CURRICULUM VITÆ of LUCA CRISTOFOLINI - …...• Consensus development in collaboration with other research centers and international organizations. Development of instrumentation

CURRICULUM VITÆ

of

LUCA CRISTOFOLINI

CONTENTS CONTENTS ............................................................................................................................................................2GENERAL DATA..................................................................................................................................................1STUDIES.................................................................................................................................................................2

MASTER DEGREE...............................................................................................................................................2EUROPEAN COURSE IN BIOMEDICAL ENGINEERING ....................................................................................2PH.D (DOTTORATO DI RICERCA).....................................................................................................................2SPOKEN LANGUAGES ....................................................................................................................................2

CONTINUING EDUCATION ..............................................................................................................................3COURSES AND SEMINARS.................................................................................................................................3RESEARCH PERIODS ABROAD.....................................................................................................................4

PROFESSIONAL CAREER .................................................................................................................................5ACADEMIC CAREER .......................................................................................................................................5RESEARCH CAREER........................................................................................................................................5OTHER PROFESSIONAL ACTIVITIES............................................................................................................5

RESEARCH TOPICS............................................................................................................................................6METHODOLOGICAL STUDIES: DEVELOPMENT AND OPTIMIZATION OF TEST PROCEDURES .........................6DEVELOPMENT OF INSTRUMENTATION AND SENSORS DEDICATED TO IN VITRO TESTING...........................6DEVELOPMENT AND PRE-CLINICAL VALIDATION OF ORTHOPAEDIC DEVICES ..............................................7SURGICAL INSTRUMENTATION AND TOOLS FOR ASSISTED SURGERY ..............................................................8BIOMECHANICAL CHARACTERIZATION OF BONE STRUCTURES.......................................................................8OTHER ACTIVITIES ..............................................................................................................................................9

PARTICIPATION IN RESEARCH PROJECTS .............................................................................................10COORDINATOR OF INTERNATIONAL RESEARCH PROJECTS.............................................................10PARTICIPATION IN INTERNATIONAL RESEARCH PROJECTS................................................................10COORDINATOR OF NATIONAL PROJECTS ..............................................................................................11PARTICIPATION IN NATIONAL PROJECTS ..............................................................................................11NATIONAL AND INTERNATIONAL SCIENTIFIC COLLABORATIONS ................................................12

PUBLICATIONS..................................................................................................................................................14IMPACT OF MY RESEARCH ACTIVITY .....................................................................................................14PAPERS ON INTERNATIONAL JOURNALS (PEER-REVIEWED, WITH ISI IMPACT FACTOR) ................15BOOKS..............................................................................................................................................................24CHAPTERS OF BOOKS ..................................................................................................................................24INVITED SPEECHES ......................................................................................................................................25PRESENTATIONS AT INTERNATIONAL CONGRESSES .........................................................................26PRESENTATIONS NATIONAL CONGRESSES ...........................................................................................27PATENTS..........................................................................................................................................................27

ACTIVE ROLE IN THE SCIENTIFIC COMMUNITY .................................................................................28ACTIVITY IN SCIENTIFIC SOCIETIES........................................................................................................28ACTIVITY IN SCIENTIFIC JOURNALS .......................................................................................................28PARTICIPATION IN THE ORGANIZATION OF CONGRESSES..................................................................29EVALUATOR FOR FUNDING BODIES........................................................................................................30

HONORS...............................................................................................................................................................31STUDENTSHIPS AND FELLOWSHIPS .........................................................................................................31AWARDS..........................................................................................................................................................31

TEACHING ..........................................................................................................................................................33SUPPORT TO ACADEMIC TEACHING........................................................................................................33TEACHING FACULTY COURSES ................................................................................................................33QUALITY OF ACADEMIC TEACHING........................................................................................................34OTHER TEACHING ACTIVITY: SEMINARS/LECTURE/COURSES IN ITALY ......................................34OTHER TEACHING ACTIVITY: SEMINARS/LECTURES/COURSE ABROAD ........................................35SUPERVISOR OF UNDERGRADUATE AND GRADUATE THESES ................................................................35SUPERVISION OF DOCTORATE STUDIES.................................................................................................35SUPERVISION OF THE EXCHANGE OF STUDENTS.........................................................................................36SUPERVISION OF FOREIGN PHD STUDENTS...........................................................................................36PREPARATION OF TEXTBOOKS AND HANDOUTS ................................................................................37

OTHER ACADEMIC ACTIVITIES..................................................................................................................38FACULTY BOARDS........................................................................................................................................38

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GENERAL DATA

Born: 29th December 1967 in Trieste (Italy)

Address: Via San Leonardo 22, 40125 Bologna, Italy

Citizenship: Italian

Family status: Married, two sons

Current position: Full Professor of Biomechanics at the University of Bologna,

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STUDIES

MASTER DEGREE I registered in 1986 at the Engineering Faculty of the University of Bologna for the Master in Mechanical Engineering (5 years). With my final dissertation “About the experimental methods in the Biomechanical investigation of hip prostheses”, I earned the Laurea in Ingegneria Meccanica (Master in Mechanical Engineering) in July 1992 with the grade 100/100 cum LAUDE.

European Course in Biomedical Engineering EU-Funded international course in Biomedical Engineering at the University of Patras (Greece): September 1991 – February 1992.

PH.D (DOTTORATO DI RICERCA) In December 1992 I was assigned a position for the Ph.D. in Bioengineering (3 years) in Bologna University. I defended the thesis “Experimental methods for the functional validation of hip prostheses” and in September 1996 I was awarded the title of Dottore di Ricerca in Bioingegneria (PhD in Bioengineering).

SPOKEN LANGUAGES

Mother tongue: Italian.

Understanding Speaking Writing Listening Reading Spoken interaction Spoken production

English C2 C2 C1 C2 C2

French B1 B2 B1 B2 A2

Spanish B1 C1 B1 B1 A2

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CONTINUING EDUCATION

COURSES AND SEMINARS Specialization courses in biomedical engineering, statistics, experimental mechanics, including: • 21 June 1992: Instructional course “Strain measurement in bone biomechanics”, as part of the 8th

ESB Congress • 4 July 1993: Instructional course “Biology and biomechanics of ligaments and tendons”, prof. Savio

L. Woo, as part of the 14th ISB Congress • 16 September 1993: Instructional course “Optical methods in biomechanics” promoted by BSSM

and AIAS, at Queen Mary and Westfield College, London • 10-14 July 1995: Course “Bone cell and tissue mechanics” at the Centre International des Sciences

Mecaniques (CISM) in Udine, organized by prof. S.C. Cowin • 8-13 July 1996: Instructional course “Design and analysis of experiments”, Prof. Paul D. Berger,

Massachusetts Institute of Technology • 26 - 29 September 1997: Course “Mechanics of living tissues”, organized by the Italian Research

Council (CNR) • 23 - 24 October 1997: Theoretical-practical training “Calibration and measurement errors”,

promoted by National Association for Quality (ANGQ), Calibration Centre SIT QUINTEL • 10 - 11 February 2000: Instructional Course “Musculo-skeletal loading and its implication in clinical

practice”, Charité, Berlin • 23 November 2001: Workshop “Evidence-based health care” organized by the Italian Group for

Evidence Based Medicine (GIMBE) • 12-14 February 2002: Instructional course “Intellectual Property”, University of Bologna • 11 April – 6 June 2002: Instructional course “Advanced statistics for medical research”, organized

by the Scientific Board of Istituto Ortopedico Rizzoli • 16 - 20 September 2002: Summer school “Engineering of Biological tissues”, promoted by the

National Bioengineering Association • 14 November 2002: Workshop “Experimental stress analysis with Photostress”, Vishay

Measurements Group • 22 - 25 September 2003: Summer school “Posture and human movement”, promoted by the National

Bioengineering Association • 26 – 29 September 2005: Summer school “Biomaterials: from prostheses to regenerative medicine”

promoted by the National Bioengineering Association • 24 - 28 September 2007: Summer school “Genomics and Computational Proteomics” promoted by

the National Bioengineering Association • 23 April 2008: “Correlation methods for experimental stress analysis” workshop, Dantec Dynamics • 10 November 2011: “Contact and contactless displacement measurements” workshop, Micro-

Epsilon Messtechnik.

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RESEARCH PERIODS ABROAD I spent several periods abroad, for training and research, including: • September 1991 – February 1992: European Course in Biomedical Engineering at the University of

Patras • April - November 1994: University College of London and Biomedical Engineering Department del

Royal National Orthopaedic Hospital in Stanmore • May - June 1996: Dept. of Experimental Analysis of Engineering and Biomechanical Constructions,

Faculty of Mechanical Engineering, Wroclaw University, Poland • April 1998: Mechanical Engineering Department, Trinity College, Dublin

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PROFESSIONAL CAREER

ACADEMIC CAREER

December 2012 - current: Full Professor of Biomechanics, at the Department of Industrial Engineering (DIN), School of Engineering and Architecture, University of Bologna

January 2004 – December 2012: Associate Professor of Biomechanics, at the Department of Mechanical Engineering (DIEM), Engineering Faculty, University of Bologna

October 1995 – January 2004: Research assistant in Experimental Mechanics at the Department of Mechanical Engineering (DIEM), Engineering Faculty, University of Bologna.

RESEARCH CAREER 1996 – January 2013: research supervisor at Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna.

