Curriculum Vitae Barry Paul SleckmanCurriculum Vitae Barry Paul Sleckman Contact: Department of Pathology and Laboratory Medicine Weill Cornell Medical College 1300 York Avenue Box

July 2019

Curriculum Vitae

Barry Paul Sleckman Contact: Department of Pathology and Laboratory Medicine Weill Cornell Medical College

1300 York Avenue Box 69 New York, New York 10065 212-746-4842

[email protected]. Born: July 29, 1960. Hamilton, Bermuda. Present Position: Professor of Pathology and Laboratory Medicine Professor of Microbiology and Immunology

Weill Cornell Medical College Co-Chair, Joint Program in Immunology and Microbial Pathogenesis

Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center Associate Director, Meyer Cancer Center

Weill Cornell Medical College Education: 1983 B.A. Lafayette College (Biology) 1989 Ph.D. Harvard University (Immunology, Steven Burakoff) 1989 M.D. Harvard Medical School Harvard-MIT, Health Sciences and Technology (HST) 2012 D.Sc. Lafayette College (honoris causa) Postdoctoral Training:

Residency and Clinical Fellowship: 1990-1992 Intern and Resident in Internal Medicine (Research Residency)

Brigham and Women's Hospital, Boston, MA 1993 Clinical Fellow in Infectious Diseases,

Brigham and Women's Hospital, Boston, MA Research Fellowships:

1990-1992 Postdoctoral Fellow in Cellular Immunology (Steven Burakoff) (Research Residency) Dana-Farber Cancer Institute, Boston, MA

1994-1998 Postdoctoral Fellow in Molecular Immunology (Frederick Alt) Harvard medical School, Boston, MA

Academic Appointments:

2016- Professor of Microbiology and Immunology Weill Cornell Medical College 2016-2019 Executive Vice Chair

Department of Pathology and Laboratory Medicine Weill Cornell Medical College

Barry P. Sleckman, M.D., Ph.D. July 2019

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Academic Appointments (continued): 2015-2019 Vice Chair for Experimental Pathology

Department of Pathology and Laboratory Medicine Weill Cornell Medical College

2015- Professor of Pathology and Laboratory Medicine Weill Cornell Medical College 2009-2015 Conan Professor of Laboratory and Genomic Medicine

Washington University School of Medicine 2008-2015 Professor of Pathology and Immunology Washington University School of Medicine 2008-2015 Chief, Division of Laboratory and Genomic Medicine

Department of Pathology and Immunology Washington University School of Medicine

2003-2008 Associate Professor of Pathology and Immunology Washington University School of Medicine

1998-2003 Assistant Professor of Pathology and Immunology Washington University School of Medicine

1995-1998 Instructor in Medicine, Harvard Medical School Hospital Appointments:

2005-2015 Medical Director, Clinical Immunology Laboratory, Barnes-Jewish Hospital, St. Louis, MO

1996 Attending Physician, Infectious Diseases Service, Dana-Farber Cancer Institute, Boston, MA Other Professional Appointments:

2018- Affiliate Member, New York Genome Center 2017- Co-Chair, Joint Program in Immunology and Microbial Pathogenesis

Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center 2016- Senior Leader, Meyer Cancer Center Weill Cornell Medical College 2016- Associate Director, Meyer Cancer Center Weill Cornell Medical College 2016-2019 Co-Director, Hematologic Malignancy Program, Meyer Cancer Center Weill Cornell Medical College 2013-2015 Associate Director for Basic Science, Alvin J. Siteman Cancer Center

Washington University School of Medicine 2013-2015 Co-Director, Solid Tumor Therapeutics Research Program

Alvin J. Siteman Cancer Center, Washington University School of Medicine 2010-2015 Founding Director, Physician Scientist Training Program

Department of Pathology and Immunology Washington University School of Medicine

2008-2015 Senior Leader, Alvin J. Siteman Cancer Center, Washington University School of Medicine 2008-2013 Associate Director for Shared Resources, Alvin J. Siteman Cancer Center

Washington University School of Medicine


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Other Professional Appointments (continued): 2008-2014 Program Director, DNA Metabolism and Repair Research Program

Alvin J. Siteman Cancer Center, Washington University School of Medicine 2006-2015 Member, Institute of Clinical and Translational Science

Washington University School of Medicine 2006-2008 Director, Graduate Program in Immunology, Washington University 2001-2015 Member, Tumor Immunology Research Program,

Alvin J. Siteman Cancer Center, Washington University School of Medicine 1989-1991 Pre-Medical Advisor, Lowell House, Harvard University

1989-1990 Professional Advisor, Blackwell Scientific Publishers 1987-1989 Medical Student Advisor, Blackwell Scientific Publishers Licensure and Certification:

2016- New York State Medical License 2009-2017 Missouri State Medical License 1996 American Board of Internal Medicine,

Subspecialty in Infectious Diseases, Certificate 1993 American Board of Internal Medicine, Certificate

Professional Associations:

2016- American Association of University Pathologists 2013- Alpha Omega Alpha Honor Medical Society 2010- Association of American Physicians 2010- The Henry Kunkel Society for Immunology 2009- American Association of Clinical Chemists 2008- Academy of Clinical Laboratory Physicians and Scientists 2008- American Association for Cancer Research 2006- American Society for Microbiology 2004- American Society for Clinical Investigation 2000- American Association for the Advancement of Science 2000- American Association of Immunologists

Awards and Honors:

2016 Elected to American Association of University Pathologists 2013 Elected as Fellow of the American Association for the Advancement of Science 2013 Elected to Alpha Omega Alpha Honor Medical Society 2012 Doctor of Science degree (honoris causa), Lafayette College 2012 Preclinical Teacher of the Year, Washington University School of Medicine Several Stanley Lang Lecturer of the Year (2012, 2002),

Washington University School of Medicine Several Distinguished Service Teaching Award (2011, 2007, 2001), Washington University School of Medicine Several Professor of the Year (2010, 2009, 2008, 2006, 2005, 2004, 2003), Washington University School of Medicine 2010 Elected to Association of American Physicians


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Awards and Honors (continued): 2009 Samuel R. Goldstein Leadership Award in Medical Education Washington University School of Medicine 2006 Elective Course of the Year, Washington University School of Medicine 2006 Hope Award, American Cancer Society 2004 Elected to American Society for Clinical Investigation 2004 Research Scholar Award, American Cancer Society 2000 Investigator Award in General Immunology and Cancer Immunology,

Cancer Research Institute 1996 Career Award in the Biomedical Sciences, Burroughs Wellcome Fund

