Updated 3/14/2013 1

Curriculum Vita

Linheng Li, Ph.D.

Personal Birth Date: January 3, 1958

Birth Place: P. R. China

Citizenship: U. S. A.

Phone: 816-926-4081

Fax: 816-926-2023

Email: lil@stowers.org

Appointment history May 2008-present Investigator

Stowers Institute for Medical Research

1000 East 50th

Street

Kansas City, Missouri 64110 USA

July 2009-present Affiliate Professor

Department of Pathology

University of Kansas Medical Center (KUMC)

Kansas City, Kansas USA

2010-present Co-leader, Cancer Biology

University of Kansas Cancer Center (NCI-CC)

Fairway, Kansas USA

Jan 2006-May 2008 Associate Investigator, Stowers

July 2006-June 2009 Affiliate Associate Professor, KUMC

Nov 2000-Dec 2005 Assistant Investigator, Stowers

Sept 2001-June 2006 Affiliate Assistant Professor, KUMC

1999-Oct 2000 Affiliate Assistant Professor

Department of Molecular Biotechnology & affiliate position in Pediatrics

Department /Division of Genetics and Development

University of Washington Medical Center

Seattle, Washington USA

1995-May 1998 Senior Associate

Laboratory of Dr. Leroy Hood

Department of Molecular Biotechnology

University of Washington

Seattle, Washington USA

1990-Jan 1995 Pre-doctoral student

Laboratory of Dr. Edward Ziff

Department of Biochemistry

New York University Medical Center

New York, New York USA

1989-Aug 1990 Assistant Research Scientist

Laboratory of Dr. Meneck Goldstein

Linheng Li

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New York University Medical Center

New York, New York USA

1985-1988 Graduate student

Laboratory of Dr. Shouyuan Zhao

Fudan University, Institute of Genetics

Shanghai, China

Education:

Ph.D. (1995) New York University, Medical Center, New York USA

Molecular and Cellular Biology

M.S. (1993) New York University, Medical Center, New York USA

Molecular and Cellular Biology

M.S. (1988) Fudan University, Shanghai, P.R. China

Genetics

B. S. (1985) Fudan University, Shanghai, P.R. China

Biology

Honors and Awards:

Fellow of the American Gastroenterological Association (AGA) 2013

Fellow of the American Association for the Advancement of Science (AAAS) 2011

Missouri Biotechnology Association Excellence in Life Sciences Award in Basic Research 2003

Hudson Prize for excellence in basic biomedical research, presented by the M.R. and Evelyn

Hudson Foundation 2004

Active Memberships:

American Association for Cancer Research (AACR)

American Association for the Advancement of Science (AAAS)

American Society for Cell Biology (ASCB)

American Society of Developmental Biology (SDB)

American Society of Hematology (ASH)

International Society for Stem Cell Research (ISSCR)

American Gastroenterological Association (AGA)

International Society for Hematology and Stem Cells (ISEH)

Research Grants:

1996-2015 Institutional funding from Stowers Institute for Medical Research

Role: Principal Investigator

“Investigation of micro environmental regulatory signals for stem cell

development”

9/2009-8/2014 National Institutes of Health Grant U01 DK085507

National Institute of Diabetes and Digestive and Kidney Diseases

Role: Principal Investigator

“Isolation and Characterization of Intestinal Stem Cells”

7/2009-6/2010 Children’s Leukemia Research Association

Role: Principal Investigator

“Targeting leukemia stem cells in the PTEN and beta-catenin mutant models”

Linheng Li

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9/2005-8/2009 National Institutes of Health Grant R01 DK070001

National Institute of Diabetes and Digestive and Kidney Diseases

Role: Principal Investigator

“Role of BMP Signaling in Intestine Stem Cell Development”

2/2005-1/2007 March of Dimes Birth Defects Foundation

Basil O’Connor Starter Scholar Research Award

“Analysis of the Genetic and Molecular Mechanisms Leading to Juvenile Polyps”

Service:

Chinese Biological Investigators Society President, Board of Directors

National Institutes of Health ad hoc Reviewer Hematopoiesis Study Section

University of Kansas Cancer Center Leadership Council

Connecticut Stem Cell Research Program Peer Review Committee Member

Faculty of 1000 Medicine Contributing Faculty

Natural Sciences and Engineering Research Council of Canada (NSERC) Research Proposal Reviewer

International Society for Stem Cell Research 2011 Program Committee

National Science Council of Taiwan, Stem Cell Research Program Research Proposal Reviewer

Ministry of Sciences and Technology, National Major Research Programs of Sciences (MOST) International Advisory Council Member

The Institute for Stem Cell and Regenerative Medicine University of Washington Scientific Advisory Board

Editorial Board Member:

Cancer Research (AACR), Journal of Biological Chemistry (JBC), Stem Cells,

Cell Stem Cell

ad hoc Reviewer: Blood

Cancer Cell

Cell

Cell Stem Cell

Development Cell

Developmental Biology

Gastroenterology

Genes & Development

Gene Therapy

Immunity

J. Clinical Investigation

J. Cellular Physiology

J. Experimental Medicine

J. Am Soc Nephrology

J. Cell Biology

J. Clinical Investigation

Leukemia

J. Molecular Cell Biology

Nature

Nature Genetics

Nature Insight

Nature Medicine

Nature Review Cancer

Nature Review Genetics

Nature Review MCB

Oncogene

Plos Biology

Procedures of the National

Academy of Sciences

Science

Trends

Linheng Li

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Publications:

M.S. Training period

1. Linheng Li and Shouyuan Zhao (1988). The advances in the research of gene transfer vector for

mammalian system. Journal of Nature (Chinese) 11: 132-138.

2. Linheng Li, Wenyi Zhuang, Jianhua Cai, Chengben Li, and Shouyuan Zhao (1990). Isolation and

physical mapping of human lymphotoxin gene. Journal of Biotechnology (Chinese) 6: 24-31.

Ph.D. Training period

3. Linheng Li, Claus Nerlov, George Prendergast, Douglas MacGregor, and Edward B Ziff (1994). c-

Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and

Myc box II. EMBO J 1994 Sep 1;13(17): 4070-9.

4. Douglas MacGregor, Linheng Li and Edward B Ziff (1995). Dominant negative mutants indicate that

Myc requires more than max to cooperate with Ras in cell transformation and that E1a-Ras

cooperation shares these requirements. J. Cell. Physiology Apr;167(1): 95-105.

5. Robert Hopewell, Linheng Li, Douglas MacGregor, Claus Nerlov and Edward Ziff (1995) Regulation

of Cell Proliferation and Differentiation By Myc. J. of Cell Sci Suppl. 1995;19:85-9.

