Curriculum Vitae Andreia Marques Valente · Enyedy, Andreia Valente, η6-(2-Phenoxyethanol) ruthenium(II)-complexes of 2,2-bipyridine and its derivatives: solution speciation and

Curriculum Vitae Andreia Marques Valente

Index

Annex:

A. Valente - July 2016 - Curriculum Vitae 2/14

Andreia Marques Valente

WWoorrkk

Centro de Química Estrutural Edifício C8, 8.5.46/ 8.3.58, Faculdade de Ciências, Universidade de Lisboa Campo Grande, 1749-016 Lisboa Phone. +351 217 500 898 Fax: +351 217 500 088 [email protected] [email protected]

Researcher ID : D-9251-2011

http://www.researcherid.com/rid/D-9251-2011

Ph.D. in Chemistry (“Molécules et Matières Condensées”), Université des Sciences et Technologies de Lille 1, France,

October 2010; Thesis title: “Lanthanide based coordinative chain transfer polymerization for architecture control in

(co)polymers and ruthenium catalysed ring-opening polymerization: two aspects of atom economy in polymerization

catalysis”.

Supervisors: Prof. André Mortreux, Prof. M. H. Garcia, Philippe Zinck and Marc Visseaux

M.Sc. in Biomedical Inorganic Chemistry – Applications in Diagnosis and Therapy, Faculdade de Ciências, Universidade

de Lisboa, 2007; Thesis title: “Ruthenium metallocene syntheses and evaluation of their potentialities as anticancer

agents”.

Supervisor: M. Helena Garcia

Graduated in Technological Chemistry, Faculdade de Ciências, Universidade de Lisboa, September 2006 (15/20)

Erasmus research period at École Nationale Supérieure de Chimie de Lille (France) for graduation conclusion: “Controlled,

“living” and syndioselective styrene polymerization using rare earth borohydrides associated with dialkylmagnesium

compounds”; Supervisors: Philippe Zinck and Marc Visseaux (19/20).

JJaannuuaarryy 22001144 –– PPrreesseenntt ((ccuurrrreenntt ppoossiittiioonn))

Assistant Researcher (FCT Investigator Programme) at Centro de Química Estrutural – Bioinorganic Chemistry and Drug

Development Group, Faculdade de Ciências da Universidade de Lisboa (CQE-FC/UL). Independent area of research:

“Polymer-Metal Complexes for targeted drug delivery: a new approach to fight cancer”.

JJuunnee –– JJuullyy 22001144,, JJaann –– AApprriill 22001155

Sabbatical leave at Rutgers University, USA, Brian T. Buckley’s Group: Speciation of ruthenium metallodrugs by ion

chromatography coupled to an ICPMS. In situ binding experiments with measurement of all Ru complexes being

separated by a size exclusion column and detected using ICP/MS. Further characterization with UPLC/MSn experiments

on specific size fractions separated off line and enzymatically digested.

AApprriill 22001122 –– DDeecceemmbbeerr 22001133

Post-Doctoral Fellow from Fundação para a Ciência e Tecnologia (FCT) grant: SFRH/BPD/80459/2011. “Polymeric Metal

Complexes: New antitumoral agents with applications in controlled drug delivery”, Centro de Ciências Moleculares e

Materiais – Faculdade de Ciências da Universidade de Lisboa (CCMM-FCUL) — Prof. M. Helena Garcia Group

mailto:[email protected]

mailto:[email protected]


NNoovveemmbbeerr 22001100 –– AApprriill 22001122

Post-Doctoral Fellow within the project “Synthesis of new compounds with non-linear optic activity” (PTDC-QUI-66148-

2006), Centro de Ciências Moleculares e Materiais – Faculdade de Ciências da Universidade de Lisboa (CCMM-FCUL) —

Prof. M. Helena Garcia Group

OOccttoobbeerr 22000077 –– OOccttoobbeerr 22001100

Ph.D. Student at Synthèses Organométalliques et Catalyse, Unité de Catalyse et Chimie du Solid, UMR, CNRS, 8181, USTL

– France (Supervisors: Prof. André Mortreux, Prof. M. Helena Garcia, Prof. Philippe Zinck and Prof. Marc Visseaux). Area of

research: synthesis of lanthanide and ruthenium catalysts for application in (co)polymerization of styrene, isoprene and

caprolactone; new strategies in polymerization catalysis; new materials.

FFeebbrruuaarryy 22000066 –– AAuugguusstt 22000066

Training period under the Erasmus program at the École National de Chimie de Lille. This work was performed in the

frame of the Technologic Chemistry Graduation in the area of polymerization catalysis.

IIVV..11.. SSuummmmaarryy ooff SScciieennttiiffiicc oouuttppuutt IInnddiiccaattoorrss

ResearcherID: D-9251-2011

h-index: 12

Cumulative citations: 371

24 papers published in International Peer review Journals

1 paper placed at the first position of the Chemistry/Multidisciplinary journals (IF=45.795)

4 papers as scientific responsible author

4 book chapters (2 as scientific responsible author)

1 National Patent Application

1 International Patent Application

20 Oral communications (16 in International Scientific Meetings), 9 as speaker

32 Poster communications

IIVV..22.. PPaappeerrss iinn IInntteerrnnaattiioonnaall PPeeeerr--rreevviieewweedd JJoouurrnnaallss

24. Guilherme Nogueira, Orsolya Dömötör, Adhan Pilon, M. Paula Robalo, Fernando Avecilla, M. Helena Garcia, Éva A.

Enyedy*, Andreia Valente*, “η6-(2-Phenoxyethanol) ruthenium(II)-complexes of 2,2’-bipyridine and its derivatives:

solution speciation and kinetic behaviour”, accepted at J. Organomet. Chem.

23. Nuno Mendes, Francisco Tortosa, Andreia Valente, Fernanda Marques, António Matos, Tânia S. Morais, Ana Isabel

Tomaz, Fátima Gärtner, M. Helena Garcia, “In vivo Performance of a Ruthenium-cyclopentadienyl Compound in an

Orthotopic Triple Negative Breast Cancer Model”, accepted for publication at Anti-cancer Agents in Medicinal Chemistry.

22. Guilherme Nogueira, Audrey Favrelle, Marc Bria, João P. Prates Ramalho, Paulo J. Mendes, Andreia Valente, Philippe

Zinck, “Adenine as organoinitiator for the ring-opening polymerization of lactide: scope, mechanism and access to

adenine-functionalized polylactide”, React. Chem. Eng., 2016, DOI: 10.1039/C6RE00061D.

