CURRICULUM VITAE NAME : Braulio D. Jiménez, Ph.D. Toxicologist Braulio.jimenez@upr.edu Tel. 787-457-2503 cel Work 787-753-8784 CITIZENSHIP : USA ADDRESS : School of Medicine, dept. of Biochemistry Medical Sciences Campus University of Puerto Rico PO Box 365067 San Juan, Puerto Rico 00936-5067 ACADEMIC TRAINING : Post-doctoral- Environmental Toxicology,

Environmental Sciences Division, Oak Ridge National Laboratory (1982-1984)

Ph.D. in Marine Sciences University of Puerto Rico (1981) Bachelor in Biology Sciences University of Puerto Rico (1972) POST-TRAINING : Medical Toxicology, Cytochrome P450.

PXR receptor, training at the Medical Toxicology Lab. at the Health Sciences Center, University of Colorado, Denver.

HONORS AND AWARDS: 2011 Merck Innovation award in Environmental Sciences 2010 Member of the Puerto Rican Academy of Art and Sciences 1999 Glaxo Research Award, 2nd place as Experienced Researcher in Basic Sciences EPSCoR Scholarly Productivity Award in Recognition of the Contribution to the Development of Research in Puerto Rico (August 1996) Issued by the President of the University of Puerto Rico EPSCoR Scholarly Productivity Award (SPA), in recognition of excellence in research (December 5, 1994)

Technical Communication Award, 1988-1989, given for achievement in scholarly professional articles by The East Tennessee Chapter of the Society for Technical Communication. Postdoctoral Ford Fellow, National Research Council, Environmental Sciences (1984) Postdoctoral Fellow, Oak Ridge Association Universities, Research conducted at Oak Ridge National Laboratory in the Environmental Sciences Division (1983-1984) Puerto Rico Environmental Quality Award-for professional training in Environmental Sciences (1982-1983)

PROFESSIONAL EXPERIENCE: Academic 1998 to present Director, Center for Environmental and Toxicological Research,

School of Medicine, Medical Sciences Campus, University of Puerto Rico.

1998 to present Professor, Depart. of Bioch., School of Medicine, Med. Sci. Campus, Univ. of Puerto Rico.

2009-present Joint Professor, Depart. of Environ. Health, School of Public Health, Univ. of Puerto Rico, Med. Sci. Campus.

1996 to1998 Professor (Toxicology), Department of Pharmaceutical Sciences, School of Pharmacy, Medical Sciences Campus, University of Puerto Rico

1993 to date Visiting Scientist, University of Colorado, Health Sciences Center, Medical Toxicology at the Hepatobiliary Research Center, School of Medicine

1990-1996 Associate Professor (Toxicology), Department of Pharmaceutical Sciences, School of Pharmacy, Medical Sciences Campus, University of Puerto Rico

1991 to date Staff Toxicologist, Laboratory for Chemical Analysis and Doping Control

1985-1986 Research Associate, Ecology Department at The University of Tennessee

1981 Professor at the Inter American University of Puerto Rico Administrative 1994-present Director, Center for Environmental and Toxicological Research,

School of Medicine, Medical Sciences Campus, University of Puerto Rico.

1980-1982 Principal Environmental Scientist at Environmental Quality Board: Director of the Office of Environmental Research

1978-1981 Natural Resources Specialist: Environmental Quality Board of Puerto Rico Director Office of Scientific Assessment

1998-2001 President of the Caribbean regional chapter of the American Asso. for the Advancement in Science (AAAS Caribbean Division).

1996-1999 Elected Member to the Educational Committee for the Society of

Toxicology with headquarters in Washington D.C. 2004-2006 Continuing Education committee member for the Society of

Toxicology 2002-2004 Treasurer of the Association of residents of Lomas del Sol,

Guaynabo, Puerto Rico 2004-2006 Vice president and founder of the Hispanic Organization of

Toxicologists (Specialty section of the Society of Toxicology) 2009-2010 President Elect of the Hispanic Organization of Toxicologists

(Special Interest Group of the Society of Toxicology) 2007-2010 Senator elect at the University of Puerto Rico, Medical Sciences

Campus Research 1987-1989 Research Associate, Environmental Toxicology Section,

Environmental Sciences Division at Oak Ridge National Laboratories

1985-1986 Research Associate, Ecology Department at The University of

Tennessee Summer 1985 Guest Investigator, Biology Department at Woods Hole

Oceanographic Institution, Massachusetts 1982-83 Guest Investigator at the Environmental Sciences Division

Oak Ridge National Laboratory Teaching: Have graduated over 20 master and 5 PhD students

Have mentored more than 40 undergraduates many of which have been channeled towards Toxicology programs in the US

1989—98 School of Pharmacy, UPR Medical Sciences Campus

Undergraduate Level 1. Undergraduate Toxicology (PHARM 4035) 2. Undergraduate Research in Pharmacy (PHARM 4275 ) Graduate Level 1. Drug Metabolism (FAFI 6355) 2. Special Topics in Pharmaceutical Sciences (Applied

Toxicology FAGG 6213)

3. MS Research in Pharmaceutical Sciences (FAGG 6800) 1999-2003 Courses taught at Interamerican University, Metropolitan Campus

Graduate Level 1. Toxicology

1998-present School of Medicine, UPR Medical Sciences Campus

1. Biochemistry for Dental Students (BINU 7402) 2. Biochemistry for Medical Students (MPRI 7119) 3. Biochemistry (BCHM 8500) 4. Graduate Seminar (BCHM 8531-36) 5. Investigation in nucleic acid biochemistry (BCHM 8573) 6. Proposal preparation and design (BCHM 8526) 7. Special topics in biochemical toxicology (8527)

1989-present Continuing Education Courses at various campuses

1. Toxicology for Nursing students 2. Aspects in Industrial Toxicology

Invited Lectures

1. University of PR, School of Pharmacy, Medical Sciences Campus. Uptake and elimination of BaP using a fish metabolic chamber. 1989, San Juan Puerto Rico.

2. University of Wursburg, 1992, Institute of Toxicology, Biological Markers of Environmental Contaminants. Wursburg, Germany.

3. University of Wursburg, Chemistry Department, Biomarkers of environmental Exposure in fish 1994 Wursburg, Germany.

4. RCMI Biomarkers of Contamination, Research Triangle Park, North Carolina. 1994.

5. Meharry Medical College, Metabolism of marine toxins by Cytochrome P450s 1996, Nashville TN.

6. University of Utah, Marine Toxins: Effects on Murine-Liver, School of Pharmacy (March 1996).

7. Department of Natural Resources, Jobos Bay Estuary Program. Caracteristicas del Aire en Guayama. 2003 Guayama, Puerto Rico.

8. Puerto Rico Health Department. Taller de metales pesados en

Vieques. Hospital Municipal de Vieques. Vieques, PR. 9. University of Puerto Rico Ponce Campus. The metal

composition of Particulate Matter in Puerto Rico. 2004, Ponce, Puerto Rico.

10. Athens Institute for Education and Research: Athens, Greece Role of Chemical and Biological Constituents of Saharan Dust in the Exacerbation of Asthma in Puerto Rico” 2009.

11. University of Norbert Wiener, Desafios de la Toxicología para el Nuevo Milenio October 2007, Lima Peru.

12. American Student Dental Association 38th Annual Convention 2010. Univ. PR To Amalgam or not to Amalgam.

13. Asociación Española de Toxicología; Toxicological and Pro-inflammatory characteristics of Saharan Dust constituents reaching Puerto Rico. Spain, July (2010).

14. Asociación Argentina de Toxicología; Material particulado en aire y sus respuestas inmunológicas empleando células epiteliales del pulmón. Buenos Aires, Argentina Sept. (2010).

MEMBERSHIP IN HONORARY AND PROFESSIONAL SOCIETIES

♦ Association of Forensic Toxicologists ♦ Elected Member to the Educational Committee for the Society of Toxicology with

Headquarters in Washington D.C. 1996-1999 ♦ Elected president AAAS Caribbean Division 1998-2001 ♦ Council, elected Member for the Caribbean Chapter for the American Association

for the Advancement in Science, with headquarters in San Juan Puerto Rico. ♦ Rho Chi Society- Gamma Eta Chapter ♦ Society of Environmental Toxicology and Chemistry ♦ Sigma Xi Scientific Research Society

PROFESSIONAL ACTIVITIES:

University and Other Appointments

♦ Ad Honorem Professor in the Department of Marine Sciences, University of Puerto Rico at Mayaguez

♦ Member of the review panel committee for pre-doctoral and postdoctoral fellowship for the National Research Council (NRC) on the selection of Ford Foundation Fellows

♦ Member of the review panel committee for the National Research Council (NRC) on the associate fellowship program.

