embryos: insights into cardiovascular morphogenesis and
adaptation. World Congress of Biomechanics, Munch, Germany, 2006.
117. Tobita K, Choi B, Liu LJ, Chey E, Tinney JP, Salama G, Keller BB. Impact of cyclic electric stimulation on
engineered early embryonic cardiac tissue. World Congress of Tissue Engineering, Pittsburgh, PA 2006.
118. Ahmad F, Lage ML, Janczewski AM, Tobita K, Smith S, Saba S, Conner DA, Tinney JP, Ragwe J, Moskiwitz IP,
Perez-Atayde AP, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG. Cardiomyopathies secondary to
cardiac troponin T mutations result from abnormal protein function rather than haploinsufficiency. AHA annual
meeting, Chicago, 2006.
119. Funari BJ, Witt MR, Clause KM, Keller BB, Tobita K, Ralphe JC. The impact of energy substrate on contractile
performance in a neonatal rat engineered cardiac tissue model. 2007 Pediatric Academic Societies’ meeting, Toronto,
2007.
120. Kreutzer J, Emery SP, Sherman FR, Fujimoto KL, Jaramaz B, Nikou C, Tobita K, and Keller BB. Novel computer
assisted electromagnetic navigation for prenatal catheter intervention. Pediatric Interventional Cardiac Catheterization
Conference, Las Vegas, NV, 2007
Curriculum Vitae -- Bradley B. Keller, MD
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121. Clause K, Tinney JP, Liu JL, Keller BB, Tobita K. p38 MAP-kinase regulates engineered early embryonic cardiac tissue
proliferation and contractile properties. Weinstein Cardiovascular Development Research Meeting, Indianapolis, IN
2007.
122. Clause K, Tinney JP, Liu JL, Burhan B, Fujimoto KL, Wagner W, Ralphe JC, Keller BB, Huard J, Tobita K.
Functioning engineered cardiac tissue from skeletal muscle derived stem cells. Weinstein Cardiovascular Development
Research Meeting, Indianapolis, IN 2007.
123. Momoi N, Tinney K, Liu JL, Elshershari H, Hoffman P, Ralphe JC, Keller BB, Tobita K. Modest maternal caffeine
exposure affects developing embryonic cardiovascular function and growth. Weinstein Cardiovascular Development
Research Meeting, Indianapolis, IN 2007.
124. Paladino LK, Keller SJ, Keller JM, Farrington J, Andre D, Wolf D, Gu H, Wang SB, Keller BB. Heart Rate, Oxygen
Saturation, and Blood Pressure Response to Exercise in Children With and Without Congenital Heart Disease at High
Altitude in the Tibet Autonomous Region, PRC. 2007 Children's Hospital of Pittsburgh Summer Student Research
Poster Session.
125. Park G, Clause KC, Tinney JP, Liu JL, Gharaibeh B, Fujimoto KL, Wagner W, Huard J, Keller BB, Tobita K.
Cardiomyocyte induction from skeletal muscle derived stem cells (MDSCs) using MDSC sphere formation and 3-
dimensional MDSC-engineered cardiac tissue construction. 2007 Children's Hospital of Pittsburgh Summer Student
Research Poster Session.
126. Freytes DO, Tobita K, Tinney JP, Keller BB, Wainwright JW, Martin J, Velankar SS, Badylak SF. Extracellular
Matrix Derived Gel for Cardiac Tissue Engineering Applications. International Biomaterial Meeting, Orlando, FL,
2007
127. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB. Phillippi JB, Peault B, Huard J.
Identification of a lineage of myogenic-endothelial cells in adult human skeletal muscle that are superior to myoblast
for myocardial infarct repair. 5th Annual Meeting International Society for Stem Cell Research Cairns, Australia,
2007.
128. Fujimoto KL, Tobita K, Guan J, Keller BB, Wagner WR. Elastic, biodegradable cardiac patch implantation induces
embryonic-like cellularization in the post-infarct ventricular wall. AHA annual meeting, Orlando, FL, 2007.
129. Emery SP, Kreutzer J, Sherman F, McCaffery F, Keller BB. Learning curve for a fetal cardiac intervention team.
Society for Maternal-Fetal Medicine 28th Annual Scientific Meeting, Dallas, TX, 2008.
130. Wang Y, Dur O, Patrick MJ, Tinney JP, Tobita K, Pekkan K, Keller BB. Hemodynamic investigation of normal
developing aortic arch in the chick embryo. ASME 2008 Summer Bioengineering Conference (SBC2008) Marco
Island, Florida, USA
131. Drummond A, Keller BB, Borovetz HS, Antaki JF. Anatomic database for insertion of VADS in infants and young
children.ASME 2008 Summer Bioengineering Conference (SBC2008) Marco Island, Florida, USA
132. Drowley L, Okada M, Tobita K, Keller BB, Huard J. Treatment of muscle stem cells with N-acetylcysteine increases
survival and resistance to stress. Tissue Engineering and Regenerative Medicine International Society 2008.
133. Wang Y, Patrick MJ, Dur O, Keller BB, Pekkan K. Hemodynamic investigation of normal aortic arch development
in the chick embryo. Carnegie Mellon University 2008 Bioimaging Conference, Pittsburgh, PA
134. Dur O, Pekkan K, Dasi LP, Keller BB, Fogel MA, Yoganathan A. In vitro hemodynamics of embryonic aortic arch
with tetralogy of Fallot at late gestation. 2008 CalTech Biofluids Conference, Pasadena, CA
135. Ralphe JC, Witt M, Kirk J, Clause KM, Keller BB, Tobita K. Engineered Neonatal Rat Cardiac Tissue Models
Immature in vivo Myocardium. American Heart Association 2008 Scientific Sessions, New Orleans, LA. Circulation
2008;118:S 281
Curriculum Vitae -- Bradley B. Keller, MD
24 Updated: April 23, 2012
136. Drowley L, Cassino T, Okada M, Tobita K, Keller BB, LeDuc P, Huard J. Stem Cell Transplantation for Cardiac
Repair is improved by Mechanical Preconditioning. Experimental Biology 2009.
137. Clause K, Li, JL, Powell MC, Keller BB, Gharaibeh B, Huard J, Tobita K. Skeletal muscle specific fast myosin heavy
chain is present in the developing ventricular myocardium. NHLBI Symposium on Cardiovascular Regenerative
Medicine, Bethesda, October, 2009
138. Dur O, Wang Y, Patrick MJ, Tinney J, Keller BB, Pekkan K. Correlation of wall shear stress and pharyngeal arch
lumen diameter during early embryonic development in the chick, Biomedical Engineering. Society Annual Fall
Meeting, Pittsburgh, PA, October 2009.
139. Clause KC, Tinney JP, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller BB,
Tobita K. Impact of cyclic mechanical stretch on muscle stem cell derived cardiomyocyte 3D engineered tissue.
Biomedical Engineering. Society Annual Fall Meeting, Pittsburgh, PA, October 2009.
140. Pekkan K, Jamaly M, Kara B, Sotiropoulos F, Keller BB. Early embryonic intra-cardiac flow fields at three idealized
ventricular morphologies, APS Division of Fluid Dynamics 62nd Annual Meeting, November 2009
141. Kowalski WJ, Dur O, Keller BB, Pekkan K. Investigating the growth and remodeling of the embryonic aortic arch
manifold through a CFD coupled 2D optimization framework. Sixth MIT Conference on Computational Fluid and
Solid Mechanics, Cambridge, MA, June 2010
142. Jackson D, Blake J, Miller D, Naber J, Walsh K, Woods C, Keller BB, Reimer P, Beeler S. A Wireless Body
Temperature Monitor for the Prevention of Febrile Seizures. 6th Annual Kentucky Innovation and Entrepreneurship
Conference, Lexington, K, 2010
143. Keller BB, Downs-Canner S, Hornung CA, Gu H. Detection of congenital heart disease using 5 minute exercise
screening for high altitude, rural Tibetan children. 20th World Congress of the World Society of Cardio Thoracic
Surgeons, Chenai, India, October 2010.
144. Geppert M, Wang SB, Laba ZM, Ren QCW, Meiji M, Kai W, Ng L, Geppert M, Neches WH, Yong BH, Nakanishi T,
Gu H, Keller, BB. Mid-term results of the screening and treatment of congenital heart disease at high altitude: The
Touching Hearts in Tibet Program. 20th World Congress of the World Society of Cardio Thoracic Surgeons, Chenai,
India, October 2010.
145. Wang Y, Ferreira A, Keller BB, Simon M, Antaki JF. Effect of continuous-flow left ventricular assist device on
cardiac function: simulation study with a refined computer model. ASME 2011 Summer Bioengineering Conference
SBC2011, June 22-25, Farmington, PA
146. Tchao JS, Clause KC, Keller BB, Huard J, Shroff S, Franks J, Davidson L, Tobita K. Local mechanical strain
influences cardiomyocyte differentiation in skeletal muscle stem cell within 3-dimensional collagen gel bioreactor.
NHLBI Symposium on Cardiovascular Regenerative Medicine, DC, 2011.