6. Xi He, KY Lee, Linheng Li, E Meller, Meneck Goldstein (1996). Relationship between enzymatic

activity and oligomerization state of tyrosine hydroxylase. J Biomed Sci. 1996 Sept-Oct;3(5): 332-

337.

7. Theodore C Lee, Linheng Li, Lennart Philipson, Edward B Ziff (1997). Myc represses transcription

of the growth arrest gene gas-1. Pro Natl Aca Sci USA 1997 Nov 25;94(24):12886-12891.

Postdoctoral Training period

8. Linheng Li, ID Krantz, Y Deng, A Genin, A Banta, C Collins, M Qi, BJ Trask, W Kuo, J Cochran, T

Costa, M Ella, M Pierpont, E Rand, D Piccoli, L Hood, N Spinner (1997). Alagille syndrome is

caused by mutations in hJagged1 (JAG1), which encodes a ligand for Notch1. Nat Genet 1997

Jul;16(3): 243-251.

9. L Li, L Milner, Y Deng, W Iwata, A Banta, L Graf, S Marcovina, C Friedman, BJ Trask, L Hood, and

B Torok-Storb (1998). The human homolog of rat Jagged1 expressed by marrow stroma inhibits

differentiation of 32D cells through interaction with Notch1. Immunity. 1998 Jan;8(1):43-55.

10. Linheng Li, GM Huang, L Rowen, A Banta, Y Deng, and L Hood (1998). Cloning, characterization,

and the complete 56.8-kilobase DNA sequence of the human Notch4 gene. Genomics 1998 Jul

1;51(1):45-58.

11. ID Krantz, R P Colliton, A Genin, EB Rand, L Li, DA Piccoli and NB Spinner (1998). Spectrum and

frequency of Jagged1 (JAG1) mutations in Alagille syndrome patients and their families. Am. J.

Hum. Genet. 1998 Jun;62(2):1361-1369.

12. Yu Deng, Anup Madan, Amy Banta, Cynthia Friedman, Barbara Trask, Leroy Hood, and Linheng Li

(2000). Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the

human Jagged2 (JAG2) gene. Genomics 2000 Jan 1;63(1): 133-138.

13. In-Kyung Park, Christopher A Klug, Kaijun Li, Libuse Jerabek, Linheng Li, Masakatsu Nanamori,

Richard R Neubig, Leroy Hood, Irving L Weissman, and Michael F Clarke (2001). Molecular cloning

and characterization of a novel regulation of G-protein Signaling from Mouse Hematopoietic Stem

Cells. J Biol Chem 2001 Jan 12;276(2):915-23.

14. AV Terskikh, MC Easterday, L Li, L Hood, HI Kornblum, DH Geschwind, IL Weissman (2001).

From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci

U S A 2001 Jul 3;98(14):7934-9.

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Assistant Investigator (Nov 2000 – Dec 2005)

15. Park I, He Y, Lin F, Laerum O, Tian Q, Bumgarner R, Klug C, Li K, Kuhr C, Doyle M, Xie X,

Schummer M, Sun Y, Goldsmith A, Clarke M, Weissman I, Hood L, and Li, Linheng (2002).

Differential Gene Expression Profiling of Adult Murine Hematopoietic Stem Cells. Blood 99(2): 488-

98.

16. Xue-Han Ning, Shi-Han Chen, Cheng-Su Xu, Linheng Li, Kun Qian, and Michael A Portman (2002).

Hypothermic protection of the ischemic heart via alteration in apoptotic pathways as assessed by gene

array analysis. Applied Physiology. 2002 May;92(5):2200-7.

17. Kevin G Leong, Xiaolong Hu, Linheng Li, Michela Noseda, Bruno Larrivee, Patrick J Duriet,

Christopher Hull, Leroy Hood, Fred Wong, and Aly Karsan (2002). Activated Notch4 Inhibits

angiogenesis: Roles of beta-1 Integrin Activation. Mol. Cell. Biology, 22(8):2830-41.

18. Koichi Akashi, Xi He, Jie Chen, Hiromi Iwasaki, Chao Niu, Brooke Steenhard, Jiwang Zhang, Jeff

Haug, and Linheng Li (2003). Transcriptional Accessibility for Genes of Multiple Tissues and

Hematopoietic Lineages is Hierarchically Controlled During Early Hematopoiesis. Blood, 2003 Jan

15;101(2): 383-390. (cover and plenary paper)

19. Fangming Lin, Kimberly Cordes, Linheng Li, Leroy Hood, William Couser, Stuart Shankland, and

Peter Igarashi (2003). Hematopoietic stem cells contribute to the regeneration of renal tubules after

renal ischemia-reperfusion injury in mice. J Am Soc Nephrol 2003 May;14(5):1188-99.

20. Jiwang Zhang, Chao Niu, Ling Ye, Haiyang Huang, Xi He, Wei-Gang Tong, Jason Ross, Jeff Haug,

Teri Johnson, Jian Q Feng, Stephen Harris, Leanne M Wiedemann, Yuji Mishina & Linheng Li

(2003). Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003

Oct 23;425(6960):836-841.

21. M Noseda, G McLean, K Niessen, L Chang, I Pollet, R Montpetit, R Shahidi, K Dorovini-Zis, L Li,

B Beckstead, R Durand, P Hoodless, A Karsan (2004). Notch activation results in phenotypic and

functional changes consistent with endothelial-to-mesenchymal transformation. Circulation

Research 2004 Vol. 94, No.7, 910-917.

22. Jie Chen, Xi He, and Linheng Li (2004). Identifying the Patterns of Hematopoietic Stem Cells Gene

Expressions Using Clustering Methods: Comparison and Summary. J Data Science 2004 Vol. 2, No.

3, 297–309.

23. Xi C He, Jiwang Zhang, Wei-Gang Tong, Ossama Tawfik, Jason Ross, David H Scoville, Qiang Tian,

Xin Zeng, Xi He, Leanne M Wiedemann, Yuji Mishina, and Linheng Li (2004). BMP Signaling

Inhibits Intestinal Stem Cell Self-Renewal Through Suppression of Wnt/β-catenin Signaling. Nature

Genetics 2004 Oct;36(10):1117-21.

24. Qiang Tian, Megan C Feetham, W Andy Tao, Xi C He, Linheng Li, Ruedi Aebersold, Leroy Hood

(2004). Proteomic analysis identifies that 14-3-3- interacts with β-catenin and facilitates its

activation by Akt. Proc Natl Acad Sci USA. 2004 Oct 26;101(43);15370-15375.