1994 Howard Hughes Medical Institute Fellowship 1990 David Abraham Fellowship in Bone Marrow Transplantation 1983 Summa cum laude graduate, Lafayette College

1983 Willis Roberts Hunt Biology Prize 1983 Teagle Foundation Scholarship

1983 Joseph Watt Kubler Memorial Prize Lectureships:

2018 Susan Swerling Lecture, Dana-Farber Cancer Institute 2016 Keynote speaker, Immunology Graduate Program Retreat, Johns Hopkins University 2015 Easton Lecture, University of Toronto Immunology Department 2014 Keynote speaker, Immunology Training Program Retreat, Case Western Reserve University 2014 Student invited speaker, Immunology Program, University of Pennsylvania 2013 John H. Blaffer Lecture, MD Anderson Cancer Center 2013 Keynote speaker, National Institute of Arthritis and Musculoskeletal and Skin

Diseases retreat 2011 Fred S. Rosen Lecture, Harvard Medical School 2011 Visiting Professor, Department of Pathology and Laboratory Medicine University of Pennsylvania School of Medicine

Organization of Meetings:

2008-2009 Organizer: Tolmach Symposium on DNA Repair 2007 Organizer: AAI Annual Meeting Major Symposium:

DNA Repair: Immune Diversity vs. Death Review and Editorial Panels:

2019- Member, Cellular and Molecular Immunology (CMIB) Study Section, NIH 2011-2016 Career Development Program Grant Review Subcommittee, The Leukemia & Lymphoma Society 2011-2013 Section Editor, Journal of Immunology 2008-2011 Member, Cellular and Molecular Immunology (CMIB) Study Section, NIH


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Intramural Committee Assignments: 2018 Weill Cornell Medicine Strategic Plan Four - Basic Science Committee 2017- Meyer Cancer Center Executive Governance Committee 2017 Co-Chair, Basic Science Faculty Recruitment Committee, Weill Cornell Medicine 2016 Basic Science Faculty Recruitment Committee, Weill Cornell Medicine 2016- Committee of Review, Weill Cornell Medical College 2015- Admissions Committee, Immunology Graduate Program, Weill Cornell Medical College 2013-2014 Oncology Strategic Planning Committee, St. Louis Children’s Hospital 2012-2013 Alvin J. Siteman Cancer Center Strategic Planning Committee 2009-2012 Basic Science Leadership Committee, Alvin J. Siteman Cancer Center,

Washington University School of Medicine 2008-2015 Chair, DNA Metabolism and Repair Seminar Series, Washington University School of Medicine 2006 Educational Programs Committee, Washington University School of Medicine 2005-2009 Committee on Academic Evaluation of Students,

Washington University School of Medicine 2004-2012 Immunology Graduate Program Steering Committee, Washington University 1999 Medical Housestaff Selection Committee, Brigham and Women’s Hospital 1994-1998 M.D./Ph.D. Program Standing Committee, Harvard Medical School 1989 M.D./Ph.D. Program Admissions Committee, Harvard Medical School 1984-1985 Chair, Student Council, Harvard Medical School

1983-1984 Representative, Student Council, Harvard Medical School Extramural Committee Assignments:

2019- External Advisory Board, Siteman Comprehensive Cancer Center, Washington University School of Medicine.

2018- Scientific Advisory Board, Ludwig Center for Cancer Immunotherapy Memorial Sloan Kettering Cancer Center 2017- Scientific Advisory Board, Burroughs Wellcome Fund

2015-2017 External Advisory Board, Sabin Family Foundation Fellows Award, MD Anderson Cancer Center

2015-2018 Chair, External Advisory Board, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine. 2014- Keystone Symposia Scientific Advisory Board 2012-2015 External Advisory Board, Jonsson Comprehensive Cancer Center, University of California Los Angeles School of Medicine. 2011- External Advisory Board, Winship Comprehensive Cancer Institute, Emory University School of Medicine. 2008-2011 Education Committee, American Association of Immunologists 2003-2006 Program Committee, American Association of Immunologists


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Teaching Experience: 2017- Lecturer, Medical School Cancer Biology

Weill Cornell Medical School 2016- Lecturer, Fundamentals of Immunology, Weill Cornell Medical School Graduate Program 2008-2011 Lecturer, Advanced Course in Immunology,

American Association of Immunologists 2008 Co-director, Contemporary Immunobiology, Washington University 2000-2015 Co-director, Medical Immunology, Washington University School of Medicine 2000-2013 Director, Contemporary Molecular Immunology,

Washington University School of Medicine 1999-2006 Director, Advanced Topics in Immunology, Washington University 1999-2015 Lecturer, Foundations in Immunology, Washington University 1995 Preceptor, Introduction to Clinical Medicine, Harvard Medical School

1983 Laboratory Instructor, General Biology, Lafayette College 1982-1983 Teaching Assistant, Organic Chemistry, Lafayette College Current Research Funding: 2000-2022 Principal Investigator, NIH/NIAID R01 AI047829

The V(D)J recombination reaction and its impact on lymphocyte development 2008-2023 Principal Investigator, NIH/NIAID R01 AI074953

ATM Function during V(D)J recombination 2018-2020 Co-Principal Investigator, WCM-Cornell Ithaca Pilot Grant Novel DDR kinases and their roles in cancer 2019-2021 Principal Investigator, Emerson Collective Cancer Research Fund Exploring the kinome for DNA repair and cancer regulatory pathways 2019-2021 Co-Principal Investigator, Starr Cancer Consortium Genomic instability in the chromosomal context of physiological DNA double-strand break formation Pending Research Funding: 2020-2025 Principal Investigator, NIH/NCI R01 CA247912

Maintenance of genome integrity in G1/G0-phase cells Completed Research Funding:

2014-2017 Principal Investigator, R01 CA177759 Novel DNA Double-Strand Break Repair Targeting Therapeutics for Cancer Treatment 2013-2014 Principal Investigator, NIH/NIEHS R21 ES022685 Inhibitors of compensatory NHEJ pathways 2012-2014 Principal Investigator, Alvin J. Siteman Cancer Research Fund

Identification of novel DNA double strand break repair targeting therapeutics for the treatment of cancer

2009-2014 Co-Principal Investigator (with Craig Bassing), NIH/NCI R01 CA136470 Activation of cellular signaling pathways by DNA double strand breaks


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Completed Research Funding (continued): 2012-2013 Principal Investigator, Mark Kay Cancer Foundation Grant, 079-12