21. Tânia S. Morais, Andreia Valente, A. Isabel Tomaz, Fernanda Marques, M. Helena Garcia, “Tracking anti-tumor

metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds”, Future Medicinal Chemistry 2016,

8, 527-544.

20. Leonor Côrte-Real, Fernanda Marques, M. Paula Robalo, Guilherme Nogueira, Fernando Avecilla, Filipa C. Santos, A.

Isabel Tomaz, M. Helena Garcia*, Andreia Valente*, “The significant role of coligands in novel ruthenium(II)-


cyclopentadienyl bipyridine derivatives: ranging from non-cytotoxic to highly cytotoxic compounds”, Journal of Inorganic

Biochemistry 2015, 150, 148–159.

19. Andreia Valente, Gregory Stoclet, Fanny Bonnet, André Mortreux, Marc Visseaux and Philippe Zinck, "Isoprene-styrene chain shuttling copolymerization mediated by lanthanide half-sandwich complex and lanthanidocene: a straightforward access to a new type of thermoplastic elastomers", Angewandte Chemie 2014, 53, 4638-41.

18. Fernanda Marques, Leonor Côrte-Real, Filipa Mendes, Joana Coimbra, Tânia Morais, Ana Isabel Tomaz, Andreia Valente, Maria Helena Garcia, Isabel Santos, Manuel Bicho, “ Anticancer Activity of Structural Related Ruthenium(II) Cyclopentadienyl complexes”, Journal of Biological Inorganic Chemistry 2014, 19(6):853-67.

17. Andreia Valente,* M. Helena Garcia, “Syntheses of macromolecular ruthenium compounds: a new approach to the search of anticancer drugs”, Inorganics 2014, 2, 96-114.

16. Andreia Valente, Ana Margarida Santos, Leonor Côrte-Real, M. Paula Robalo, Virtudes Moreno, Mercè Font-Bardia,

Teresa Calvet, Julia Lorenzo, M. Helena Garcia, “New iron(II) cyclopentadienyl derivative complexes: synthesis and

preliminary antitumor screening” , Journal of Organometallic Chemistry 2014, 756, 52-60.

15. Andreia Valente,* Maria Helena Garcia, Fernanda Marques, Yong Miao, Cyril Rousseau, Philippe Zinck, “First polymer

“ruthenium-cyclopentadienyl” complex as potential anticancer agent”, Journal of Inorganic Biochemistry 2013, 127, 79-

81.

14. A. Valente, A. Mortreux, M. Visseaux, P. Zinck, “Coordinative Chain Transfer Polymerization”, Chemical Reviews 2013,

113, 3836-3857.

13. A. Valente, S. Royer, M. Narendra, T. J. L. Silva, P. J. G. Mendes, M. P. Robalo, M. Abreu, J. Heck, M. H. Garcia, “Synthesis of new Fe(II) and Ru(II) η5-monocyclopentadienyl compounds showing significant second order NLO

properties”, Journal of Organometallic Chemistry, 2013, 736, 42-49.

12. C.P. Matos, A. Valente, F. Marques, M.P. Robalo, P. Adão, J.C. Pessoa, I. Santos, M.H. Garcia, A. I. Tomaz, “New

polydentate ruthenium(III) complexes: synthesis, characterization and anti-tumour activity”, Inorganica Chimica Acta

2013, 394, 616-626.

11. A. Valente, P. Zinck, A. Mortreux, M. Bria, M. Visseaux, P. J. G. Mendes, T. J. L. Silva, M.H. Garcia, “Polymerization of ε-

caprolactone using ruthenium(II) mixed metallocene catalysts and isopropyl alcohol: living character and mechanistic

study”, Journal Molecular Catalysis A: Chemical 2011, 346,102-110.

10. A. Valente, P. Zinck, A. Mortreux, M. Bria, M. Visseaux, “Half lanthanocene/dialkylmagnesium mediated coordinative

chain transfer copolymerization of styrene and hexane”, Journal of Polymer Science: Part A: Polymer Chemistry 2011, 49,

17, 3778-3782.

9. V. Moreno, M. Font-Bardia, T. Calvet, J. Lorenzo, F. X. Alvilés, M. H. Garcia, T. S. Morais, A. Valente, M. P. Robalo, “DNA

interaction and cytotoxicity of new ruthenium (II) cyclopentadienyl derivative complexes containing heteroaromatic

ligands”, J. Inorg. Biochem. 2011, 105, 241-249.

8. A. Valente, P. Zinck, A. Mortreux, M. Visseaux, “Borohydrido rare earth based coordinative chain transfer

copolymerization: a convenient tool for tuning the microstructure of isoprene/styrene copolymers”, Journal of Polymer

Science: Part A: Polymer Chemistry 2011, 49, 7, 1615-1620.

7. A. Valente, P. Zinck, M. J. Vitorino, A. Mortreux, M. Visseaux, “Rare Earths / Main Group Metal Alkyls Catalytic Systems

for the 1,4-trans Stereoselective Coordinative Chain Transfer Polymerization of Isoprene”, Journal of Polymer Science: Part

A: Polymer Chemistry 2010, 48, 4640-4647.

6. M. H. Garcia, A. Valente, P. Florindo, T. S. Morais, M. F. M. Piedade, M. T. Duarte, V. Moreno, F. X. Avilés, J. Loreno,

“New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation

on DNA interaction by atomic force microscopy”, Inorganica Chimica Acta 2010, 363, 3765-3775.


5. P. Zinck, A. Valente, F. Bonnet, A. Violante, A. Mortreux, M. Visseaux, S. Ilinca, R. Duchateau, P. Roussel, “Reversible

coordinative chain transfer polymerization of styrene by rare earth borohydrides, chlorides/dialkylmagnesium systems”,

Journal of Polymer Science: Part A: Polymer Chemistry 2010, 48, 802-814.

4. A. Valente, P. Zinck, A. Mortreux, M. Visseaux, "Catalytic chain transfer (co-)polymerization: unprecedented

polyisoprene CCG and a new concept to tune the composition of a statistical copolymer”, Macromolecular Rapid

Communications 2009, 30, 528-531.

3. Philippe Zinck, Andreia Valente, Michaël Terrier, André Mortreux, Marc Visseaux, "Half-

lanthanidocenes catalysts via the “borohydride/alkyl” route: A simple approach of ligand

screening for the controlled polymerization of styrene”, C. R. Chimie 2008, 11, 595 – 602.

2. Philippe Zinck, Andreia Valente, André Morteux, Marc Visseaux, “In situ generated half-

lanthanidocene based catalysts for the controlled oligomerisation of styrene: selectivity,

block copolymerisation and chain transfer”, Polymer 48 (2007) 4609-4614.