Associate Investigator (Jan 2006 - May 2008)

25. Jiwang Zhang, Justin C Grindley, Tong Yin, Sachintha Jayasinghe, Xi C He, Jason T Ross, Jeffrey S

Haug, Dawn Rupp, Kimberly S Porter-Westpfahl, Leanne M Wiedemann, Hong Wu, Linheng Li

(2006). PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia

prevention. Nature 2006 May 25;441(7092):518-22.

26. Jayasinghe SM, Wunderlich J, McKee A, Newkirk H, Pope S, Zhang J, Staehling-Hampton K, Li L,

Haug JS (2006). Sterile and Disposable Fluidic Subsystem Suitable for Clinical High Speed

Fluorescence-Activated Cell Sorting. Cytometry B Clin Cytom. 2006 Sep 15;70(5):344-54.

27. Jiwang Zhang, Xi C He, Wei-Gang Tong, Teri Johnson, Leanne M Wiedemann, Yuji Mishina, Jian Q

Feng, Linheng Li (2006). BMP signaling inhibits hair follicle anagen induction by restricting

epithelial stem/progenitor cell activation and expansion. Stem Cells 2006 Dec;24(12):2826-39.

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28. Xi C He, Tong Yin, Justin C Grindley, Qiang Tian, Toshiro Sato, W Andy Tao, Ramanarao Dirisina,

Kimberly S Porter-Westpfahl, Mark Hembree, Teri Johnson, Leanne M Wiedemann, Terrence A

Barrett, Leroy Hood, Hong Wu, and Linheng Li. PTEN-deficient intestinal stem cells initiate

intestinal polyposis. Nature Genetics 2007 Feb 39(2):189-92.

29. S Blueming, X He, L Kodach, J Hardwick, F Koopman, F ten Kate, S van Deventer, D Hommes, M

Peppelenbosch, G Offerhaus, L Li, and G van den Brink (2007). BMP Signaling Suppresses

Tumorigenesis at Gastric Epithelian Transition Zones in Mice. Cancer Research 2007 67;8149.

30. Jeffrey S Haug, Xi C He, Justin C Grindley, Joshua P Wunderlich, Karin Gaudenz, Jason T Ross,

Ariel Paulson, Kathryn P Wagner, Yucai Xie, Ruihong Zhu, Tong Yin, John M Perry, Mark J

Hembree, Erin P Redenbaugh, Glenn L Radice, Christopher Seidel, and Linheng Li (2008). N-

cadherin Expression Level Distinguishes Reserved versus Primed States of Hematopoietic Stem Cells.

Cell Stem Cell 10 April 2008, 2:367-379.

Investigator (May 2008 - present)

31. M Wang, S Keilbaugh, T Cash-Mason, X He, L Li, G Wu (2008). Immune-mediated signaling in

intestinal goblet cells via PI3-Kinase and AKT-dependent pathways. American Journal of

Physiology-Gastrointestinal and Liver Physiology 2008; 295:G1122-G1130.

32. Yucai Xie, Tong Yin, Winfried Wiegraebe, Xi He, Diana Miller, Danny Stark, Katherine Perko,

Richard Alexander, Joel Schwartz, Justin Grindley, Jungeun Park, Jeff Haug, Joshua Wunderlich, Hua

Li, Simon Zhang, Teri Johnson, Ricardo Feldman & Linheng Li (2009). Detection of functional

haematopoietic stem cell niche using real-time imaging. Nature. 2009 Jan; 457:97-102. doi:10.1038;

published online 3 Dec. 2008.

33. Jeffrey B Brown, Goo Lee, et al, Linheng Li, Terrence A Barrett (2009). 5-ASA inhibits epithelial β-

catenin activation in chronic ulcerative colitis. Gastroenterology, 2009 Oct 28.

34. J Brown, G Lee, E Managlia, G Grimm, R Dirisina, T Goretsky, P Cheresh, N Blatner, K Khazaie, G

Yang, L Li, T Barrett (2010). Mesalamine Inhibits Epithelial Beta-Catenin Activation in Chronic

Ulcerative Colitis. Gastroenterology 2010, 138:595-605.

35. Kentaro Hosokawa, Fumio Arai, et al, Linheng Li and Toshio Suda (2010). Cadherin-based adhesion

is a potential target for niche manipulation to protect HSCs in adult bone marrow. Cell Stem Cell, 5

March 2010.

36. Nava, P, Koch, S, Laukoetter, MG, Lee, WY, Kolegraff, K, Capaldo, CT, Beeman, N, Addis, C,

Gerner-Smidt, K, Neumaier, I, Skerra, A, Li, Linheng, Parkos, C.A., Nusrat, A. (2010). Interferon-γ

Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways.

Immunity. 2010 March;32(3):392-402.

37. Da Zhang, Maura F O’Neill, Mark T Cunningham, Fang Fan, Moitaba Olvasee, Linheng Li. (2010).

Abnormal Wnt signaling and stem cell activation in reactive lymphoid tissue and low-grade marginal

zone lymphoma. Leukemia & Lymphoma, May 2010; 51(5):906-910.

38. G Lee, T Goretsky, E Managlia, R Dirisina, A Singh, J Brown, R May, G Yang, J Rogheb, B Evers, C

Weber, J Turner, X He, R Katzman, L Li, T Barrett (2010). Phosphoinositide 3-Kinase Signaling

Mediates Beta-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis.

Gastroenterology 2010, 139:869-881.

39. N He, Z Xiao, T Yin, J Stubbs, L Li, D Quarles (2011). Inducible expression of Runx2 results in

multi-organ abnormalities in mice. Journal of Cellular Biochemistry 2011, 112:653-665.

40. Helen He Zhu, Kaihong Ji, Nazilla Alderson, Zhao He, Shuangwei Li, Wen Liu, Dong-Er Zhang,

Linheng Li and Gen-Sheng Feng (2011). Kit-Shp2-Kit signaling acts to maintain a functional

hematopoietic stem and progenitor cell pool. Blood 2011; 117 (20), 5350-5361.

41. P Nava, C Capaldo, S Koch, K Kolegraff, C Rankin, A Farkas, M Feasel, L Li, C Addis, C Parkos, A

Nusrat (2011). JAM-A regulates epithelial proliferation through Akt/Beta-catenin signaling. EMBO

Reports 2011; 12:314-320.

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42. S Koch, P Nava, C Addis, A Kim, T Denning, L Li, C Parkos, A Nusrat (2011). The Wnt antagonist

Dkk1 regulates intestinal epithelial homeostasis and wound repair. Gastroenterology 2011; 141:259-

268.