147. Black AK, Raymon S, Hornung C, Mascio C, Keller BB. Interim results of the pediatric cardiovascular home
telehealth project. Research Louisville!2011. Louisville, KY October, 2011
148. Sadanala U, Ymalay R, Raymon S, Tinney JP, Kriss V, Keller BB. Initial observations using high resolution
VEVO2100 ultrasound imaging in neonates. Research Louisville!2011. Louisville, KY October, 2011
149. Kmetz DJ, Tinney JP, Dale J, Krishnan L, Hoying JB, Keller BB. Characterization of vascular maturation within
engineered cardiovascular tissues. Research Louisville!2011. Louisville, KY October, 2011
Curriculum Vitae -- Bradley B. Keller, MD
25 Updated: April 23, 2012
150. Ymalay R, Sadanala U, Tinney JP, Kriss V, Keller BB. Initial observations and limitations of VEVO2100 high
resolution ultrasound imaging in neonates. Souther Society for Pediatric Research, New Orleans, February 2012.
Accepted for poster presentation.
151. Black AK, Raymon S, Hornung C, Mascio C, Keller BB. Interim results of the pediatric cardiovascular home
telehealth project. American Pediatric Society, Boston, MA, May 2012 (in review)
152. Ymalay R, Sadanala U, Tinney JP, Kriss V, Keller BB. Initial observations and limitations of VEVO2100 high
resolution ultrasound imaging in neonates. American Pediatric Society, Boston, MA, May 2012 (in review)
L. Patent Filings
1. Biodegradable Elastomeric Patch for Treating Cardiac or Cardiovascular Condition. Inventors: William Wagner, Kazuro L.
Fujimoto, Kimimasa Tobita, Bradley B. Keller. University of Pittsburgh. Serial No.: 60/808,980 Filed June 27, 2006, Country:
US-Provisional
2. Functioning Cardiomyocyte Induction from Skeletal Muscle Derived Stem Cell using Rotation and 3-Dimensional Collagen
Culture. Inventors: Kimimasa Tobita; Johnny Huard; Kazuro L. Fujimoto; Bradley B. Keller. IDF 1518. Disclosure Filed
June 27, 2007. University of Pittsburgh
Curriculum Vitae -- Bradley B. Keller, MD
26 Updated: April 23, 2012
M. Research Funding
GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT
Ventricular Mechanics in the Developing Chick Heart. 07/01/88 - 06/31/90 $53,400
PI, 85% FTE, NIH-NRSA #F32-HL07824.
Ventricular Mechanics in the Chick Embryo 07/01/90 - 06/31/95 $371,730
PI, 85% FTE, NIH-PSA-K11-HL02498.
Calcium Kinetics in the Embryonic Chick Myocyte 07/01/91 - 06/31/93 $6,000
PI, Univ. of Roch. Strong Childrens Research Center
Ventricular Mechanics in the Developing Embryonic Heart 07/01/91 - 06/31/96 $854,095
L. Taber, PI, B. Keller, co-PI, 10% FTE, NIH-RO1-HL46367.
Ventricular/Vascular Coupling in the Chick Embryo 07/01/93 - 06/31/96 $118,000
PI, 20% FTE, American Heart Association, Grant-in-Aid, 93-1013
NIH SCOR: Bench to Bedside, Biomechanics of the 05/31//93 - 12/31/98 $4,750,000
Developing Cardiovascular System. 75% FTE, NIH-P50-HL51498
E. Clark, PI 1/1/93 - 5/31/95, B. Keller, PI 5/31/95 – 12/31/98
Murine Embryonic Cardiovascular Functional Maturation 07/01/95 - 06/31/96 $15,000
PI, 15% FTE, Strong Childrens Research Center
Mechanical Properties of Chick Embryonic Myocardium 07/01/95 - 06/31/98 $60,000
Fogarty International Award. B. Keller, P.I., 5% FTE;
P. Tsyvian, Russian collaborator, NIH-RO3-TW00527
Active Myocardial Mechanics During Development and Disease 07/01/97 - 06/31/99 $45,000
PI, 5% FTE, Civilian Research and Development Foundation, #5270
V. Markhasin, Russian co-PI
In Utero Murine Embryo CV Phenotype Screening 09/01/00 - 07/31/04 $1,480,897
B. Keller, PI, 30% FTE, NHLBI RFA RO1 HL65219-01
Adaptation of the embryonic myocardium to altered load. 02/01/01 - 01/31/05 $1,421,951
B. Keller, PI, 30% FTE, NHLBI RO1 HL64626-01-A1
Modulation of T-type Calcium Channels. J. Satin, P.I. 07/01/00 - 06/31/04 consultant
NHLBI RO1 HL63416-01 B. Keller, consultants
Biomechanical Adaptation of Embryonic Myocardium to 09/01/00 - 08/31/03 $18,000
Chronic Hemodynamic Alteration. NATO Collaborative Linkage Grant.
B. Keller, PI, P. Tsyvian, Partner Country PI
Prenatal Fetal Cardiovascular Interventions 10/01/03 – 09/31/04 $58,500
PNC Charitable Trust. B. Keller, PI
Novel Technology Development for Fetal Cardiac Intervention 12/01/03 - 11/31/04 $60,000
Pittsburgh Life Science Greenhouse award to Verimetra, Inc,
B. Keller, PI CHP subcontract
NIH SBIR Circulatory Support Device for Toddlers/Small Children 02/04 - 01/05 consultant
J. Antaki (Launch Point Technologies), PI, B. Keller, CHP subcontract PI, 3% FTE
Curriculum Vitae -- Bradley B. Keller, MD
27 Updated: April 23, 2012
GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT Prenatal Fetal Cardiovascular Interventions 10/01/03 – 09/31/04 consultant
NHLBI Phase I SBIR, CASurgica, Inc, B. Keller, CHP consultant R43HL076961-01
NHLBI RFA SCCOR in Pediatric Cardiovascular Disease 01/01/04 - 12/31/09 $13,450,000
Optimizing Outcomes After Pediatric Heart Transplantation
S. Webber, PI, B. Keller, co-PI, 10% FTE P50-HL074732-02
NIH BAA Pediatric Ventricular Assist Device for the 3 to 15 Kilogram 03/15/04 – 02/14/09 $4,490,691
Patient. H. Borovetz, PI, B. Keller, CHP subcontract PI, 8% FTE NIH- HSN268200448192C
Engineered Early Embryonic Cardiac Tissue (EEECT) 05/15/05 - 03/31/07 $387,665
B. Keller, PI, 20% FTE, NHLBI R21 HL079998-01
Prenatal Fetal Cardiovascular Interventions 04/01/06 – 03/31/08 $272,875
NHLBI Phase II SBIR, CASurgica, Inc, B. Keller, PI CHP subcontract, 15% FTE,
NIH/NHLBI 2R44 HL076961-02A1
Tissue Engineered Grafts for Congenital Heart Surgery 7/1/06 – 5/31/07 $60,000
PA Department of Health, MIRM, B. Keller, PI
MEMS Blood Pressure Sensor for Pediatric VAD 07/01/07 - 05/31/08
B. Norling, PI (Launchpoint Technologies), B. Keller, consultant
NIH SBIR R43-HL087446-01-A1
Bioengineering Analysis of Embryonic Hypoplastic Aortic Arch 07/01/07 – 06/31/09 $132,000
During the Period of Arterial Morphogenesis. K. Pekkan (CMU), PI, B. Keller, Co-I,
Mid-Atlantic AHA Affiliate Beginning Grant-in-Aid
Mitochondrial Maturation and Function in the Engineered Embryonic 07/01/07 – 06/31/09
Heart Model J. Carter Ralphe, PI, B. Keller, consultant, Mid-Atlantic AHA Affiliate Grant-in-Aid
Engineered Cardiac Tissues for Pediatric and Adult Patients 7/1/07 – 5/31/08 $60,000
PA Department of Health, MIRM, B. Keller, PI
VisualSonics Vevo770 Ultrasound Biomicroscopy and Microinjection Core. 09/29/0 7 377,815
B. Keller, PI NCRR/NIH 1S10RR024741-01
Magnetic Navigated Image Overlay for Vascular Access- MNIO-VA 12/1/07 – 07/31/09 147,279
B. Keller, PI, NIH 1R41HL091553-01
Engineered Early Embryonic Cardiac Tissue 07/01/08 – 06/31/12 1,817,125
B. Keller, PI, NHLBI RO1 HL085777-01-A2
PELEX-C: A high-resolution wireless ECG system for infants/children 09/01/08 – 08/31/09 155,815
B. Keller, PI (PinMed, Inc). NIH R41HL093953-01
Ultrasound-Enhanced Gene Delivery Validation in Genetic Mouse Models 07/01/08-06/31/09 50,000
E. Goetzman and B. Keller co-PIs, VisualSonics, Inc. product enhancement grant
Three-Dimensional Cardiac Gel Bioreactor for Functioning 07/01/09 – 11/30/11 250,000
Cardiomyocyte Induction from Human Skeletal Muscle Derived Stem Cells
K. Tobita PI, B. Keller, co-I, NHLBI R21 HL094402-01
Curriculum Vitae -- Bradley B. Keller, MD
28 Updated: April 23, 2012
GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT A Wireless Temperature Monitor for Children 01/01/10 – 12/31/10 75,000
J. Naber, PI, B. Keller, co-PI (5% FTE) and Simon Sounds, Inc. Kentucky Commercialization Funds
University of Louisville Pediatric Home TeleHealth Demonstration 07/01/10 – 06/31/12 $200,000
Project: Home TeleCare for High-Risk Pediatric Cardiac Patients
B. Keller, PI (10% FTE). University of Louisville Clinical Translational Science Pilot Project Program
Regenerative Potential of Umbilical Cord Derived Mesenchymal Stem 08/01/11 – 07/31/12 $50,000
Cells in Pediatric Cardiovascular Repair.