Identification of novel DNA double strand break repair targeting therapeutics for the treatment of breast cancer 2012-2013 Contract Investigator (PI, Patrick Swanson) NIH/NIGMS R01 GM102487 Role of VprBP in B cell development and V(D)J recombination 2012-2013 Principal Investigator, Washington University CTSA

High throughput screening for inhibitors of NHEJ-mediated DNA repair 2010-2012 Co-Principal Investigator (with Eugene Oltz), NIH/NIEHS R21 ES19779

Localized revision of epigenetic landscapes induced by DNA double-strand breaks. 2010-2015 Associate Director of Basic Science, NIH/NCI P30 CA91842,

NCI designated Cancer Center Support Grant (PI Timothy Eberlein) 2001-2011 Co-Principal Investigator (with Dr. Michael Krangel), NIH/NIAID R01 AI049934 Control of TCR V beta Rearrangement and Allelic Exclusion

2005-2008 Principal Investigator, American Cancer Society RSG-05-070-01-LIB Regulation of T Lymphocyte Development 2001-2004 Investigator award, Cancer Research Institute 1997-2002 Career Development Award, Burroughs Wellcome Fund

Patents:

2002 Gene isolation by Cre-trap cloning, U.S. patent #2004-0229230.


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Trainees: Graduate Students (PhD and Masters):

Robert Tillman (1999-2002) Associate Director of Faculty Development, MD Anderson Maureen Hughes (1999-2003) Business Bernard Khor (2000-2005) Assistant Member, Benaroya Research Institute Andrea Bredemeyer (2001-2006) Assistant Professor of Medicine, Washington University Grace Mahowald (2004-2008) Clinical Fellow in Pathology, MGH/Harvard Beth Helmink (2006-2010) Surgical Oncology Fellow, MD Anderson Eric Gapud (2006-2009) Assistant Professor of Medicine, Johns Hopkins Jason Baron (2007-2008) Assistant Professor of Pathology, MGH/Harvard Anthony Tubbs (2008-2014) Post-doctoral fellow, NCI/NIH Abigail Morales (2009-2015) Assistant Professor, Hunter University Putzer Huang (2013-2018) Clinical clerkships, Washington University Caitlin Purman (2013-2019) Post-doctoral fellow,

Post-doctoral Fellows: Len Maggi (2002) Assistant Professor of Medicine, Washington University Ching-Yu Huang (2003-2007) Editor, Nature Communications Andrea Bredemeyer (2006-2008) Assistant Professor of Medicine, Washington University Jeff Bednarsky (2007-2013) Assistant Professor of Pediatrics, Washington University Baeck-Seung Lee (2008-2014) Industry/Biotechnology Ruchi Pandey (2008-2011) Post-doctoral Fellow, University of Michigan Yair Dorsett (2009-2015) Associate Research Scientist, Jackson Labs/U. Conn. Amanda Trott (2011-2012) Private practice allergist Abigail Morales (2015-2018) Assistant Professor, Hunter University Bo-Ruei Chen (2012-current) Yinan Wang (2016-current) Zih-Jie Shen (2017-current) Chun-Chin Chen (2018-current) Giulia Zago (2018-current)


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PUBLICATIONS: 1981

1. Sherma J*, Sleckman BP. Reversed phase thin layer chromatography of phenols on chemically bonded C18 layers. HRC & CC 1981; 4:557-560.

1982

2. Sleckman BP, Sherma J*. A comparison of amino acid separation on silica gel, cellulose, and ion exchange thin layers. Jour. Liq. Chrom. 1982; 5:1051-1068.

1983

3. Sherma J*, Sleckman BP, Armstrong DW. Chromatography of amino acids on reversed phase thin layer plates. Jour. Liq. Chrom. 1983; 6:95-108.

4. Sleckman BP, Sherma, J*. Separation and quantification of epinephrine, norepinephrine and

dopamine by chromatography on diphenyl thin layers. HRC & CC 1983; 6:156-157. 5. Sleckman BP, Sherma J, Mineo LC*. Determination of pulegone in H. pulegioides and

peppermint oil by thin layer chromatography with densitometry. Jour. Liq. Chrom. 1983; 6:1175-1182.

1984

6. Sleckman BP, Fried B*. Glycogen and protein content in adult Echinostoma revolutum (Trematoda). Proc. Helminthol. Soc. (Wash.) 1984; 51:355-356.

1985

7. Sleckman BP, Touchstone JC, Sherma J*. Thin layer chromatography of nucleotides and nucleosides. In: Touchstone JC, Sherma J, eds. Techniques and applications of thin layer chromatography, New York: John Wiley and Sons, 1985:331-341.

1986

8. Ferrara J, Guillen FJ, Sleckman BP, Burakoff SJ, Murphy GF*. Cutaneous acute graft-versus- host disease to minor histocompatibility antigens in a murine model: Histologic analysis and correlation to clinical disease. J. Invest. Derm. 1986; 86:371-375. PMID:3528309

1987

9. Sleckman BP, Peterson A, Jones WK, Foran JA, Greenstein JL, Seed B, Burakoff SJ*. Expression and function of CD4 in a murine T-cell hybridoma. Nature 1987; 328:351-353.

PMID:3037388.

1988 10. Sleckman BP, Peterson A, Foran JA, Gorga JC, Kara CJ, Strominger JL, Burakoff SJ,

Greenstein JL*. Functional analysis of a cytoplasmic domain-deleted mutant of the CD4. J. Immunol. 1988; 141:49-54. PMID:3259970.


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11. Diamond DC, Sleckman BP, Gregory T, Laskey LA, Greenstein JL, Burakoff SJ*. Inhibition of

CD4+ T cell function by the HIV envelope protein, gp120. J. Immunol. 1988; 141:3715-3717. PMID:2846691.

12. Bierer BE, Greenstein JL, Sleckman B, Ratnofsky S, Peterson A, Seed B, Burakoff SJ*.

Functional analysis of CD2, CD4 and CD8 in T-cell activation. Ann. N.Y. Acad. Sci. 1988; 532:199-206. PMID:3052208. 13. Sleckman BP, Ratnofsky SE, Bierer BE, Burakoff SJ*. The T-cell receptors. In: ISI Atlas of Science: Immunology, Philadelphia: ISI Press, 1988:74-78. PMID:2653377

1989 14. Sleckman BP, Bigby M, Greenstein JL, Burakoff SJ, Sy MS*. Requirements for modulation of the

CD4 molecule in response to PMA: Role of the cytoplasmic domain. J. Immunol. 1989; 42:1457-1462. PMID:2783943.