♦ Puerto Rico Liaison for Ford Foundation Fellowship Program (2000-present)

♦ Member of the review panel for the National Institute of Occupational Safety and Health (NIOSH 2006)

♦ Ad Hoc Reviewer

♦ Reviewer for Aquatic Toxicology Journal

♦ Reviewer for the Environmental International Journal

♦ Reviewer for the Chemical Speciation and Bioavailability Journal

♦ Reviewer for the Environmental Health Perspective Journal

♦ Reviewer for Environmental Research

♦ Peer Reviewer, Medical Science Monitor (Impact Factor 1.514)

♦ Participation in Meetings in the International Symposium of Ions in Biology and Medicine

♦ Participant in the annual meetings of the Society of Toxicology

Training experiences Training at the Medical Toxicology Lab in the Health Sciences Center, University of Colorado, Denver. Primary hepatocyte tissue culture techniques. Visited with a graduate student Alice Maite for two weeks during February 14-29, 1996. Participant of the Preparation of the Toxicology training course for Latin American Countries (prepared and organized through the Hispanic Organization of Toxicologist)

MEMBERSHIP IN HONORARY AND PROFESSIONAL SOCIETIES

Member of The Puerto Rican Academy of Art and Sciences (2010). Full Member of the Society of Toxicology (1991-present), Headquarters in Washington D.C. Full Member and past-president of the Hispanic Organization of Toxicologists (Society of Toxicology) (2010) Headquarters in Washington D.C. Association of Forensic Toxicologists Council, elected Member for the Caribbean Chapter for the American Association for the Advancement in Science, with headquarters in San Juan Puerto Rico (1996-1998). President Elect AAAS Caribbean Division 1998-2001

Vice-President of the Hispanic Organization of Toxicologist, specialty section of the American Society of Toxicology 2005-2006 President Elect of the Hispanic Organization of Toxicologist, specialty section of the American Society of Toxicology 2009 Elected Member to the Educational Committee for the Society of Toxicology with Headquarters in Washington D.C. 1996-1999 Society of Environmental Toxicology and Chemistry (SETAC) Rho Chi Society- Gamma Eta Chapter Sigma Xi Scientific Research Society Toxicology Consultant (Toxicology related cases in Puerto Rico and Virgin Islands) PUBLICATIONS In Preparation:

1. Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., Cadilla, C.L., and Jiménez-Vélez, B.D., Drug Metabolism and Immune System Crosstalk: Role of Pregnane X Receptor (PXR) and the Transcriptional Regulation of Major Histocompatibility Complex Class II Genes. Submitted to Immunotoxicology.

2. Acevedo-Marin L.A., Mansilla-Rivera I., Rodriguez-Sierra C.J and Jiménez-Vélez B. Trace metals in tropical coastal fishes from Vieques, Puerto Rico

PUBLICATIONS:

1. Adriana Gioda, Enrique Fuentes-Mattei, and Braulio Jiménez-Vélez Evaluation of cytokine expression in BEAS cells exposed to fine particulate matter (PM2.5) from specialized indoor environments. International Journal of Environmental Health Research (2011) 21:2; 106-119.

2. M. Ortiz-Martínez, E. Rivera-Ramírez, L. Méndez-Torres, and B.D. Jiménez-Vélez. Role of chemical and biological constituents of PM10 from Saharan Dust in the exacerbation of asthma in Puerto Rico. In: Biodiversity Science for Humanity. Ed. by Michael Theophanides and Theophile Theophanides. Athens Institute for Education and Research (ATINER), ISBN: 978-960-6672-41-5, 300 pages, 2 (2010) 101-118.

3. Enrique Fuentes-Mattei, Evasomary Rivera, Adriana Gioda, Diana Sanchez-Rivera,

Felix R. Roman-Velazquez, and Braulio D. Jiménez-Velez. Use of human bronchial epithelial cells (BEAS-2B) to study immunological markers resulting from exposure to PM2.5 organic extract from Puerto Rico. Toxicology and Applied Pharmacology 243 (2010) 381-389.

4. Braulio Jiménez-Vélez, Yasmin Detrés, Roy A. Armstrong, and Adriana Gioda.

Characterization of African dust (PM2.5) across the Atlantic Ocean during AEROSE 2004. Atmospheric Environ. 43 (2009) 2659-2664.

5. Adriana Gioda, Gilberto Hanke, Augusto Elias, and Braulio Jiménez-Velez. A

pilot study to determine mercury levels in a dental environment at the School of Dentistry. Toxicology and Industrial Health. 2007; 23: 103-113.

6. Adriana Gioda, Ulda Peréz, Zenaida Rosa and Braulio D. Jiménez-Velez.

Particulate matter (PM10 and PM2.5) from different areas of Puerto Rico. Fresenius Environmental Bull. Vol. 16; No. 4 2007.

7. Alejandro R. Molinelli,, Guido Santacana, Michael C. Madden, and Braulio D.

Jiménez-Vélez. Cytotoxicity and metal content of Organic Solvent Extracts from Airborne Particulate Matter in Puerto Rico. Environmental Research, 102:314-325, 2006.

8. Acevedo D., B.D. Jiménez-Vélez and C. J. Rodríguez-Sierra Trace metals in

sediments of two estuarine lagoons from Puerto Rico. Environ. Poll. 141:336-342, 2006.

9. Adriana Gioda, Ulda Pérez, Zenaida Rosa and Braulio D. Jiménez-Vélez.

Concentration of heavy metals in airborne PM10 from Jobos Bay National Estuary, Puerto Rico. Water Air and Soil Pollution. 174 (1-4): 141-159 JUL 2006.

10. Figueroa, David Acevedo; Rodríguez-Sierra, Carlos J.; and Jiménez-Velez, Braulio

D. Concentrations of Ni and V, other heavy metals, arsenic, elemental and organic carbon in atmospheric fine particles (PM2.5) from Puerto Rico. Toxicol. Indust. Health 22 (2): 87-99 2006.

11. B. Jiménez-Vélez, A. Gioda, Fuentes-Mattei, E. Organic and aqueous extracts from

particulate matter (PM2.5) and their effect on the immunological response of human bronchial epithelial cells BEAS-2B. In Metals Ions in Biology and Medicine Publ. John Libbey 8; 267-272 (2006).

12. Adriana Gioda, and Braulio D. Jiménez-Vélez. Assessment of heavy metals in fine

particulate matter (PM2.5) from a workplace environment in Puerto Rico. Proceedings of Indoor Air Conference Beijing China. (2): 1526-1530 2005.

13. Jaime F. Puig-Hernández, PhD. and Braulio D. Jiménez-Vélez, PhD. HPLC Determination of the Concentration and Integrity of L-Thyroxine (T4) in Free T4 Stock Solution. Puerto Rico Health Sciences Journal, 25 (2): 151-156 (2005).

14. Mónica I. Torres-Pérez , MS; Braulio D. Jiménez-Vélez, PhD; Imar Mansilla-Rivera, PhD, Carlos J. Rodríguez-Sierra, PhD. Effect of three extraction techniques on submitochondrial particle and Microtox bioassays by airborne particulate matter. Puerto Rico Health Science Journal 24 (1): 35-39 (2005).

15. K. Kientz, B. D. Jiménez, L. Pérez, C. J. Rodríguez-Sierra In Vitro Bioaccessibility of Metals in Soils from a Superfund Site in Puerto Rico Bull. Environ. Contam. Toxicol. 70:927-934 (2003).

16. Carlos J. Rodríguez and Braulio D. Jiménez (2002). Trace Metals in Striped Moharra (Diapterus plumierri) Fish from Puerto Rico. Mar. Pollution Bull. 44: (10) pp. 1039-1045.

17. B.D. Jiménez, L. Maldonado, R.H. Dahl, L.C. Quattrochi, P.S. Guzelian. Ectopic

Expression of MHC Class II Genes (RT1.B (I) (/() in Rat Hepatocytes in vivo and in Culture Can be Elicited by Treatment with the Pregnane X Receptor Agonists Pregnenolone 16(-Carbonitrile and Dexamethasone. Life Sci. 71:(3) 311-323, June, 2002.