L. Krishnan, PI, B. Keller, co-PI (NSS). Kosair Charities Pediatric Heart Research Program Pilot Grant
RESEARCH PROPOSALS IN REVIEW Aortic Arch Biomechanical Selection and Remodeling in the Chick Embryo (04/01/12 -03/31/17) $1,109,931
K. Pekkan, M-PI, B. Keller, M-PI NIH 1R01HL111387-01A1(15th percentile)
A non-contact, low-cost, passive blood pulse profilometer for the 07/01/12 – 12/31/12 $17,112
assessment of CV health and the long term monitoring of CV history
J. Hay (RDI, Inc) PI, B. Keller, co-I (5% FTE) NIH R43 HL110578-01A1
A disposable immunoassay for rapid diagnosis of cardiac and 07/01/12 – 06/30/13 NSS
inflammatory events.
A. Gandini (Tropical Health Systems, LLC) PI, B. Keller, consultant (NSS) NIH R43 SBIR Phase I
Blood filtration system for the treatment of severe malaria patients 07/01/12 – 06/30/13 NSS
inflammatory events.
A. Gandini (Tropical Health Systems, LLC) PI, B. Keller, consultant (NSS) NIH R43 SBIR Phase I
Multidisciplinary Training in Cardiovascular Research. 12/01/12 -11/30/17 NSS
A. Batnagar, PI, B. Keller, mentor NIH NHLBI T32
Pediatric Asthma Care Integration and Point-of-Care Innovation 04/01/12 – 03/31/15 $9,217,849
B. Keller, PI CMMI Grants.gov Tracking Number:GRANT11043612
RESEARCH PROPOSALS IN REVISION
University of Louisville’s Clinical and Translational Sciences Institute 07/01/1* – 06/31/1*
C. McClain, PI, B. Keller, co-I (15% FTE) NIH U54 RR026087-01-A3
Pressure-Flow Relations and Mechanical Support in Failing Fontan 12/01/1* – 11/30/1*
K. Pekkan, PI, B. Keller, co-I, NHLBI R21 (in revision)
Comparative Effectiveness of Ultrasound-Guided Nerve Blocks vs. 01/01/1* – 12/31/1*
Procedural Sedation for Pediatric Orthopedic Injuries"
K. Cross, PI, B. Keller, Primary Mentor, NIH K23 HD068551-01 (NSS)
Ultra-thin Anisotropic Conducting Cardiac Biofabric. 12/01/1*– 11/30/1*
E. Boland, PI, B. Keller, co-I , 1R01 HL105724-01A1
Three-Dimensional Heart Patch for Ischemic Myocardium 07/01/1* – 06/31/1*
S. Williams, PI, B. Keller, co-I (5% FTE), NIH 1R01 HL106095-01
A non-contact, low-cost, passive respiration monitor capable for use 07/01/1* – 06/30/1*
in detecting apnea and respiratory function
J. Hay (Research, Design, and Innovation Tech.) PI, B. Keller, co-I (5% FTE) NIH R43 SBIR Phase I
Curriculum Vitae -- Bradley B. Keller, MD
29 Updated: April 23, 2012
MENTORED TRAINING GRANTS
GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT Creation and Palliation of Functional and Structural 07/01/98 - 06/31/00 $70,000
Cardiovascular Defects in Chick Embryos. K. Tobita, fellow, B. Keller, sponsor AHA Fellowship Award (NY State
Affiliate)
Functional Maturation of Embryonic Myocardium. 07/01/99 - 06/31/02 $135,000
E. Schroder, PI, B. Keller, sponsor, 1F32-HL10200 NIH-individual NRSA post-doctoral fellowship award
Functional Maturation of Embryonic Myocardium. 07/01/99 - 06/31/01 $50,000
E. Schroder, PI, B. Keller, sponsor AHA, Ohio Affiliate, Individual post-doctoral fellowship award (declined due to NIH award)
NHLBI RFA SCCOR in Pediatric Cardiovascular Disease 01/01/04 - 12/31/09 $500,000
Optimizing Outcomes After Pediatric Heart Transplantation, B. Keller, PI, Clinical Research Training Core
NHLBI Cardiovascular Bioengineering Training Grant. 02/01/05 - 01/31/10 mentor
S. Shroff, NIH T32HL76124-01 A1 PI, B. Keller, faculty mentor
Functional Maturation of Embryonic Myocardium. 05/01/05 - 04/30/10 $633,150
NIH clinician/scientist training award K08 NIH HL074224-A1, J. Carter Ralphe, PI, B. Keller, sponsor
Simulation of Optimal Surgical Insertion of a Pediatric Ventricular 07/01/07 – 06/31/12 mentor
Assist Device. NIH K31 HL090267-01. A. Drummond, PI, B. Keller, mentor
Role of mechanical forces on cardiomyocyte induction from 07/01/08 – 06/31/10 mentor
skeletal muscle derived stem cells in 3D culture. AHA pre-doctoral fellowship. K. Clause, PI
Are Overweight Children with T1DM at Increased Risk of 07/01/08 – 06/31/11 mentor
Cardiovascular Disease? American Diabetes Association Beginning Faculty Award I. Libman, PI
Are Overweight Children with T1DM at Increased Risk of 07/01/08 – 06/31/13 mentor
Cardiovascular Disease? NIH clinician/scientist training award K23 HL085287-01-A2 I. Libman, PI
Oxidative stress in regional cerebral blood flow alterations 07/01/08 – 06/31/13 mentor
after pediatric cardiac arrest. NIH clinician/scientist training award K08 HD058798-01 M. Manole PI
Curriculum Vitae -- Bradley B. Keller, MD
30 Updated: April 23, 2012
CLINICAL RESEARCH GRANTS AND PROTOCOLS
PATH-1, Pediatric use of Amlodipine in the Treatment of 07/01/99 - 06/31/00 $75,000
Hypertension. Pfizer Central Research, J.D. Moore, site-PI, University of Kentucky, B. Keller, co-P.I.
Long-term Outcomes in Adult Congenital Heart Disease 07/01/00 - 07/31/02
B. Keller, PI, IRB#00-0482-P1R (University of Kentucky)
Anatomic Modeling of Pediatric Patients for PVAD 07/01/06 – 06/30/08
B. Keller, PI, CORID #85 (University of Pittsburgh)
Accuracy of Heart Rate and Oxygen Saturation Response to Exercise 07/01/07 – 05/01/09
At High Altitude (Tibet) to Detect Congenital Heart Disease, B. Keller, PI, SEAPC
University of Pittsburgh IRB Protocol #PRO08030108 Approved 5/12/08 (200 subjects)
PELEX-C: A high-resolution wireless ECG system for infants/children 07/01/07 – 05/01/09
B. Keller, PI, NIH/NHLBI, University of Pittsburgh IRB Protocol #PRO07100403 (5/15/08 -5/1/09)
Pediatric Cardiovascular Home Telehealth Project 12/22/11 – 12/21/12
B. Keller, PI, University of Louisville IRB Protocol # 10.0619, NHORA# 10.0201
Capillary Leak Syndrome 04/01/11 – 03/31/12
B. Keller, PI, University of Louisville IRB Protocol # 10.0661, NHORA# 11.0046
High Resolution Ultrasound Imaging in Neonates 04/14/11 – 04/13/12
B. Keller, PI, University of Louisville IRB Protocol # 11.0119, NHORA# 11.0062
Self-management of oral anticoagulation therapy with web-based 04/14/11 – 04/13/12
decision support in children with cardiac indications for anticoagulation protocol
B. Keller, PI, University of Louisville IRB Protocol (in revision)
N. Clinical Service: Inpatient and outpatient pediatric cardiology since 7/1/91 without interruption 1. Ambulatory Pediatric Cardiology Office Hours in Louisville.
2. Outreach Pediatric Cardiology Office Hours at sites throughout the Commonwealth of Kentucky and southern Indiana.
Paducah, Bowling Green, Elizabethtown, Glasgow, Campbellsville, Owensboro, Madisonville, Madison, Ashland, Murray
3. Inpatient Pediatric Cardiology Attending service at Kosair Children’s Hospital and Norton Hospital.
Curriculum Vitae -- Bradley B. Keller, MD
31 Updated: April 23, 2012
O. Publications, Book Chapters, Monographs and Textbooks INVITED REVIEWS
1. Keller BB and Clark EB: Cardiovascular structural and functional maturation. Current Opinion in Cardiology 1993;8:98-107.