43. C Arnold, R Tan, B Zhou, S Yue, S Schaffert, J Biggs, R Doyonnas, M Lo, J Perry, V Renault, A

Sacco, T Somervaille, P Viatour, A Brunet, M Cleary, L Li, J Sage, D Zhang, H Blau, C Chen, CZ

Chen (2011). MicroRNA programs in normal and aberrant stem and progenitor cells. Genome

Research 2011; 21:798-810.

44. JM Perry, XC He, R Sugimura, JC Grindley, JS Haug, S Ding, and L Li (2011). Cooperation

between both Wnt/β-catenin and PTEN/Akt signaling promotes primitive hematopoietic stem cell

self-renewal and expansion. Genes and Development 2011; 25:1928-1942.

45. Sugimura, R., He, X.C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J.S., Peng, L.,

Zhong, X., Suda, T., and Li, L. Non-canonical Wnt Signaling Maintains Hematopoietic Stem Cell

through Flamingo and Frizzled8 in the Niche. Cell 2012; 150:351-365.

46. M Zhao, JT Ross, T Itkin, JM Perry, A Venkatraman, JS Haug, M Hembree, C Deng, T Lapidot, XC

He, and L Li. FGF Signaling Facilitates Post-injury Recovery of Mouse Hematopoietic System.

Blood 2012; 120 (9), 1831-1842.

Recent Submitted Papers

A Venkatraman, XC He, M Christenson, J Thorvaldsen, R Sanchez, L Peng, JS Haug, A Paulson, H

Li, X Zhong, M Bartolomei, L Li. (2012) Maternal-specific imprinting in the H19-Igf2 locus maintains

quiescent long-term hematopoietic stem cells. Submitted to Nature - in revision

Book Chapters 1. Hans Moises, Tómas Zoega, Linheng Li, and Leroy Hood. Genes and Neurodevelopment in

Schizophrenia. In: Lisabeth F. DiLalla (ed.) Behavior Genetic Principles – Development, Personality,

and Psychopathology. Washington, DC: American Psychological Association, 2004; pages 145-157.

2. David H Scoville, Xi C He, Goo Lee, Toshiro Sato, Terrence A Barrett, Linheng Li. Intestinal Stem

Cells in Physiologic Regeneration and Disease. In: Moody, SA (ed.) Principles of Developmental

Genetics. Washington, DC: Elsevier Academic Press, 2007.

3. Jason T Ross, David H Scoville, Xi He, Linheng Li. PTEN in Hematopoietic and Intestinal Stem Cells

and Cancer. In: Bagley, RG, Teicher, BA, (eds.) Stem Cells and Cancer. New York, NY: Humana

Press, Springer, 2009; pages 59-73.

4. John M Perry and Linheng Li. Functional Assays for Hematopoietic Stem Cell Self-Renewal. In:

Ding, S, (ed.) Cellular Programming and Reprogramming: Methods and Protocols, Methods in

Molecular Biology. Springer Science+Business Media, 2010; pages 45-54.

Invited Reviews

1. Linheng Li, Koichi Akashi (2003). Unraveling the molecular components and genetic blueprints of

stem cells. BioTechniques 2003 Dec;35: 1233-1239.

2. Jiwang Zhang and Linheng Li (2003). 25-year Mystery Unveiled: Hematopoietic stem cell niche is

found. Discovery Med Dec 2003;3(19):54-58.

3. Qiang Tian, Xi C He, Leroy Hood, and Linheng Li (2004). Extra Views Bridging the BMP and Wnt

pathways by PI3 kinase/Akt and 14-3-3Cell Cycle 2005 Feb;4(2):215-6.

4. Linheng Li (2005) (Preview). Finding the Hematopoietic Stem Cell Niche in Placenta. Dev Cell.

2005;8:297-298.

5. Xi He, Jiwang Zhang, and Linheng Li (2005). Cellular and Molecular Regulation of Hematopoietic

and Intestinal Stem Cell Behavior. Stem Cell Biology: Development and Plasticity, Vol. 1049 of the

Ann N Y Acad. Sci. 2005 May;1049:28-38.

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6. Jiwang Zhang and Linheng Li (2005). BMP signaling and stem cell regulation.

Dev Biol. 2005 Aug 1;284(1):1-11.

7. Linheng Li and Ting Xie (2005). Stem cell niche: Structure and Function. Ann. Rev. Cell. & Dev.

Biology. June 2005 21:605-31.

8. Linheng Li and William B Neaves (2006). Normal Stem Cells and Cancer Stem Cells: the Niche

Matters. Cancer Research 2006 May 1;66(9):4553-7.

9. Tong Yin and Linheng Li (2006). The stem cell niches in bone. J. Clin. Invest., May 2006;116:1195 -

1201.

10. Jason Ross and Linheng Li (2006). Recent advances in understanding extrinsic control of

hematopoietic stem cell fate. Curr Opin Hematol 2006 July;13(4):237-42.

11. Zhixing Li and Linheng Li (2006). Understanding hematopoietic stem-cell microenvironments.

Trends Biochem Sci 2006 Oct;31(10):589-95.

12. Ting Xie and Linheng Li (2007). Stem cells and their niche: an inseparable relationship. Development

2007 Jun;134(11):2110-06. (meeting review)

13. John M Perry and Linheng Li (2007). Disrupting the Stem Cell Niche: Good seeds in bad soil. Cell

June 15 2007;129:1045-47.

14. Linheng Li (2007) (Research Highlight). Does ‘Immortal DNA strand’ exist in ‘immortal’ stem cells?

Cell Research (2007) 17:834-35.

15. Jiwang Zhang and Linheng Li (2008). Stem Cell Niche: Microenvironment and Beyond. Journal of

Biological Chemistry 2008; 283:9499-9503.

16. David H Scoville, Toshiro Sato, Xi C He, and Linheng Li (2008). Current View: Intestinal Stem Cells

and Signaling. Gastroenterology 2008;134:849-864.

17. John M Perry and Linheng Li (2008). Self-renewal versus transformation: Fbxw7 deletion leads to

stem cell activation and leukemogenesis. Genes and Development 22:1107-1109.

18. RS Blumberg, L Li, A Nusrat, CA Parkos, DC Rubin and JL Carrington (2008). Recent insights into

the integration of the intestinal epithelium within the mucosal environment in health and disease.

Mucosal Immunology 25 June 2008; doi:10.1038/mi.2008.29. (meeting review)

19. Tong Yin, Yucai Xie and Linheng Li (2009). Visualize eHPCs in different zones, Inside Blood.

Blood; 2009 July 9; 114(2): 230-231.