OTHER PROFESSIONAL ACTIVITIES In parallel to my academic and research career, I regularly serve as a consultant for some companies in the field of orthopaedics (three major international ones, and a national one). This activity focused on the design and validation of implantable devices.

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RESEARCH TOPICS

Because of my original background (mechanical engineering) and my first position at the University of Bologna (research assistant in Experimental Mechanics), during the first year I focused on the methods for experimental stress analysis (strain gauges, photoelasticity, fracture mechanics), and on their application to biomechanics. From the beginning, I adopted the methods of the design of the Experiment in my research.

Currently my focus is on orthopaedic biomechanics. I main expertise remains on experimental methods: my focus is on in vitro tests of biomaterials, implantable devices, bone tissues and bony structures. This includes some activity towards the development of new tools to assist the surgeon. A significant part of my recent activity features a very intense synergy between experimental investigations and numerical simulations. This provides a validation to numerical methods and at the same time enables complementing the in vitro tests using numerical sensitivity analysis (also featuring a statistical approach).

Methodological studies: development and optimization of test procedures In my entire research career, I dedicated great effort to the development and validation of my experimental methods. This part of scientific research is often underestimated in our field. In all my research projects a methodological investigation preceded the applicative part. This is particularly critical for those applications where the methods are not yet consolidated. Some instances: • Improvement of the accuracy of strain measurement in bone biomechanics; • Assessment of the accuracy of photoelastic coatings in bone biomechanics; • Validation of synthetic bone models for in vitro biomechanical testing; • Improvement of the performance of strain gauges on bone tissue and bone models; • Identification of the most relevant loading configuration for the proximal femur; • Methods to assess primary stability of cementless hip prostheses; • Methods to assess cement damage and long-term stability of cemented hip prostheses; • Adaptation of the Design of the Experiment to in vitro biomechanical investigations; • Critical review of existing standards; • Consensus development in collaboration with other research centers and international

organizations.

Development of instrumentation and sensors dedicated to in vitro testing In some cases, state-of-the-art instrumentation is not adequate to address certain clinical or biomechanical questions. In such cases IO developed (with the collaboration of other colleagues and research groups) new methods and tools: • New methods to accurately measure strain within acrylic surgical cement;

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• Development of miniaturized piezoelectric sensors to measure interface stress between implantable orthopaedic devices and the host bone or the acrylic cement;

• Development of a miniaturized 6-component load cell to measure the loads transmitted across a device to fix sternotomy;

• A method to test to failure bone segments while monitoring fracture initiation and propagation;

• A transducer to accurately measure the actual point of load application when testing long bones.

Development and pre-clinical validation of orthopaedic devices In the past 15 years I collaborated both with surgeons and with manufacturing companies, working on the development of materials and implantable devices, and on their pre-clinical validation. In this process I contributed to the assessment and optimization of some 20 devices currently on the market. My main areas of expertise include: • Total hip prostheses:

- Strength of the prosthetic components; - Functional assessment: primary stability of cementless components; - Functional assessment: long-term stability of cemented components; - Functional assessment: load transfer and stress shielding of the femoral component; - Optimization of the cement mantle for cemented components; - Assessment of the biomechanical effects of bone remodeling; - Assessment of the biomechanical effects of the formation of a fibrous tissue layer.

• Resurfacing hip prostheses: - Primary stability of the femoral component; - Risk of notching and neck fractures; - Load transfer and stress shielding of the femoral component; - Combined numerical-experimental investigation of the failure modes and effects.

• Minimally invasive hip prostheses (currently unpublished): - Primary stability of cementless components; - Design optimization of the femoral component.

• Total knee prostheses: - Wear assessment of bi-compartmental total knee prostheses; - Long-term stability and cement damage of the cemented component of total knee

replacement; - Assessment of the load transfer of the tibial component;

• Tumor prostheses: - Load transfer and stress shielding;

• Spinal devices: - I collaborated to the validation of a new test method for spinal devices (disk prostheses); - A recently started project involves the investigation of the biomechanics of healthy and

diseased vertebrae, and of the efficacy of augmentation methods. • Surgical bone cements:

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- Assessment of radiopacity of different cement formulations; - Static and dynamic properties of classic and modified bone cements; - Fatigue strength of modified bone cements; - Investigation of the fracture surface of different bone cements;

Surgical instrumentation and tools for assisted surgery The surgical instrumentation plays a crucial role in the success of prosthetic surgery. In the framework of my collaborations with the clinical environment and with the manufacturing companies, I developed some innovative solutions, some of which affected current instrumentation and practice: • Development and validation of a device to measure the stability of a cementless hip stem

intraoperatively; • Development of a device to assess the stability of a cementless hip stem using vibrations; • Development of a procedure to assess intra-operatively if the stem selected can achieve a

satisfactory degree of primary stability; • Identification of possible causes of damage of the prosthetic component in modular hip

stems, and modification of clinical practice to reduce risk of damage; • I am participating in a project where minimally invasive prostheses and the surgical

instrumentation are being revised and optimized.

Biomechanical characterization of bone structures • Femur:

- Analytical model for interpreting the strain distribution in the femoral diaphysis; - Stress distribution in the proximal femoral metaphysis; - In vitro replication of traumatic and spontaneous fractures of the proximal femur; - Combined numerical-experimental investigation: validation of Finite Element models

featuring inhomogeneous material properties. • Tibia and fibula:

- Identification of repeatable reference frames; - Strain distribution, anisotropy and viscoelasticity in the physiological range; - Validation of Finite Element models of the human tibia to predict the stress distribution.

• Bone tissue: - Measurement of anisotropy of bone tissue in specimens obtained from the human femur; - I contributed to studies on the interaction between microstructure and mechanical

properties of bone tissue. • Bone remodeling:

- I marginally got involved in studies concerning bone remodeling and the formation of fibrotic tissue: experimental measurements and Finite Element models.

• Multi-scale approach:

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- A very promising approach, that has received a great momentum in the recent years, incorporates investigation of bone structures at different dimensional scales. Inclusion of multi-scale information in a single integrative model is one of the great challenges of the Physiome project.

Other activities I am coordinating a project aimed at inspecting and recycling orthopaedic devices (mainly osteosyntheses) in developing countries. This project involves volunteers from Rizzoli, an association of engineering students (Ingegneri Senza Frontiere) and some non-profit organizations that operate in developing countries.

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PARTICIPATION IN RESEARCH PROJECTS

COORDINATOR OF INTERNATIONAL RESEARCH PROJECTS 2004-ongoing: industry-funded technology transfer projects related to the development, optimization and validation of orthopaedic implantable devices, in collaboration with leading industries including: Aesculap, Biomet, DePuy, Johnson & Johnson, Lima, Medacta, Stryker, Tecres, Zimmer. 2010-2013: Principal investigator for the Italian Partner within the Collaborative Project (CP): “Enhanced patient safety by computational Modelling from clinically available X-rays to minimise the risk of overload and instability for optimised function and joint Longevity (MXL)”, ICT Project funded by the EU within the 7th FP (Grant #248693). 2008-2010: Principal scientist of the Host Unit for the Marie Curie: “Integrating outcome registers, retrieval analysis programs and preclinical validation methods into a synergistic post-marketing surveillance program for orthopedic devices (ORTHOWATCH)”, UE Grant, 7th FP(Grant #219978). 2006-2009: Coordinator of the Italy-Israel bilateral project (partners: University of Bologna, Istituto Ortopedico Rizzoli, Technion-Haifa, University of Jerusalem): “Development and industrial implementation of wireless micro-sensors for monitoring orthopaedic prostheses” funded by the Italian Ministry of Education as part of the FIRB-International chapter (contract nr.: RBIN04JFN).

PARTICIPATION IN INTERNATIONAL RESEARCH PROJECTS 2009-: Participation in the EU-funded 7th Framework Program Network of Excellence “Virtual Physiological Human Network of Excellence (VPH-NoE)” 2008-2012: Participation in the EU-funded 7th Framework Program Network of Excellence “Virtual Physiological Osteoporotic Human (VPH-OP)” (Prime Contractor: Istituto Ortopedico Rizzoli; contract nr.: FP7-ICT2008-223865). 2006-2009: Participation in the EU-funded 6th Framework Program Specific Targeted Research Project “Living Human Digital Library (LHDL)” (Prime Contractor: Istituto Ortopedico Rizzoli; contract nr.: Grant: IST-2004-026932). 2008-2012: Participation in the EU-funded 6th Framework Program Marie Curie Research and Training Network “3D Anatomical functional models of the human musculoskeletal system (3DAH)” (contract nr.: MRTN-CT-2006-035763). 2001-2002: Cooperative Research (CRAFT): “PRE-HIP- Predicting clinical performances of cementless hip replacement in the early stage of design” EU-funded, 5th Framework Program, IST-1999 (Prime Contractor: Istituto Ortopedico Rizzoli; contract nr.: CRAF-1999-70359). 2000-2002: Take-up Action (EUTIST): “ISAC - Intra-operative Stability Assessment Console” EU-funded, 5th Framework Program, IST-1999 (Prime Contractor: University of Bologna; contract nr.: IST-1999-20226/ISAC). 2006-2009: Specific Targeted Research Project (STREP): “LHDL – Living Human Digital Library: Interactive digital library services to access collections of complex biomedical data on the musculo-skeletal apparatus”, EU-funded, 6th Framework Program, IST-1999 (Prime

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Contractor: Istituto Ortopedico Rizzoli and CINECA Supercomputing Centre; contract nr.: IST-2004-026932). 1996-2001: “Pre-clinical testing of orthopaedic implants. Pre-normative research for European standards” EU-funded, 4th Framework Program, Standard, Measurements and Testing (Prime Contractor: University of Nijmegen; contract nr.: SMT4-CT96-2076).