2. Keller BB: Functional maturation and coupling of the embryonic cardiovascular system. In Developmental Mechanisms of
Heart Disease, (eds) EB Clark, RR Markwald, and A Takao, Futura Publishing, Mount Kisco, NY, 1995, 367-386.
3. Keller BB: Function, biomechanics and control of the embryonic cardiovascular system. In Etiology and Morphogenesis of
Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology. (eds) EB Clark, M Nakazawa,
and A Takao, Futura Publishing, Mount Kisco, NY, 2000, 271-274
4. Keller BB: Function and biomechanics of developing cardiovascular systems. In Formation of the Heart & Its Regulation. (ed)
R Tomanek. Springer-Verlag, 2001,251-271.
5. Keller BB: Practical applications derived from basic studies of developing cardiovascular systems. In Comparative
Developmental Physiology: Contributions, Tools and Trends. (eds) SJ Warburton, WW Burggren, B Pelster, CL Reiber and J
Spicer. Oxford University Press, Inc, USA, 2006, 148-160.
BOOKS 1. Burggren WW and Keller BB: Development of Cardiovascular Systems: Molecules to Organisms. Cambridge Univ Press,
New York, 1997, 360 pages.
BOOK CHAPTERS
1. Keller BB: Heart Failure. In Primary Pediatric Care, ed 2; (eds) Hoekelman RA, Friedman SB, Nelson NM, Seidel HM, CV
Mosby Co, St Louis, 1990,pp1620-1621, and ed 3, 1997,pp1713-4.
2. Keller BB. Embryonic Cardiovascular Function, Coupling, and Maturation: A Species View. In Development of
Cardiovascular Systems: Molecules to Organisms. (eds) Burggren W and Keller BB. Cambridge Univ Press, New York,
1997, pp65-87.
3. Keller BB and Markwald RR. Embryonic Structural and Functional Cardiovascular Maturation. In The Heart: Arteries and
Veins, ed 9; (eds) Hurst JW, Logue RB, Rackley CE, Schlant RC, Sonnenblick EH, Wallace G, Wenger NK, McGraw-Hill
Book Co, New York 1998, 195-221.
4. Keller BB. Analysis of Murine Embryonic Structural and Functional Phenotype. In Cardiovascular Physiology in the
Genetically Engineered Mouse. (eds) Hoit BD and Walsh RA. Kluwer Academic Publishers, New York, 1998;259-280.
5. Keller BB, Wessels A, Schwartz Roberts R, and Markwald RR. Molecular Development and Embryology of the Heart. In
Hurst’s the Heart, ed 10; (eds) Fuster, V, Roberts R, Alexander RW O’Rourke RA, King SP III, and Wellens HJJ, McGraw-
Hill Book Co, New York 2000,167-192.
6. Tobita K, Tinney J, and Keller BB. Cardiovascular Phenotype Analysis of Murine Embryos. In Cardiovascular Physiology in
the Genetically Engineered Mouse, 2nd
Edition. (eds) Hoit BD and Walsh RA. Kluwer Academic Publishers, New York 2002,
353-376.
7. Schroder EA, Satin J, Routkevitch S, Tsyvian P, and Keller BB. T-type and L-Type Calcium Currents Modulate Force in
Embryonic Chick Myocardium. In Cardiac Development. (eds) Ostadal B, Nagano M, and Dhalla NS. Kluwer Academic
Publishers, Boston 2002, 113-132.
8. Keller BB, Wessels A, and Markwald RR. Molecular Development and Embryology of the Heart. In Hurst’s the Heart, ed
11; (eds) Fuster, V, Roberts R, Alexander RW O’Rourke RA, King SP III, and Wellens HJJ, McGraw-Hill Book Co, New York
2004, 155-180
9. Tobita K, Garrison JB, and Keller BB. Differential effects of cyclic stretch on embryonic ventricular cardiomyocyte and
non-cardiomyocyte orientation. In Cardiovascular Development and Congenital Malformations: Molecular and Genetic
Curriculum Vitae -- Bradley B. Keller, MD
32 Updated: April 23, 2012
Mechanisms(eds) Artman M, Benson DW, Srivastava D, Nakazawa M. Blackwell Futura, Malden, MA 2005, 177-179.
10. Keller BB. Physiology and biomechanics of developing cardiovascular systems: expanding frontiers. In Cardiovascular
Development and Congenital Malformations: Molecular and Genetic Mechanisms(eds) Artman M, Benson DW, Srivastava
D, Nakazawa M. Blackwell Futura, Malden, MA 2005, 180-185
11. Tobita K, Garrison JB, and Keller BB. Three-dimensional fiber architecture of the embryonic left ventricle during normal
development and reduced mechanical load. In Cardiovascular Development and Congenital Malformations: Molecular
and Genetic Mechanisms(eds) Artman M, Benson DW, Srivastava D, Nakazawa M. Blackwell Futura, Malden, MA 2005,
186-189
12. Kaushik N, Wessels A, Markwald RR, and Keller BB. Molecular Development and Embryology of the Heart. In Hurst’s
the Heart, ed 12; (eds) Fuster, V, O’Rourke RA, Walsh RA, Wilson PP, McGraw-Hill Book Co, New York 2008, 155-176
13. Keller BB. Genetic and Epigenetic Mechanisms for Congenital Heart Disease. In: Pediatric Heart Disease: A Practical
Guide; (eds) Daubeney PE, Rigby M, Niwa K, and Gatzoulis MA, Blackwell Publishing, Edinburgh, UK 2007
14. Burggren W, Chapman K, Keller B, Monticino M, and Torday J. Interdisciplinarity in the Biological Sciences. In:
Handbook of Interdisciplinarity. Oxford University Press 2010, 119-132
15. Keller BB, Hoying JA, Markwald RR. Molecular Development of the Heart. In Hurst’s the Heart, ed 13; (eds) Fuster, V,
Walsh RA, Harrington RA, McGraw-Hill Book Co, New York 2011, 172-194
16. Keller BB. Epidemiology and Genetics. In: Pediatric Heart Disease: A Practical Guide; ed 2; (eds) Daubeney PE, Rigby
M, Niwa K, and Gatzoulis MA, Blackwell Publishing, Edinburgh, UK 2012
LETTERS TO THE EDITOR
1. Tobita K and Keller BB. Response to comments on embryonic stress-strain measurements. Am J Physiol 2001;281:464-466.
INVITED EDITORIALS
1. Keller BB. Developmental structure-function insights from the Tbxfdel/+
mouse model of Holt-Oram syndrome. Am J
Physiol Heart Circ Physiol 2005;289:H975-H976.
2. Keller BB. New insights into the developmental biomechanics of the atrioventricular valves. Circ Res 2007;110:1399-
1401
Curriculum Vitae -- Bradley B. Keller, MD
33 Updated: April 23, 2012
ARTICLES (first or senior author)
1. Keller BB, Mehta AV, Shamszadeh M, Marino TA, Sanchez GR, Huff DS, Dunn JF: Oncocytic Cardiomyopathy of Infancy
With Wolff-Parkinson White Syndrome and Ectopic Foci Causing Tachydysrhythmias in Children. Am Heart J 1987;82-792.
PMID: 3310564
2. Keller BB, Hu N and Clark EB: Correlation of Ventricular Area, Perimeter, and Conotruncal Diameter with Mass and
Function in the Stage 12 to 24 Chick Embryo. Circ Res 1990;66:109-14. PMID: 2295133
3. Keller BB, Hu N, Serrino PJ, and Clark EB: Ventricular Pressure-Area Loop Characteristics in the Stage 16 to 24 Chick
Embryo. Circ Res 1991;68:226-231. PMID: 1984865
4. Campbell KA, Hu N, Clark EB, and Keller BB: Analysis of dynamic atrial dimension and function during early cardiac
development in the chick embryo. Ped Res 1992;32:333-337. PMID: 1408472
5. Carstensen EL, Duck FA, Meltzer RS, Schwarz KQ, and Keller BB: Bioeffects in echocardiography. Echocardiography
1992;6:605-623. PMID: 10147799
6. Taber LA, Hu N, Pexieder T, Clark EB and Keller BB: Residual strain in the embryonic ventricle of the stage 16 to 24 chick
embryo heart. Circ Res 1993;72:455-462. PMID: 8418994
7. Keller BB, Hu N, and Tinney JP: Embryonic ventricular diastolic and systolic pressure-volume relation. Cardiology in the
Young 1994,4:19-27
8. Casillas CB, Tinney JP, and Keller BB: Influence of acute alterations in cycle length on ventricular function in the chick
embryo. Am J Physiol 1994;267:H905-911. PMID: 8092294
9. Taber LA, Sun H, Cartmell JS, Clark EB, and Keller BB: Epicardial strains in the stage 16 - 24 embryonic chick ventricle.