18. Alan M. Preston, Fred B. Bercovitch, Braulio D. Jiménez, José F. Rodriguez Orengo, Wilfredo Delgado Morales, Cindy A. Rodriguez, Manuel R. Lebrón and Cynthia E. Rivera. Plasma homocysteine concentrations in a population of Rhesus Monkeys (Macaca mulatta): reference ranges and accompanying plasma concentrations of folate and Vitamin B12. Contemporary Topics (41) No.1 pp 28-30. 2002.

19. U. J. Pérez, B. Jiménez, W. Delgado, and C. J. Rodriguez-Sierra. Heavy Metals in

the False Mussel, Mytilopsis domingensis, from Two Tropical Estuarine Lagoons. Bull. Environ. Contam. Toxicol. 66:206-213 (2001).

20. José L. Roig-López, Pedro Santiago, Carlos Santiago, Braulio Jiménez and José E.

GarcÌa-Arraras. Strategies to identify differentially expressed genes during regeneration. Echinoderms 2000, Baker (ed.), Swelts & Zeitlinger, Lisse, ISBN 90 5809189 9 (2001).

21. P. Melendez, N. Longo B.D. Jiménez and C.L. Cadilla. Insulin induced gene 33

mRNA expression in CHO cells is insulin receptor dependent. J. Cell Biochem, 77 (3): 432-444 (2000).

22. Darwin Reyes, Osvaldo Rosario, José F. Rodriguez, and Braulio Jiménez. Toxic

Evaluation of organic extracts from airborne particulate matter in Puerto Rico. Environmental Health Perspectives 108: (7) 635-640 (2000).

23. Braulio D. Jiménez, L.C. Quattrochi, C.B. Yockey, and P.S. Guzelian.

Identification by Differential Display of the IF1 Inhibitor Peptide of ATP Synthase/ATPase as a Gene Inducible in Rat Liver by Pregnenolone 16α-Carbonitrile. Life Sciences 67 15: 1825-1832 (2000).

24. David Acevedo, Carlos J. Rodríguez-Sierra, Darwin Reyes, and Braulio D.

Jiménez. Heavy metals in sediments and water from San Jose and Joyuda Lagoons in Puerto Rico. In Metal Ions in Biology and Medicine, Publ. John Libbey 6: 169-172 (2000).

25. Ana B. Henríquez-Alberdeston, René R. Dávila, José F. Rodríguez Orengo, Braulio

Jiménez, and Carlos J. Rodríguez Sierra. Blood Lead Levels of Low-Income Urban and Rural Puerto Rican Children. In Metal Ions in Biology and Medicine. Publ. John Libbey 6: 328-330 (2000).

26. Romero, N., Calzadilla, S., Jiménez, B. D., and Cadilla, C., Insulin and Phorbol

Esther regulation of gene 33 expression in CHO Cells. Puerto Rico Health Sciences Journal (PRHSJ), 18: 257-265 (1999).

27. Clark, J.T., Jiménez, B., Evans, S.L., Barrow, R., Winfree, M. and Mrotek, J. Cd-

Induced sexual dysfunction does not involve increased hepatic metabolism nor increased corticosterone. Physiology and Behavior 56:(5) 975-981 (1994).

28. Oikari, A. and Jiménez, B.D. Effects of hepatotoxicants on the induction of

microsomal mono-oxygenase activity in sunfish liver by B-naphthoflavone and B(a)P. Ecotoxicol. Environ. Safety 23:(1) 89-102 (1992).

29. Loar, J.M., Adams, S.M., Allison, L.J., Black, M.C., Boston, H.L., Gatz, A.J. Jr.,

Hinzman, R.L., Huston, M.A., Jiménez, B.D., McCarthy, J.F., Reagan, S.D., Smith, J.G., Southworth, G.R. and Stewart, A.J., Report on the Ridge Y-12 Plant biological monitoring and abatement program for East Fork Poplar Creek. Environ. Sci. Division publication Num. Y-TS-886. Oak Ridge National lab, TN (1992).

30. McCarthy, Shugart, L.R., and B.D. Jiménez, 1992. Biomarker-based biomonitors

for evaluating health and ecological effects of environmental contaminants. In:Hazardous Waste Site Investigations: Towards Better Decisions. editors R.B. Gamage, and B.A. Berven, Lewis Publ. Inc., Boca Raton, Fl. 177-207.

31. Shugart, L. R., Jiménez, B. D. and McCarthy J. F. 1991. DNA Damage as a

Biological Marker in Aquatic Organisms exposed to Benzo[a]pyrene. In: Eleventh International Symposium on Polynuclear Aromatic Hydrocarbons, edited by W.E. May and M. Cooke. Batelle Press, Columbus, OH pp 839-846 Washington DC. pp 123-142

32. McCarthy J. F., B.D. Jiménez, L.R. Shugart, F. V. Sloop and A. Oikari, 1990.

Biological markers in animal sentinels: Laboratory studies improve interpretation of field data. In Situ Evaluation of Biological Hazards of Environmental Pollutants, Ed.

S. Sandhu Plenum Press, New York. pp 163-175. 33. Jiménez, B. D. 1990. Laboratory and field responses in the bluegill sunfish

(Lepomis sp.) In: Biological Markers of Environmental Contaminants. Ed. J.F. McCarthy and L. R. Shugart. American Chemical Society, Washington DC. pp 123-142.

34. Jiménez, B. D. and J.J. Stegeman, 1990. Detoxication enzymes as indicators of

stress. Special edition Trans. Amer. Fish. Soc. 8: 67-79. 35. Shugart, L. R., S. M. Adams, B. D. Jiménez, S. S. Talmage, and J.F. McCarthy.

1989. Biological markers to study exposure in animals and bioavailability of environmental contaminants. In: Biological Monitoring for Pesticide Exposure.: Measurements, Estimation, and Risk Reduction, edited by Rhonda G. M. Wang, C. A. Franklin, R. C. Honeycutt, and J. C. Reinert. ACS symposium series 382. American Chemical Society, Washginton, DC. pp 85-95.

36. Jiménez, B. D. and L. S. Burtis, 1989. Influence of environmental variables on the

hepatic MFO system in the bluegill sunfish, (Lepomis Macrochirus). Comp. Biochem. Physiol. 93C: No.1 11-21.

37. McCarthy, J. F., D. N. Jacobson L. R. Shugart and B. D. Jiménez. 1989. Pre-

exposure to 3-methylcholanthrene increases benzo(a)pyrene adducts on DNA of bluegill sunfish. Mar. Environ. Res. 28: 323-328

38. Adams, S. M., K. L. Shepard, M. S. Greeley Jr., B. D. Jiménez, M. G. Ryon, L. R.

Shugart, J. F. McCarthy, and D. E. Hinton. 1989. The use of bioindicators for assessing the effects of pollutant stress on fish. Mar. Environ. Res. 28: 459-464.

39. Jiménez, B. D. and L. S. Burtis, 1988. Response of the mixed function oxidase

system to toxicant dose, food and acclimation temperature in the bluegill sunfish. Marine Environ. Res. 24:45-49.

40. Jiménez, B. D., G. H. Ezell, B. Z. Egan, N. E. Lee, and J. F. McCarthy, 1988.

Effects of environmental variables on the mixed function oxidase (MFO) in bluegills (Lepomis macrochirus). Environ. Toxicol. Chem. 7:623-634

41. Jiménez, B. D., C. P. Cirmo, and J. F. McCarthy, 1987. Uptake elimination and

metabolism of Benzo(a)pyrene in bluegill sunfish ( Lepomis macrochirus). Aquat. Toxicol. 10:41-57.

42. Shugart, L., J. F. McCarthy, B. D. Jiménez, and J. Daniels. 1987. Analysis of

adduct formation in the bluegill sunfish (Lepomis macrochirus) between benzo(a)pyrene and DNA of the liver and hemoglobin of the erythrocyte. Aquat. Toxicol. 9: No. 6 319-325.

CHAPTER IN BOOKS: 43. McCarthy, J.F., Shugart, L.R. and Jiménez, B.D. Biomarker Based Biomonitors for

Evaluating Health and Ecological Effects of Environmental Contaminants In: Hazardons Waste Site Investigation: Toward Better Decision. R.B. Gamage and B.A. Berven. Eds. Lewis Pub. Inc., Boca Raton, Florida, pp. 177-207 (1992).