1. Philippe Zinck, Michaël Terrier, André Mortreux, Andreia Valente and Marc Visseaux, "A New family of Styrene/Diene Rubbers”, Macromolecular Chemistry & Physics 2007, 208, 973-978 (This paper was prized for the back cover of the issue).

IIVV..33..BBooookk CChhaapptteerrss

4. Andreia Valente*, Tiago J. L. Silva, Paulo J. G. Mendes, Ana Isabel Tomaz, M. Helena Garcia, “Polymerization of ε-caprolactone using a ruthenium(II) mixed metallocene catalyst”, Comprehensive Organic Chemistry Experiments for the Laboratory Classroom – Chapter 16.5, accepted.

3. António Matos, Filipa Mendes, Andreia Valente, Tânia Morais, Ana Isabel Tomaz, Philippe Zinck, Maria Helena Garcia,

Manuel Bicho, Fernanda Marques, “Ruthenium-based anticancer compounds: insights into their cellular targeting and

mechanism of action”. Accepted at Wiley-VCH book “Ruthenium Complexes – Photochemical and Biomedical

Applications” (Editors: Alvin A. Holder, Jimmie L. Bullock Jr., Marc A. Lawrence, Wesley R. Browne, Lothar Lilge)

2. Tiago J. L. Silva, Paulo J. Mendes, Tânia S. Morais, Andreia Valente, M. Paula Robalo, M. Helena Garcia, “’RuCp’ a

versatile moiety: from NLO to antitumor properties”, RUTHENIUM: SYNTHESIS, PHYSICOCHEMICAL PROPERTIES AND

APPLICATIONS, In press, Nova Science Publishers, Inc. (NOVA), USA, 2014. ISBN: 978-1-63321-657-0

1. Andreia Valente,* Philippe Zinck, “Polymer-Metal Complexes (PMC) for Cancer Therapy”, Recent Research

Developments in Polymer Science, 11 (2012):99-128, published by Transworld Research Network, Trivandrum, India

(ISBN: 978-81-7895-538-4)

IIVV..44.. PPaatteennttss ..

2. Garcia, M.H.; Valente, A.; Morais, T.S.F.; Tomaz, A.I.; Macromolecular Transition Metal Complexes For Treatment Of

Cancer And Process For Their Preparation, PCT/IB2015/002312.

1. Garcia, M.H.; Valente, A.; Morais, T.S.F.; Tomaz, A.I.; Novos complexos macromoleculares de metais de transição para

tratamento do cancro; 2014, Patente PT, n.º108.082.

IIVV..55.. CCoonnffeerreennccee PPrroocceeeeddiinnggss ..

2. “The mode of action of new promising anticancer agents: multifunctional polymer-ruthenium conjugates”, Andreia

Valente, M H Garcia, A Pilon, A P Matos, F Tortosa, N Mendes, F Gärtner, A Preto, R Francisco, B T Buckley, F Marques,

Med Chem 2015, 5:10, http://dx.doi.org/10.4172/2161-0444.C1.015

1. “Ruthenium drugs for cancer therapy: small structural changes, different in vivo performances”, M. Helena Garcia,

Tânia S. Morais, A. Isabel Tomaz, Fernanda Marques, Andreia Valente, Med Chem 2015, 5:10,

http://dx.doi.org/10.4172/2161-0444.C1.015

http://dx.doi.org/10.4172/2161-0444.C1.015

http://dx.doi.org/10.4172/2161-0444.C1.015


IIVV..66.. EElleeccttrroonniicc PPuubblliiccaattiioonnss ..

Paper selected by the Global Medical Discovery to be on permanently online:

1. 2014 “Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes", L. Côrte-Real, F. Mendes, J.

Coimbra, T. S. Morais, A. I. Tomaz, A. Valente, M. H. Garcia, I. Santos, M. Bicho - featured at Global Medical Discovery

[ISSN 1929-8536] website:

https://globalmedicaldiscovery.com/?s=Anticancer+activity+of+structurally+related+ruthenium%28II%29+cyclopentadien

yl+complexes

IIVV.. 77.. OOrraall CCoommmmuunniiccaattiioonnss

IInnvviitteedd SSppeeaakkeerr

5. Andreia Valente, Leonor Côrte-Real, Guilherme Nogueira, Anabela Sanches, Fernanda Marques, Francisco Tortosa, Fátima Gärtner, Nuno Mendes, M. Helena Garcia, “Polymer-metal conjugates: versatile scaffolds for the synthesis of new antitumor drugs”, European Chemistry Congress, June 16-18, Rome, Italy.

4. A. Valente, M.H. Garcia, A. Pilon, A.P. Matos, F. Mendes, M.A.F. Faustino, N. Mendes, F. Gärtner, A. Preto, R. Francisco, F. Marques, "Multifunctional polymer-ruthenium cyclopentadienyl complexes: new promising anticancer agents", I International Caparica Christmas Congress on Translational Chemistry 7th-10th December 2015, Portugal

3. A. Valente, M.H. Garcia, A. Pilon, A.P. Matos, F. Tortosa, N. Mendes, F. Gärtner, A. Preto, R. Francisco, B. T. Buckley, F. Marques, "On the mode of action of new promising anticancer agents: multifunctional polymer-ruthenium conjugates", 4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing, November 02-04, 2015 Atlanta, USA

2. Andreia Valente, M. Helena Garcia, Leonor Côrte-Real, Guilherme Nogueira, Philippe Zinck, António Matos, Fernanda Marques, “Polymer ‘ruthenium-cyclopentadienyl’ conjugates: a new approach to fight cancer”, 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing Dec 08-10, 2014 San Francisco, USA – Andreia Valente

1. Andreia Valente, M. Helena Garcia, Fernanda Marques, Philippe Zinck, “New polymeric “ruthenium-cyclopentadienyl”

complexes for drug delivery in cancer therapy”, 2nd International Conference on Medicinal Chemistry & Computer Aided

Drug Designing, 15-17th October 2013, Las Vegas, USA.

IInnvviitteedd CCoo--aauutthhoorr

5. M. Helena Garcia, Andreia Valente, Tânia S. Morais, Fernanda Marques, “Ruthenium Organometallic compounds as promising anti- metastatic drugs for breast cancer chemotherapy”, European Chemistry Congress, June 16-18, Rome, Italy.

4. M. Helena Garcia, Tânia S. Morais , A. Isabel Tomaz, Fernanda Marques, Andreia Valente, “Ruthenium drugs for cancer therapy: small structural changes, different in vivo performances”, 4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing, November 02-04, 2015 Atlanta, USA.