15. Bierer BE, Sleckman BP, Ratnofsky SE, Burakoff SJ*. The biologic roles of CD2, CD4, and CD8

in T cell activation. Ann. Rev. Immunol. 1989; 7:579-599. PMID:2653377.

1990 16. Veillette A, Sleckman BP, Ratnofsky S, Bolen JB, Burakoff SJ*. The cytoplasmic domain of CD4

is required for stable association with the lymphocyte-specific tyrosine protein kinase p56lck. Eur. J. Immunol. 1990; 20:1397-1400. PMID:2369920.

17. Diamond DC, Finberg R, Chaudhuri S, Sleckman BP, Burakoff SJ*. Human immunodeficiency

virus infection is efficiently mediated by a glycolipid anchored form of CD4. Proc. Natl. Acad. Sci. (USA) 1990; 87:5001-5005. PMID:2142306.

1991

18. Sleckman BP, Rosenstein Y, Igras V, Greenstein JL, Burakoff SJ*. Glycolipid-anchored form of CD4 increases intercellular adhesion but is unable to enhance T cell activation. J. Immunol. 1991; 147:428-431. PMID:1677022.

1992

19. Sleckman BP, Shin J, Collins TL, Igras VE, Strominger JL, Burakoff SJ*. Disruption of the

CD4:p56lck complex is required for rapid internalization of CD4. Proc. Natl. Acad. Sci. (USA) 1992; 89:7566-7570. PMID:1502168.

1993

20. Burakoff SJ, Collins T, Hahn WC, Park JK, Sleckman BP, Igras V, Rosenstein Y, Bierer BE*. The role of the co-receptors in T cell activation. In: Progress in Immunology VIII. Berlin: Springer-Verlag, 1993:275-281.

1996

21. Sleckman BP, Gorman JR, Alt FW*. Accessibility control of antigen receptor variable region gene assembly: Role of cis-acting elements. Ann. Rev. Immunol. 1996; 14:459-481. PMID:8717521.


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1997

22. Sleckman BP, Bardon CG, Ferrini R, Davidson L, Alt FW*. Function of the TCRa enhancer in ab and gd T cells. Immunity 1997; 7:505-515. PMID: 9354471.

1998

23. Sleckman BP, Khor B, Monroe R, Alt FW*. Assembly of T cell receptor d variable region genes exhibits allelic inclusion. J. Exp. Med. 1998; 188:1465-1464. PMID:9782123.

24. Sleckman BP, Bassing CH, Bardon CG, Okada A, Khor B, Bories J-C, Monroe R, Alt FW*.

Accessibility control of variable region gene assembly during T cell development. Immunol. Rev. 1998; 165:121-130. PMID:9850857.

1999 25. Sakai E, Bottaro A, Davidson L, Sleckman BP, Alt FW*. Recombination and transcription of the

endogenous IgH locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proc. Natl. Acad. Sci. (USA) 1999; 96:1526-1531. PMID:9990057.

26. Frazer BA, Fried B, Fujino T, Sleckman BP*. Host-parasite relationships between Echinostoma

caproni and RAG-2-deficient mice. Parasitol. Res. 1999; 85:337-342. PMID:10099018. 27. Monroe RJ, Sleckman BP, Monroe B, Khor B, Claypool S, Ferrini R, Davidson L, Alt FW*.

Developmental regulation of TCRd locus accessibility and expression by the TCRd enhancer. Immunity 1999; 10:503-513. PMID:10367896

28. Gartner F, Alt FW, Monroe R, Chu M, Sleckman BP, Davidson L, Swat W*. Activated Ras

expression in immature thymocytes activates only a subset of the signals generated by TCRb and activated Lck. Immunity 1999; 10:537-546. PMID:10367899.

29. Hernandez-Munian C, Sleckman BP, Krangel M*. A developmental switch from TCR d to TCR

a enhancer function during thymocyte development. Immunity 1999; 10:723-733. PMID:10403647.

30. Pappu R, Cheg A, Li B, Gong Q, Chiu C, Griffin N, White M, Sleckman BP, Chan A*.

Requirement for B Cell linker protein (BLNK) in B cell development. Science 1999; 286:1949-1954. PMID:10583957.

2000

31. Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn BA, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM, Jenkins NA, Berman JE, Alt FW*. Cloning and functional characterization of the early lymphoid specific Pb99 gene. Mol. Cell. Biol. 2000; 20:4405-4410. PMID:10825203.

32. Sleckman BP, Bassing CH, Hughes MM, Okada A, D'Auteuil M, Wehrly T, Woodman BB,

Davidson L, Chen J, Alt FW*. Mechanisms that direct ordered assembly of T cell receptor b locus V, D, and J gene segments. Proc. Natl. Acad. Sci. (USA) 2000; 97:7975-7980. PMID:9850857.


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33. Bassing CH, Alt FW, Hughes MM, D'Auteuil M, Wehrly TD, Woodman BB, Gartner F, White JM, Davidson L, Sleckman BP*. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 2000; 405:583-586. PMID:10850719.

2001

34. Sleckman BP, Carabana J, Zhong X, Krangel MS*. Enhancer-blocking activity is not required to maintain distinct gene activation profiles within the murine T cell receptor a/d locus. Immunology 2001; 102:1-13. PMID:11576215.

2002

35. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH*. Distinct effects of T-bet in TH1 lineage commitment and IFN-g production in CD4 and CD8 T cells. Science 2002; 295:338-342. PMID:11786644.

36. Tillman RE, Wooley AL, Hughes MM, Wehrly TD, Swat W, Sleckman BP*. Restrictions limiting

the generation of DNA double stranded breaks during chromosomal V(D)J Recombination. J. Exp. Med. 2002; 195:309-316. PMID: 11828005.

37. Khor B, Sleckman BP*. Allelic exclusion at the TCRb locus. Curr. Opinion in Immunol. 2002;

14:230-234. PMID:11869897. 38. Ye Q, Press B, Kissler S, Yang X-F, Lu L, Bassing CH, Sleckman BP, Jansson M,

Pantoutsakopoulou V, Trimble LA, Alt FW, Cantor H*. T cell costimulation through CD28 depends on induction of the Bcl-x� isoform: analysis of Bcl-xg-deficient mice. J. Exp. Med. 2002; 196:87-95. PMID:12093873.