44. Shugart, L.R., Jiménez, B.D. and McCarthy, J.F. DNA Damage as a Biological

Marker in Aquatic Organisms. In: Eleventh International Symposium on Polynuclear Aromatic Hydrocarbons: Measurements, mens and metabolism. J. Mercitt, M. Cook. Edited by Betelle Press, Columbus, OH pp. 839-846 (1991).

45. Jiménez, B.D., Oikari, A., Adams, S.M., Hinton, D.E. and McCarthy, J.F. Hepatic

enzymes as biomarkers: Interpreting the effects of environmental, physiological, and toxicological variables. In: Biological Markers of Environmental Contaminants. Ed. J.F. McCarthy and L.R. Shugart. Lewis Publishers Press. American Chemical Society, Washington, D.C., pp. 123-142 (1990).

46. Jiménez, B.D. and Stegeman, J.J. Fish detoxification enzymes as indicators of

pollution. In Biological Indicators of Stress in Fish. Amer. Fish Soc. 8: 67-79 (1990).

47. McCarthy, J.F., Jiménez, B.D., Shugart, L.R., Sloop, F.V. and Oikari, A. Biological

markers in animal sentinels: Laboratory studies improve interpretation of field data. In Situ Evaluation of Biological Hazards of Environmental Pollutants, Ed. S. Sandhu Plenum Press, New York, pp. 163-175 (1990).

48. Shugart, L.R., Adams, S.M., Jiménez, B.D., Talmage, S.S. and McCarthy, J.F.

Biological markers to study exposure in animals and bioavailability of environmental contaminants. In: Biological Monitoring for Pesticide Exposure: Measurements, Estimation, and Risk Reduction, edited by Rhonda G.M. Wang, C.A. Franklin, R.C. Honeycutt, and J.C. Reinert. ACS symposium series 382. Washington, D.C., pp. 85-95 (1989).

REPORTS:

49. Adriana Gioda and Braulio D. Jimenez-Velez, Ph.D. Particulate Matter PM2.5 fungi and metal analyses and toxicological evaluation from an indoor environment at the Puerto Rico Health Department. Prepared for the Health Department. 2005. pp1-26.

50. Braulio D. Jimenez-Velez, Ph.D. Zenaida Rosa, Ms., Ulda Pérez, Ms. and Adriana

Gioda, Ph.D. Evaluating heavy metal concentrations in airborne PM10 from the Jobos

Bay National Estuary, at Salinas, Puerto Rico. Prepared for the Puerto Rico Department of Natural Resources Dec 2003 pp1-14.

51. David Acevedo Carlos J. Rodríguez Sierra Weldin Ortiz, Guido Santacana and

Braulio D.Jiménez-Velez. Toxicity assessment of airborne particulate matter and heavy metal evaluation in fish from Vieques. Prepared for the Univ. of PR (2003)

52. David Acevedo, Wilfredo Delgado, Carlos J. Rodríguez Sierra Weldin Ortiz, and

Braulio D.Jiménez-Velez Environmental pollutants in aquatic organisms from the San Jose Lagoon Prepared for University of Puerto Rico (UPR) Sea Grant College Program 1999 pp 1-13.

53. Carlos J. Rodríguez Sierra and Braulio D. Jiménez. Assessment of metals in sediments, fish, and shellfish food from the San Juan Bay estuary system. Prepared for the Puerto Rico Department of Natural Resources 1998.

54. Jimenez B, C. J. Rodríguez, J. F. Rodriguez. Analisis de pH de suelos y aguas del

area del manglar impactado por aguas acidas en la Planta de Energia Electrica de Palo Seco. Centro de Estudios Ambientales y Toxicologicos, Escuela de Farmacia, Universidad de Puerto Rico, Recinto de Ciencias Médicas. Prepared for the P.R. Power Authority October de 1995 pp12.

55. Jimenez B., C.J. Rodriguez and F. Fuentes. Evaluation of mangrove recovery after a

spill of acidic water at the Palo Seco Thermoelectric Power Plant in Puerto Rico. Prepared for the P.R. Power Authority April 1997 pp1-37.

56. Frohn, R.C., Dale, V.H. and Jimenez, B.D. Colonization, Road Development and

Deforestation in the Brazilian Amazon Basin of Rhondonia. Environmental Sciences Division Publication No. 3394. Oak Ridge National Laboratory ORNL\TM 11470, pp. 1-82 (1990)

57. Loar, J.M., Adams, S.M., Black, M.C., Boston, H.L., Gatz, Jr., A.J., Huston, M.A.,

Jimenez, B.D., McCarthy, J.F., Reagan, S.D., Smith, J.G., Southworth, G.R. and Stewart, A.J., First annual report on the Y-12 Plant biological monitoring and abatement program. Draft Report Publication No. 2984. Oak Ridge National Laboratory, Oak Ridge, Tennessee, pp. 1-307 (1988)

58. Jimenez, B.D. and Cintrón, B. Environmental Quality Summary for Puerto Rico.

Report to region II, Environmental Protection Agency, New York, New York, pp. 1-58 (1980)

59. Jimenez, B.D. Fish kill guidelines and contingency plan for Puerto Rico. Special

report submitted to Environmental Quality Board of Puerto Rico, pp. 1-20 (1980) 60. Jimenez, B.D., Garcia, R. and Gelabert, P. "Efecto ambiental de la extracción de

arena en Isabela, P.R." (The environmental effects of sand extraction in Isabela, P.R.). Report submitted to Aguadilla District Court of Puerto Rico, Pp. 1-35 (1980).

61. Tosteson, T.R., Tsai, R.S.C., Ballantine, D., Chang, J.S.Y., Zimmerman, R. and

Jimenez, B.D. A re-evaluation of the biota affected by petrochemical contamination. Technical Report of Department of Marine Sciences. Report submitted to EQB Board of PR (1977).

62. Jimenez, B.D. "Hidrocarburos derivados del petroleo en el ambiente de Puerto

Rico"(Petroleum derived hydrocarbons in the environment of Puerto Rico). Environmental Quality Board of Puerto Rico, Santurce, P.R., JCA 001, pp. 1-25 (1982)

63. Jimenez, B.D. and Cintron, B. Guidelines for mixing zone, bioassay design,

selection of species, composite sample preparation test methods, and reporting of results. Environmental Quality Board of Puerto Rico, pp. 35 (1981)

PUBLISHED ABSTRACTS AND PRESENTATIONS: B. Jiménez-Vélez, M. Ortiz-Martínez, R. Rodríguez-Cotto, E. Rivera-Ramírez, L. Méndez-Torres. “Toxicological and Pro-inflammatory characteristics of Saharan Dust constituents reaching Puerto Rico”. XII International Congress of Toxicology. Barcelona Spain, Jul, 2010. M. Ortiz-Martínez, E. Rivera-Ramírez, L. Méndez-Torres and B. D. Jiménez-Vélez. “Endotoxins in African Dust (PM10): possible implication with asthma exacerbation among Puerto Ricans”. 49th SOT Annual Meeting and ToxExpo. Salt Palace Convention Center, Salt Lake City, UT. Mar, 2010. E. Fuentes-Mattei, D. Sánchez-Rivera, M.G. Ortiz-Martínez, N.E. Crespo-Hernández, A. Gioda, F.R. Román-Velázquez and B.D. Jiménez-Vélez. “Association of Copper to Immunological Markers resulting from Exposure to Polar Organic Extracts from Airborne Particulate Matter (PM2.5) from Puerto Rico in BEAS-2B Cells”. 49th SOT Annual Meeting and ToxExpo. Salt Palace Convention Center, Salt Lake City, UT. Mar, 2010. M. Ortiz-Martínez and B. D. Jiménez-Vélez. “Pro-inflammatory Potential of Endotoxins found in Saharan Dust reaching Puerto Rico”. XXX Foro Anual de Investigación y Educación. University of Puerto Rico, Medical Sciences Campus. Mar, 2010. Rosa I. Rodríguez, Loyda Méndez-Torres, and Braulio D. Jiménez-Vélez. Partial Characterization of Ambient PM2.5 extract from Saharan Dust Events. Society of Toxicology, Annual Meeting, Salt Lake City, Utah, 2010.