COORDINATOR OF NATIONAL PROJECTS 2016-2018: PI for the University of Bologna for the technology transfer project “Development of a 4-axis biomechanical simulator for orthopaedic prostheses (BIO-4-ORTHO)” funded by Regione Emilia-Romagna 2008-2014: Italian Ministry of University and Research – RFO grant (ex quota 60%), funded as a “Grade A” project. 2007: “Analisi della stabilita’ di protesi ortopediche”, funded by the Ministry of University – (RFO, ex quota 60%), funded as a “Grade A” project. 2005: “Analisi della biomeccanica del femore prossimale in condizioni fisiologiche ed in presenza di diversi tipi di impianto”, funded by the Ministry of University – (RFO, ex quota 60%). 2000: “Analisi sperimentale della meccanica dell’accoppiamento osso-protesi”, funded by the Ministry of University - (RFO, ex quota 60%). 1999: “Analisi sperimentale della meccanica dell’accoppiamento osso-protesi”, funded by the Ministry of University - (RFO, ex quota 60%). 2010-12: Coordinator of the National project “Un approccio multimodale per lo studio della biomeccanica del ginocchio umano sano e patologico (Multimodal approach to the biomechanics of the healthy and diseased human knee)”, Funded by the Italian Ministry of University and Research MURST – (“PRIN 2008”, ex quota 40%). 2001-2002: “Sviluppo di metodi per la verifica dell'ancoraggio osso protesi”, funded by the Ministry of University - (RFO, ex quota 60%). 2003-2004: “Studio e validazione di strumenti per la caratterizzazione della stabilità primaria delle protesi ortopediche”, funded by the Ministry of University - (RFO, ex quota 60%). 2004-2006: “Indicatori intraoperatori di stabilità primaria protesica per il corretto utilizzo di protesi articolari non cementate”, funded by the Ministry of Healthcare (Ricerca Finalizzata 2003.124).

PARTICIPATION IN NATIONAL PROJECTS 2010-2014: “Fall risk estimation and prevention in the elderly using a quantitative multifactorial approach” Funded by the Italian Ministry of University and Research MURST – (“PRIN 2010”, ex quota 40%). 2006: “Proprieta' dei compositi con elevata resistenza agli urti per applicazioni biomediche” (Coordinator: dr. G. Minak), funded by the Ministry of University - quota 60%. 1999: “Progetto e verifica di elementi di macchine per applicazioni motociclistiche ed automobilistiche” (Coordinator: Ing. D. Croccolo), funded by the Ministry of University - quota 60%.

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1999: “Il progetto dell’esperimento nella progettazione” (Coordinator: Prof. A. Freddi), funded by the Ministry of University - quota 60%. 1998-99: “Il ruolo del progetto dell’esperimento nell’ottimizzazione del progetto”, (Coordinator Prof. G. Monno), funded by the Natioanl Research Council (CNR). 1997-98: “Il progetto dell’esperimento nella progettazione” (Coordinator: Prof. U. Pighini), funded by the Ministry of University - quota 40%. 1996: “Reingegnerizzazione della piccola industria: nuove strutture organizzative della progettazione per ridurre i costi” (Coordinator: Prof. E. Manfredi), funded by the Ministry of University - quota 40%. 1996-97: “Metodi della meccanica sperimentale nella progettazione” (Coordinator: Prof. A. Freddi), finanziamento MURST - quota 60%. 1995: “Ruolo della meccanica sperimentale nella progettazione meccanica” (Coordinator: Prof. A. Freddi), funded by the Ministry of University - quota 60%. 1995: “Metodi di progettazione orientati alla riduzione dei costi (design for cost)” (Coordinator: Prof. E. Manfredi), funded by the Ministry of University - quota 40%. 1995: “Applicazione dello standard 7206/3 per la determinazione della resistenza a fatica della componente femorale di protesi d’anca” (Coordinator: dr. M. Viceconti), funded by the Ministry of Healthcare - Ricerca Corrente. 1994: “Metodi affidabilistici nella meccanica sperimentale” (Coordinator: Prof. A. Freddi), funded by the Ministry of University - quota 60%. 1994: “Messa a punto di un sistema di acquisizione dati su autoveicolo e esecuzione delle misure relative” (Coordinator Prof. C. Pappalettere), funded by the Ministry of University - quota 40%. 1994-95: “Dinamica muscolo-scheletrica: clinica e validazione di protesi” (Coordinator: Prof. A. Cappello), finanziamento MURST - quota 60%. 1993: “Protocolli di misura per lo studio del cammino umano” (Coordinator: Prof. A. Cappello), funded by the Ministry of University - quota 60%.

NATIONAL AND INTERNATIONAL SCIENTIFIC COLLABORATIONS 2013 – University of Denver, US (prof. Peter Laz) 2013 – Flinders University, Adelaide, Australia (prof. John Costi, prof. Mark Taylor) 2008 –Computational Biomechanics Group, Colorado School of Mines, Golden, Colorado, USA: development and validation of numerical models of the spine. 2004 –Stryker-Howmedica (Mahwah, NJ, USA company manufacturing orthopaedic prostheses) validation and design refinement of hip prostheses. 2003 -: Technical University of Iceland (Reykjavik) validation of numerical models of the musculoskeletal system. 2003 -: Technical University of Haifa (Technion: development of implantable transducers. 2003 -: Hebrew University of Jerusalem: validation of implantable sensors. 2003 -: DePuy (Warsaw, Indiana, USA, company manufacturing orthopaedic prostheses) validation of hip prostheses. 2002 – Department of Anatomy, Free University of Brussels (dr. Serge Van Sint Jan) biomechanical investigation of the musculoskeletal system. 2002 - 2003: E.T.S.I. Industriales-Univ. Polit. Madrid, U.D. Elasticidad y Resistencia de Materiales: numerical modelling of bone tissue. 2000 - : Aesculap (Tuttlingen, company manufacturing orthopaedic prostheses) development of innovative prostheses and test methods.

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1998 -: Hit Medica (Forlì: company manufacturing orthopaedic fixation devices): validation and optimization of implantable devices. 1998 -: Forschunglabor, Von Humboldt University, Charité, Berlin (dr. G. Duda): trauma and orthopaedic implantable devices. 1997 -: Free University Berlin (Prof. G. Bergmann, Prof. A. Rohlmann) physiological loading conditions at the hip joint. 1996 - 2000: Experimentelle Festigkeitslehre, Technical University Vienna (Prof. Rudolf Beer) methods for freezing stress in biomechanical models. 1996 - : Tecres (Verona: company manufacturing surgical cement): testing and improvement of acrylic cements. 1995 - 2004: Department of Orthopaedics, University of Nijmegen, The Netherlands (Prof. R. Huiskes, dr. N. Verdonschot) experimental-numerical testing of orthopaedic devices. 1994 - 2000: University College of London and Biomedical Engineering Dept, Royal National Orthopaedic Hospital, Stanmore (Prof. P.S. Walker): testing of hip prostheses. 1994 - : Department of Experimental Analysis of Engineering and Biomechanical Constructions, Faculty of Mechanical Engineering, Wroclaw University of Technology in Wroclaw, Poland (Prof. R. Bedzinski): optical methods in biomechanics. 1993 -: Mechanical Engineering Department, Trinity College, Dublin, Ireland (Prof. D. Taylor e P. Prendergast) testing of orthopaedic prostheses; mechanics of bone tissue. 1992 -: School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin, Ireland (Dr. B. McNamara) biomechanical properties of surface coatings. 1992 -: Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli: design and testing of orthopaedic implantable devices and surgical instrumentation. 1992 -: Electronics Department, University of Bologna (Prof. A. Cappello): movement analysis, electrical transducers.

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PUBLICATIONS

IMPACT OF MY RESEARCH ACTIVITY Below are some indicators of the scientific impact of my research (May 2016). My ORCID: orcid.org/0000-0002-7473-6868 ISI Web of Science

Google Scholar

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PAPERS ON INTERNATIONAL JOURNALS (peer-reviewed, with ISI impact factor) I authored or co-authored 148 papers on peer-reviewed, ISI-assessed international journals. Nearly half of them were published in the last three years, indicating a very positive trend of productivity of my research group. 1. Schileo, E., Ballistreri, L., Grassi, L., Cristofolini, L., and Taddei, F., IN PRESS, "To

what extent can linear finite element models of human femora predict failure under stance and fall loading configurations?," J. Biomechanics.

2. Falcinelli, C., Schileo, E., Baruffaldi, F., Cristofolini, L., and Taddei, F., 2017, "The effect of computed tomography current reduction on proximal femur subject-specific finite element models," Journal of Mechanics in Medicine and Biology, 17(2), p. 1750012 (1750014 pages).

3. Cristofolini, L., Brandolini, N., Danesi, V., Erani, P., Viceconti, M., and Ferguson, S. J., 2016, "A preliminary in vitro biomechanical evaluation of prophylactic cement augmentation of the thoracolumbar vertebrae," Journal of Mechanics in Medicine and Biology, 16(5), p. 1650074 (1650023 pages).