39. Brewer JA, Sleckman BP, Swat W, Muglia LJ*. GFP-Glucocorticoid receptor knock-in mice

reveal dynamic receptor modulation during thymocyte development. J. Immunol. 2002; 169:1309-1318. PMID:12133953

40. Wang X-F, Ye Q, Press B, Han R-Z, Bassing CH, Sleckman BP, Alt FW, Cantor H*. Analysis of

the complex genomic structure of Bcl-x and its relationship to Bcl-xg expression after CD28-dependent costimulation. Mol. Immunol. 2002; 39:45-55. PMID:12213327.

41. Brewer JA, Kanagawa O, Sleckman BP, Muglia LJ*. Thymocyte apoptosis induced by T cell

activation requires glucocorticoid mobilization in vivo. J. Immunol. 2002; 169:1837-1843. PMID:12165507.

42. Brewer JA, Vogt SK, Sleckman BP, Swat W, Kanagawa O, Muglia LJ*. Knock-ins and

conditional knockouts: in vivo analysis of glucocorticoid receptor regulation and function. Endocr. Res. 2002; 28:545-550. PMID:12530661.

2003

43. Tillman RE, Wooley AL, Khor B, Wehrly TD, Little CA, Sleckman BP*. Cutting Edge: Targeting of Vb to Db rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid specific factors. J. Immunol. 2003; 170:5-9. PMID:12496374.


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44. Bassing CH, Tillman RE, Woodman BB, Monroe BC, Canty D, Monroe RJ, Sleckman BP, Alt

FW*. TCRa/d locus enhancer identity and position are critical for the assembly of TCR d and a variable region genes. Proc. Natl. Acad. of Sci. (USA). 2003; 100:2598-2603. PMID:12604775.

45. Hughes MM, Yassai M, Sedy JR, Wehrly TD, Huang C-Y, Kanagawa O, Gorski J, Sleckman

BP*. T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J Recombination reaction. Eur. J. Immunol. 2003; 33:1568-1575. PMID:12778474.

46. Brewer JA, Khor B, Vogt SK, Fujiwara H, Haegele KE, Sleckman BP, Muglia LJ*. T cell

glucocorticoid receptor is required for suppression of COX-2 mediated lethal immune activation. Nature Med. 2003; 9:1318-1322. PMID:12949501.

47. Hughes MM, Tillman RE, Wehrly TD, White JM, Sleckman BP*. The B12/23 restriction is critically

dependent on the recombination signal nonamer and spacer sequences. J. Immunol. 2003; 171:6604-6610. PMID:14662863.

2004

48. Tillman RE, Wooley AL, Hughes MM, Khor B, Sleckman BP*. Regulation of TCRb chain gene assembly by recombination signals: The beyond 12/23 restriction. Immunol. Rev. 2004;

200:36-43. PMID:15242394.

2005 49. Sleckman BP*. Lymphocyte antigen receptor gene assembly: Many layers of regulation.

Immunologic Res. 2005; 32:253-258. PMID:16106077 50. Kim J, White JM, Shaw AS, Sleckman BP*. MAP Kinase p38a is dispensable for lymphocyte

development and proliferation. J. Immunol. 2005; 174:1239-1244. PMID:15661878. 51. Jackson A, Kondilis HD, Khor, B, Sleckman BP, Krangel M*. Regulation of T cell receptor b

allelic exclusion at a level beyond accessibility. Nature Immunol. 2005; 6:189-97. PMID:15640803.

52. Khor B, Wehrly TD, White JM, Sleckman BP*. Chromosomal excision of TCRd chain gene is

dispensable for ab T cell lineage commitment. Int. Immunol. 2005; 17:225-232. PMID:15642954

53. Khor B, Sleckman BP*. Intra- and Inter-allelic ordering of T cell receptor b chain gene assembly.

Eur. J. Immunol. 2005; 35:964-970. PMID:15719363. 54. Huang CY, Sleckman BP, Kanagawa O*. Revision of TCRa chain gene is required for normal T

lymphocyte development. Proc. Natl. Acad. of Sci. (USA). 2005; 102:14356-14361. PMID:16186502.


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2006 55. Khor B, Bredemeyer AL, Huang C, Turnbull IR, Evans R, Maggi LB, White JM, Walker LM,

Carnes K, Hess RA, Sleckman BP*. Proteasome activator PA200 is required for normal spermatogenesis. Mol. Cell. Biol. 2006; 26:2999-3007. PMID:16581775.

56. Berenson LS, Yang J, Sleckman BP, Murphy TL, Murphy KM*. Selective requirement of p38a

MAPK in cytokine-dependent, but not antigen receptor dependent, Th1 responses. J. Immunol. 2006; 176:4616-4621. PMID:16585552.

57. Bredemeyer AL, Sharma GG, Huang C, Helmink BA, Walker LM, Khor KC, Nuskey B, Sullivan

KE, Pandita TK, Bassing CH, Sleckman BP*. ATM stabilizes DNA double strand break complexes during V(D)J recombination. Nature 2006; 442:466-470. PMID:16799570.

58. Mandik-Nayak L, Racz J, Sleckman BP, Allen P*. Autoreactive MZ B cells are spontaneously

activated but LN B cells require T cell help. J. Exp. Med. 2006; 203:1985-1998. PMID:16880262.

2007

59. Huang CY, Sharma GG, Walker LM, Bassing CH, Pandita TK, Sleckman BP*. Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J. Exp. Med. 2007; 204:1371-1381. PMID:17502661.

60. Huang CY, Sleckman BP*. Developmental stage-specific regulation of TCRa chain gene

assembly by intrinsic features of the TEA promoter. J. Immunol. 2007; 179: 449-454. PMID:17579065.

61. Tarakanova VL, Leung-Pineda V, Hwang S, Yang C-W, Golder K, Basson M, Sun R, Piwnica-

Worms H, Sleckman BP, Virgin HW*. Herpesvirus kinase initiates DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host & Microbe 2007; 1:275-286. PMID:18005708.

62. Bredemeyer AL, Sleckman BP*. SWI-SNF: Promoter of accessibility. Nature Immunol. 2007;

8:795-796. PMID:17641658. 63. Callén E, Jankovic M, Difilippantonio S, Daniel J, Chen HT, Celeste A, Pellegrini M, McBride K,

Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A*. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell 2007; 130:63-75. PMID:17599403.

2008

64. Huang CY, Berdemeyer AL, Walker LM, Bassing CH, Sleckman BP*. Dynamic regulation of c-Myc expression during lymphocyte development revealed by a GFP-c-Myc Knock-in mouse. Eur. J. Immunol. 2008; 38:342-349. PMID:18196519.