Rosa I. Rodríguez, Loyda Méndez-Torres, and Braulio D. Jiménez-Vélez. Studying Ambient PM2.5 Extracts from Saharan Dust Collected in Puerto Rico. Trigésimo Foro

Anual de Investigación y Educación. Salud Pública en la Sociedad del Conocimiento: Retos y Opciones, University of Puerto Rico, Medical Sciences Campus, March, 2010 Fuentes-Mattei, Enrique, Rodriguez-Cotto, Rosa and Jimenez-Velez, Braulio D. Transcriptional Regulation of Histocompatibility Complex Class II (MHC-II) Gene by Pregnane X Receptor (PXR) Activators and the Possible Role of PXR in the IFNT-Mediated Transcriptional Up-Regulation of MHC-II Gene. Society of Toxicology, Annual Meeting, Salt Lake City, Utah, 2010. M. Ortiz-Martínez, L. Méndez-Torres and B. D. Jiménez-Vélez. “Endotoxin in PM10 Aqueous Extracts from Saharan Dust: possible implications in the exacerbation of asthma in Puerto Rican children”. XXIX Foro Anual de Investigación y Educación. University of Puerto Rico, Medical Sciences Campus Apr, 2009. Ortiz-Martínez Mario, E. Rivera-Ramírez, Méndez-Torres, Loyda and B. Jiménez-Vélez. “Role of Chemical and Biological Constituents of Saharan Dust in the Exacerbation of Asthma in Puerto Rico”. 4th International Symposium on Environment, Athens, Greece; May, 2009. M. Ortiz-Martínez, L. Méndez-Torres and B. D. Jiménez-Vélez. “Endotoxin in PM10 Aqueous Extracts from Saharan Dust: possible implications in the exacerbation of asthma in Puerto Rican children”. 1st UPR Medical Sciences Campus MBRS-RISE Program Student Retreat. Rincón, PR. Mar, 2009. Fuentes-Mattei, E., Gioda, A., and Jiménez, B.D., (March 2009). Organic extracts of Airborne Fine Particulate Matter (PM2.5) from Puerto Rico, can induce pro-inflammatory cytokines in Human lung cells (BEAS-2B), Abstract Number/Poster Board number: EA49-2297, 48th Annual Meeting of the Society of Toxicology, Baltimore, Maryland. C.W. Pluguez and Braulio Jimenez-Velez. Decreased viability in human bronchial cells (BEAS-2B) exposed to airborne Particulate matter in PR during volcanic eruption events of Soufiere Hills Volcanic system in Monserrat mediated by Antimony. Presented at the 44th ACS LSAMP Junior technical meeting. March 14, 2009. Fuentes-Mattei, E., and Jiménez, B.D., (March 2008). Drug Metabolism and Immune Response Crosstalk: The Role of Pregnane X Receptor In The Transcriptional Regulation of MHC-II, 47th Annual Meeting of the Society of Toxicology, Seattle, Washington. Fuentes-Mattei, E., and Jiménez, B.D., (March 2008). Drug Metabolism and Immune Response Crosstalk: The Role of Pregnane X Receptor In The Transcriptional Regulation of MHC-II, XXVIII Annual Forum for Investigation and Education, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico. Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., and Jiménez, B.D., (March 2007). Pregnane X Receptor (PXR) and the Major Histocompatibility Complex Class II

Genes, XXVII Annual Forum for Investigation and Education, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico. Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., and Jiménez, B.D., (March 2007). Pregnane X Receptor (PXR) and the Major Histocompatibility Complex Class II Genes, (Hispanic Organization of Toxicologists Award), 46th Annual Meeting of the Society of Toxicology, Charlotte, North Carolina. Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., and Jiménez, B.D., (August 2006). The Role of the Steroid and Xenobiotic Receptor (SXR) in the Induction of MHC-II genes by Rifampicin, MBRS- RISE Summer Poster Presentation Forum, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico. Fuentes-Mattei E., L.C. Quattrochi, J.L. Barwick, P.S. Guzelian and B.D. Jiménez. Role of the Steroid and Xenobiotic-sensing Receptor in the Induction of Major Histocompatibility Complex Class II Genes by Rifampicin. Presented at the Gordon Research Conference, Mechanisms of Toxicity held at Colby College, Maine July 2006. Salamán C., A. González-Sierra, E. Méndez-Moralez, E. Fuentes-Mattei, and B.D. Jiménez-Vélez. Evaluation of Cytotoxicity and MHC II induction by Dexamethasone, Rifampicin, and DMSO in HEP2G cells. Forum MBRS-RISE Summer Research Program 2006, University of Puerto Rico, August 6, 2006, San Juan, PR. González-Sierra A., E. Méndez-Moralez, C. Salamán, E. Fuentes-Mattei, and B.D. Jiménez-Vélez, Effects of copper sulfate pentahydrate, dexamethasone and rifampicin on bronchial epithelial cells (BEAS2A). MBRS-RISE Research Forum, Summer Program 2006, University of Puerto Rico, August 6, 2006, San Juan, PR. B.D. Jiménez-Vélez, A. Gioda, and E. Fuentes-Mattei Organic and aqueous extracts with metal content from particulate matter (PM2.5) and the effect on the immunological response on BEAS cells, 9th International Symposia on Metal Ions in Biology and Medicine, 21-24 de mayo, 2006, Lisboa, Portugal. B.D. Jiménez-Vélez, , E. Fuentes-Mattei, and A. Gioda. Effects of organic and aqueous Extracts of airbone particulate matter on the immunological response of human bronchiotracheal cells, XIV Congresso Brasileiro de Toxicología, 9-12 October 2005, Recife, Brasil. Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., and Jiménez, B.D., (March 2006). Putative Role of the Steroid and Xenobiotic Receptor (SXR) in mechanism of HLA-DRα induction by Rifampicin, Abstract No. 1341 (Honorary Mention by the Hispanic Organization of Toxicologists), 45th Annual Meeting of the Society of Toxicology, San Diego, California. Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., and Jiménez, B.D., (July 2006). The Role of the Steroid and Xenobiotic Receptor (SXR) in the Induction of

MHC-II genes by Rifampicin, Gordon Research Conference: Mechanism of Toxicology 2006, Colby College, Maine.

Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., and Jiménez, B.D., (December 2005). HLA-DRα Gene Regulation and the Putative Role of the Steroid and Xenobiotic Receptor (SXR) in HT1080 Fibrosarcoma Cell Line by Rifampicin, XXIV Annual Forum for Abstract Control No. 05-LA-3780-ASCB (Board No.L307), 45th American Society for Cell Biology Annual Meeting, San Francisco, California. E. Fuentes-Mattei, Imilce Rodríguez-Fernández, A. Gioda, W. Delgado-Morales, and B.D. Jiménez-Vélez. (March 2005) Immune response of human Lymphoblastoid and bronchial epithelial cell lines to organic compounds from fine particles (PM2.5) in Puerto Rico, 44rd Annual Meeting of the Society of Toxicology, New Orleans, Louisiana. B.D. Jiménez-Vélez, E. Fuentes-Mattei, and A. Gioda. Assessment of heavy metals in fine particulate matter (PM2.5) from the workplaces in Puerto Rico, The 10th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2005, 4-9 de September, 2005, Beijing, China. E. Fuentes-Mattei B.D. Jiménez-Vélez, , A. Gioda, and Cytotoxicity of organic extract from Fajardo and Guaynabo PM2.5 in bronchial epithelial cells, Forum MBRS-RISE Summer Research Program 2005, University of Puerto Rico, 5 de agosto, 2005, San Juan, PR. C. Salamán, E. Fuentes-Mattei, and B.D. Jiménez-Vélez Evaluation of cytotoxicity of dexamethasone, rifampicin and DMSO on fibroblast HT-1080 cells, Forum MBRS-RISE Summer Research Program 2005, University of Puerto Rico, 5 de agosto, 2005, San Juan, PR. Gioda, E. Fuentes-Mattei, B. Bolaños, and B.D. Jiménez-Vélez. (March 2005). Chemical, microbiological and toxicological characterization of fine particulate matter (PM2.5) from an indoor environment in Puerto Rico, 44th Annual Meeting & Tox-Expo - Society of Toxicology, 6-11 March, 2005, New Orleans, USA. A. Gioda, B.D. Jiménez-Vélez, and E. Fuentes-Mattei Immune response of human lymphoblastoid and bronchial epithelial cell lines to organic compounds from fine particles (PM2.5) in Puerto Rico, 44th Annual Meeting & ToxExpo - Society of Toxicology, 6-11 March, 2005, New Orleans, USA. Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., and Jiménez, B.D., (March 2006). Putative Role of the Steroid and Xenobiotic Receptor (SXR) in mechanism of HLA-DRα induction by Rifampicin, Abstract No. 1341(Honorary Mention by the Hispanic Organization of Toxicologists), 45th Annual Meeting of the Society of Toxicology, San Diego, California.