4. Palanca, M., Tozzi, G., and Cristofolini, L., 2016, "The use of digital image correlation in the biomechanical area: a review," International Biomechanics, 3(1), pp. 1-21.

5. Cristofolini, L., 2015, "In vitro evidence of the structural optimization of the human skeletal bones," J Biomech, 48(5), pp. 787-796.

6. Palanca, M., Brugo, T. M., and Cristofolini, L., 2015, "Use of digital image correlation to investigate the biomechanics of the vertebra," Journal of Mechanics in Medicine and Biology, 15(2), p. 1540004 (1540010 pages).

7. Palanca, M., Tozzi, G., Cristofolini, L., Viceconti, M., and Dall'Ara, E., 2015, "Three-Dimensional Local Measurements of Bone Strain and Displacement: Comparison of Three Digital Volume Correlation Approaches," J Biomech Eng, 137(7).

8. Zani, L., Erani, P., Grassi, L., Taddei, F., and Cristofolini, L., 2015, "Strain distribution in the proximal Human femur during in vitro simulated sideways fall," Journal of Biomechanics, 48(10), pp. 2130-2143.

9. Ali, A. A., Cristofolini, L., Schileo, E., Hu, H., Taddei, F., Kim, R. H., Rullkoetter, P. J., and Laz, P. J., 2014, "Specimen-specific modeling of hip fracture pattern and repair," Journal of Biomechanics, 47(2), pp. 536-543.

10. Brandolini, N., Cristofolini, L., and Viceconti, M., 2014, "Experimental methods for the biomechanical investigation of the human spine: a review " Journal of Mechanics in Medicine and Biology, 14(1), p. 1430002 (1430033 pages).

11. Cristofolini, L., Baleani, M., Schileo, E., Van Sint Jan, S., Juszczyk, M. M., Öhman, C., I., Z., Lefèvre, P., Juszczyk, J. M., and Viceconti, M., 2014, "Differences between contralateral bones of the human lower limbs: a multiscale investigation," Journal of Mechanics in Medicine and Biology, 14(3), p. 1450032 (1450028 pages).

12. Danesi, V., Zani, L., Scheele, A., Berra, F., and Cristofolini, L., 2014, "Reproducible reference frame for in vitro testing of the human vertebrae," Journal of biomechanics, 47(1), pp. 313-318.

13. Lionello, G., and Cristofolini, L., 2014, "A practical approach to optimizing the preparation of speckle patterns for digital-image correlation," Measurement Science and Technology, 25(10), p. 107001 (107009 pages).

14. Mulargia, S., Dooley, C., Cristofolini, L., and Taylor, D., 2014, "Fracture and fatigue in osteocytes," J Mech Behav Biomed Mater, 39, pp. 231-237.

15. Schileo, E., Balistreri, L., Grassi, L., Cristofolini, L., and Taddei, F., 2014, "To what

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extent can linear finite element models of human femora predict failure under stance and fall loading configurations?," J Biomech, 47(14), pp. 3531-3538.

16. Zani, L., Cristofolini, L., Juszczyk, M. M., Grassi, L., and Viceconti, M., 2014, "A new paradigm for in vitro simulation of sideways fall loading of the proximal human femur," Journal of Mechanics in Medicine and Biology, 14(1), p. 1450005 (1450020 pages).

17. Cristofolini, L., Brandolini, N., Danesi, V., Juszczyk, M. M., Erani, P., and Viceconti, M., 2013, "Strain distribution in the lumbar vertebrae under different loading configurations," The Spine Journal, 13(10), pp. 1281-1292.

18. Widmer Soyka, R.P., Lopez, A., Persson, C., Cristofolini, L., Ferguson, S.J., 2013. Numerical description and experimental validation of a rheology model for non-Newtonian fluid flow in cancellous bone. J Mech Behav Biomed Mater 27, 43-53.

19. Juszczyk, M.M., Cristofolini, L., Salvà, M., Zani, L., Schileo, E., Viceconti, M., 2013. Accurate in vitro identification of fracture onset in bones: Failure mechanism of the proximal human femur. J Biomechanics 46, 158-164.

20. Cristofolini, L., Angeli, E., Juszczyk, J.M., Juszczyk, M.M., 2013. Shape and function of the diaphysis of the human tibia. J Biomech 46, 1882-1892.

21. Danesi, V., Cristofolini, L., Juszczyk, M.M., Erani, P., Viceconti, M., 2012. Mechanical properties of the human metatarsal bones. Journal of Mechanics in Medicine and Biology 12, 1250062-1 to 1250062-15.

22. Cristofolini, L., Erani, P., Viceconti, M., 2012. Comments on ‘Experimental versus computational analysis of micromotions at the implant - bone interface’. Proc Inst Mech Eng [H] 226, 417-419.

23. Viceconti M., Taddei F., Cristofolini L., Martelli S., Falcinelli C., Schileo E. (2012) Are spontaneous fractures possible? An example of clinical application for personalised, multiscale neuro-musculo-skeletal modelling. J Biomech 45, 421-426.

24. Martelli S., Taddei F., Schileo E., Cristofolini L., Rushton N., Viceconti M. (2012) Biomechanical robustness of a new proximal epiphyseal hip replacement to patient variability and surgical uncertainties: A FE study. Med Eng Phys 34, 161-171.

25. Bialoblocka-Juszczyk E., Cristofolini L., Erani P., Viceconti M. (2012) Method to analyse the fatigue damage in acrylic bone cement. Journal of Mechanics in Medicine and Biology 12, 1250017-1250011 - 1250014.

26. Grassi L., Schileo E., Taddei F., Zani L., Juszczyk M., Cristofolini L., Viceconti M. (2012) Accuracy of finite element predictions in sideways load configurations for the proximal human femur. J Biomech 45, 394-399.

27. Danesi V., Cristofolini L., Stea S., Traina F., Beraudi A., Tersi L., Harman M.K., Viceconti M. (2011) Re-use of explanted osteosynthesis devices: A reliable and inexpensive reprocessing protocol. Injury 42, 1101-1106.

28. Martelli S., Taddei F., Cristofolini L., Schileo E., Rushton N., Viceconti M. (2011) A new hip epiphyseal prosthesis: design revision driven by a validated numerical procedure. Med Eng Phys 33, 1203-1211.

29. Martelli S., Taddei F., Cristofolini L., Gill H.S., Viceconti M. (2011) Extensive risk analysis of mechanical failure for an epiphyseal hip prothesis: a combined numerical-experimental approach. Proc Inst Mech Eng H 225, 126-140.

30. Juszczyk M.M., Cristofolini L., Viceconti M. (2011) The human proximal femur behaves linearly elastic up to failure. J Biomech 44, 2259-2266.

31. Harman M., Cristofolini L., Erani P., Stea S., Viceconti M. (2011) A pictographic atlas for classifying damage modes on polyethylene bearings. Materials in Medicine - J

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Materials Science 22, 1137-1146. 32. Cristofolini L., Juszczyk M., Taddei F., Field R.E., Rushton N., Viceconti M. (2011)

Assessment of femoral neck fracture risk for a novel proximal epiphyseal hip prosthesis. Clin Biomech (Bristol, Avon) 26, 585-591.

33. Varini E., Bialoblocka-Juszczyk E., Lannocca M., Cappello A., Cristofolini L. (2010) Assessment of implant stability of cementless hip prostheses through the frequency response function of the stem-bone system Sensors and Actuators A: Physical 163, 526-532.

34. Juszczyk M., Schileo E., Martelli S., Cristofolini L., Viceconti M. (2010) A method to improve experimental validation of Finite Element models of long bones. Strain 46, 242-251.

35. Juszczyk M., Cristofolini L., Kaniuk J., Schileo E., Viceconti M. (2010) A novel method for determining the time and location of abrupt fracture initiation in bones. J. Strain Analysis in Engineering Design 45, 481-493.

36. Cristofolini L., Erani P., Bialoblocka-Juszczyk E., Ohashi H., Iida S., Minato I., Viceconti M. (2010) Effect of undersizing on the long-term stability of the Exeter hip stem: a comparative in vitro study. Clin Biomech (Bristol, Avon) 25, 899-908.

37. Traina F., Cristofolini L., De Fine M., Brunetti L., Frakulli I., Abati C.N., D'Uva L., Toni A. (2010) A reproducible and inexpensive method of measuring hip abductor strength. Hip Int 20, 512-517.

38. Spinelli M., Affatato S., Cristofolini L., Erani P., Tigani D., Viceconti M. (2010) Combined wear behaviour and long-term implant-bone fixation of total knee replacement: a novel in vitro set-up. Artif Organs 34, E177-E183.

39. Cristofolini L., Schileo E., Juszczyk M., Taddei F., Martelli S., Viceconti M. (2010) Mechanical testing of bones: the positive synergy of FE models and in vitro experiments. Philos Transact A Math Phys Eng Sci 368: 2725-2763.

40. Cristofolini L., Conti G., Juszczyk M., Cremonini S., Van Sint Jan S., Viceconti M. (2010) Structural behaviour and strain distribution of the long bones of the human lower limbs. J Biomechanics 43: 826-835.