Circ Res 1994;75:896-903. PMID: 7923636
10. Hu N, Hansen AL, Clark EB, and Keller BB: Atrial natriuretic peptide reduces diastolic filling in the stage 21 chick embryo.
Ped Res 1995;37:465-468. PMID: 7596686
11. Hu N and Keller BB: Relationship of simultaneous atrial and ventricular pressures in the stage 16 to 27 chick embryo. Am J
Physiol 1995;269:H1359-H1362. PMID: 7485568
12. Bowers PN, Tinney JP, and Keller BB: Nitroprusside selectively reduces ventricular preload in the stage 21 chick embryo.
Cardiovasc Res 1996;31:E132-E138. PMID: 8681337
13. Yoshigi M, Hu N, and Keller BB: Dorsal aortic impedance in the stage 24 chick embryo following acute changes in
circulating blood volume. Am J Physiol 1996;270:H1597-1606. PMID: 8928864
14. Keller BB, MacLennan MJ, Tinney JP, and Yoshigi M: In vivo assessment of embryonic cardiovascular dimensions and
function in day 10.5 To 14.5 mouse embryos. Circ Res 1996;79:247-255. PMID: 8756001
15. Yoshigi M and Keller BB: Linearity of pulsatile pressure–flow relations in the embryonic chick vascular system. Circ Res
1996;79:864-870. PMID: 8831512
16. Yoshigi M and Keller BB: Characterization of the embryonic aortic impedance with lumped parameter models. Am J Physiol
1997;273:H19-H27. PMID: 9249470
17. Babbitt K, Fuller L, and Keller BB: A surface micromachined capacitive pressure sensor for biomedical applications. IEEE
Proceedings #97CH36030, Twelfth Biennial University/Government/Industry Microeletronics Symposium 1997;150-153.
18. Miller CE, Vanni MA, Taber LA, and Keller BB: Passive stress-strain measurements in the stage 16 and stage 18 embryonic
chick heart. JBME 1997;119:445-451. PMID: 9407284
Curriculum Vitae -- Bradley B. Keller, MD
34 Updated: April 23, 2012
ARTICLES (first or senior author, continued) 19. Miller CE, Vanni MA, and Keller BB: Characterization of passive embryonic myocardium by quasi-linear viscoelasticity
theory. J Biomech 1997;30:985-988. PMID: 9302625
20. Yoshigi M, Ettel JM, and Keller BB: Developmental changes in flow wave propagation velocity in the embryonic chick
vascular system. Am J Physiol 1997;273:H1523-H1529. PMID: 9321845
21. Keller BB, Yoshigi M, and Tinney JP: Ventricular-vascular uncoupling by acute conotruncal occlusion in the stage 21 chick
embryo. Am J Physiol 1997;273:H2861-H2866. PMID: 9435625
22. Tsyvian PB, Routkevich SM, Protsenko YL, Tsyvian EP, Miller CE, and Keller BB: The role of the intra- and extracellular
sources in “Force-Frequency” relations in the chick embryonic myocardium. Russian J Physiol 1998;84:1402-1411.
23. Furukawa S, MacLennan MJ, and Keller BB: Hemodynamic response to anesthesia in pregnant and nonpregnant ICR mice.
Lab Animal Sci 1998;48:357-363. PMID: 10090043
24. Solovyeva OE, Markhasin VS, Tsyvian PB, and Keller BB: Experimental and theoretical investigation of force-interval
relationships in the developing chick myocardium. Biophysica (Ru) 1999;44:337-349.
25. MacLennan MJ and Keller BB: Murine embryonic umbilical arterial velocity during development and following acutely
increased heart rate. Ultrasound in Med Biol 1999;25:361-370. PMID: 10374980
26. Tobita K and Keller BB: End-systolic myocardial stiffness is a load independent index of contractility in the stage 24 chick
embryonic heart. Am J Physiol 1999;276:H2101-H2108. PMID: 10362693
27. Yoshigi M, Keller BB. Pressure-volume relationships of the embryonic heart analyzed by custom-developed IMAQ image
analysis system [Japanese]. InterLab. 1999;4:58-59.
28. Tobita K and Keller BB: Maturation of end-systolic stress-strain relations in chick embryo myocardium. Am J Physiol
2000;279:H216-H224. PMID: 10899059
29. Yoshigi M, Knott G, and Keller BB: Lumped parameter estimation for the embryonic chick vascular system: a time domain
approach using MLAB. Computer Programs Biomed J 2000;63(1):29-41. PMID: 10927152
30. Tobita K and Keller BB: Ventricular epicardial deformation patterns during normal development and during the development
of left heart hypoplasia in the chick embryo. Am J Physiol 2000;279:H959-H969. PMID: 10993756
31. Tsyvian PB, MarkhasinVS, Solovyeva OE, Rutkevitch SM, Protsenko LL, Artemeva OG, Schroder EA, and Keller BB:
Contraction-relaxation dynamics and mechanical restitution in the developing myocardium of the chick embryo. Rossiiskii
Fiziologicheskii Zhurnal Imeni I.M. Sechenova Rossiiskaia Akademiia Nauk. 2001;87:901-910. PMID: 11575123
32. Tobita K, Schroder EA, Tinney JP, Garrison JB, and Keller BB: Regional passive ventricular pressure-strain relations during
development of altered loads in the chick embryo. Am J Physiol 2002;282:H2386-H2396. PMID: 12003850
33. Schroder EA, Tobita K, Tinney JP, and Keller BB: Microtubule involvement in the adaptation to altered mechanical load in
the developing chick myocardium. Circ Res 2002;91:353-359. PMID: 12193469
34. Markhasin VS, Nikitina LV, Routkevich SM, Katsnelson LB, Schroder EA, and Keller BB: Effects of mechanical interaction
between two rabbit cardiac muscles connected in parallel. J Gen Physiol 2002;21:277-301. PMID: 12537352
35. Tobita K, Garrison JB, Liu LJ, Tinney JP, and Keller BB: Three dimensional myofiber architecture of the embryonic left
ventricle during normal and development of altered mechanical loads. Anat Rec A Discov Mol Cell Evol Biol
2005;283(1):193-201. PMID: 15678488
Curriculum Vitae -- Bradley B. Keller, MD
35 Updated: April 23, 2012
ARTICLES (first or senior author, continued) 36. Lucitti JL, Tobita K, and Keller BB: Arterial hemodynamics and mechanical properties after circulatory intervention in the
chick embryo. J Exp Biol 2005;208(10):1877-1885. PMID: 15879068
37. Sharma SK, Lucitti JL, Nordman C, Tinney JP, Tobita K, and Keller BB: Impact of Hypoxia on Early Chick Embryo
Growth and Cardiovascular Function. Pediatr Res 2005;58(4):818-824. PMID: 16327005
38. Manole MD, Hickey RW, Momoi N, Tobita K, Tinney JP, Suciu GP, Johnnides M, Clark RS, and Keller BB: Preterminal
gasping during anoxic arrest increases cardiac function in immature rats. Pediatr Res 2006;60(2):174-179. PMID: 16864699
39. Tobita K, Liu LJ, Janczewski AM, Tinney JP, Nonemaker JM, Augustine S, Stolz DB, Shroff SG, and Keller BB:
Engineered early embryonic cardiac tissue (EEECT) retains proliferative and contractile properties of developing embryonic
myocardium. Am J Physiol Heart Circ Physiol 2006;291(4):H1829-H1837. PMID: 16617136
40. Lucitti JL, Visconti R, Novak J, and Keller BB: Increased arterial load alters aortic structural and functional properties
during embryogenesis. Am J Physiol Heart Circ Physiol 2006;291(4):H1919-H1926. PMID: 16648183
41. Furukawa S, Tinney JP, Tobita K, and Keller BB: Hemodynamic vulnerability to acute hypoxia in day 10.5 to 16.5 murine
embryos. J Obstet Gynecol Res 2006;33:114-127. PMID: 17441882
42. Keller BB, Liu LJ, Tinney JP, and Tobita K. Cardiovascular developmental insights from embryos. Ann NY Acad Sci
2007;100:1399-1401. PMID: 17303838
43. Emery SP, Kreutzer J, Sherman FR, Fujimoto KL, Jaramaz B, Nikou C, Tobita K, and Keller BB. Computer-assisted
navigation applied to fetal cardiac intervention. Int J Med Rob Comp Asst Surg 2007;3(3):187-198. PMID: 17729376
44. Emery SP, Kreutzer J, McCaffrey F, Sherman FR, Simhan HN, and Keller BB. The learning curve of a fetal cardiac
intervention team. Min Invasive Surg 2010;2010:674185. PMID 22091354
45. Das BB, Christensen J, Brock G, Barnes C, Sobczyk W, and Keller BB. Compaction ratio guidelines in the diagnosis of
isolated left ventricular noncompaction in infants and children. J Kentucky Medical Assoc 2011 (in press)
46. Ralphe JC, Tobita K, Witt MR, Kirk J, DeLange WJ, and Keller BB. Modeling the immature heart: contractile
performance and calcium transients in neonatal rat 3D engineered cardiac tissue. Pediatr Res (in revision).