3. Brian Buckley, Andreia Valente, Ill Yang, Min Liu, Kyle Buckley, Frances Acevedo Mariani, Stephanie Marco, Elizabeth McCandlish, “Finding Homes for all of the Orphan Assays”, Eastern Analytical Symposium, November 17th-19th 2014, Somerset NJ, USA.

2. M. Helena Garcia, Tânia Morais, Andreia Valente, Fernanda Marques, “Tracking antitumor drugs: ruthenium(II) cyclopentadienyl complexes as promising agents”, 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing Dec 08-10, 2014 San Francisco, USA.

1. Andreia Valente, Grégory Stoclet, Fanny Bonnet, André Mortreux, Marc Visseaux, Philippe Zinck, “Access to amorphous thermoplastic elastomers of tunable transition temperatures via chain shuttling copolymerization”, 2014 IUPAC World Polymer Congress, 6-11 July Chiang Mai, Thailand.

SSppeeaakkeerr


4. Andreia Valente, L. Côrte-Real, A.P. Matos, M. H. Garcia, F. Marques, “Multifunctional polymer-ruthenium conjugates: new promising anticancer agents”, 2nd European Conference on Smart Inorganic Polymers, 24th-26th of September, 2015, Upsalla, Sweden.

3. Andreia Valente, M. H. Garcia, F. Marques, P. Zinck, “New polymer-ruthenium conjugates for targeted drug delivery in

cancer chemotherapy”, Nanoparticles for early Diagnostics of inflammatory diseases, November 20/21 2013, Lisbon –

Flash Presentation

2. Andreia Valente, “Dois aspectos para uma economia de catalisador em polimerizações por transferência de cadeia”,

Ciência QB - 1º Encontro dos Alunos de Doutoramento do DQB - FCUL 7 de Junho de 2011, Faculdade de Ciências da

Universidade de Lisboa

1. Andreia Valente, “Polymérisation coordinative par transfert de chaîne : vers de nouvelles applications", Journée des

jeunes chercheurs en polymère 1-2 December 2009, Lille, France.

CCoo--aauutthhoorr

7. Leonor Côrte-Real, Alejandro P. Soto, Ana S. Viana, M. Helena Garcia, Andreia Valente; Self-assembled polymer-ruthenium micelles: new promising anticancer agents; Third European Conference on Smart Inorganic Polymers, 12th-14th

September 2016, Porto, Portugal.

6. Leonor Côrte-Real; M. Helena Garcia; Ana S. Viana; Andreia Valente; Self-assembled polymer-metal micelles: new

promising anticancer agents; 5PYChem/EyChem, 2016 April 26-29, Guimarães, Portugal.

5. Andreia Valente, Thibaut Pinalie, Fanny Bonnet, Grégory Stoclet, Jean-Marc Lefèbvre, Marc Visseaux, André Mortreux,

Philippe Zinck, “Access to a new type of thermoplastic elastomer via rare earth catalysts mediated chain shuttling

polymerization”, Eufen 4, Fourth joined meeting of COST Action CM1006: European f-Element Chemistry, Lisbon,

Portugal, 11-12 April 2015

4. Guilherme Nogueira, Andreia Valente, "New ruthenium-polymer conjugates for drug delivery in cancer therapy"; 2º Encontro Nacional de Estudantes de Química, Março de 2014, Covilhã - PT.

3. Cristina P. Matos, Andreia Valente, Fernanda Marques, Pedro Adão, Rodrigo F. M. Almeida, João Costa Pessoa, M.

Helena Garcia, Ana Isabel Tomaz, “New polydentate Ru(III)-Salan complexes: synthesis, characterization, antitumour

activity and interaction with human serum proteins”, International Symposia on Metal Complexes – ISMEC, June 18th –

22nd 2012 – Lisbon (Portugal).

2. Matos, C.P.; Valente, A.; Marques, F.; Adão, P.; Robalo, M.P.; Almeida, R.F.M.; Costa Pessoa, J.; Garcia, M.H.; Tomaz, A.I.; Polydentate Octhaedric Ru Complexes: Synthesis, Characterization, Anti-Tumour Activity and Interaction with Human Serum Proteins, Flash Oral Commun. F3.25, XXV International Conference on Organometallic Chemistry, Lisbon, September 2012.

1. A. Valente, P. Zinck, A. Mortreux, M. Visseaux, "Coordinative chain transfer polymerization: recent advances and a new

paradigm using rare earth catalysts”, Eufen 1, First joined meeting of COST Action CM1006: European f-Element

Chemistry, Tarragone, Spain, 2-4 April 2012.

SSppeeaakkeerr

8. A. Valente, “Targeted cancer nanotherapy using metal-polymer conjugates”, Lecture on the Post-graduated course – “Bionanoparticles: challenges and therapeutic opportunities”, 23rd May to 3rd June 2016, Departamento de Biologia, Universidade do Minho.

7. A. Valente, “Ruthenium-polymer conjugates: new promising anticancer agents”, 27th April 2016. Conferences Cycle from Centro de Química de Évora, Ph.D. Program in Chemistry and M.Sc. in Chemistry.

6. Andreia Valente, “Medicinal Inorganic Chemistry: Metal-polymer conjugates for cancer therapy”, Lecture on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 8-19 June 2015, Department of Biology, Universidade do Minho.

5. A. Valente, “Ruthenium drugs: born to kill”, Chemforum, 17 of June 2015, Instituto Superior Técnico, Lisboa.


4. Andreia Valente, “Polymer ‘ruthenium-cyclopentadienyl’ conjugates: a new approach to fight cancer”, 24th November 2014, Invited Seminar at École Nationale Supérieure de Chimie de Lille.

3. Andreia Valente, “New polymer ‘ruthenium-cyclopentadienyl’ complexes for drug delivery in cancer therapy”, CCMM Seminars, 29 January 2014, Lisboa, Portugal.

2. Andreia Valente, “New polymer-ruthenium conjugates for drug delivery in cancer chemotherapy”, lecture on Inorganic Biochemistry from the 2nd academic year of the Biochemistry Course, Faculdade de Ciências da Universidade de Lisboa 2014.

1. Andreia Valente, “Metal-polymer conjugates for cancer therapy”, 23rd May 2014. Post-graduated course Bionanotechnology for diagnosis and therapy of cancer”, 19-30 May 2014, CBMA – Department of Biology, University of Minho, Portugal.

Principal Investigator in one research project funded by the Portuguese Foundation for Science and Technology (FCT) -

ongoing; Principal Investigator in one research project funded by the Royal Society of Chemistry – ongoing; Team

member in one ongoing research project funded by the Portuguese Foundation for Science and Technology (FCT); two

already concluded.