20. Jason Ross and Linheng Li (2009). HSC Mobilization: New Incites and Insights, Inside Blood. Blood;

2009 Aug 3; 114(7): 1283-1284.

21. Tong Yin and Linheng Li (2010). Fountain of Youth: aged blood-forming stem cells could be

rejuvenated by young microenvironment. Cell Research 2010; 20:504.

22. Linheng Li and Hans Clevers (2010). Coexistence of Quiescent and Active Adult Stem Cells in

Mammals. Science 29 January 2010.

23. R Sugimura and L Li (2010). Shifting in balance between osteogenesis and adipogenesis substantially

influences hematopoiesis. Journal of Molecular Bell Biology 2010; 2:61-62.

24. R Sugimura and L Li (2010). Noncanonical Wnt signaling in vertebrate development, stem cells, and

diseases. Birth Defects Research Part C:Embryo Today 2010, 90:243-256.

25. R Sugimura and L Li (2011). Bone metastasis targets the endosteal hematopoietic stem cell niche.

IBMS BoneKEy. 2011 August;8(8):381-384.

26. Perry, J. M. and L. Li (2012). To be or not to be a stem cell: dissection of cellular and molecular

components of haematopoietic stem cell niches. EMBO J 31(5): 1060-1061.

27. Roland Jurecic, Linheng Li, and R. Keith Humphries (2012). Heterogeneity, Self-Renewal, and

Differentiation of Hematopoietic Stem Cells. Stem Cells International, vol. 2012, 2 pages, 2012.

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Meetings and Lectures:

Session Chair / Co-Chair at International and National Scientific Meetings: June 2007 Co-Chair, Session on “Intestinal stem cell”, 12

th US-Japan GI & Liver Meeting, Kyoto,

Japan

November 2007 Chair, Session on “Embryonic and germ Line Stem Cell”, Shanghai Stem Cell

Symposium, Shanghai, China

January 2008 Chair, Session on “Stem Cell Niches”, EuroSTELLS Workshop, European Science

Foundation, Barcelona, Spain

March 2008 Chair, Session on “Stem Cell Biology of the Intestine”, NIDDK Local Influences on

Health and Repair of Intestinal Epithelium meeting, NIH, Bethesda, Maryland USA

June 2008 Co-Chair, Session on “Stem Cell Microenvironments”, ISSCR 6th

Annual Meeting,

Philadelphia, Pennsylvania USA

June 2009 Chair, Session on “Stem Cell Biology and Regenerative Medicine: Mechanism and

Regulation”, 12th

SCBA International Symposium, Academia Sinica, Taipei, Taiwan

December 2009 Co-Chair, Session on “Stem Cell Biology and Regenerative Medicine”, CBIS

Conference, La Jolla, California USA

October 2010 Co-Organizer, “Functional Stem Cell and Regeneration Workshop”, Chair, Adult Stem

Cell Session, Stowers Institute for Medical Research, Kansas City, Missouri

June 2011 Co-Organizer, Program Committee, 9th

Annual Meeting, International Society for Stem

Cell Research, Toronto, Canada

Invited Lectures at Scientific Centers and Meetings:

January 2003 “Adult stem cell development” First Annual K-BRIN Student Symposium, University

of Kansas Medical Center, Kansas City, Kansas USA

March 2003 “BMP signaling through BMPR1A negatively controls stem cell compartments in bone

marrow, hair follicle, and intestine” Keystone Symposium-From Stem Cells to Therapy,

Steamboat Springs, Colorado USA

June 2003 “The BMP signal controls stem cell numbers through the regulation of the niche size”

Midwestern Developmental Biology 43rd

Annual Meeting, Kansas City, Missouri USA

August 2003 “Identification of hematopoietic stem cell niche” The American Society for Cell

Biology 2003 Summer Meeting, Bozeman, Montana USA

February 2004 “BMP Signaling and Adult Stem Cell Development” Stowers Institute for Medical

Research, Kansas City, Missouri USA

March 2004 “BMP Signaling and Adult Stem Cell Development” University of Washington, Seattle,

Washington USA

March 2004 “Regulation of Adult Stem Cell Regeneration by BMP Signaling” Research Seminar,

Children’s Mercy Hospital, Kansas City Missouri USA

April 2004 Beijing University, Beijing, China

May 2004 Keynote speaker, Sigma Xi annual banquet, University of Kansas Medical Center,

Kansas City, Kansas USA

May 2004 “Signaling regulation of adult stem cell development” The University of Missouri

School of Dentistry, Kansas City, Missouri USA

June 2004 “BMP signaling and adult stem cell development” Kansas City Area Life Sciences

Institute Research Day, Kansas City, Missouri USA

July 2004 “BMP signaling controls stem cell compartments in bone marrow, hair follicle, and

intestine” 10th

International Symposium of the Society of Chinese Bioscientists in

America, Beijing, China

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September 2004 “Signaling regulation of stem cell development in the hematopoietic and intestinal

systems” Growth Factor and Signal Transduction Symposia, Iowa State University,

Ames, Iowa USA

September 2004 “Signaling regulation of adult stem cell development” Department of Biological

Chemistry, University of Michigan Medical School, Ann Arbor, Michigan USA

September 2004 “Signaling regulation of stem cell development in hematopoietic and intestinal

systems”. The first Kansas City stem cell symposium. Kansas City, Missouri USA

November 2004 “Cellular and molecular regulation of adult stem cell development”, The Tony & Shelly

Malkin Stem Cell Symposium, Harvard University Stem cell Institute, Boston,

Massachusetts USA

November 2004 “Regulation of intestinal stem cells by BMP signaling” Harvard Medical

School, Massachusetts General Hospital, Boston, Massachusetts USA

February 2005 “Cellular and Molecular regulation of adult stem cell development” University of

Kansas Medical Center, Department of Pathology, Kansas City, Kansas USA

February 2005 “Cellular and Molecular regulation of adult stem cell development” Duke University,

Pharmacology Department, Durham, North Carolina USA

March 2005 “Signaling and stem cell regulation” University of Missouri-Kansas City, Department

of Pharmacology, Kansas City, Missouri USA

March 2005 “Cellular and molecular regulation of adult stem cell development”

Washington University, St. Louis, Missouri USA

April 2005 “Stem cell regulation, niche and signaling.” Kansas City Area Life Sciences Institute

Annual Life Sciences Research Day, Overland Park, Kansas USA

May 2005 “Stem Cell Regulation: Niche and Signaling”. NIH / NIDDK Cellular Niche Workshop,