47. Downs-Canner S, Ng L, Peng D, Keller JM, Nakanishi T, Gu H, Keller BB. Change in oxygen saturation in response to
exercise as a screening method to detect congenital heart disease in remote, rural Tibetan children, J Pediatrics (in
preparation).
Curriculum Vitae -- Bradley B. Keller, MD
36 Updated: April 23, 2012
ARTICLES (contributing author) 1. Hu N, Connuck D, Keller BB, and Clark EB: Passive and active diastolic ventricular function in stage 12 to 27 chick embryos.
Ped Res 1991;29:334-337. PMID: 1852525
2. Dalecki D, Keller BB, Carstensen EL, Neel DS, Palladino JL, Noordergraaf A: Thresholds for premature ventricular
contractions caused by lithotripter shocks. Ultrasound Med Biol 1991;17:341-346. PMID: 1719683
3. Taber LA, Keller BB, and Clark EB: Cardiac mechanics in the stage 16 chick embryo. J Biomech Eng 1992;114:427-434.
PMID: 1487893
4. Dalecki D, Keller BB, Raeman CH, and Carstensen EL: Effects of pulsed ultrasound on the frog heart: I. Thresholds for
changes in cardiac rhythm and aortic pressure. J Ultrasound Med Biology 1993;19:385-390. PMID: 8356782
5. Ursem NTC, Brinkman HJF, Struijk PC, Hop WCJ, Kempski MH, Keller BB, and Wladimiroff JW. Umbilical artery
waveform analysis based on maximum, mean, and mode velocity in early human pregnancy. Ultrasound Med Biol 1998;24:1-
7. PMID: 9483765
6. Ursem NTC, Struijk PC, Hop WCJ, Clark EB, Keller BB, and Wladimiroff JW. Heart rate and flow velocity variability as
determined from umbilical doppler velocimetry at 10-20 weeks of gestation. Clinical Science 1998;95:539-545. PMID:
9791039
7. Ursem NTC, Clark EB, Keller BB, and Wladimiroff JW. Fetal heart rate and umbilical artery velocity variability in pregnancies
complicated by insulin-dependent diabetes mellitus. Ultrasound Obstet Gynecol 1999;13:312-6. PMID: 10380294
8. Ursem NTC, Clark EB, Keller BB, Hop WCJ and Wladimiroff JW. Do heart rate and velocity variability derived from
umbilical artery velocity waveforms change prior to clinical pregnancy induced hypertension? Ultrasound Obstet Gynecol
1999;14:244-9. PMID: 10586475
9. Ursem NTC, Clark EB, Keller BB, Hop WCJ and Wladimiroff JW. Assessment of fetal heart rate and velocity variability by
Doppler velocimetry of the descending aorta at 10-20 weeks of gestation. Ultrasound Obstet Gynecol 1999 14:397-401.
PMID: 10658278
10. Cribbs LL, Schroder EA, Keller BB, Delisle BP, and Satin J. Identification of the CaV3.1d gene product in developing
mouse heart: A contributor to embryonic contractility. Circ Res 2001;88:403-407. PMID: 11230107
11. Struijk PC, Ursem NTC, Mathews J, Clark EB, Keller BB , and Wladimiroff JW. Power spectrum analysis of heart rate and
blood flow velocity variability in the umbilical artery and uterine artery in early pregnancy. A comparative study.
Ultrasound Obstet Gynecol 2001;17:316-321. PMID: 11339188
12. Sedmera D, Hu N, Weiss KM, Keller BB, Denslow S, and Thompson RP. Cellular changes in experimental left heart
hypoplasia. Anat Rec 2002;267:137-145. PMID: 11997882
13. Chalothorn D, McCune DF, Edelmann SE, Tobita K, Keller BB, Lasley RD, Perez DM, Tanoue A, Tsujimoto G, Post GR,
and Piascik MT: Differential Cardiovascular Regulatory Activities of the Alpha1B- and Alpha1D-Adrenoceptor Subtypes. J
Phamacol Exp Ther 2003;305:1045-1053. PMID: 12649302
14. Jeffries JL, Noonan JA, Keller BB, Wilson JF, and Griffith C III: Quality of life and social outcomes in rural adults with
congenital heart disease. Am J Cardiol 2004;94:263-266. PMID: 15246920
15. Law YM, Feingold BM, Keller BB, and Boyle GJ: Use of Plasma B-type Natriuretic Peptide to Identify Ventricular
Dysfunction in Pediatric and Adult Congenital Heart Disease Patients. Am J Cardiol 2005;95:474-478. PMID: 15695131
16. Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tobita K, Keller BB, Cummins JH, and Huard J:
Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Therapy 2005;12(6):1130-1141.
PMID: 16125468
Curriculum Vitae -- Bradley B. Keller, MD
37 Updated: April 23, 2012
ARTICLES (contributing author, continued) 17. Wearden P, Morell V, Keller BB, Webber SA, Borovetz HS, Badylak SF, Boston JR, Kormos R, Kameneva MV, Simaan
M, Snyder TA, Tsukui H, Wagner WR, Antaki JF, Diao C, Vandenberghe S, Gardiner J, Li CM, Noh D, Paden D, Paden B,
Wu J, Bearnson GB, Jacobs G, Kirk J, Khanwilkar P, Long JW, Miles S, Hawkins JA, Kouretas PC, and Shaddy RE. The
PediaFlowTM
Pediatric Ventricular Assist Device. Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac
Surgery Annual 2006. (ed) Richard A. Jonas, pp. 92 – 98. PMID: 16638553
18. Borovetz HS, Badylak S, Boston JR, Johnson C, Kormos R, Kameneva MV, Simaan M, Snyder TA, Tsukui H, Wagner
WR, Woolley J, Antaki J, Diao C, Candenberghe S, Keller B, Morell V, Wearden P, Webber S, Gardiner J, Li CM, Paden
D, Paden B, Snyder S, Wu J, Bearnson G, Hawkins JA, Jacobs G, Kirk J, Khanwilkar P, Kouretas PC, Long J, and Shaddy
RE. Towards the development of a pediatric ventricular assist device. Cell Transplantation 2006;15:S69-S74. PMID:
16826798
19. Fujimoto KL, Tobita K, Merryman DW, Guan J, Momoi N, Stolz DB, Sacks MS, Keller BB, Wagner WR. An elastic,
biodegradable cardiac patch induces contractile smooth muscle and prevents cardiac remodeling in sub-acute myocardial
infarction. JACC 2007;49(23):2292-300. PMID: 17560295
20. Payne TR, Oshima H, Okada M, Momoi N, Tobita K, Keller BB, Peng H, Huard J: A relationship between vascular
endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts.
JACC 2007;50:1677-1684. PMID: 17950150
21. Pekkan K, Dasi LP, Nourparvar P, Yerneni S, Tobita K, Fogel M, Keller BB, Yoganathan A: In Vitro hemodynamic
investigation of the embryonic aortic arch at late gestation. J Biomechanics 2008;41(8):1697-1706. PMID: 18466908
22. Momoi N, Tinney JP, Liu LJ, Elshershari H, Hoffman PJ, Ralphe JC, Keller BB, Tobita K: Modest maternal caffeine
exposure affects developing embryonic cardiovascular function and growth. Am J Physiol Heart Cir 2008;294(5):H2248-
56. PMID: 18359892
23. Zahka K, Kalidas K, Cross H, Humbush J, Keller B, Galambos C, Gurtz K, Patton MA, Crosby AH. Homozygous
mutation of MYBPC3 associated with severe infantile hypertrophic cardiomyopathy at high frequency amongst the Amish.
Heart 2008;94(10):1326-30. PMID: 18467358
24. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB, Phillippi JA, Peault B, Huard J:Myogenic
endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted
myocardium. JACC 2008;52:1869-1880. PMID: 19038685
25. Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith SH, Saba S, Rager J, Conner DA, Janczewski AM, Tobita K, Tinney
JP, Moskowitz IP, Perez-Atayde AR, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG. The role of cardiac
troponin T quantity and function in cardiac development and dilated cardiomyopathy. PLoS ONE. 2008 Jul 9;3(7):e2642.
PMID: 18612386
26. Park TS, Zambidis ET, Lucitti JL, Logar A, Keller BB, Péault B. , Human embryonic stem cell-derived hematoendothelial
progenitors efficiently engraft chicken embryos. Exp Hematol 2009;37(1):31-41. PMID: 17560295
27. Urish KL, Vella JB, Okada M, Deasy BM, Tobita K, Keller BB, Cao B, Piganelli JD, Huard J. Antioxidant levels
represent a major determinant in the regenerative capacity of muscle stem cells. Mol Biol Cell 2009;20(1):509-20. PMID:
19005220
28. Clause KC, Tinney JP, Liu LJ, Keller BB, Tobita K. Engineered early embryonic cardiac tissue increases cardiomyocyte
proliferation by cyclic mechanical stretch via p38-MAP kinase phosphorylation. Tissue Eng Part A 2009;12(6):1373-80.