Team member in one European Network (COST) – ongoing.

Team member in Transnational Cooperation Programme - Portugal-Poland – ongoing.

Principal Researcher

M-ERA.NET Call 2016, “Polymer-drug conjugates as new delivery systems in photodynamic therapy of cancer”. Total

requested funding: 594396€ for 3 years. - submitted

IF/01302/2013, “Polymer-Ruthenium Complexes for targeted drug delivery: a new approach to fight cancer”,

Funding: € 50000. From 2015 to 2018.

RSC Research Fund Grant, “Multifunctional polymer-metal complexes: an innovative approach to treat cancer”.

Funding: £3920. From 01-Jan/31Dec 2016.

Team Member

FCT RD0480 - Transnational Cooperation Programme - Portugal-Poland (2015-2016), “Complexes of Flavonoid’s Schiff bases: Impact of structural modification on the chelating ability and evaluation of biological and therapeutic properties” - ongoing

COST action EUROPEAN NETWORK ON SMART INORGANIC POLYMERS (SIPs) – member of the working groups “WG2 Smart inorganic polymers” and “WG3 Advanced applications” – ongoing

FCT Project PTDC/QUI-QUI/118077/2010 – "Preclinical evaluation of ruthenium potential drugs for cancer therapy" – opened on 1/03/2012- concluded

FCT Project PTDC/Qui-Qui/101187/2008 – “ Ruthenium Complexes for anti-cancer applications ” - concluded FCT Project PTDC/QUI/66148/2006 - "Synthesis of Organometallic Molecular and Polymeric Materials with Nonlinear

Optical Properties" – concluded

VVIIII..11.. UUnnddeerrggrraadduuaattee ssttuuddeennttss

PPaattrríícciiaa GGíírriioo (September 2015 – July 2016) – undergraduate student from the Chemistry course from FCUL, final

graduation project entitled “New iron cyclopentadienyl complexes as anticancer agents: a structure-activity study” –

Evaluated with 19/20.

MMaacciieejj MMaacckkoowwiiaakk (July 2015 – October 2015) - Summer Internship from Erasmus + Program, undergraduate student

from Faculty of Chemistry, Lodz University of Technology. Project titled “Synthesis of biocompatible (co)polymers for

application in cancer therapy”


FFrraanncceess AAzzeevveeddoo (June-July 2014) – summer undergraduate student from University of Puerto Rico, in the frame of the RiSE (Research in Science and Engineering) programme at Rutgers University, USA.

RRiiccaarrddoo TTeeiixxeeiirraa (September 2013 – July 2014) – undergraduate student from the Chemistry course from FCUL, final

graduation project entitled "Development of potential metallodrugs for cancer therapy". Evaluated with 19/20.

AAddhhaann PPiilloonn (September 2013 – July 2014) – undergraduate student from the Technological Chemistry course from

FCUL, final graduation project entitled “New ruthenium-polymer complexes syntheses in view of photodynamic

therapy in melanoma cancer”. Evaluated with 20/20.

GGuuiillhheerrmmee NNoogguueeiirraa (September 2012 – July 2013) – undergraduate student from the Technological Chemistry course

from FCUL, final graduation project entitled “New ruthenium-polymer complexes syntheses for controlled drug delivery

in cancer therapy”; Project awarded with a Amadeu Dias Scholarship. Evaluated with 19/20.

TToommookkaa YYaammaaddaa (2 months in 2010) - undergraduate Erasmus student from Japan – CCoo--ssuuppeerrvviissiioonn of the project with Prof. Philippe Zinck at École Nationale Supèrieure de Chimie de Lille

VVIIII..22.. GGrraadduuaattee ssttuuddeennttss

Ph.D.

LLeeoonnoorr CCôôrrttee--RReeaall (January 2015 – Present) – Ph.D. Thesis entitled “Polymer-metal based compounds to target

hormone-responsive cancers: synthesis and mechanistic evaluation”. (in co-supervision with Prof. Helena Garcia) –

ongoing.

M.Sc.

MMaarriiaa IInnêêss GGeennrroo PPeerreeiirraa (2015/2016), MSc. Thesis in Chemistry, FCUL, entitled “Development of new metalodrugs:

new ruthenium complexes bearing macromolecular ligands as antitumor agents” (in co-supervision with Dr. Ana Isabel

Tomaz) – ongoing.

AAddhhaann PPiilloonn (2015/2016), MSc. Thesis in Technological Chemistry, FCUL, entitled “A importância de moléculas

azotadas nas estruturas poliméricas de novos complexos de ferro macromoleculares como agentes anticancerígenos”

(in co-supervision with Dr. Luís Alves) – ongoing.

BBeebbiiaannaa MMaarriiaa SSoouussaa PPiinnttoo (2015/2016), MSc. Thesis in Chemistry, Universidade de Évora, entitled “New metal-based

micelles as targeted anticancer agents” (in co-supervision with Prof. Paulo Mendes) – ongoing.

TTiiaaggoo MMaannuueell MMaarrttiinnss MMoorreeiirraa (2015/2016), MSc. Thesis in Molecular Genetics, Universidade do Minho, entitled

“Unraveling the molecular targets of new ruthenium-based anticancer drugs” (in co-supervision with Prof. Ana Preto)

– ongoing.

AAnnaabbeellaa SSaanncchheess (September 2014 – Present) – MSc. Thesis in Chemistry, FCUL, entitled “Development of new ruthenium compounds as potential drugs for the treatment of hypophysis adenomas”. (in co-supervision with Dr. Fernanda Marques) – ongoing.

MMSScc.. RRiittaa FFrraanncciissccoo, (May-November 2015) – research grant - SSuuppeerrvviissiioonn in the scope of the project IF/01302/2013

GGuuiillhheerrmmee NNoogguueeiirraa (2014/2015) – MSc. Thesis in Technological Chemistry, FCUL, entitled “Functionalization of biocompatible polyesters with substrates of biological interest via organocatalyzed ring-opening polymerization: application in cancer therapy”. Evaluated with 20/20.

LLeeoonnoorr CCôôrrttee--RReeaall (May 2013 – December 2013) – M.Sc. under the frame of ongoing projects

Master

26.Nov.2015 – Ana Sofia Assis, M.Sc. in Chemistry. Thesis title: “Synthesis of new metal complexes and evaluation of

their potential as anticancer agents” - Thesis Committee Main Examiner – Faculdade de Ciências da Universidade de

Lisboa


Ph.D.