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65. Bredemeyer AL, Huang C-Y, Walker LM, Bassing CH, Sleckman BP*. Aberrant V(D)J joining in ATM-deficient lymphocytes is dependent on non-homologous DNA end joining. J. Immunol. 2008; 181:2620-2625. PMID:18684952.

66. Cadwell K, Liu J, Briown SL, Miyoshi H, Loh J, Lennerz J, Kishi C, Carrero JA, Hunt S, Stone C,

Brunt EM, Sleckman BP, Lee E, Mizushima N, Stappenbeck TS, Virgin HW*. A unique role for autophagy and the autophagy gene Atg16L1 in murine and human intestinal paneth cells. Nature 2008; 456:259-264. PMID:18849966.

67. Difilippantonio S, Gapud E, Wong N, Huang C-Y, Mahowald GK, Chen HT, Kruhlak MJ, Callen

E, Livak F, Nussenzweig M*, Sleckman BP*, Nussenzweig A*. 53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature 2008; 456:529-533. PMID:18931658.

68. Mahowald GK, Barron JM, Sleckman BP*. Collateral damage from antigen receptor gene

diversification. Cell. 2008: 135:1009-1012. PMID:19070571. 69. Bredemeyer AL, Helmink BA, Innes CL, Calderon, B, McGinnis L, Mahowald GK, Gapud E,

Walker LM, Collins J, Weaver B, Mandik-Nayak L, Schreiber RD, Allen PM, May MJ, Paules RS, Bassing CH, Sleckman BP*. DNA double strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature 2008; 456:819-823. PMID:18849970.

2009

70. Khor B, Mahowald GK, Khor K, Sleckman BP*. Functional overlap in the cis-acting regulation of the V(D)J recombination reaction at the TCRb locus. Mol. Immunol. 2009; 46:321-326. PMID:19070901.

71. Helmink BA, Bredemeyer AL, Lee B-S, Huang C-Y, Sharma G, Walker L, Bednarski J, Lee W-L,

Pandita, TK, Bassing CH, Sleckman BP*. MRN complex function in the repair of chromosomal RAG-mediated DNA double strand breaks. J. Exp. Med. 2009; 206:669-679. PMID:19221393.

72. Hewitt S, Yin B, Marszalek K, Tenthorey J, Chaumeil J, Steinel N, Ji Y, Farrar M, Sleckman BP,

Busslinger M, Schatz DG, Bassing CH, Skok JA*. RAG1 and ATM co-ordinate mono-allelic recombination and nuclear positioning of immunoglobulin loci. Nature Immunol. 2009; 10:655-664. PMID:19448632.

73. Savic V, Bredemeyer AL, Carpenter AC, Helmink BA, Yang-Iott K, Sleckman BP, Bassing CH*.

ATM generates and maintains a g-H2AX chromatin structure that marks broken DNA strands. Molecular Cell 2009; 34:298-310. PMID:19450528.

74. Dose M, Sleckman BP, Bredemeyer AL, Han J, Bendelac A, Gounari F*. Intrathymic proliferation

wave essential for natural killer T cell development depends on c-Myc. Proc. Natl. Acad. of Sci. (USA) 2009; 106:8641-8646. PMID:19423665.

75. Callén E, Bunting S, Huang C-Y, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ,

Ried T, Sleckman BP*, Nussenzweig A*. Chimeric IgH-TCRa/d translocations in T lymphocytes mediated by RAG. Cell Cycle 2009; 8:2408-2412. PMID:19556863.


16

76. Gonzalez-Suarez I, Redwood AB, Perkins SM, Vermolen B, Lichtensztejin D, Grotsky DA,

Morgado-Palacin L, Gapud E, Sleckman BP, Sullivan T, Sage J, Stewart CL, Mai S, Gonzalo S*. Novel roles for A-type lamins on telomere biology and the DNA damage response pathway. EMBO 2009; 28:2414-2427. PMID:19629036.

77. Yin B, Savic V, Juntilla MM, Bredemeyer AL, Yang-Iott K, Helmink BA, Koretzky GA, Sleckman

BP, Bassing CH*. Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J. Exp. Med. 2009; 206:2625-2639. PMID:19887394.

78. Mahowald GK, Baron JM, Mahowald MA, Kulkarni S, Bredemeyer AL, Bassing CH, Sleckman

BP*. Aberrantly resolved Rag-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc. Natl. Acad. of Sci. (USA) 2009; 106:18339-18344. PMID:19820166.

2010

79. Reavie L, Dela-Gatta G, Thomson B, Palomero T, Zavadil J, Bredemeyer AL, Helmink B, Alt FW, Sleckman BP, Ferrando A, Aifantis I*. Adult stem cell quiescence regulated by a single ubiquitin ligase: substrate complex. Nature Immunol. 2010; 11:207-215. PMID:20081848.

2011

80. Helmink BA, Tubbs A, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP*. H2AX prevents CtIP-mediated DNA end resection and access to distinct end joining pathways in G1-phase cells. Nature 2011; 469:245-249. PMID:21160476.

81. Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer AL, Mahowald GK, Omi KQ, Walker LM,

McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP*. Atm and DNA-PKcs have overlapping activities during chromosomal signal joint formation. Proc. Natl. Acad. of Sci. (USA) 2011; 108:2022-2027. PMID:21245316.

82. Zhang S, Yajima H, Huynh H, Callen E, Zheng J, Lin Y-F, Story M, Chen H-T, Wong N, Bunting

S, Gapud E, Sleckman BP, Nussenzweig A, Zhang C, Chen DJ, Chen BP*. Severe anemia and stem cell failure in DNA-PKcs mutant mice associated with deficiencies in multiple DNA repair pathways. J. Cell Biol. 2011; 193:295-305. PMID:21482716.

83. Gapud EJ, Sleckman BP*. Unique and redundant functions of the Atm and DNA-PKcs during

V(D)J recombination. Cell Cycle 2011; 10:1928-1935. PMID:21673501. 84. Mahowald GK, Mahowald MA, Moon C, Khor B, Sleckman BP*. Out-of-frame T cell receptor b

transcripts are eliminated by multiple pathways in vivo. PLoS One 2011; 6:1-6. PMID:21765899. 85. Gapud EJ, Lee BS, Mahowald GK, Bassing CH, Sleckman BP*. Repair of chromosomal RAG-

mediated DNA breaks by mutant RAG proteins lacking PI-3-like kinase consensus phosphorylation sites. J. Immunol. 2011; 187:1826-1834. PMID:21742970.