PMID: 19196150
29. Wang Y, Dur O, Patrick MJ, Tinney JP, Tobita K, Keller BB, and Pekkan K. Aortic arch morphogenesis and flow
modeling in the chick embryo. Ann Biomed Eng 2009:37(6):1069-81. PMID: 19337838
Curriculum Vitae -- Bradley B. Keller, MD
38 Updated: April 23, 2012
ARTICLES (contributing author, continued) 30. Fujimoto KL, Miki T, Liu LJ, Hashizume R, Strom SC, Wagner W, Keller BB, Tobita K: Naive rate amnion-derived cell
transplantation improved left ventricular function and reduced myocardial scar of post-infarcted heart. Cell Transplantation
2009;18(4):477-86. PMID: 19622235
31. Drowley L, Okada M, Payne T, Botta G, Oshima H, Keller BB, Tobita K, Huard J. Sex of muscle stem cells does not
influence potency for cardiac cell therapy. Cell Transplantation 2009;18(10):1137-1146 PMID: 19523348
32. Clause KC, Tinney JP, Liu LJ, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller
BB, Tobita K. A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle derived
stem cells. Tissue Eng Part C Methods 2010;16(3):375-85. PMID: 19601695
33. Dur O, Lara M, Arnold D, Vandenberghe S, Keller BB, DeGroff K, Pekkan K. Pulsatile in vitro simulation of the pediatric
univentricular circulation for evaluation of cardiopulmonary assist scenarios. Artif Organs 2009;33:967-976. PMID:
20021470
34. Dur O, DeGroff CG, Keller BB, Pekkan K. Optimization of inflow waveform phase-difference for minimized total
cavopulmonary power loss. J Biomed Eng 2010;132:031012. PMID: 20459200
35. Hashizume R, Fujimoto KL, Hong Y, Amoroso NJ, Tobita K, Miki T, Keller BB, Sacks MS, Wagner WR. Morphological
and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable
polyurethane elastomer scaffold. Biomaterials 2010;31:3253-65. PMID: 20138661
36. Drowley L, Okada M, Beckman S, Vella J, Keller BB, Tobita K, Huard J. Cellular antioxidant levels influence muscle
stem cell therapy. Mol Therapy 2010;18(10):1865-7. PMID: 20664528
37. Abdulkadir AA, Tobita K, Bell MJ, Macpherson TA, Keller BB, Yanowitz TD. Placental maturation and fetal
hemodynamics in a rat model of chorioamnionitis. Ped Res 2010; 68(6):513-518 PMID: 20736882
38. Fujimoto K, Clause KC, Tinney JP, Verma S, Wagner W, Keller BB, Tobita K. Engineered fetal cardiac graft preserves
its cardiomyoctye proliferation within post-infarcted myocardium and sustains cardiac function. Tissue Eng Par A 2011
17:585-96 PMID: 20868205
39. Okada M, Payne TR, Drowley L, Janowski RJ, Momoi N, Beckman S, Chen WCW, Keller BB, Tobita K, Huard J:
Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of
ischemic hearts. Molecular Therapy 2012;20(1):138-145 PMID: 22068427
40. Cassino TR, Drowley L, Okada M, Keller BB, Tobita K, LeDuc PR, and Huard J. The use of mechanical preconditioning
on the regenerative potential of stem cells. Tissue Engineering Part A 2011 (in press)
41. Kowalski WJ, Teslovich NC, Dur O, Keller BB, Pekkan K. Computational hemodynamic optimization predicts dominant
aortic arch selection is driven by embryonic outflow tract orientation in the chick embryo. Biomech Modeling in
Mechanobiology –BMMB 2012 (in press).
42. Momoi N, Tinney JP, Keller BB, Tobita K: Maternal hypoxia and caffeine exposure depress fetal cardiovascular function
during primary organogenesis. JOGR 2012 (in press)
43. Clause KC, Tchao JS, Powell MC, Liu LJ, Huard J, Keller BB, Tobita K. Developing cardiac and skeletal muscle share
fast-skeletal myosin heavy chain and cardiac troponin-I expression. PLoS ONE (in revision)
44. Wang Y, Ferreira A, Vandenberghe S, Mano A, Keller BB, Gorcsan J, Antaki JF. Simulation of mechanical circulatory
support with unimodal elastance model for optimal ventricular energetics. (in preparation)
PATIENT EDUCATIONAL MATERIALS 1. Solinger R and Keller BB (eds). Congenital Heart Disease Health Maintenance Information Guide. Chapter: Coarctation of
the Aorta (CoA) (in preparation)
Curriculum Vitae -- Bradley B. Keller, MD
39 Updated: April 23, 2012
P. LECTURES Date Title and Institution
October, 1989 Ventricular Mechanics in the Chick Embryo, Children's Memorial Hospital, Chicago, IL.
March, 1990 Diagnosis and Management of Heart Failure in Children, Pediatric Grand Rounds, Belle Glade, FL.
September, 1990 Ventricular Mechanics in the Developing Heart, Strong Children's Research Center, Rochester, NY.
July, 1991 Biomechanics of the Developing Cardiovascular System, Japan Heart Institute, Tokyo Women's
Medical College, Tokyo, Japan.
September, 1991 Embryonic and Fetal Cardiovascular Mechanics. Northeast Ped. Cardiology Society, Hyannis, MA
August, 1992 Fetal Cardiovascular Screening. Grand Rounds, Department of Obstetrics and Gynecology, The
Genesee Hospital, Rochester, NY.
June, 1993 Embryonic Cardiovascular Structural and Functional Maturation, Complutense University, Madrid,
SPAIN.
November, 1993 Cardiovascular Structural and Functional Maturation. University of South Carolina, Columbia, SC.
November, 1993 Embryonic Integrated Physiology, Engineering, and Mechanics. Kyoto Prefectural University, Kyoto,
JAPAN.
January, 1994 Tetralogy of Fallot: An Example of Congenital Heart Disease in Evolution. Grand Rounds, Dept of
Pediatrics, University of Rochester, Rochester, NY
May, 1994 Tetralogy of Fallot: Clinical and Basic Science Advances. 75 annual meeting of the Central New
York
Pediatric Club, New Hartford, NY.
November, 1994 Embryonic Cardiovascular Maturation. Burgher Cardiovascular Institute. UCSD, La Jolla, CA.
November, 1994 Embryonic Structural and Functional Maturation. Spontaneous Comparative Physiology Workshop,
UNLV, Las Vegas, NV
December, 1994 Cardiac Developmental and Mechanical Forces. NIH SCOR in Neonatology, Department of
Pediatrics, University of Rochester, NY.
August, 1995 Avian and Mammalian Embryonic Cardiovascular Function. Perinatal Cardiology Conference,
Pennsylvania Hospital, Philadelphia, PA.
August, 1995 Normal and Experimentally Altered Embryonic Cardiovascular Function. Perinatal Management
Conference, Pennsylvania Hospital, Philadelphia, PA.
August, 1995 Normal and Experimentally Altered Embryonic Cardiovascular Function. Dept of Cell Biology, Univ.
Med. and Dent. of New Jersey, Stratford, NJ.
October, 1995 Cardiovascular Embryology and Physiology. Fetal Echocardiography Program. The Jefferson
Feb and Sept, 1996 Ultrasound Research and Education Institute and Pennsylvania Hospital, Philadelphia, PA.
Feb and Oct, 1997
March, 1996 Novel Approaches in the Experimental Investigation of Cardiovascular Development: Chick, Mouse,
and Human. Reproductive/Development Workshop, University of Rochester.
April, 1996 Tetralogy of Fallot: Past, Present, and Future Challenges. Cardiology Update 1996, American Heart
Association Long Island Affiliate, Mineola, NY.
Curriculum Vitae -- Bradley B. Keller, MD
40 Updated: April 23, 2012
LECTURES (continued) October, 1996 Physiologic and Engineering Investigation of Cardiovascular Development. Ural Branch, Russian
Academy of Science, Yekaterinburg, Russia.
January, 1997 Tetralogy of Fallot -From Bench to Bedside. Department of Pediatrics Grand Rounds, New York
University Medical Center, New York, NY.
January, 1997 Embryonic Cardiovascular Physiology, Evolving Strategies. Department of Pediatrics, Division of
Pediatric Cardiology, NYU Medical Center, New York.
March, 1997 Cardiovascular Physiology and Mechanics in the Embryo. Department of Cell Biology and Anatomy,
Medical University of South Carolina, Charleston, SC.
April, 1997 Tetralogy of Fallot - At the Leading Edge. Department of Pediatrics Grand Rounds, New York
Medical College, Valhalla, NY.
April, 1997 Physiology and Mechanics of the Developing Myocardium. Physiology Department Grand Rounds,
New York Medical College, Valhalla, NY.
July, 1997 Physiology and Mechanics in the Developing Cardiovascular System. Departments of Pediatrics,
Rainbow Babies Childrens Hospital, Cleveland, OH.
February, 1998 Congenital Cardiovascular Malformations: New Ideas About Old Problems. Regional Mother and
Child Hospital, Yekaterinburg, Siberia, Russia.