Fuentes-Mattei, E., Quattrochi, L., Barwick, J., Guzelian, P., and Jiménez, B.D.,

(December 2005). HLA-DRα Gene Regulation and the Putative Role of the Steroid and Xenobiotic Receptor (SXR) in HT1080 Fibrosarcoma Cell Line by Rifampicin, XXIV Annual Forum for Abstract Control No. 05-LA-3780-ASCB (Board No.L307), 45th American Society for Cell Biology Annual Meeting, San Francisco, California. E. Fuentes-Mattei, Imilce Rodríguez-Fernández, A. Gioda, W. Delgado-Morales, and B.D. Jiménez-Vélez. (March 2005) Immune response of human Lymphoblastoid and bronchial epithelial cell lines to organic compounds from fine particles (PM2.5) in Puerto Rico, 44rd Annual Meeting of the Society of Toxicology, Baltimore, New Orleans, Louisiana. Gioda, E. Fuentes-Mattei, B. Bolaños, and B.D. Jiménez-Vélez. (March 2005). Chemical, microbiological and toxicological characterization of fine particle matter (PM2.5 ) from an indoor environment in Puerto Rico, Abstract No. 445, 44rd Annual Meeting of the Society of Toxicology, Baltimore, New Orleans Imilce Rodríguez-Fernández, E. Fuentes-Mattei, A. Gioda, W. Delgado-Morales, and B.D. Jiménez-Vélez. (August 2004) Effect of organic compounds in fine particles (PM2.5) from Puerto Rico on cytokine repertoire of human Lymphocytes: Developing methodologies, MBRS- RISE Summer Poster Presentation Forum, University of Puerto Rico, Medical Sciences Campus, San Juan Puerto Rico. Fuentes, E., Quattrochi, L., Barwick, J., Hendershot, R.W., Guzelian, P., and Jiménez-Velez, B.D., (April 2004) "MHC Class II gene regulation in G3A, G3Ap4, C6 and 9L cell lines co-transfected with human steroid and xenobiotic-sensing X receptor (SXR) and in primary rat hepatocytes, XXIV Annual Forum for Investigation and Education, University of Puerto Rico, Medical Sciences Campus, San Juan Puerto Rico. Fuentes, E., Quattrochi, L., Barwick,J., Hendershot, R.W., Jiménez, B.D., and Guzelian, P., (March 2004) "Response of Major Histocompatibility Complex (MHC) Class II Promoter Region to DEX and RIF in G3A, G3Ap4, C6, and 9L Cell Lines and in Primary Rat Hepatocytes Cotransfected with Human Steroid and Xenobiotic-sensing Receptor (SXR)“, 43rd Annual Meeting of the Society of Toxicology, Baltimore, Maryland. B.D. Jiménez-Vélez., D. Acevedo, and C. J. Rodríguez-Sierra. (2004) Heavy metals and elemental and organic carbon in atmospheric fine particles PM2.5 from Puerto Rico. Presented at the 43rd Annual Meeting of the Society of Toxicology, Baltimore, Maryland. Leslie A. Acevedo-Marin, Imar Mansilla-Rivera, Lourdes Perez-Negron Carlos J. Rodriguez-Sierra, and Braulio D. Jiménez. Estmating risk for heavy metal ingestion from fish in Vieques-Puerto Rico. Presented at the 8th International Symposium on Metal Ions in Biology and Medicine Held in May 2004 at Budapest. Fuentes, E., Quattrochi, L., Barwick, J., Hendershot, R.W., Guzelian, P., and Jiménez,

B.D., (November 2003) " MHC Class II gene regulation in G3A, G3Ap4, C6 and 9L cell lines cotransfected with human steroid and xenobiotic-sensing X receptor (SXR) and in primary rat hepatocytes”, Annual AAAS/PREPSCoR meeting and the PRSGC's 2nd Congress on Integrating NASA Research and Education Projects in Puerto Rico, San Juan Puerto Rico. Fuentes, E., Jiménez, B.D., Quattrochi, L., Barwick,J., Guzelian, P., and Cadilla, C. (October 2003) "Response of Major Histocompatibility Complex (MHC) class II promoter region to DEX and rifampicin in transfected G3A cells and primary rat hepatocytes with human pregnane X receptor (SXR)”, Annual Biomedical Research Conference for Minority Students, San Diego, California. Leslie A. Acevedo-Marin, Imar Mansilla-Rivera, Lourdes Perez-Negron Carlos J. Rodriguez-Sierra, and Braulio D. Jiménez. Distribution of trace metals in edible fish from Vieques Puerto Rico. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) held at Texas 2003. Zenaida Rosa, David Acevedo, Carlos J. Rodriguez-Sierra and Braulio Jimenez. Heavy Metals in Airborne Particulate Matter (pm10) from Vieques-Puerto Rico. Presented at the 7th International Symposium on Metal Ions in Biology and Medicine and the 1st International Symposium on Metals Ions: Microorganisms and Plants. Held in May 2002 at Saint Petersburg State University, Russia. K. Kientz, B. Jimenez, L. Perez, and C. Rodriguez-Sierra. In vitro Bioaccessibility of Metals in Soil from a former landfill in Puerto Rico. Presented at the 7th International Symposium on Metal Ions in Biology and Medicine and the 1st International Symposium on Metals Ions: Microorganisms and Plants. Held in May 2002 at Saint Petersburg State University, Russia. L.A. Acevedo-Marin, I. Mansilla-Rivera, C.J. Rodriguez-Sierra, and B. D. Jimenez. Trace Metals in Edible fish from Vieques Puerto Rico. Presented at the 7th International Symposium on Metal Ions in Biology and Medicine and the 1st International Symposium on Metals Ions: Microorganisms and Plants. Held in May 2002 at Saint Petersburg State University, Russia. Ortiz F.W. Rodriguez-Sierra C.J. and B.D. Jimenez The role of metals in biomarker evaluation using the striped mojarra fish (Diaterus plumieri) from two estuarine environments of Puerto Rico. Primer foro de Salud Publica (Caribe Hilton), March 2002. L. R. Maldonado, Carlos J. Rodriguez, and Braulio Jimenez. Trace metals distribution in tissues of the fish yellow fin mojarra (Gerres Cinereus) from San Jose lagoon, Puerto Rico. Primer foro de Salud Publica en el Caribe Hilton, March del 2002. Torres, M.I,. Jimenez, B., Mansilla-Rivera I, and Rodriguez-Sierra, C J. Comparison of three air particulate matter extraction methods using mammalian submitochondrial particles (SMP) and vibro fisheri (microtox) toxicity assays. Presented at the 22nd

Annual Meeting of the Society of Toxicology and Chemistry Baltimore MD Nov 2001. Kientz, K., Perez, L., Jimenez, B., and Rodriguez-Sierra, C. Bioaccessibility of Metal-contaminated Tropical Soil and sediment. Society of Environmental Toxicology and Chemistry 21st Annual Meeting. Nashville, Tennessee. Fall 2000. Ortiz, W., Ruiz, J., Jimenez, B.D. Fish Hepatic Enzymes in a Tropical Lagoon from Puerto Rico. Presented at the "Society of Toxicology 38th Annual Meeting in New Orleans, March 1999. Reyes, D.R., Maldonado, L., Rosario, O., Rodriguez, J. and Jiménez, B.D. Toxicity Testing of Airborne Particulate Extracts Using Neutral Red Bioassays with Keratinocytes and Bronchiotreacheal Cells. "Society of Toxicology 38th Annual Meeting. March 1999. Molinelli, A., Rodríguez, Y., Cadilla, C., and Jiménez, B.D. Use of Differential Display for Identification of PCN Inducible Genes in Rat Liver. Presented at the Society of Toxicology 38th Annual Meeting in New Orleans, March 1999. Maldonado, L., Shih, H., Quattrochi, L., Guzelian, P., and Jiménez, B.D. Use of Differential Display for Identification of PCN Inducible Genes in Rat Liver. Presented at the Society of Toxicology 38th Annual Meeting in New Orleans, March 1999. Maldonado-Baez, L., Reyes, D.R., Rodriguez, J.F., and Jimenez, B.D. Assessing Toxicological Effects of Compounds Adsorbed to Particulate Matter Using the Neutral Red Bioassay with Human Bronchial Epithelial Cells. Presented at 98th General Meeting of the American Society of Microbiology. Atlanta, Georgia. May 1998. Reyes, D.R., Rodriguez, M., Rosario, O., Rodriguez, J.F., and Jimenez, B.D. Seasonal Toxicological and Chemical Characterization of Atmospheric Particulate Matter from Northern Area of Puerto Rico. Presented at 28th International Symposium of Environmental Analytical Chemistry. Geneva, Switzerland. March 1998. Reyes, D.R., Rodriguez, M., Rosario, O., Rodriguez, J.F., and Jiménez, B.D. Toxicological Screening of Airborne Particulate Matter Extracts Using Neutral Red Uptake Bioassay. Presented at the 37th Annual Meeting of the Society of Toxicology, Seattle, Washington, March 1998. Jordan, M., Lopez, R., Cardona, A. and Jimenez, B.D. Isolation of Colorectal Cancer Genes for Puerto Rican Patients by means of Differential Display. Presented at the 18th Annual Research Forum, Medical Sciences Campus, University of Puerto Rico ( 1997). Santiago, D., Aguilo, F. and Jimenez, B.D. Expression of Glutationes S-transferase _ in Human Lymphocytes from type I Diabetic Patients. Presented at the 18th Annual Research Forum, Medical Sciences Campus, University of Puerto Rico (April 1997) Aviles, A., Guzelian, P. and Jimenez, B.D. Effects of Calcium-Related Agents on