17

86. Kondilis-Magnum H, Shih, H, Mahowald GK, Sleckman BP, Krangel M*. Regulation of T cell

receptor b allelic exclusion by gene segment proximity and accessibility. J. Immunol. 2011; 187:6374-6381. PMID:22079986.

2012

87. Sleckman BP, Oltz EM*. Preparing targets for V(D)J recombinase: transcription paves the way. J. Immunol. 2012; 188:7-9. PMID:22187481. 88. Bednarski JJ, Nickless A, Bhattacharya, D, Amin RH, Schlissel MS, Sleckman BP*. Interleukin-7

and RAG-mediated DNA breaks signal through distinct Pim family kinases to regulate Pre-B cell survival and proliferation. J. Exp. Med. 2012; 209:11-17. PMID:22201128.

89. Helmink BA, Sleckman BP*. The response to and repair of RAG-mediated DNA double strand

breaks. Ann. Rev. Immunol. 2012; 30:175-202. PMID:22224778. 90. Yin, B, Lee B-S, Yang-Iott KS, Sleckman BP, Bassing CH*. Non-redundant functions of ATM

and H2AX in maintenance of genomic stability during lymphocyte proliferation. J. Immunol. 2012: 189:1372-1379. PMID:22730535.

91. Daniel JA, Pellegrini M, Lee B-S, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP,

Feigenbaum L, Nussenzweig A*. Loss of ATM kinase activity leads to embryonic lethality in mice. J. Cell Biol. 2012; 198:295-304. PMID:22869595.

92. Bednarski JJ, Sleckman BP*. Lymphocyte development: Integrating DNA damage response

signals. Adv. in Immunol. 2012; 116:175-204. PMID:23063077. 93. Bednarski JJ, Sleckman BP*. Integrated signaling in developing lymphocytes: DNA damage

responses and surface receptor signals. Cell Cycle 2012; 11:4129-4134. PMID:23063077. 94. Calado DP, Sasaki Y, Godinho SA, Pellerin A, Köchert K, Sleckman BP, de Alborán IM, Janz M,

Rodig S, Rajewsky K*. MYC is essential for the formation and maintenance of germinal center B-cells. Nature Immunol. 2012; 13:1092-1101. PMID:23001146.

2013

95. Steinel, N, Lee B-S, Tubbs AT, Bednarski JJ, Schulte E, Yang-Iott KS, Schatz DG, Sleckman BP, Bassing CH*. The ataxia telangiectasia mutated kinase enforces Igk allelic exclusion by inhibiting secondary Vk-to-Jk rearrangements. J. Exp. Med. 2013; 210:233-239. PMID:23382544.

96. Sandoval GJ, Graham DB, Bhattacharya D, Sleckman BP, Xavier RJ, Swat W*. Cell-

autonomous control of IL-7 response revealed in a novel stage of precursor B cells. J. Immunol. 2013; 190:2485-2489. PMID:23420891.


18

97. Innes CL, Hesse JE, Palii SS, Helmink BA, Holub AJ, Sleckman BP, Paules RS*. DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs. BMC Genomics. 2013; 14: 163-173. PMID:23496831.

98. Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen H-T, Faryabi R, Polato F,

Santos M, Starnes LM, Wesemann D, Lee J-E, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig M, Nussenzweig A*. 53BP1 mediates productive and mutagenic DNA repair through distinct phospho-protein interactions. Cell 2013; 153:1266-1280. PMID:23727112.

99. Um J-H, Brown AL, Singh S, Chen Y, Lee B-S, Luckey MA, Kim MK, Park J-H, Sleckman BP,

Gellert M, Chung JH*. The metabolic sensor AMPK directly phosphorylates the recombination activating gene 1 (RAG1) protein and regulates V(D)J recombination. Proc. Natl. Acad. of Sci. (USA) 2013; 110:9873-9878. PMID:23716691.

100. Lee B-S, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA,

Osipovuch O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP*. Functional intersection of ATM and DNA-PKcs in coding end joining during V(D)J Recombination. Mol. Cell Biol. 2013; 33:3568-3579. PMID:23836881.

2014

101. KC W, Rapaport A, Satpathy AT, Russler E, Albring JC, Briseno C, Wu X, Edelson BT, Cella M, Colonna M, Sleckman BP, Murphy TL, Murphy KM*. L-myc provides cytokine-autonomous dendritic cell proliferation required for optimal T-cell priming during infection. Nature 2014; 507:243-247. PMID:24509714.

102. Dose M, Emmanuel AO, Konstantinou-Tegou T, Chaumeil J, Zhang J, Sun T, Germar K,

Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, La Beau MM, Georgopoulos K, Gounari F*. β-catenin induces T-cell transformation by promoting genomic instability. Proc. Natl. Acad. Sci. 2014; 111:391-396. PMID:24371308.

103. Ehninger A, Boch T, Uckelmann H, Essers MA, Mudder K, Sleckman BP, Trumpp A*. Post-

transcriptional regulation of c-Myc expression in adult mouse HSCs during homeostasis and interferon-g induced stress response. Blood 2014; 123:3909-3913. PMID:24795346.

104. Makharashvili N, Tubbs AT, Yang S-H, Wang H, Barton O, Lobrich M, Sleckman BP, Wu X,

Paull TT*. CtIP is an endonuclease that processes DNA adducts from double-strand breaks for homologous recombination. Molecular Cell 2014; 54:1022-1033. PMID:24837676.

105. Tubbs AT, Dorsett Y, Chan E, Helmink B, Lee B-S, Hung P, George R, Bredemeyer AL, Mittal A,

Pappu R, Chowdhury D, Mosammaparast N, Krangel M and Sleckman BP*. KAP-1 promotes resection of broken DNA ends not protected by g-H2AX and 53BP1 in G1-phase lymphocytes. Mol. Cell. Biol. 2014; 34:2811-2821. PMID:24842905.


19

106. Tubbs AT and Sleckman BP*. ATM deficiency: Revealing the pathways to cancer. Cell Cycle. 2014; 13:2992. PMID:25486558.

107. Dorsett Y, Zhou Y, Tubbs AT, Chen B-R, Purman C, Lee B-S, George R, Bredemeyer AL, Zhao

JY, Sodergen E, Weinstock GM, Han ND, Reyes A, Oltz EM, Dorsett D, Misulovin Z, Payton JE*, Sleckman BP*. HCoDES reveals chromosomal DNA ends structures with single nucleotide resolution. Molecular Cell 2014; 56:808-818. PMID:25435138.

2015

108. Bredemeyer AL, Sleckman BP*. DNA damage responses: Beyond double strand break repair. Current Biology 2015; 25:R45-46. PMID:25562302.