March, 1998 Integrated Embryonic Cardiovascular Physiology and Mechanics, Japan Heart Institute, Tokyo
Women's Medical College, Tokyo, Japan.
April, 1998 Tetralogy of Fallot - Bedside to Bench. Department of Pediatrics Grand Rounds, State Univ. of New
York, Winthrope Univ Hospital, Mineola, NY
June, 1998 Dysrhythmias in the Newborn. 18th Annual Townsend Teaching Day in Neonatal/Perinatal Medicine,
Rochester General Hospital, Rochester, NY.
October, 1998 Approaches to Mend the Broken Heart. Department of Pediatrics Grand Rounds. University of
Kentucky, Lexington, KY.
January, 1999 Function, Biomechanics and Control of Developing Cardiovascular Systems. University of Arizona,
Department of Biomedical Engineering, Tucson, AZ.
March, 1999 Function and Biomechanics of the Developing Heart. Department of Physiology Lecture Series.
University of Kentucky, Lexington, KY..
April, 1999 Congenital Heart Disease in Adulthood. 2nd
Coronary Valley Symposium, Raddison Hotel, Lexington,
KY.
April, 1999 Function and Biomechanics of the Developing Cardiovascular System. Bioengineering Program
Lecture Series, University of Kentucky, Lexington, KY.
April, 1999 Pediatric Cardiology Update. Department of Pediatrics, Central Baptist Hospital, Lexington, KY.
May, 1999 Common Pediatric Cardiology Dilemmas, Contemporary Pediatrics for the Practicing Physician
Conference, Lexington, KY.
October, 1999 News from the First Noonan Congenital Cardiovascular Symposium, Department of Pediatrics Grand
Rounds. University of Kentucky, Lexington, KY.
Curriculum Vitae -- Bradley B. Keller, MD
41 Updated: April 23, 2012
LECTURES (continued) November, 1999 Cardiovascular Screening of the Young Athlete. First Annual Pikeville College School of Osteopathic
Medicine Pediatric Symposium, Pikeville, KY.
November, 1999 Basic Approaches in Ambulatory Pediatric Cardiology. Lake Cumberland Regional Nursing
Continuing Medical Education Conference, Somerset, KY.
December, 1999 Embryonic Cardiovascular Structure-Function Paradigms: Insights into Normal Development and
Congenital Cardiovascular Malformations. Samuel Lunenfeld Research Institute, University of
Toronto, Canada.
March, 2000 Clinical and Basic Science Advances in Congenital Heart Disease, Department of Emergency
Medicine Grand Rounds, Lexington, KY.
May, 2000 Structure-Function Paradigms in Developing Cardiovascular Systems. The Institute for Child Health,
Great Ormond Street, London, England.
May, 2000 Structure-Function Paradigms in Developing Cardiovascular Systems. The National Heart and Lung
Institute at the Brompton Hospital, London, England.
January, 2001 Profiles in Aortic Valve Disease: Natural and Unnatural Histories. Department of Pediatrics Grand
Rounds. University of Kentucky, Lexington, KY.
June, 2001 New Horizons in Pediatric Cardiovascular Diseases for the 21st Century. New Horizons in Fetal
Cardiology. The National Heart and Lung Institute at the Brompton Hospital, London.
October, 2001 Structure, Function, and Adaptation of Developing Cardiovascular Systems: Insights from Embryos.
University of Pittsburgh, Pittsburgh, PA.
January, 2002 Basic Approaches to the Spectrum of Pediatric Arrhythmias. Department of Pediatrics Grand Rounds.
University of Kentucky, Lexington, KY.
January, 2002 Insights into Cardiovascular Malformations Learned from the Embryo. Gill Cardiovascular Research
Symposium, University of Kentucky, Lexington, KY.
December, 2002 Physiology and Biomechanics of Developing Cardiovascular Systems from Embryo to Adult.
Department of Pediatric Cardiology, Kyoto Prefectural University, Kyoto, JAPAN.
January, 2003 Physiology and Biomechanics of Developing Cardiovascular Systems: From Embryo to Adult.
Department of Pediatrics Research Conference, Children’s Hospital of Pittsburgh, Pittsburgh, PA.
April, 2003 Physiology and Biomechanics of Developing Cardiovascular Systems: Research Overview.
Magowan Institute of Regenerative Medicine Seminar Series, University of Pittsburgh, Pittsburgh, PA.
June, 2003 Innovations in the Diagnosis and Management of Congenital Heart Disease. Department of Pediatrics
Grand Rounds, Children’s Hospital of Pittsburgh, Pittsburgh, PA
March 2004 Fetal Cardiovascular Malformations: Novel Approaches to Pathogenesis and Intervention.
Department of Obstetrics and Gynecology Grand Rounds, Magee Womens Research Institute,
Pittsburgh, PA
March 2004 Congenital Cardiovascular Malformations in Adults - the Developmental Perspective. Cardiovascular
Institute Grand Rounds, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
Curriculum Vitae -- Bradley B. Keller, MD
42 Updated: April 23, 2012
LECTURES (continued) April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult: Part I – Developmental
Mechanisms. 3rd
Five-Continent International Symposium on Cardiovascular Diseases and 20th
Anniversary Celebration of the Founding of Anzhen Hospital, Beijing, China
April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult: Part II – Clinical
Applications. 3rd
Five-Continent International Symposium on Cardiovascular Diseases and 20th
Anniversary Celebration of the Founding of Anzhen Hospital, Beijing, China
April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult. Department of Pediatric
Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
March 2005 Physiology and Biomechanics of Developing Cardiovascular Systems: Insights from Embryos.
Department of Pediatrics Combined Allergy/Immunology Conference, Children’s Hospital of
Pittsburgh, Pittsburgh, PA
October 2005 Evolution in the Assessment of Embryonic Ventricular Function. Department of Obstetrics and
Gynecology, Erasmus University, Rotterdam, the Netherlands
March 2007 Insights From Embryos on Cardiovascular Morphogenesis, Adaptation, and Repair. University of
Pittsburgh Graduate School of Public Health, Department of Environmental and Occupational Health,
University of Pittsburgh, Pittsburgh, PA
April 2007 Mending the Broken Embryonic Heart. 2007 Annual Science Lecturer. Heart Research Center.
Oregon Health & Science University, Portland, OR
April 2007 Genetic Mechanism of Congenital Cardiovascular Malformations. Fellow’s Conference. Division of
Pediatric Cardiology, Department of Pediatrics. Oregon Health & Science University, Portland, OR
June 2007 Update on Maternal-Embryonic Cardiovascular Coupling. Samuel Lunenfeld Research Institute,
University of Toronto, Canada.
February 2008 Insights from Embryos on How to Repair a Broken Heart. Department of Pediatrics. Yale School of
Medicine, Yale New Haven Children’s Hospital, New Haven, CT.
April 2008 Congenital Heart Disease: Engineering Challenges and Opportunities. Surgery for Engineers
Course, Carnegie Mellon University, Pittsburgh, PA.
January 2009 Molecular Biology and Bioengineering Insights into How to Repair a Broken Heart. Neonatology
Grand Rounds. Magee-Women’s Hospital of UPMC, Pittsburgh, PA.
January 2009 Molecular Biology and Bioengineering Insights into How to Repair a Broken Heart. Department of
Pediatrics, Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY
October 9, 2009 Pediatric Cardiology in Emerging Nations. 7th
Annual Cardiovascular Diseases and Stroke
Symposium. Louisville, KY
October 30, 2009 Insights into the Causes and Consequences of Congenital Heart Disease. Annual Cardiovascular
Symposium. Kings Daughters Heart and Vascular Center, Ashland, KY.
April 9, 2010 Insights into the Causes and Treatments of Congenital Heart Disease with an Update on High
Resolution Ultrasound Imaging for Humans. Christine M. Kleinert Institute for Hand and
Microsurgery, Louisville, KY
July 8, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Department of
Pharmacology and Toxicology, University of Louisville, Louisville, KY
Curriculum Vitae -- Bradley B. Keller, MD
43 Updated: April 23, 2012
LECTURES (continued)
October 19, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Frontier
Lifeline Hospital and the K.M. Cherrian Heart Foundation, Chennai, India
November 5, 2010 Insights from Embryos into Cardiac Morphogenesis and Repair. 2010 Carolina Cardiovascular
COBRE Conference, University of South Carolina, Columbia, SC
December 13, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Department
of Pediatrics, University of Louisville, Louisville, KY
March 14, 2010 Asking and Answering Pediatric Relevant Research Questions. Department of Pediatrics, University
of Louisville, Louisville, KY
April 14, 2011 Insights from Embryos into Cardiac Morphogenesis and Repair. 9th Annual Spring Symposium of
the Cardiovascular Developmental Biology Center (CDBC): Formation and Remodeling of the
Cardiovascular System in Health and Disease. Medical University of South Carolina, Charleston,SC
September 10, 2011 Expanding our Understanding and Treatment of Heart Disease in Children. Kosair Charities Annual
Luncheon, Louisville, KY