41. Taddei F., Martelli S., Gill H.S., Cristofolini L. and Viceconti M. (2010) Finite element modelling of resurfacing hip prosthesis: estimation of accuracy through experimental validation. J Biomech Eng (ASME) 132(2): 021002 (11 pages).

42. Bialoblocka-Juszczyk E., Cristofolini L., Erani P., Viceconti M. (2010) Effect of long-term physiological activity on the long-term stem stability of cemented hip arthroplasty: in vitro comparison of three commercial bone cements. Proc Inst Mech Eng [H] 224: 53-65.

43. Viceconti M., Affatato S., Baleani M., Bordini B., Cristofolini L., Taddei F. (2009) Pre-clinical validation of joint prostheses: a systematic approach. J. Mechanical Behavior of Biomedical Materials 2: 120-127.

44. Traina F., Tassinari E., Pilla F., De Fine M., Biondi F., Cristofolini L., Toni A. (2009) Outcome of hybrid stem fixation in osteoporotic female patients. A minimum five-year follow-up study. Int Orthop 33: 1489-1494.

45. Bialoblocka-Juszczyk E., Baleani M., Cristofolini L., Viceconti M. (2009) Effect of stem preheating on the fatigue behaviour of bone cement around hip prostheses. Proc Inst Mech Eng [H] 223: 637-641.

46. Cristofolini L. and Viceconti M. (2009) Comments on: “In vitro analysis of Exeter stem torsional stability”. J Arthroplasty 24: 657-659.

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47. Cristofolini L., Juszczyk M., Taddei F. and Viceconti M. (2009) Strain distribution in the proximal human femoral metaphysis. Proc Inst Mech Eng [H] 223:273-288.

48. Cristofolini L., Juszczyk M., Taddei F., Field R.E., Rushton N. and Viceconti M. (2009) Stress-shielding and stress-concentration of contemporary epiphyseal hip prostheses. Proc Inst Mech Eng [H] 223:27-44.

49. Cristofolini L., Affatato S., Erani P., Tigani D. and Viceconti M. (2009) Implant fixation in knee replacement: preliminary in vitro comparison of ceramic and metal cemented femoral components. Knee 16:101-108.

50. Juszczyk M., Borgognoni E., Zioupos P., Schileo E., Baleani M., Cristofolini L. (2008) Multi-scale testing of the mechanical properties of the human femoral diaphysis. J Biomech 41: s502. (Abstract)

51. Gray H., Zavatsky A., Cristofolini L., Gill H. (2008) Variation of results with number of material properties in a human tibia finite element model. J Biomech 41: s487. (Abstract)

52. Schileo E., Taddei F., Martelli S., Cristofolini L., Moindreau M., Viceconti M. (2008) FE probabilistic approach to define the clinical indications of a new proximal epiphyseal replacement. J Biomech 41: s35. (Abstract)

53. Martelli S., Taddei F., Moindreau M., Cristofolini L., Viceconti M. (2008) Pre-clinical validation of a new proximal epiphyseal replacement:design revision and optimisation by means of finite element models. J Biomech 41: s34. (Abstract)

54. Malandrino A., Taddei F., Schileo E., Juszczyk M., Cristofolini L., Viceconti M. (2008) Prediction of failure load and location on proximal femur under a single leg stance loading condition. J Biomech 41: s201. (Abstract)

55. Conti G., Cristofolini L., Juszczyk M., Leardini A., Viceconti M. (2008) Comparison of three standard anatomical reference frames for the tibia-fibula complex. J Biomech 41: 3384-3389.

56. Juszczyk M., Schileo E., Martelli S., Cristofolini L. and Viceconti M. (2010) A method to improve experimental validation of Finite Element models of long bones. Strain: in press (DOI: 10.1111/j.1475-1305.2008.00500.x)

57. Affatato S, Cristofolini L, Leardini W, Erani P, Zavalloni M, Tigani D, Viceconti M, (2008) A new method of in vitro wear assessment of the UHMWPE tibial insert in total knee replacement. Artif Organs 32: 942-948.

58. Gray H.A., Zavatsky A.B., Cristofolini L., Gill H. S. (2008) Experimentally validated finite element model of a human tibia with a unicompartmental knee replacement. Journal Bone Joint Surgery (Br) 90B: 370-371

59. Cristofolini L., Taddei F., Baleani M., Baruffaldi F., Stea S. and Viceconti M. (2008) Multiscale investigation of the functional properties of the human femur. Philos Transact A Math Phys Eng Sci 36: 3319-3341 (Invited paper)

60. Viceconti M., Taddei F., Van Sint Jan S., Leardini A., Cristofolini L., Stea S., Baruffaldi F. and Baleani M. (2008) Multiscale modelling of the skeleton for the prediction of the risk of fracture. Clin Biomech (Bristol, Avon) 23(7): 845-52 (Invited paper)

61. Varini E., Cristofolini L., Traina F., Viceconti M. and Toni A. (2008) Can the rasp be used to predict intra-operatively the primary stability that can be achieved by press-fitting the stem in cementless hip arthroplasty? Clin Biomech (Bristol, Avon) 23: 408-414.

62. Schileo E., Taddei F., Cristofolini L. and Viceconti M. (2008) Subject-specific finite element models implementing a maximum principal strain criterion are able to estimate failure risk and fracture location on human femurs tested in vitro. J Biomech 41: 356-367.

63. Reggiani B., Cristofolini L., Taddei F. and Viceconti M. (2008) Sensitivity of the primary

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stability of a cementless hip stem to its position and orientation Artif Organs 32: 555-560. 64. Helgason B., Taddei F., Palsson H., Schileo E., Cristofolini L., Viceconti M. and

Brynjolfsson S. (2008) A modified method for assigning material properties to FE models of bones. Med Eng Phys 30: 444-453.

65. Gray H.A., Taddei F., Zavatsky A.B., Cristofolini L. and Gill H.S. (2008) Experimental validation of a finite element model of a human cadaveric tibia. J Biomech Eng 130: 031016.

66. Cristofolini L., Erani P., Savigni P., Grupp T., Thies O. and Viceconti M. (2008) Letter to the Editor: “Increased long-term failure risk associated with excessively thin cement mantle in cemented hip arthroplasty. A comparative in vitro study”. Clin Biomech (Bristol, Avon) 23: 501-503.

67. Cristofolini L., Affatato S., Erani P., Leardini W., Tigani D. and Viceconti M. (2008) Long-term implant-bone fixation of the femoral component in total knee replacement. Proc Inst Mech Eng [H] 222: 319-331.

68. Taddei F., Schileo E., Helgason B., Cristofolini L. and Viceconti M. (2007) The material mapping strategy influences the accuracy of CT-based finite element models of bones: an evaluation against experimental measurements. Med Eng Phys 29: 973-979.

69. Schileo E., Taddei F., Malandrino A., Cristofolini L. and Viceconti M. (2007) Subject-specific finite element models can accurately predict strain levels in long bones. J Biomech 40: 2982-2989.

70. Reggiani B., Cristofolini L., Varini E. and Viceconti M. (2007) Predicting the subject-specific primary stability of cementless implants during pre-operative planning: preliminary validation of subject-specific finite-element models. J Biomech 40: 2552-2558.

71. Pallini F., Cristofolini L., Traina F. and Toni A. (2007) Modular hip stems: determination of disassembly force of a neck-stem coupling. Artif Organs 31: 166-170.

72. Lannocca M., Varini E., Cappello A., Cristofolini L. and Bialoblocka E. (2007) Intra-operative evaluation of cementless hip implant stability: a prototype device based on vibration analysis. Med Eng Phys 29: 886-894.

73. Gray H.A., Zavatsky A.B., Taddei F., Cristofolini L. and Gill H.S. (2007) Experimental validation of a finite element model of a composite tibia. Proc Inst Mech Eng [H] 221: 315-324.

74. Erani P., Cristofolini L., Baleani M., Bignozzi M.C., Cotifava M., Ihaddadene N., Tomei F. and Viceconti M. (2007) Quantitative crack surface morphology of bone cements in relation to propagation rate. Fatigue & Fracture of Engineering Materials & Structures 30: 783-795.

75. Cristofolini L., Varini E. and Viceconti M. (2007) In-vitro method for assessing femoral implant-bone micromotions in resurfacing hip implants under different loading conditions. Proc Inst Mech Eng [H] 221: 943-950.

76. Cristofolini L., Juszczyk M., Martelli S., Taddei F. and Viceconti M. (2007) In vitro replication of spontaneous fractures of the proximal human femur. J Biomech 40: 2837-2845.

77. Cristofolini L., Erani P., Savigni P., Grupp T., Thies O. and Viceconti M. (2007) Increased long-term failure risk associated with excessively thin cement mantle in cemented hip arthroplasty: a comparative in vitro study. Clin Biomech (Bristol, Avon) 22: 410-421.

78. Cristofolini L., Erani P., Savigni P., Bordini B. and Viceconti M. (2007) Preclinical

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assessment of the long-term endurance of cemented hip stems. Part 2: in-vitro and ex-vivo fatigue damage of the cement mantle. Proc Inst Mech Eng [H] 221: 585-599.

79. Cristofolini L., Saponara Teutonico A., Savigni P., Erani P. and Viceconti M. (2007) Preclinical assessment of the long-term endurance of cemented hip stems. Part 1: effect of daily activities--a comparison of two load histories. Proc Inst Mech Eng [H] 221: 569-584.