Bethesda, Maryland USA

May 2005 “Stem cell regulation: Niche and signaling.” Johns Hopkins Medical Institute,

Baltimore, Maryland USA

June 2005 “Stem cell regulation, Niche and signaling” The 58th

Annual Meeting of Japan Society

for Cell Biology, Saitama, Japan

June 2005 “Stem cell niche” Osaka University, Osaka, Japan

June 2005 “Regulation of HSC by osteoblastic niche” European Calcified Tissue Society (ECTS)

and International Bone and Mineral Society (IBMS) joint meeting, Geneva, Switzerland

July 2005 “Intestinal Stem Cell and Tumorigenesis,” American Association for Cancer Research

Summer Workshop, Pathobiology of Cancer, Snowmass, Colorado. Sponsored by the

National Cancer Institute. USA

August 2005 Beijing International Symposium on Stem Cell Research, Peking University Stem Cell

Research Center, Beijing, China

October 2005 “Cellular and molecular regulation of adult stem cells,” CABM Symposium Stem Cells

in Development and Organogenesis, Robert Wood Johnson Medical School, Newark,

New Jersey USA

November 2005 “Hematopoietic Stem Cells and Niche Regulation,” Bortree Lecture Series/Molecular

Toxicology Seminar, Department of Veterinary and Biomedical Sciences, Pennsylvania

State University, University Park, Pennsylvania USA

November 2005 “Hematopoietic stem cell regulation: niche and signaling,” Immunology Seminar

Series, Dept. of Microbiology, Columbia University Medical Center, New York, New

York USA

November 2005 “Stem Cells: Maintenance and regulation in the body,” Student Symposium, University

of Missouri-Kansas City, Kansas City, Missouri USA

January 2006 “Adult Vertebrate Stem Cells: Their niche and molecular regulation,” Genetics Society

of America Annual Meeting, San Diego, California USA

Linheng Li

Updated 3/14/2013 11

February 2006 The Burnham Institute for Medical Research, La Jolla, California USA

March 2006 “Stem Cell Niche: Structure & Function,” Cincinnati Children’s Hospital, Cincinnati,

Ohio USA

March 2006 “Stem cell regulation in the gut,” Ohio State University Medical Center, Cleveland,

Ohio USA

April 2006 “Stem Cell Regulation in Intestinal and Hematopoietic Systems,” Shapiro Lecture

Series, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

June 2006 “Hematopoietic stem cell regulation: Niche and Signaling,” Black Family Stem Cell

Institute, Mount Sinai School of Medicine, New York, New York USA

June 2006 “Coordination of extrinsic and intrinsic signals in stem cell regulation,” 4th

annual

meeting of the International Society for Stem Cell Research, Toronto, Ontario, Canada

July 2006 “PTEN controls both proliferation and the niche interaction of hematopoietic stem

cells,” American Society of Cell Biology, Boston, Massachusetts USA

July 2006 “Molecular control of stem cell activation,” Society of Chinese Bioscientists in

America, San Francisco, California USA

August 2006 “Coordination of extrinsic and intrinsic signals in stem cell regulation,”

Mouse Molecular Genetics, Cold Spring Harbor Laboratory, Cold Spring

Harbor, New York USA

September 2006 “Stem cell regulation in intestine,” Stem Cells in Gastrointestinal Development,

Regeneration and Neoplasia. AGA Institute and British Society of Gastroenterology.

Tyson’s Corner, Virginia USA

October 2006 “Stem Cells: Maintenance and regulation in the body,” Heartland Association of

Research Professionals, Kansas City, Missouri USA

October 2006 “Gastrointestinal Stem Cells and Cancer,” 59th

Annual Symposium on Cancer Research,

MD Anderson Cancer Center, Houston, Texas USA

November 2006 “Regulation of stem cells by their niche and signals,” American Society

of Nephrology annual meeting, San Diego, California USA

December 2006 “Stem Cell Niche and Tumor Stem Cells,” Seattle Chinese Biomedical

Association, Seattle, Washington USA

December 2006 “Stem Cell Regulation: Niche and signaling,” University of Miami School

of Medicine, Miami, Florida USA

December 2006 “Towards Defining the Regulatory Properties of the Stem Cell Niche,”

48th

American Society for Hematology Annual Meeting, Orlando, Florida

January 2007 “Stem cell niche and cancer stem cells”, University of Connecticut School of Medicine,

Farmington, Connecticut USA

March 2007 “Deregulation of the niche signals and cancer stem cell.” Keystone Cancer stem cells

and stem cell niches, Keystone, Colorado USA

March 2007 “Stem cell niche and cancer stem cells” University of Chicago, Chicago, Illinois

March 2007 “Stem cell niche and cancer stem cells”, Northwestern University, Chicago, Illinois

April 2007 “Normal stem cells vs. cancer stem cells and their niches”, the University of Texas

Southwest Medical Center, Dallas, Texas USA

April 2007 “Stem cell regulation, niche, and signaling”, 14th

Annual Symposium on Recent

Advances in Stem Cell Transplantation, Heidelberg, Germany

May 2007 “The Stem Cell Niche and Cancer Stem Cells”, Baylor College of Medicine, Houston,

Texas USA

May 2007 “The Stem Cell Niche and Cancer Stem Cells”, M. D. Anderson Cancer Center,

Houston, Texas USA

June 2007 ‘Stem Cell Niche and Cancer Stem Cells’ Fudan University, Shanghai China

June 2007 ‘Hematopoietic Stem Cell Niche and signal’ Keio University Tokyo, Japan

Linheng Li

Updated 3/14/2013 12

July 2007 “Molecularly distinct osteoblastic and vascular niches”, Chinese Biological

Investigators Society, Frontiers in Biological Sciences, Tsinghua University, Beijing,

China

August 2007 “Signaling regulation of intestinal stem cells”, Federation of American Societies for

Experimental Biology Summer Research Conference, Snowmass Village, Colorado

September 2007 “Stem Cell Niche and Zones”, University of Maryland School of Medicine, Baltimore,

Maryland USA

October 2007 “Stem Cell Regulation: Niche and Signaling”, Vanderbilt University School of

Medicine, Nashville, Tennessee USA

October 2007 “Stem Cell Niche and Cancer Stem Cells”, University of Nebraska Medical Center,

Omaha, Nebraska USA

November 2007 “Stem Cells, Niche and Zones”, Workshop in Beijing University, Beijing, China

February 2008 “Stem Cells, Niches and Zones”, Lineberger Comprehensive Cancer Center Seminar