10.Dec.2015 – Eugénia Sofia da Costa Nogueira, Ph.D. in Environmental and Molecular Biology, specialty in Health and

Cellular Biology. Thesis title: “Development of folate-targeted liposomes for rheumatoid arthritis therapy” – Thesis

Committee Main Examiner – Universidade do Minho, Escola de Ciências.

Since November 2015 is an evaluator for the Fulbright Program in Portugal.

Peer Reviewer for:

European Journal of Medicinal Chemistry (Elsevier, IF = 3.946)

Journal of Inorganic Biochemistry (Elsevier, IF = 3.447)

Inorganic Chemistry (ACS, IF = 4.762)

XXII..11.. IInntteerrnnaattiioonnaall

France, Université des Sciences et Technologies de Lille - Prof. Philippe Zinck

France, Faculté des Sciences Jean PERRIN – Dr. Sophie Duban-Deweer

France, Sanofis-Aventis – Dr. Jerôme Meneyrol

France, Institut de Biologie et Chimie des Protéines – Dr. Pierre Falson

Spain, Universitat de Barcelona - Prof. Virtudes Moreno

Spain, Universitat de Barcelona – Dr. Julia Lorenzo

Spain, Universidad de Oviedo – CSIC (IUQOEM) – Dr. Alejandro Presa Soto

Spain, Institut de Ciència de Materials de Barcelona – Dr. Clara Viñas

USA, Rutgers University – Dr. Brian Buckley

USA, Rutgers University - Dr. Lauren Aleksunes

XXII..22.. NNaattiioonnaall

Lisboa, Instituto Tecnológico Nuclear - Dr. Fernanda Marques

Lisboa, Faculdade de Ciências da Universidade de Lisboa - Dr. Ana Isabel Tomaz

Lisboa, Faculdade de Medicina da Universidade de Lisboa – M.D. Francisco Tortosa

Lisboa, Egas Moniz - Cooperativa de Ensino Superior, CRL - Dr. António Matos

Lisboa, CQB, Faculdade de Ciências da Universidade de Lisboa – Dr. Paulo Costa

Lisboa, CQB, Faculdade de Ciências da Universidade de Lisboa – Dr. Ana Viana

Braga, Universidade do Minho - Campus de Gualtar, Departamento de Biologia – Prof. Ana Preto

Porto, IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto – Dr. Fátima Gärtner

Porto, Faculdade de Ciências da Universidade do Porto - Ana Silva

Aveiro, Universidade de Aveiro – Prof. Amparo Faustino

TTeeaacchhiinngg EExxppeerriieennccee

Laboratory of syntheses and product development / Laboratório de Sínteses e Desenvolvimento de Produtos (1st

cycle); 2015/2016, 2nd semester - Faculdade de Ciências da Universidade de Lisboa. A. Valente is the coordinator

for the 2015/2016 scholar year.

Biochemistry (introductory) / Bioquímica; Health Sciences Course (1st cycle); Since 2010/2011 until the present; 2nd

semester; 1 PL and 1 TP (3h/week) – Faculdade de Ciências da Universidade de Lisboa


Chemistry / Química Geral; Biology Course/Integrated Master Course on Biomedical Engineering and Biophysics;

Since 2011/2012 until the present; 1st semester; 2 PL (3h/week) – Faculdade de Ciências da Universidade de Lisboa

Chemical Engineering / "Génie Chimique"; 2007/2008, 2008/2009; 1st semester ; 1PL/year (Total : 80h) -

Université des Sciences et Technologies de Lille (USTL) - IUT A – Département de Chimie

“Formação Profissional de Sensibilização em Controlo de Acidentes com Matérias Perigosas” – Escola Nacional de

Bombeiros – Formação Empresas (2016)

First Certificate in English – The British Council in Oporto (2002)

XXIIVV..11.. RReesseeaarrcchh IInntteerreessttss

My research interests are now mainly focused in the development of new nanodrugs as drug-delivery systems in cancer

therapy. These new compounds carrying out our ruthenium or iron efficient drugs comprise a targeting molecule to more

efficiently reach the cancer cells. Besides, the biological studies that are also being developed will reveal possible targets,

internalization of drugs and mechanisms of action constituting an important step forward in the complicated process of

chemotherapy. The will to synthesize these new (pro)drugs was born from a synergy between the competences that I

have acquired in Biomedical Inorganic Chemistry and Polymerization Catalysis. Accordingly, my path is marked by a

thematic mobility and competences synergy allowing me to gain an extensive and wide-ranging experience in the several

aspects (described below).

XXIIVV..22.. SScciieennttiiffiicc aanndd TTeecchhnniiccaall EExxppeerrttiissee

Synthesis and characterization of new inorganic/organometallic compounds for different applications, such as,

polymerization catalysis, non-linear optics (NLO) and antitumoral agents;

Handling air-sensitive compounds under inert atmosphere using Schlenk techniques and glove boxes;

Purification techniques, such as, chromatography (thin layer chromatography, in column) and recrystallization;

Spectroscopic techniques like UV-Vis, Circular Dichroism (CD), Steady-state fluorescence, Infrared (FTIR), and

multinuclear NMR (1H, 13C, 31P, COSY, NOESY, HMQC, HMBC, DEPT);

Mass spectrometry: ICP-MS (Inductively coupled plasma mass spectrometry);

Electrochemical techniques - cyclic voltammetry;

Development of new polymerization strategies of (a)polar monomers using the newly synthesized catalysts in

combination with different chain transfer agents;

Characterization of polymers by means of Gel Permeation Chromatography (GPC), Differential Scanning Calorimetry

(DSC), Thermogravimetry (TG), Matrix-assisted laser desorption/ionization (MALDI-ToF), Atomic Force Microscopy (AFM)

techniques, between others.

Experience in handling and growing several human tumour cell lines and cytotoxic evaluation of organometallic

complexes in tumour cells.

XXVV..11 PPrriizzeess

Royal Society of Chemistry Research Fund Grant, “Multifunctional polymer-metal complexes: an innovative approach to treat cancer”, Jan-Dec 2016.


Biographical profile selected to be present in the Marquis Who’s Who in the World 2016 - 33rd Edition (Classic); ISBN: 978-0-8379-1156-4.

Andreia Valente, Young Investigator Award at the 2nd European Conference on Smart Inorganic Polymers; 24th-26th of September, 2015, Upsalla, Sweden

M. Helena Garcia, Andreia Valente, Ana Isabel Tomaz, Tânia Morais, “RuPharma”, 1st position in the ScienceIN2Business 2015 call.