80. Cristofolini L., Erani P., Saponara Teutonico A., Traina F., Viceconti M. and Toni A. (2007) Partially cemented AncaDualFit hip stems do not fail in simulated active patients. Clin Biomech (Bristol, Avon) 22: 191-202.

81. Cristofolini L., Erani P., Grupp T., Jansson V. and Viceconti M. (2007) In vitro long-term fatigue endurance of the secondary “Cement Injection Stem” hip prosthesis. Artif Organs 31: 441-451.

82. Cristofolini L. (2007) Fractures of the proximal femur: correlates of radiological evidence of osteoporosis. Skeletal Radiology 36: 703-704.

83. Viceconti M., Pancanti A., Varini E., Traina F. and Cristofolini L. (2006) On the biomechanical stability of cementless straight conical hip stems. Proc Inst Mech Eng [H] 220: 473-480.

84. Viceconti M., Brusi G., Pancanti A. and Cristofolini L. (2006) Primary stability of an anatomical cementless hip stem: a statistical analysis. J Biomech 39: 1169-1179.

85. Varini E., Vandi M., Cristofolini L., Cappello A. and Toni A. (2006) Intra-operative tests of cementless hip stem mechanical stability. Journal of Mechanics in Medicine and Biology 6: 25-34. (Invited paper)

86. Varini E., Cristofolini L., Viceconti M. and Traina F. (2006) Stem damage during implantation of modular hip prostheses. Artif Organs 30: 564-567.

87. Taddei F., Martelli S., Reggiani B., Cristofolini L. and Viceconti M. (2006) Finite-element modeling of bones from CT data: sensitivity to geometry and material uncertainties. IEEE Trans Biomed Eng 53: 2194-2200.

88. Taddei F., Cristofolini L., Martelli S., Gill H.S. and Viceconti M. (2006) Subject-specific finite element models of long bones: An in vitro evaluation of the overall accuracy. J Biomech 39: 2457-2467.

89. Varini E., Lannocca M., Bialoblocka E., Cappello A. and Cristofolini L. (2006) Primary stability assessment in hip arthroplasty: a device based on the vibrational technique. J Biomech 39: S127. (Abstract)

90. Perilli E., Baruffaldi F., Bisi M.C., Cristofolini L. and Cappello A. (2006) A physical phantom for the calibration of three-dimensional X-ray microtomography examination. J Microsc 222: 124-134.

91. Schileo E., Taddei F., Helgason B., Pallini F., Cristofolini L. and Viceconti M. (2006) Accurate prediction of strain values from subject specific finite element models of long bones. J Biomech 39: S12. (Abstract)

92. Juszczyk M., Pallini F., Schileo E., Taddei F. and Cristofolini L. (2006) Improvement of experimental-numerical cross-validation in studies of the proximal femur. J Biomech 39: S473. (Abstract)

93. Gray H., Zavatsky A., Cristofolini L. and Gill H. (2006) Experimentally validated finite element model of a human tibia. J Biomech 39: S494. (Abstract)

94. Erani P., Cotifava M., Cristofolini L., Bignozzi M.C. and Baleani M. (2006) Discrimination of PMMA fatigue crack surface. J Biomech 39: S262. (Abstract)

95. Cristofolini L., Duda G. and Prendergast P. (2006) In-vitro pre-clinical assessment of hip

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stem loosening. J Biomech 39: S126. (Abstract) 96. Cristofolini L. and Viceconti M. (2006) Comments on “Stair climbing is more critical

than walking in pre-clinical assessment of primary stability in cementless THA in vitro”. J Biomech 39: 3085-3087.

97. Cristofolini L., Varini E., Pelgreffi I., Cappello A. and Toni A. (2006) Device to measure intra-operatively the primary stability of cementless hip stems. Med Eng Phys 28: 475-482.

98. Cristofolini L., Baleani M. and Toni A. (2006) Comments on: “Analysis of 16 retrieved proximal cemented femoral stems”. J Arthroplasty 21: 464-465.

99. Baleani M., Peroni C., Cristofolini L., Traina F., Silbermann M., Sawaed S. and Viceconti M. (2006) Multiaxial miniaturized load cell for measuring forces acting through a sternotomy. Experimental Techniques 30: 23-28.

100. Varini E., Cristofolini L. and Toni A. (2005) Cementless hip stem primary stability: an intra-operative device. J Bone Joint Surgery (Br) Proceedings 87-B: 61-a. (Abstract)

101. Waide V., Cristofolini L. and Toni A. (2004) An experimental analogue to model the fibrous tissue layer in cemented hip replacements. J Biomed Mater Res B Appl Biomater 69: 232-240.

102. Waide V., Cristofolini L., Stolk J., Verdonschot N., Boogaard G.J. and Toni A. (2004) Modelling the fibrous tissue layer in cemented hip replacements: experimental and finite element methods. J Biomech 37: 13-26.

103. Viceconti M., Pancanti A., Dotti M., Traina F. and Cristofolini L. (2004) Effect of the initial implant fitting on the predicted secondary stability of a cementless stem. Med Biol Eng Comput 42: 222-229.

104. Cristofolini L., Saponara Teutonico A., Cappello A. and Toni A. (2003) Letter to the editor: Comparative in vitro study on the long term performance of cemented hip stems. Validation of a protocol to discriminate between “good” and “bad” designs. J Biomech 39: 395-396.

105. Waide V., Cristofolini L., Stolk J., Verdonschot N. and Toni A. (2003) Experimental investigation of bone remodelling using composite femurs. Clin Biomech (Bristol, Avon) 18: 523-536.

106. Allard P., Cristofolini L., D'Lima D.D., Kirtley C., Leardini A., Rosenbaum D., Schmid O., Siegler S., Stokes I., Whittle M., Witte H. and Wu G. (2003) Letter to the Editor: ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion - Part I. Ankle, hip, and spine. J Biomech 36: 303-304.

107. Cristofolini L., Metti C. and Viceconti M. (2003) Stress patterns induced by press-fitting and by external loads in cementless hip arthroplasty measured with photoelastic coatings. J Strain Analysis in Engineering Design 38: 289-301.

108. Baleani M., Cristofolini L., Minari C. and Toni A. (2003) Fatigue strength of PMMA bone cement mixed with gentamicin and barium sulphate vs pure PMMA. Proc Inst Mech Eng [H] 217: 9-12.

109. Cristofolini L., Saponara Teutonico A., Monti L., Cappello A. and Toni A. (2003) Comparative in vitro study on the long term performance of cemented hip stems: validation of a protocol to discriminate between “good” and “bad” designs. J Biomech 36: 1603-1615.

110. Stolk J., Verdonschot N., Cristofolini L., Toni A. and Huiskes R. (2002) Finite element and experimental models of cemented hip joint reconstructions can produce similar bone and cement strains in pre-clinical tests. J Biomech 35: 499-510.

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111. Croccolo D., Cristofolini L., Bandini M. and Freddi A. (2002) Fatigue strength of shot-peened nitrided steel. Fatigue & Fracture of Engineering Materials & Structures 25: 695-707.

112. Cristofolini L., Minari C. and Viceconti M. (2002) A methodology and criterion for acrylic bone cement fatigue tests: Letter to the Editor. Fatigue & Fracture of Engineering Materials & Structures 25: 317-318.

113. Wu G., Siegler S., Allard P., Kirtley C., Leardini A., Rosenbaum D., Whittle M., D'Lima D.D., Cristofolini L., Witte H., Schmid O. and Stokes I. (2002) ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion--part I: ankle, hip, and spine. International Society of Biomechanics. J Biomech 35: 543-548.

114. Waide V., Cristofolini L. and Toni A. (2001) A CAD-CAM methodology to produce bone-remodelled composite femurs for preclinical investigations. Proc Inst Mech Eng [H] 215: 459-469.

115. Viceconti M., Cristofolini L. and Toni A. (2001) Design revision of a partially cemented hip stem. Proc Inst Mech Eng [H] 215: 471-478.

116. Viceconti M., Cristofolini L., Baleani M. and Toni A. (2001) Pre-clinical validation of a new partially cemented femoral prosthesis by synergetic use of numerical and experimental methods. J Biomech 34: 723-731.

117. Monti L., Cristofolini L. and Viceconti M. (2001) Interface biomechanics of the Anca Dual fit hip stem: an in vitro experimental study. Proc Inst Mech Eng [H] 215: 555-564.

118. Monti L., Cristofolini L., Toni A. and Ceroni R.G. (2001) In vitro testing of the primary stability of the VerSys enhanced taper stem: a comparative study in intact and intraoperatively cracked femora. Proc Inst Mech Eng [H] 215: 75-83.

119. Minari C., Baleani M., Cristofolini L. and Baruffaldi F. (2001) The effect on the fatigue strength of bone cement of adding sodium fluoride. Proc Inst Mech Eng [H] 215: 251-253.

120. Cristofolini L. and Viceconti M. (2001) Comments on “femoral surface strain in intact composite femurs: a custom computer analysis of the photoelastic coating technique.”. IEEE Trans Biomed Eng 48: 944-945.

121. Baleani M., Cristofolini L. and Toni A. (2001) Temperature and ageing condition effects on the characterization of acrylic bone cement. Proc Inst Mech Eng [H] 215: 113-118.