109. Felgentreff, K, Lee YN, Frugoni F, Du L, van der Burg M, Giliani S, Tezcan I, Reisli I, Mejstrikova

E, deVillartay JP, Sleckman BP, Manis J, Notarangelo LD*. Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency. J. Allergy Clin. Immunol. 2015; 136:140-150. PMID:25917813.

2016

110. Bednarski JJ, Pandey R, Schulte E, White LS, Chen B-R, Sandoval GJ, Kohyama M, Haldar M, Nickless A, Trott A, Cheng G, Murphy KM, Bassing CH, Payton JE, Sleckman BP*. RAG-mediate DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals. J. Exp. Med. 2016; 213:209-223. PMID:26834154.

111. Franco M, Panas MW, Marino ND, Lee MC, Buchholz KR, Kelly FD, Bednarski JJ, Sleckman BP,

Pourmand N, Boothroyd JC*. A novel secreted protein, MYR1, Is central to Toxoplasma's manipulation of host cells. MBio 2016; 7:1-15. PMID:26838724.

112. Jacobs KM, Misri S, Meyer B, Raj S, Zobel CL, Sleckman BP, Hallahan DE, Sharma GG*.

Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses. Mol. Biol. Cell. 2016; 27:1332-1345. PMID:26941327.

113. Brauer PM, Pessach I, Clarke E, de Bruin LO, Lee YN, Dominguez-Brauer C, Comeau AM,

Awong G, Felgentreff K, Bredemeyer A, Du L, Ververs F, Kennedy M, Giliani S, Keller G, Sleckman BP, Bushman R, Notarangelo LD, Zúñiga-Pflücker JC*. Modeling altered T cell development with human induced pluripotent stem cells from patients with RAG1 mutations and distinct immunological phenotypes. Blood 2016; 128:783-793. PMID:27301863.

114. Canela A, Sridharan S, Sciassia N, Tubbs A, Meltzer P, Sleckman BP, Nussenzweig A*. DNA

breaks and end resection measured genome wide by end sequencing (END-seq). Molecular Cell 2016; 63:898-911. PMID:27477910.

2017

115. Hung PJ, Chen B-R, George R, Liberman C, Morales AJ, Colon-Ortiz P, Tyler JK, Sleckman BP*, Bredemeyer AL. Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes. Cell Cycle 2017; 16:286-295. PMID:27830975.


20

116. Morales AJ, Carrero JA, Hung PJ, Tubbs AT, Edelson BT, Calderon B, Innes CL, Paules RS, Payton JE, Sleckman BP*. A Type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. ELife 2017; 6e24655:1-20. PMID:28362262.

2018

117. Lee B-S, Lee B-K, Iyer VR, RI, Sleckman BP, Shafer AL, Ippolito GC, Tucker HO, Dekker JD*. BCL11A is a critical component of a transcriptional network that activates RAG expression and VDJ recombination. Mol. Cell Biol. 2018; 38:e00362-17:1-19. PMID:29038163.

118. Huang T-H, Fowler F, Chen C-C, Shen Z-J, Sleckman BP, Tyler JK*. The Histone Chaperones

ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. Molecular Cell 2018; 69:879-892. PMID:29478807.

119. Hung PJ, Johnson B, Chen B-R, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ,

Deivasigamani S, Hindi, I, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chaudhuri J, Petrini JJH, Mosammaparast N, Amarasinghe GK, Zha S, Tyler JK, Sleckman BP*. MRI is a DNA damage response adaptor during classical non-homologous end joining. Molecular Cell 2018; 71:332-342. PMID:30017584

120. Bredemeyer AL, Edwards BS, Haynes MK, Morales A, Huang Y, Ursu O, Waller A, Sklar LA,

Sleckman BP*. High-throughput screening approach for identifying compounds that inhibit non-homologous end joining. SLAS Discovery 2018; 23:624-633. PMID:29232168.

121. Huang T-H, Shen Z-J, Sleckman BP, Tyler JK*. The Histone Chaperone ASF1 Regulates the

Activation of ATM and DNA-PKcs in response to DNA double-strand breaks. Cell Cycle 2018; 17:1413-1424. PMID:29954236.

122. Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP*. Cell

circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development. J. Exp. Med. 2018; 215:2586-2599. PMID:30158115.

123. Ryan TA*, Sleckman BP. A path(way) to keeping your synapses on an even keel. Neuron

2018; 100:1013-1014. PMID:30521772.

2019 124. Bednarski JJ, Sleckman BP*. At the intersection of DNA damage and immune responses.

Nature Rev. Immunol. 2019; 19:231-242. PMID:30778174. 125. Chen B-R, Quinet A, Byrum AK, Jackson J, Berti M, Thangvel S, Bredemeyer AL, Hindi I,

Mosammaparast N, Tyler JK, Vindgni A*, Sleckman BP*. XLF and H2AX function in series to promote replication fork stability. J. Cell Biol. 2019; 218:2113-2123. PMID:31123184.


21

126. Purman CE, Collins PL, Porter SI, Saini A, Gupta H, Sleckman BP*, Oltz EM*. Local transcriptional responses to DNA double-strand breaks in G1 phase cells. Mol. Cell Biol. 2019; Under revision.

127. Chen B-R, Tyler JK*, Sleckman BP*. Identifying novel non-homologous end joining factors

through combined deficiencies. Cell Cycle 2019; Under revision. 128. Innes CL, Hesse JE, Morales AR, Helmink BA, Schurman SH, Sleckman BP, Paules RS*. DNA

damage responses in murine Pre-B cells with genetic deficiencies in damage response genes. Cell Cycle 2019; Under revision.

129. Chu SH, Chabon JR, Matovina CN, Minehart JC, Chen B-R, Zhang J, Kumar V, Callen-Moreu E,

Hung PJ, Feng Z, Koche RP, Liu XS, Chaudhuri J, Nussenzweig A, Alt FW, Sleckman BP, Armstrong SA*. H3K36 methyltransferase SETD2 regulates NHEJ during lymphoid and neural development. Nature 2019; Under review.

130. Chen B-R, Wang Y, Bennett A, Hindi I, Tyler JK, Sleckman BP*. The RNF8 and RNF168

ubiquitin ligases function in NHEJ and DNA double strand break end protection. In preparation.

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Curriculum Vitae Barry Paul SleckmanCurriculum Vitae Barry Paul Sleckman Contact: Department of Pathology and Laboratory Medicine Weill Cornell Medical College 1300 York Avenue Box