Fulbright grant for Portuguese Scholars and Researchers entitled “On the mode of action of cyclopentadienyl ruthenium (macro)metallodrugs”, Jan – March 2015

Best poster prize, M. Helena Garcia, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, Fernanda Marques, "Cyclopentadienyl ruthenium (macro)metallodrugs: large spectrum antitumor agents”, Drug Discovery & Therapy World Congress 2013 Cover of the issue in Macromolecular Chemistry & Physics 2007, 208, 973-978

XXVV..22 MMeeddiiaa CCiittaattiioonnss

In the Portuguese news–“Jornal das 8(TVI): Os comentários do Prof. Marcelo Rebelo de Sousa”, 14th July 2013 (http://www.tvi.iol.pt/videos/13918230, 3min11seg) “Cancro: Portuguesas vencem prémio mundial nos EUA", http://boasnoticias.sapo.pt (25th June 2013) “1.º Prémio no "Drug Discovery & Therapy World Congress 2013", http://www.fc.ul.pt/en/noticia/24-06-2013/1%C2%BA-pr%C3%A9mio-no-drug-discovery-therapy-world-congress-2013 (24th June 2013)

Member of the Royal Society of Chemistry (MRSC) Member of the Associação Portuguesa de Investigação em Cancro (ASPIC) Member of the European Association for Cancer Research Member of the Sociedade Portuguesa de Química

“3rd European Conference on Smart Inorganic Polymers”, 12th-14th of September 2016, Porto, Portugal – Member of the

organizing committee

CQE@Ciências invited seminars 2015-16 – Member of the organizing committee

“4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing”, November 02-04, 2015 Atlanta,

USA - Member of the organizing committee

CQE@Ciências seminars 2014-15 – Member of the organizing committee

CQE@Ciências seminars 2013-14 – Member of the organizing committee

“3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing”, Dec 08-10, 2014 San Francisco, USA

Member of the organizing committee

2016

32. A. Valente, A. Pilon, A. Sanches, M. H. Garcia, F. Marques, A. M. Martins, L. G. Alves, “Functionalization of iron complexes with polymer-based macroligands: application in cancer therapy”. Third European Conference on Smart Inorganic Polymers, 12th-14th September 2016, Porto, Portugal. 31. A. Matos, F. Marques, R. Francisco, T. Moreira, A. Preto, M. H. Garcia, A. Valente, "Unraveling the mode of action of new promising polymer-ruthenium conjugates”. ULTRAPATH XVIII July 11-15, 2016, Lisbon, Portugal. 30. C. Antunes, A. Valente, P. J. Costa, "Interaction of D-glucose end-capped polylactide ruthenium cyclopentadienyl complexes with GLUT: insights from molecular docking", CQB Day 2016, DQB-FCUL, Lisbon, Portugal, June 28th (2016). 29. P. J. Mendes, J. P. P. Ramalho, A. Valente, P. Zinck, G. Nogueira, A. Favrelle, “DFT Studies On The Mechanism Of Ring-Opening Polymerization Of Lactide With Adenine”, 12º Encontro Nacional de Química-Física / 1º Simpósio de Química Computacional, 22 – 24th June 2016. 28. B. Pinto, A. S. Viana, M. H. Garcia, P. J. Mendes, A. Valente, “New metal-based micelles as anticancer agents”, 12º Encontro Nacional de Química-Física / 1º Simpósio de Química Computacional, 22 – 24th June 2016. 27. Moreira, T., Sanches, A., Pilon, A., Francisco, R., Ferreira, A. G., Garcia, M.H., Preto, A., Valente, A., “Exploring The Effect Of Multifunctional Polymer-Ruthenium Conjugates: New Promising Anticancer Agents”. 2nd ASPIC International Congress April 28-29, 2016, Porto, Portugal.

http://www.fc.ul.pt/en/noticia/24-06-2013/1%C2%BA-pr%C3%A9mio-no-drug-discovery-therapy-world-congress-2013

http://www.fc.ul.pt/en/noticia/24-06-2013/1%C2%BA-pr%C3%A9mio-no-drug-discovery-therapy-world-congress-2013


2015

26. António Pedro Matos, Lurdes Gano, Francisco Tortosa, Teresa Pinheiro, Tânia Morais, Andreia Valente, Ana Isabel Tomaz, Maria Helena Garcia, Fernanda Marques, Microscopic Analysis of the Antitumor Effects of Ruthenium Complexes in a Prostate Cancer Model, “From Basic Sciences to Clinical Research”, Lisboa, November 27 and 28, 2015 - Poster P62. 25. Ana Cristina Poeta, A. Sofia Assis, Andreia Valente, Tânia S. Morais, Fernanda Marques, M. Paula Robalo, Susana Santos, Ana Isabel Tomaz, M. Helena Garcia, On the field of metallodrugs: novel ruthenium(II) complexes with thiosemicarbazones, 19th European Symposium on Organic Chemistry (ESOC), 12-16 Julho 2015, Lisboa, Portugal. 24. Andreia Valente, M. Helena Garcia, Fernanda Marques, António Matos, Philippe Zinck, “Smart ruthenium nanodrugs for tumor targeted delivery: a new approach to fight cancer”. 1st European Conference on Pharmaceutics: Drug Delivery 13-14 April, 2015, Reims, France. 23. Fernanda Marques, Adhan Pilon, Amparo Faustino, Hélia Jeremias, M. Helena Garcia, Andreia Valente, "Multifunctional polymer-ruthenium cyclopentadienyl complexes: application as anticancer agents for photodynamic therapy", 16th Congress of the European Society for Photobiology, Aveiro (Portugal), 31 August - 4 September 2015. 22. M. Helena Garcia, Andreia Valente, Philippe Zinck, Fernanda Marques, “Organometallic ruthenium nanodrugs as potential anticancer agents”, EuCOMC XXI, July 5-9 2015, Bratislava, Slovakia.

2014

21. Frances M. Acevedo Mariani, Andreia Valente, Elizabeth Mccandlish, Brian Buckley "A Straightforward Method Of Cisplatin Speciation In Human Blood", 2014 Annual Biomedical Research Conference For Minority Students, San Antonio, Tx From Nov. 12-15, 2014 20. Frances M. Acevedo Mariani, Andreia Valente, Elizabeth Mccandlish, Brian Buckley "A Straightforward Method Of Cisplatin Speciation In Human Blood", Rise At Rutgers Research In Science And Engineering, Summer Research Symposium, 30 July 2014, USA.

2013

19. M. Helena Garcia, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, Fernanda Marques, “Cyclopentadienyl ruthenium (macro)metallodrugs: large spectrum antitumor agents”, Drug Discovery & Therapy World Congress 2013, poster 54, Boston, USA – 3-6.june.2013 18. A. Valente, S. Georges, A. Mortreux, M. Visseaux, P. Zinck “Polymerisation coordinative par transfert de chaine : un nouveau concept pour le controle de la composition d’un copolymere statistique”, Journee Scientifique de la Catalyse Homogene, 2013, 14 June, Lille, France.