122. Viceconti M., Muccini R., Bernakiewicz M., Baleani M. and Cristofolini L. (2000) Large-sliding contact elements accurately predict levels of bone-implant micromotion relevant to osseointegration. J Biomech 33: 1611-1618.

123. Minari C., Cristofolini L., Baruffaldi F. and Pierotti L. (2000) Radiopacity and fatigue characterization of a novel acrylic bone cement with sodium fluoride. Artif Organs 24: 751-757.

124. Cristofolini L. and Viceconti M. (2000) Development and validation of a technique for strain measurement inside polymethylmethacrylate. J Strain Analysis in Engineering Design 35: 21-33.

125. Cristofolini L. and Viceconti M. (2000) Mechanical validation of whole bone composite tibia models. J Biomech 33: 279-288.

126. Cristofolini L., Minari C. and Viceconti M. (2000) A methodology and criterion for acrylic bone cement fatigue tests. Fatigue & Fracture of Engineering Materials & Structures 23: 953-957.

127. Cristofolini L., Marchetti A., Cappello A. and Viceconti M. (2000) A novel transducer for

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the measurement of cement-prosthesis interface forces in cemented orthopaedic devices. Med Eng Phys 22: 493-501.

128. Baleani M., Cristofolini L. and Toni A. (2000) Initial stability of a new hybrid fixation hip stem: experimental measurement of implant-bone micromotion under torsional load in comparison with cemented and cementless stems. J Biomed Mater Res 50: 605-615.

129. Monti L., Cristofolini L. and Viceconti M. (1999) Methods for quantitative analysis of the primary stability in uncemented hip prostheses. Artif Organs 23: 851-859.

130. Cristofolini L. and Viceconti M. (1999) Towards the standardisation of in-vitro load transfer investigations of hip prostheses. A reproducible protocol and its application. J Strain Analysis in Engineering Design 34: 1-15.

131. Cristofolini L. and Viceconti M. (1999) In vitro stress shielding measurements can be affected by large errors. J Arthroplasty 14: 215-219.

132. Baleani M., Cristofolini L. and Viceconti M. (1999) Endurance testing of hip prostheses: a comparison between the load fixed in ISO 7206 standard and the physiological loads. Clin Biomech (Bristol, Avon) 14: 339-345.

133. Viceconti M., Bellingeri L., Cristofolini L. and Toni A. (1998) A comparative study on different methods of automatic mesh generation of human femurs. Med Eng Phys 20: 1-10.

134. Cristofolini L., Bini S. and Toni A. (1998) Stress shielding evaluation of a highly compliant massive prosthesis for the distal femur. Journal Bone Joint Surgery (Br) 81-B: 60-61.

135. Cristofolini L., Bini S. and Toni A. (1998) In vitro testing of a novel limb salvage prosthesis for the distal femur. Clin Biomech (Bristol, Avon) 13: 608-615.

136. McNamara B.P., Cristofolini L., Toni A. and Taylor D. (1997) Relationship between bone-prosthesis bonding and load transfer in total hip reconstruction. J Biomech 30: 621-630.

137. Cristofolini L. and Viceconti M. (1997) Comparison of uniaxial and triaxial rosette gauges for strain measurement in the femur. Experimental Mechanics 37: 350-354.

138. Cristofolini L., McNamara B.P., Freddi A. and Viceconti M. (1997) In-vitro measured strains in the loaded femur: quantification of experimental error. J Strain Analysis in Engineering Design 32: 193-200.

139. Cristofolini L. (1997) Muscular activity and the biomechanics of the hip. Hip International 7: 39-41.

140. Cristofolini L. (1997) A critical analysis of stress shielding evaluation of hip prostheses. Crit Rev Biomed Eng 25: 409-483.

141. Viceconti M., Casali M., Massari B., Cristofolini L., Bassini S. and Toni A. (1996) The 'standardized femur program' proposal for a reference geometry to be used for the creation of finite element models of the femur. J Biomech 29: 1241.

142. Cristofolini L., Viceconti M., Cappello A. and Toni A. (1996) Mechanical validation of whole bone composite femur models. J Biomech 29: 525-535.

143. Cristofolini L., Cappello A., McNamara B.P. and Viceconti M. (1996) A minimal parametric model of the femur to describe axial elastic strain in response to loads. Med Eng Phys 18: 502-514.

144. Harman M.K., Toni A., Cristofolini L. and Viceconti M. (1995) Initial stability of uncemented hip stems: an in-vitro protocol to measure torsional interface motion. Med Eng Phys 17: 163-171.

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145. Cristofolini L., Viceconti M., Toni A., Giunti A. (1995) Influence of thigh muscles on the axial strains in a proximal femur during early stance in gait. J Biomech 28: 617-624.

146. McNamara B.P., Cristofolini L., Toni A. and Taylor D. (1994) Evaluation of experimental and finite element models of synthetic and cadaveric femora for pre-clinical design-analysis. Clin Mater 17: 131-140.

147. Cristofolini L., Cappello A. and Toni A. (1994) Experimental errors in the application of photoelastic coatings on human femurs with uncemented hip stems. Strain 30: 95-103.

148. Cristofolini L., Viceconti M., Toni A. and Giunti A. (1993) Strains induced by thigh muscles in the proximal femur. J Biomech 27: 757. (Abstract)

BOOKS 1. Freddi, A., Olmi, G., and Cristofolini, L., 2015, Experimental Stress Analysis for

Materials and Structures: Stress Analysis Models for Developing Design Methodologies, Springer, Cham (Switzerland).

CHAPTERS OF BOOKS 1. Cristofolini, L., 2015, "Applications in Orthopaedics," in Encyclopedia of Life Support Systems (EOLSS),

Section 6.161A. Biomechanics, Developed under the Auspices of the UNESCO, M. Doblaré, and J. Merodio, eds., EOLSS, Paris, France, pp. 301-330.

2. Cristofolini, L., 2015, "Validation of Finite Element Models," Experimental Research Methods in Orthopaedics and Trauma (OTC Foundation Publications), P. Augat, and H. Simpson, eds., Thieme Verlag KG, Stuttgart, pp. 156-166.

3. Cristofolini, L., 2013, "Integrazione di metodi numerici e sperimentali: una prospettiva biomeccanica," Sesta giornata di studio Ettore Funaioli, U. Meneghetti, A. Maggiore, and V. Parenti-Castelli, eds., Società Editrice Esculapio, Bologna, pp. 149-175.

4. Cristofolini, L. (2012) Chapter 184: Anatomical reference frames for long bones: biomechanical applications. In: Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease. Preedy, V.R. (Eds). Springer, New York, pp. 2971-2999.

5. Baleani M., Peroni C., Cristofolini L., Viceconti M., Silbermann M., Sawaed S. (2004) “A multi-axial miniaturised load cell” Advances in Experimental Mechanics, Pappalettere C. ed, McGraw-Hill Publ, Milano: 74-75

6. Cristofolini L., Savigni P., Erani P., Viceconti M. (2004) “Fatigue damage in cemented hip prostheses” Advances in Experimental Mechanics, Pappalettere C. ed, McGraw -Hill Publ, Milano: 34-35

7. Varini E., Cristofolini L., Cappello A., Toni A. (2004) “Micromotions measurement to assess hip stem mechanical stability: an intra-operative device” Advances in Experimental Mechanics, Pappalettere C. ed, McGraw -Hill Publ, Milano: 36-37

8. Waide V., Cristofolini L., Toni A. (2001) “Development of experimental bone remodelled femur specimens using CAD/CAM techniques” Computer Methods in Biomechanics and Biomedical Engineering-3, Middleton J., Jones M.L., Shrive N.G., Pande G.N. eds., Gordon and Breach publ., Amsterdam: 135-140

9. Nuño-Siebrecht N., Cristofolini L. (2001) “Sensitivity analysis on the uncertainties of metal-PMMA interface characteristics “ Computer Methods in Biomechanics and Biomedical Engineering-3, Middleton J., Jones M.L., Shrive N.G., Pande G.N. eds., Gordon and Breach publ., Amsterdam: 63-68

10. Monti L., Cristofolini L., Toni A., Giacometti R.C. (2001) “The primary stability of the VerSys ET stem. An in-vitro comparative study in intact and intraoperatively cracked femurs” Computer Methods in Biomechanics and Biomedical Engineering-3, Middleton J., Jones M.L., Shrive N.G., Pande G.N. eds., Gordon and Breach publ., Amsterdam: 45-50

11. Toni A., Viceconti M., Cristofolini M., Baleani M., Acquisti G., Schreiner R. (1998) “Torsional stability of total hip arthroplasty: in-vitro and FEM analysis with new trends for the future” Computer Methods in Biomechanics and Biomedical Engineering-2, Middleton J., Jones M.L., Pande G.N. eds., Gordon and Breach publ., Amsterdam: 77-86

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12. Viceconti M., Cristofolini L., Toni A. (1998) “Numerical and experimental cross-investigation of total hip replacement” Experimental Mechanics. Advances in design, testing and analysis, Allison I.M. ed., A.A. Balkema publ., Rotterdam, Vol. 2: 845-849

13. Cristofolini L., Monti L., Viceconti M. (1998) “An in-vitro protocol for the analysis of the torsional stability of uncemented hip stems” Experimental Mechanics. Advances in design, testing and analysis, Allison I.M. ed., A.A. Balkema publ., Rotterdam, Vol. 2: 857-862