Series, University of North Carolina, Chapel Hill, North Carolina USA

February 2008 “Stem Cell Niche and Leukemia-Initiating Cells”, 4th

Annual Hematological

Malignancies Symposium, Hollings Cancer Center, Medical University of South

Carolina, Charleston, South Carolina USA

February 2008 “Stem Cells, Niches and Zones”, Keystone Symposium, Tumor Suppressors and Stem

Cell Biology, Vancouver, British Columbia, Canada

March 2008 “Stem Cells, Niches and Zones, PTEN / P13 Kinase Pathways Meeting, Cold Spring

Harbor Laboratory, Cold Spring Harbor, New York USA

May 2008 Keynote Speaker, Genomic Integrity & Tumor Development Retreat, Cancer Therapy

& Research Center, University of Texas, San Antonio

May 2008 “Stem cell niches and niche signaling”, 41st Annual Meeting, Japanese Society of

Developmental Biologists (JSDB), Tokushima City, Japan

July 2008 “Stem Cells, Niches & Zones”, ISEH (Society for Hematology and Stem Cells) 37th

Annual Scientific Meeting, Boston, Massachusetts USA

July 2008 “Stem Cell Niche and Cancer Stem Cells”, Maine Medical Center Research Institute,

Scarborough, Maine USA

August 2008 “Stem Cell Niche and Cancer Stem Cells”, European Molecular Biology Laboratory

(EMBL), Monterotondo (Rome), Italy

September 2008 “Stem Cell Niche and Expansion”, Mechanisms of Early Differentiation Medizinische

Hochschule Hannover (MHH), Barsinghausen (Hanover), Germany

September 2008 “Hematopoietic Stem Cell Niche in Bone Marrow”, Stem Cells Plenary Symposium,

30th

Annual Meeting, American Society for Bone and Mineral Research (ASBMR),

Montreal, Canada

September 2008 “Stem Cell Niche and Cancer Stem Cells”, Department of Microbiology and

Immunology Seminar, McGill University, Montreal, Canada.

October 2008 “Niche and Stem Cells”, Translational Gastrointestinal Cancer Symposium, University

of Washington School of Medicine, Seattle Washington USA

November 2008 “Stem Cell Niches and Cancer Stem Cells”, Seminar Series, Hubrecht Institute, Utrecht,

The Netherlands.

November 2008 “Stem Cell Niche, Signaling and Expansion”, Stem Cells in Development and Disease

(SCDD) International Symposium, Amsterdam, The Netherlands.

November 2008 “Hematopoietic Stem Cell Niches and Expansion”, Blood and Marrow Transplantation

Conference, University of Minnesota, Minneapolis, Minnesota

January 2009 “Stem Cell Niche and Cancer Stem Cells”, Herman B Wells Seminar Series, Indiana

University, Indianapolis, Indiana USA

January 2009 “Stem Cell Niche and Cancer Stem Cells”, Wyeth Research, Pearl River, New York

Linheng Li

Updated 3/14/2013 13

February 2009 “Stem Cell Niche and Cancer Stem Cells”, Cardinal Bernardin Cancer Center Seminar

Series, Loyola University, Chicago, Illinois USA

February 2009 “Stem Cell Niche and Cancer Stem Cells”, UIC Pharmacology Seminar Series,

University of Illinois, Chicago, Illinois USA

February 2009 Norris Cancer Center Seminar Series, USC Keck School of Medicine, University of

Southern California, Los Angeles, California USA

April 2009 “Real Time Imaging the Functional HSC Niche”, Keystone Symposium, Stem Cell

Niche Interactions, Whistler BC, Canada

May 2009 “Stem Cell Niche and Cancer Stem Cells”, Life Sciences Program, University of

Massachusetts Medical School, Worcester, Massachusetts

May 2009 “PTEN-Akt and Wnt-beta-catenin cooperate to promote hematopoietic cell self-

renewal”, International Conference “Wnt Signaling, Organogenesis and Stem Cells”,

Xiamen University, P.R. China

June 2009 “Signaling Interaction Promotes HSC Self-Renewal and Expansion”, 7th

Annual

International Umbilical Cord Blood Transplantation Symposium, Los Angeles,

California USA

June 2009 “Stem Cell Niche and Cancer Stem Cells”, National Cheng Kung University, Tainan,

Taiwan

July 2009 “Stem Cell Niche In Bone”, Bones & Teeth Gordon Research Conference, University of

New England, Biddeford, Maine USA

September 2009 “Detection of functional niche using real-time imaging”, Plenary Session, ISEH 38th

Annual Scientific Meeting, Athens, Greece

October 2009 “Detection of functional niche using real-time imaging”, Annual Conference of the

German, Austrian and Swiss Societies for Hematology and Oncology, Mannheim,

Germany

October 2009 “Hematopoietic Stem Cell Niche and Expansion”, 4th

Annual Translational SC

Research Conference, New York Stem Cell Foundation, New York NY USA

October 2009 “Stem Cell Niche and Cancer Stem Cells”, Biochemistry Seminar Series, NYU School

of Medicine, New York NY USA

November 2009 “Stem cell niches and targeting cancer stem cells”, Conference Series, Fred Hutchinson

Cancer Research Center, Seattle, Washington USA

November 2009 “Stem cell niche and cancer stem cells”, Jackson Laboratory Seminar Series, Bar

Harbor, Maine USA

March 2010 “Detection of Hematopoietic Stem Cell and its Niche using Real-Time Imaging”, CDB

Seminar Series, Vanderbilt University Medical Center, Nashville, Tennessee USA

May 2010 “Stem Cell Niches and Targeting Cancer Stem Cells”, Innovate Forum, Jiao Tong

University School of Medicine, Shanghai, China

May 2010 “Stem Cell Niches and Targeting Cancer Stem Cells”, Genetics Seminar, Yale

University, New Haven, Connecticut USA

September 2010 “Stem Cell Niches and Targeting Cancer Stem Cells”, Distinguished Lecture Research

Forum, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma USA

October 2010 “Intestinal Stem Cells in Normal and Cancerous Condition”, 4th

Annual Symposium of

Developmental Biology, Oregon Health and Science University, Portland, Oregon USA

October 2010 “Expansion of Good but Elimination of Bad Stem Cells”, Stem Cell Interest Group

Series, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland USA

October 2010 “Targeting Dormant Drug-Resistant Cancer Stem Cells”, Colorectal Cancer: Biology to

Therapy Conference, American Association for Cancer Research (AACR),

Philadelphia, Pennsylvania USA

Linheng Li

Updated 3/14/2013 14

November 2010 Keynote Address “New Strategies to Target Cancer Stem Cells”, Cancer Stem Cell