Cytochrome P4503A1 Using Primary Rat Hepatocytes. Presented at the 18th Annual Research Forum, Medical Sciences Campus, University of Puerto Rico (April 1997) Santiago, D,, Aguilo, F. and Jimenez, B.D. Expression of Glutationes Stransferase in Human Lymphocytes from Type I Diabetic Patients. Presented at the 36th Annual Meeting of the Society of Toxicology, Cincinnati, Ohio (March 1997) Aviles, A., Guzilian, P. and Jimenez, B.D., Effects of Calcium-Related Agents on Cytochrome P4503A1 Using Primary Rat Hepatocytes. Presented at the 36th Annual Meeting of the Society of Toxicology, Cincinnati, Ohio (March 1997) Rodriguez, Y., Jimenez, B.D. and Cadilla, C. Determination of the Genotoxicity of Airborne Contaminants using Quantitative XL-PCR. Presented at the 36th Annual Meeting of the Society of Toxicology, Cincinnati, Ohio (March 1997) Reyes, D., Rosario, O. and Jimenez, B.D. Toxicological Studies of Atmospheric Particulate Matter from an Industrial Northen Area of Puerto Rico. Presented at the 32nd Junior Technical Meeting, San Juan, Puerto Rico (March 1997) Rodriguez, Y., Jimenez, B. and Cadilla, C. Quantitative XL-PCR as a tool for Assessing Genotoxicity of Chemical Found in Airborne Particulates. Presented at ASM 96th Annual Meeting in New Orleans (1996) Rodríguez, Y., Jimenez, B. and Cadilla, B. Quantitative XL-PCR as a tool for Assessing Genotoxicity of Chemical Found in Airborne Particulates. Presented at the 8th Annual Meeting of AAAS and EPSCoR (May 1996) Ruiz, J., Tosteson, T.R., Alvarez, M. and Jiménez, B. Preliminary results on Hepatic Indicators in Diapterus phimeri as biomarkers of contamination in San Jose Lagoon. Presented at the 8th Annual Meeting of AAAS and EPSCoR (May 1996) Rodriguez, J.F., Rodríguez, C.J., Delgado, R., Reyes, D. and Jimenez, B.D. Toxicological Characterization of Atmospheric Particulate Matter and its Biotransformation. Presented at the 8th Annual Meeting of AAAS and EPSCoR (May 1996) Rivera-Correa, M., Escobales, N. and Jimenez, B. Preliminary Results on Adsorbed Compounds Associated to Airborne Particulate from EQB Stations on Ion Transport Properties of Vascular Endothelial Cells. Presented at the Annual Meeting of AAAS and EPSCoR (May 1996) Reyes, D.R., Rosario, O., Delgado, R., Jiménez, B. and Rodríguez, J.F. Chemical and Toxicological Characterization of Atmospheric Particulate Matter in a Northern Area of Puerto Rico. Presented at the 26th International Symposium on Environmental Analytical Chemistry, Vienna, Austria (April 1996) Jimenez, B. Marine Toxins: Effects on Murine-Liver Invited Lecture at University of

Utah, School of Pharmacy (March 1996) Rosado, C.Y., Quattrochi, L.C., Guzelian, P.S. and Jiménez, B.D. Positive Identification of Pregnenolone 16-a-Carbonotrile and Dexamethasone induced gene by differential Display Technique -Rat Adrenomedullin Precursor gene. Toxicologist pp. 320 (1996) Jiménez, B. Hepatotoxicity of Marine Toxins Invited Lecturer at Meharry Medical College Pharmacology and Toxicology Department (February 1996) Jimenez, B., Soto, J., Matta, J. and Gonzalez-Keelan, C. Hepatotoxic Effects of Maitotoxin and Marine Toxins in Mammals. Presented in the 7th Puerto Rico EPSCoR Annual Conference, Cerromar, Dorado, Puerto Rico (April 28-29, 1995) Rodriguez, J. and Jiménez, B. Toxicological Characterization of Particulate Matter from Cataño and Yabucoa. Presented in the Seventh Puerto Rico EPSCoR Annual Conference, Cerromar, Dorado, Puerto Rico (April 28-29, 1995) Jimenez, B. Marine Toxins and Cytochrome P450. Invited lecture at Michigan State University, Department of Pharmacology and Toxicology (March 14, 1995) Rosado, C.Y., Quattruchi, L.C., Guzelian, P.S., Jimenez, B.D. Hepatic Differentially Displayed genes after Dexamethame treatment in rats. Presented at the 34th Annual Meeting of the Society of Toxicology, Baltimore, MD (March 5-9, 1995) Toxicologist pp.117 Matta, J.L., Hupka, A.L., Jiménez, B. and Tosteson, T.R. The Role of oxygen-derived free radicals and lipid peroxidation in ciguatera fish poisoning. Presented at the 34th Annual Meeting of the Society of Toxicology, Baltimore, MD (March 5-9, 1995) Toxicologist pp. 156 Jimenez, B. Effects of pollution and marine toxins on fish and mammalian detoxication enzymes. Invited lecturer, University of Wurzburg (1994) Jimenez, B. and Soto, J. Marine Toxins: their effect on mammalian liver. Presented at the International Symposium of Ciguatera and Natural Products, Kina, Hawaii (August 8-10, 1994) Guerrero, G. and Jimenez, B. Effects of Gentamycin on detoxication enzymes in young and adult rats. Presented at the National Conference of Undergraduate Research, Kalamazoo, Michigan (April 1994) Rivera, A. and Jimenez, B. Effects of drugs on GST activity from human lymphocytes. Presented at the 33th Annual Meeting of the Society of Toxicology, Dallas, Texas (March 12-17, 1994) Soto, J. and Jimenez, B. Effects of marine toxins on mammalian detoxication enzymes.