2012

17. Andreia Valente, M. Helena Garcia, Tânia S. Morais, Fernanda Marques, Yong Miao, Philippe Zinck, "New targeted bifunctional polymeric

metal complexes for drug delivery in cancer therapy”, 3rd National Meeting on Medicinal Chemistry – 2012, 28 October 2012, Aveiro (Portugal)

16. Andreia Valente, M. Helena Garcia, Fernanda Marques, Yong Miao, Philippe Zinck, “Synergy in Cancer Therapy: New Targeted Bifunctional

Polymeric Metal Complexes for Drug Delivery”, XXV International Conference on Organometallic Chemistry – ICOMC 2012, 2 September 2012,

Lisbon (Portugal)

15. Cristina P. Matos, Andreia Valente, Fernanda Marques, Pedro Adão, M. Paula Robalo, Rodrigo F. M. de Almeida, João Costa Pessoa, M. Helena Garcia, Ana Isabel Tomaz, “Polydentate octhaedric Ruthenium complexes: synthesis, characterization, anti-tumour activity and interaction with human serum proteins“. Poster at International Symposium on Metal Complexes, ISMEC 2012, June 18th-22nd, 2012 - Lisbon, Portugal.

2011

14. Cristina P. Matos, Andreia Valente, Fernanda Marques, Pedro Adão, João Costa Pessoa, M. H. Garcia, Ana Isabel Tomaz, “New ruthenium

tridentate amino-phenolate complexes: characterization and study of their biological activity”, 11th International Symposium on Applied

Bioinorganic Chemistry (ISABC 11), 2 December 2011, Barcelona (Spain)

13. Andreia Valente, Philippe Zinck, André Mortreux, Marc Visseaux, " Coordinative Chain Transfer Polymerization: From catalyzed chain

growth reactions to the control of the composition of statistical copolymers”, GECOM-CONCOORD 2011, 15-20 May 2011, Merlimont (France)

12. Andreia VALENTE, Maria Helena GARCIA, Tiago J. L. SILVA, Jürgen HECK , “Synthesis and NLO properties of new Fe(II) and Ru(II) η5-

monocyclopentadienyl complexes (P390)”, EuCOMC 2011, 3-7 July 2011, Toulouse (France)

2010

11. Andreia Valente, Philippe Zinck, André Moretreux, Marc Visseaux, Régis Gauvin, "Polymérisation coordinative par transfert de chaîne: un

nouveau concept pour contrôle de la composition d'un copolymère statistique", GEOCOM-CONCORD 2010, 30 May- 4 June 2010, Lyon (France)

10. Andreia Valente, Philippe Zinck, André Mortreux, Marc Visseaux, Paulo J. G. Mendes, Tiago Silva, Maria Helena Garcia, “Polymerization of

epsilon-caprolactone using Ru(II) catalysts: Mechanistic Insights", 3rd EuCheMS Chemistry Congress, August 29 - September 2, 2010 in Nürnberg

(Germany)

9. Andreia Valente, Philippe Zinck, Andre Mortreux, Marc Visseaux, "Coordinative Chain Transfer Polymerization: a new concept to tune

composition and microstructure of statistical copolymers", MACRO 2010, 43rd IUPAC World Polymer Congress, 11-16 July 2010, SECC, Glasgow

(UK )

8. Andreia Valente, Philippe Zinck, Andre Mortreux, Marc Visseaux, "Lanthanum-Magnesium coordinative chain transfer polymerization: a new

concept to tune the composition of (co)polymers”, 3rd EuCheMS Chemistry Congress August 29 - September 2, 2010 in Nürnberg (Germany)


7. Morais, T.S.; Garcia, M.H.; Robalo, M.P.; Valente, A.; Moreno, V.; Font-Bardia, M.; Calvet, T.; Lorenzo, J.; Avilés, F.X.; Cytotoxicity Studies and DNA Interaction of New Ruthenium(II) Cyclopentadienyl Complexes with Nitrogen Coordinated Ligands, XII Iberian Meeting of Electrochemistry and XVI Meeting of the Portuguese Electrochemical Society, 8-11 Setembro 2010, Lisboa, Portugal. Portugaliae Eletrochimica Acta, (2010), pag. 76 (abst. PB10)

2009

6. Andreia Valente, Philippe Zinck, André Mortreux, Marc Visseaux, "Polymérisation catalytique par transfert de chaîne : vers de nouvelles

applications", GECOM-CONCOORD 2009, 24-29 May 2009, Albe (France)

2008

5. Andreia Valente, Philippe Zinck, André Mortreux and Marc Visseaux, "Polymérisation catalytique à économie d’atomes: vers de nouvelles

applications", GFP 2008, 25 – 27 November 2008, Lyon (France - A42)

4. M. Helena Garcia, A. Valente,T.S. Morais, P. Florindo, M.F.M. Piedade and V. Moreno, “Studies on DNA Interaction of New Mixed Metallocene

Ruthenium (II) Derived Complexes”, International Conference on Organometallic Chemistry, 13-18 July 2008, Rennes; France (P453).

3. Andreia Valente, Philippe Zinck, Michael Terrier, André Mortreux, Marc Visseaux, “Neodymium-magnesium transmetalation: the first

example of a polystyrene catalyzed chain growth”, International Conference on Organometallic Chemistry, 13-18 July 2008, Rennes (France)

2. Andreia Valente, Philippe Zinck, Michael Terrier, André Mortreux, Marc Visseaux, “Neodymium-magnesium transmetalation: the first

example of a polystyrene catalyzed chain growth”, International Symposium on Homogeneous Catalysis, 6 – 11 July 2008, Florence (Italy)

2007

1. Philippe Zinck, Michaël Terrier, Andreia Valente, André Mortreux, Pascal Roussel et Marc Visseaux, " Hemi-lanthanidocenes en calatyse

Ziegler-Natta: nouveaux catalyseurs, nouveaux matériaux", GECOM-CONCOORD, 20-25 Mai 2007

Documents

Curriculum Vitae Andreia Marques Valente · Enyedy*, Andreia Valente*, η6-(2-Phenoxyethanol) ruthenium(II)-complexes of 2,2-bipyridine and its derivatives: solution speciation and

Curriculum Vitae Andreia Marques Valente · Enyedy, Andreia Valente, η6-(2-Phenoxyethanol) ruthenium(II)-complexes of 2,2-bipyridine and its derivatives: solution speciation and