Symposia, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania USA

December 2010 “Targeting Dormant Drug-Resistant Cancer Stem Cells”, 2nd

International Forum on

Stem Cells (IFSC), Tianjin, China

March 2011 “A Novel Approach in Targeting Cancer Stem Cells”, Abramson Family Cancer

Research Institute/Hematology Oncology Seminar Series, University of Pennsylvania,

Philadelphia, Pennsylvania USA

April 2011 “Targeting Duality of Dormant and Active Cancer Stem Cells”, Cancer Stem Cell

Niche Session, AACR 102nd

Annual Meeting, Orlando, Florida USA

April 2011 “Novel Approaches to Target Cancer Stem Cells”, 12th

Annual NIH Center for

Molecular Studies in Digestive and Liver Diseases Symposium, University of

Pennsylvania School of Medicine, Philadelphia, Pennsylvania USA

May 2011 “Bone marrow niche regulates hematopoietic stem cell fate and state”, Department of

Orthopaedic Surgery, Johns Hopkins Medicine, Baltimore, Maryland USA

May 2011 “Signaling and epigenetic regulation of hematopoietic stem cells”, Frontiers in

Biological Sciences Seminar Series, Tsinghua University, Beijing, China

May 2011 “Adult stem cell expanding and tissue regeneration”, Shanghai Institute for Biological

Sciences, Shanghai, China

July 2011 “Active and quiescent stem cells in normal and cancerous tissues”, Stem Cell and

Regenerative Medicine Symposium, National Science Council Taiwan, Taipei, Taiwan

July 2011 “Leukemia stem cells and novel treatments”, Society of Chinese Bioscientists in

American 13th

Annual International Symposium, Guangzhou, China

September 2011 “Stem cell niches and targeting cancer stem cells”, Stem Cell Biology Seminar

Program, Columbia University, New York, New York USA

October 2011 “Epigenetic regulation of the imprinting gene H19 locus determines the quiescent and

active states and function of HSCs”, Inaugural Conference, ISSCR/Cold Spring Harbor

Asia, Cellular Programs and Reprogramming, Suzhou, China

February 2012 “Scrutiny of active and reserved stem cells provides insight for cancer targeting

strategy”, Outstanding Scientist Seminar Series, University of Texas M.D. Anderson

Cancer Center, Houston, Texas USA

March 2012 “Niches determine the state and fate of stem cells”, Cincinnati Children’s Hospital

Research Foundation Seminar Series, Cincinnati, Ohio USA

March 2012 “Signaling and epigenetic regulation of hematopoietic stem cells”, Institute for Stem

Cell & Regenerative Medicine, University of Washington, Seattle, Washington USA

April 2012 “Using surface markers to enrich ISCs under homeostatic and injured conditions”,

Keystone Symposia, Mechanisms of Whole Organ Regeneration, Breckenridge,

Colorado USA

May 2012 “Signaling and epigenetic regulation of HSCs”, National Center for Regenerative

Medicine Seminar, Case Western Reserve University, Cleveland, Ohio USA

June 2012 “Distinguished roles of noncanonical and canonical Wnt signaling in maintaining and

regulating hematopoietic stem cells”, Stem Cell Symposium 2012, Keio University,

Tokyo Japan

June 2012 “Signaling and epigenetic regulation of HSCs”, XIX Wilsede Meeting, Modern Trends

in Human Leukemia and Cancer, Wilsede Germany

September 2012 “Niche, signaling and epigenetic regulation of stem cells,” Regeneron Pharmaceuticals,

Tarrytown, New York USA

September 2012 “Niche, signaling and epigenetic regulation of stem cells,” Mount Sinai School of

Medicine, New York, New York USA

Linheng Li

Updated 3/14/2013 15

September 2012 “Niche, signaling and epigenetic regulation of stem cells,” Cancer Research UK,

Cambridge Research Institute, Cambridge, United Kingdom

November 2012 “Reserve and drug-resistant stem cells in normal and cancerous tissues,” Basic

Biomedical Sciences Program seminar series, Sanford School of Medicine, University

of South Dakota, Vermillion, South Dakota USA

December 2012 “Niche and signaling regulation of the state and fate of stem cells,” Stem Cells and

Development Mechanisms Conference, Cold Spring Harbor Asia, Suzhou, China

December 2012 “Niche and signaling regulation of the state and fate of stem cells,” Tumor and

Microenvironment Program, Karmanos Cancer Institute, Wayne State University

School of Medicine, Detroit, Michigan USA

February 2013 “Niche, signaling, and epigenetic regulation of stem cells,” Department of Biochemistry

& Molecular Biology, University of Georgia, Athens, Georgia USA

March 2013 “Niche, signaling, and epigenetic regulation of stem cells,” Genetics Seminar Program,

Yale University, New Haven, Connecticut USA

March 2013 “Niche, signaling, and epigenetic regulation of stem cells,” PharmaSci Seminar,

University of Connecticut Dept. of Pharmaceutical Sciences, Storrs, Connecticut USA

March 2013 Keynote Speaker: “Niche, signaling, and epigenetic regulation of stem cells,” 28th Joint

Annual Conference of Biomedical Sciences (JACBS), Taipei, Taiwan

March 2013 “Quiescent and active stem cells in normal and cancerous conditions”, College of Life

Science, National Taiwan University, Taipei, Taiwan

Patents:

Title: Human jagged polypeptide, encoding nucleic acids and methods of use

Inventors: Linheng Li, Leroy Hood

Assignee: University of Washington (Seattle, WA)

U. S. Patent No: 6136952

Patent granted: October 24, 2000

Title: Methods of Diagnosing Alagille Syndrome

Inventors: Linheng Li, Leroy Hood

Assignee: University of Washington (Seattle); The Children’s Hospital of Philadelphia (PA)

U. S. Patent No: 6703198

Patent granted: March 9, 2004

Title: Antibody that binds specifically to Phosphorylated Beta-Catenin

Inventors: Xi He, Linheng Li, Tong Yin

Assignee: Stowers Institute for Medical Research

U. S. Patent No: 8106166

Patent granted: January 31, 2012

Applications pending: Title: Methods and Compositions for Stem Cell Self-renewal

Inventors: John M. Perry, Linheng Li and Justin C Grindley

U.S. Patent Application No. 12/451038

Filing Date: April 23, 2008

Title: Methods, Kits, and Compositions for Stem Cell Self-renewal

Inventors: John M. Perry, Linheng Li and Justin C Grindley

U.S. Patent Application No. 12/589551

Filing Date: October 23, 2009