Presented at the 33rd Annual Meeting of the Society of Toxicology, Dallas, Texas (March 12-17, 1994) Jimenez, B. Cytocrome P450 and marine toxins. Invited lecturer at the University of Colorado, Health Science Center, Medical Toxicology, Denver, CO (Summer 1994) Jimenez, B. and Soto, J. Effects of two marine toxins on detoxication enzymes. Procedings of the 6th Annual Conference of AAAS & EPSCoR (1994) Jimenez, B. and Colon, F. Incidence of drug use in alcohol and blunt and penetrating trauma in PR. Proceeding of the Annual Meeting of the AAAS and EPSCoR (1994) Colon, F. and Jimenez, B. Effects of alcohol and drugs in blunt and penetrating trauma from Puerto Rico. Presented at the 33rd Annual Meeting of the Society of Toxicology, Dallas, Texas (March 12-17, 1994) Jimenez, B., Soto, J. and Tosteson, T. The use of cytochrome P450 monoclonal antibodies to assess xenobiotic exposure in tropical fish species. Presented at the Marine Natural Products: Chemical Structure and Bioactivity at la Parguera, Lajas, PR (1993) Soto, J. and Jimenez, B. The use of monoclonal antibodies against cytochrome P450 as biomarkers of pollution in temperature and tropical fish. Presented at the Meeting OF Marine Natural Products:Chemical Structure and Bioactivity, Parguera, Lajas, Puerto Rico (March 1993) Jimenez, B., Soto, J. and Tosteson, T. Evaluation of cytochrome P-450 antibodies and hepatic enzymes activity on mice treated with ciguatoxic fish extract. Fifth Puerto Rico EPSCoR Annual Conference, RUM, Mayaguez, PR (1993) Vargas, M. and Jimenez, B. Induction of cytochrome P450 in fish from the Insular shelf of Puerto Rico. Presented at the Seventh National Conference on Undergraduate Research, University of Utah (March 1993) Vargas, G. and Jimenez, B. Biochemical responses from the liver of two fish species from the Elizabeth River. Presented at the Seventh National Conference on Undergraduate Research, University of Utah (March 1993) Jimenez, B.D. Occupational and Clinical Toxicology. Lecture at University of Puerto Rico, Mayaguez Nursing School (December 10, 1992) Jimenez, B.D. The use of molecular Biology techniques as biomarkers of pollution. Research Forum on Biotechnology in Human Ecology. Sponsored by the Interamerican University at Ponce, Puerto Rico (December 2, 1992) Jimenez, B.D. Invited Lecture "Tecnicas bioquimicas para detectar contaminacion en peces". Second Latinoamerican workshop of Environmental and Analytical Chemistry,

Guatemala City, Guatemala (June 28-July 4, 1992) Santos, L., Hupka, A. and Jimenez, B. Characterization of Biotransformation enzymes of the species Ameiva exsue: A Puerto Rican iguana as potential sentinel species. XVII Congress of Scientific Research Interamerican University of Puerto Rico, Arecibo Campus (October 1992) Jimenez, B.D. Environmental pollution and its effects on our health. Invited lecture at Medical Association of Bella Vista Hospital (December 1991) Jimenez, B.D. The use of detoxication enzymes as indicators of pollution in fish. Invited lecture at the Biology Department, University of Puerto Rico (December 1991) Jimenez, B.D. Detoxication enzymes in tropical and temperate fish. Presented at the Join EPSCoR and Annual Meeting of the AAAS, Caribbean Division, San Juan, Puerto Rico (1991) Jimenez, B.D. Detoxication enzymes and DNA integrity as Biomarkers of Pollution. Invited lecture at the Institute of Toxicology, University of Wurzburg, Germany (November 1991) Jimenez, B.D. Advances on biomarkers research. Presented at the Ponce School of Medicine (May 1991) Jimenez, B.D., Evaluation of detoxication enzyme in fish species from the Elizabeth River. Presented at the RCMI symposium on Environmental Health Sciences and Toxicology at Atlanta, GA (April 1991) Jimenez, B.D. Detoxication enzymes in fish. Presented at the Medical Sciences Campus to the Department of Pharmacology and Toxicology (February 1991) Jimenez, B.D. Biomarkers of Environmental Pollution. Presented at the Center for Industry and University Research (October 1990) Jimenez, B.D. The use of organisms as indicators of contaminated. Presented at the first Congress of High Technology and Impact on Society, sponsored by the Interamerican University at Hotel Caribe Hilton (October 1990) Jimenez, B.D. Toxic compounds in food additives. Presented at the Center for advanced Pharmaceutical Manufacturing Training at the School of Pharmacy (July 1990) Jimenez, B.D. Effects of temperature on the response of detoxication enzymes and DNA integrity after exposure to environmental pollutants. Presented at the Environmental Health Sciences symposium, sponsored by the Puerto Rican Environmental Quality Board (June 1990)

Jimenez, B.D. The use of biomarkers to determine the extent of pollution in environments of concern. Presented at the Medical Sciences Campus during the Week of the Environmental, sponsored by the Environ. Quality Board of Puerto Rico (April 1990) Adams, S.M., Greeley, M.S., Jimenez, B.D., McCarthy, J.F. and Shugart, L.R., Bioindicators of Contaminant Related Stress: An Integrated Field Assessment Methodology. Presented at the 14th Symposium on Aquatic Toxicology and Risk Assessment held in San Francisco, Ca. (April 22-24, 1990) Jimenez, B.D. Induction and expression of five detoxication enzymes in Benzo(a)pyrene exposed fish. Invited lecture at the Department of Biology, University of Puerto Rico at Cayey (February 1990) Jimenez, B.D. Use of detoxication enzymes in environmental monitoring of pollution. Presented at the U.P.R. Cayey Campus for the MBRS seminar series (February 1990) Jimenez, B.D. and Lydia Rosas-Marty Evaluation of biochemical responses in the liver of the toadfish (Opsanus tau) and the croaker (Micropogonias undulatus) from the Elizabeth River. Society of Environmental Toxicology and Chemistry Toronto, Canada (Nov.1989) Jimenez, B.D. Laboratory and field studies on biotransformation enzymes in sunfish (Lepomis sp). Presented at the American Chemistry Society at Los Angeles, Ca. (September 1989) Winfree, M.L., Mrotek, J.J., Barrow, R., Jimenez, B.D., Evins, F.L. and Clark, J.T., Cadmium-induced alterations in reproductive and adrenal function. Endocrinology 122:200 (1988) Jimenez, B.D. and Burtis, L.S. Response of the mixed function oxidase system to toxicant dose, food and acclimation temperature in the bluegill sunfish. Presented at the Fourth International Symposium on Response of Marine Organisms to Pollutants at Woods Hole Massachusetts (April 22-24, 1987) Jacobson, K.B, Sloop, F.V., Shugart, L.R., Adams, S.M., Jimenez, B.D. and McCarthy, J.F. A convenient rapid assay for the methallothionein using chelex-100. UCLA colloquium on metal Ion Homeostasis: Molecular Biology and Chemistry, Frisco, Colorado (April 10-16, 1988) Jimenez,B.D. Detoxication Enzymes: Evaluating fish liver enzymes and monooxygenases (MFO) as indicators of chronic pollution stress. 117th A.F.S. Annual Meeting, Winston-Salem, N.C. (September 1987) Jimenez, B.D., Meads, S.D. and Adams, S.M. The use of liver enzymes and liver conditions as sublethal indicators of contaminants stress in the redbreast (Leopomis auritus). Aquatic Toxicol. 11:434-435 (1988)

Shugart, L., Jimenez, B.D. and McCarthy, J.F. Analysis of adducts formation in bluegill sunfish exposed to benzo(a)pyrene. Aquatic Toxicology 11: 413-414 (1988) Lee, N.E., Egan, B.Z., Burtis, C.A., Griffin, G.D. and Jimenez, B.D., Induced cytochrome P-488, mixed function oxidase activity, measured by laser excited fluorescence. Abstract submitted to the 192nd National Meeting of the American Chemical Society, Anaheim, California (September 7-12, 1986) Jimenez, B.D., Ezell, G.H., Egan, B.Z., Lee, N.E., Beauchamp, J.J., Burtis, L.S. and McCarthy, J.F., Effects of feeding and temperature on the mixed function oxidase (MFO) system in bluegill sunfish (Lepomis macrochirus). Abstract submitted for the 6th annual meeting of the Society of Environmental Toxicology and Chemistry. St. Louis, Missouri (November 10-13, 1985) Jimenez, B.D., McCarthy, J.F. and Cirmo, C.P. Effects of temperature and feeding on the metabolic fate of Benzo(a)pyrene in bluegill sunfish, Lepomis macrochrirus. Abstract submitted for the Fifth Annual Meeting of the Society of Environmental Toxicology and Chemistry. Arlington, Virginia (November 4-7, 1984) Jimenez, B.D., McCarthy, J.F. and Cirmo, C.P. Effects of environmental variables on uptake, elimination and metabolism of Benzo(a)pyrene in fish. Proc. Assoc. Is. Mar. Labs. Carib. 18:12, Trinidad (1984) McCarthy, J.F. and Jimenez, B.D. Absorption of organic contaminants to humic substances and the effect on uptake by aquatic organisms. Abstract submitted for the fifth annual meeting of the society of Environmental Toxicology and Chemistry. Arlington, Virginia (November 4-7, 1984) McCarthy, J.F. and Jimenez, B.D.Interactions between organic contaminants and dissolved humic materials: Binding and dissociation. Proc. Assoc. Is. Mar. Labs. Carib. pp. 18:10 (1984)