14. Cristofolini L. (1997) “Interazione osso-protesi nelle artroprotesi d'anca” CNR - Gruppo Nazionale di Bioingegneria Vol. 16. Meccanica nei tessuti biologici, Montevecchi ed., Patron publ., Bologna, 409-427

15. Bellingeri L., Viceconti M., Cristofolini L., Toni A. (1997) “Automeshers applied to the human femur shape” Proceedings of NAFEMS World Congress '97 on Design, simulation & optimisation. Reliability & applicability of computational methods, Vol. 2, NAFEMS Ltd. publ., Glasgow, UK: 763-772

16. McNamara B.P., Viceconti M., Cristofolini L., Toni A., Taylor D. (1996) “Experimental and numerical pre-clinical evaluation relating to total hip arthroplasty.” Computer Methods in Biomechanics and Biomedical Engineering, Middleton J., Jones M.L., Pande G.N. eds., Gordon and Breach publ., Amsterdam: 1-10

17. Viceconti M. Casali M., Massari B., Cristofolini L., Toni A., Bassini S. (1996) “The “Standardized Femur Program”: proposal for a reference geometry to be used for the creation of finite element models of the femur” Science and supercomputing at CINECA. Erbacci G., Voli M. eds. Tecnoprint, Bologna publ.: 64-66

18. Cristofolini L., Freddi A. (1994) “Pre-clinical biomechanical validation of hip prostheses. A survey of the most common techniques.” Biomechanics '94, Bedzinski R., Jankowski L., Filipiak J., Modzel P. eds., Oficyna Wydianicza Politechniki Wroclawskiej publ., Wroclaw, Poland: 67-76

19. McNamara B.P., Cristofolini L., Taylor D. (1994) “Effect of bone-prosthesis interface bonding on stress shielding in cementless THA” Advances in Bioengineering, Askew ed., ASME-BED, publ.: vol. 28, 201-12

INVITED SPEECHES I have been invited (with increasing frequency) to present my research in international congresses, workshops, and summer schools: 1. Invited lecture “Combined experimental approach to investigate the mechanical competence

of the natural and augmented vertebrae”, University of Sheffield, 7 May 2015 2. “Orthopaedic Workshop: Towards the next generation of tools for assessing the

performance of orthopaedic devices: From concept to the clinic” organized by the Flinders University, Adelaide, 7-8 may 2014.

3. Combined Meeting of Orthopaedic Research Societies (CORS, Venice, 13-16 October 2013), invited speech “Experimental identification and validation of multiscale models”.

4. 26th Congress of the International Society for Technology in Arthroplasty (ISTA, Palm Beach, 16-19 October 2013) invited speech “Why do we need both numerical models and in vitro experiments for the pre-clinical validation of prostheses”.

5. Invited lecture “Combining experimental mechanics and computational mechanics to solve complex problems - An example in bone biomechanics”, University of Clemson (USA), 20 October 2013

6. Invited lecture “Combining experimental mechanics and computational mechanics to solve complex problems - An example in bone biomechanics”, University of Sheffield, 10 December 2012

7. Keynote paper “Are spontaneous fractures possible? An example of clinical application for personalised, multiscale neuromusculoskeletal modelling” (Viceconti M., Taddei F., Cristofolini L., Martelli S., Schileo E.) at the 23rd ISB Congress, Brussels 3-7 July 2011.

8. Engineers and Surgeons: Joined at the hip III. Jointly organzied by the Institutions of Mechanical engineers and the Royal College of Surgeons. London, 1-3 november 2011, invited speech: “Is the proxinal femur optimized? For what loading scenario?”

9. ESB tutorial: “Innovative methods for the generation and validation of musculoskeletal

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models” all’interno del 17th ESB Congress, Edinburgh (4 July 2010) 10. Accademia delle Scienze dell’Istituto di Bologna (Classe di Scienze Fisiche, Sezione di

Scienze Tecniche), 23 Novembre 2010 conferenza su invito: “Sinergie tra metodi numerici e sperimentazione: applicazioni alla bio-meccanica”

11. Invited lecture: “The skeleton of the Virtual Physiological Human” (Cristofolini L.), del workshop “Numerical modelling and trauma care” organizzato dalla OTC Foundation, Cambridge, MA, USA (14-16 June 2009)

12. Invited lecture: “Multiscale biomechanical testing of bones and bone tissue”, del 4th Congress for Medical and Biomedical Engineering (“The Living Human Project: building the musculoskeletal physiome” mini-symposium), Antwerp, (23-27 November 2008)

13. Plenary lecture: “Preclinical validation of epiphyseal prostheses”, IMechE conference: Engineers and surgeons joined at the hip, London (19-21 April 2007)

14. Plenary lecture: “Identification of femoral neck fracture load and location using validated subject-specific finite element models: an in-vitro study” (Schileo E., Taddei F., Cristofolini L., Viceconti M.) ESB Sumer Workshop: Finite Element Modelling in Biomechanics and Mechanobiology. Trinity College., Dublin (26-28 August 2007)

15. Invited paper: “Accuracy of subject-specific finite element models of long bones from CT data: an in-vitro study” (Schileo E., Taddei F., Cristofolini L., Viceconti M.), del 3rd International Congress on Computational Bioengineering, Isla Margarita, Venezuela (17-19 September 2007)

16. Tutorial: “Cement fixation of ceramic and metal knee femoral component”, del 8th European Federation of Orthopaedics and traumatologo (EFORT), Firenze (12 May 2007)

17. Invited paper: “In-vitro pre-clinical assessment of hip stem loosening”, del 5th World Congress of Biomechanics, Munich (2 August2006)

18. Keynote lecture: “Endurance testing of cemented hip implants”, International Conference on Biomechanics “Biomechanics 2003”, Poznan, Poland (25 September 2003)

19. Invited paper: “In vitro simulation of bone adaptation in total hip replacement”, 15° Congresso Associazione Italiana Meccanica Teorica e Applicata, Taormina (26-29 September 2001)

20. Lecture: “Interazione osso-protesi nelle artroprotesi d'anca” XVI Scuola Annuale di Bioingnegneria: Meccanica dei tessuti biologici (23 September 1997)

21. Plenary lecture: “Pre-clinical biomechanical validation of hip prostheses. A survey of the most common techniques” 12th School of Biomechanics Wroclaw -Szklarska Poreba, Wroclaw, Poland (22 October 1994)

PRESENTATIONS AT INTERNATIONAL CONGRESSES I authored and co-authored over 150 papers (40 papers during the last 3 years) in International Congresses such as:

- ESB: European Society for Biomechanics; - ISB: International Society for Biomechanics; - ICEM: International Conference in Experimental Mechanics; - ASME-ESDA: Conference on Engineering Systems Design and Analysis; - EORS: European Orthopaedic Research Society. - CORS: Combined Meeting of the Orthopaedic Research Societies. - ISTA: International Society of Technology in Arthroplasty.

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PRESENTATIONS NATIONAL CONGRESSES I authored and co-authored over 30 papers in Italian Congresses such as:

- AIAS: Italian Society for Experimental Stress Analysis; - IORS: Italian Society for Research in Orthopaedics; - GNB: National group for Bioengineering.

PATENTS

December 2002 – European patent No EP02425761.0 “Apparatus to measure intraoperatively the mechanical stability of an orthopaedic prosthesis implanted by means of press-fitting in the bone” (Inventors: L. Cristofolini, A. Cappello, A. Toni, M. Viceconti)

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ACTIVE ROLE IN THE SCIENTIFIC COMMUNITY

ACTIVITY IN SCIENTIFIC SOCIETIES 1997-: Member of the Italian Society for Experimental Stress Analysis (AIAS) 1997-2001: I Collaborated with ISO /TC 150 “Implants for surgery” for the revision of existing standards (ISO 5833, ISO 7206) and preparation of new drafts. 2002-: Member of the European Society for Biomechanics (ESB) 2001-2002: Committee “Recommendation on definitions of joint coordinate system for the reporting of human joint motion” of the International Society for Biomechanics (ISB) 2008- : Committee “Standards and Resources” of the International Foot and Ankle Biomechanics community (i-FAB) 2011- : member of the Executive Board of the Italian Chapter of the European Society of Biomechanics. 2012- : member of the Council of the European Society of Biomechanics (ESB); Chair of the Membership Committee. 2013-: Member of the European Orthopaedic Research Society (EORS)

ACTIVITY IN SCIENTIFIC JOURNALS Editorial Board

2000- : Acta Bioengineering and Biomechanics 2007- : Journal for Mechanics in Medicine and Biology 2011- : Scientifica 2012- : J. Biomechanics 2014- : Medical Engineering and Physics 2014- : Biomechanica Hungarica

Referee: 1997- : Journal of Bone and Joint Surgery - Br 1998- : Journal of Biomechanics 1999- : Medical and Biological Engineering and Computing 2000- : Journal of Strain Analysis in Engineering Design (I Mech E) 2000- : Proc. Institution of Mechanical Engineers, Part H: J. Engineering in Medicine 2001- : Hip International 2001- : Biomaterials 2005- : Medical Engineering & Physics 2005- : J. Orthopaedic Research 2007- : International Journal of Fatigue 2007- : Journal of Mechanical Behaviour Biomedical Materials 2007- : Clinical Biomechanics 2007- : Annals of Biomedical Engineering 2007- : Journal of Biomechanical Engineering (ASME) 2009- : Philosophical Transactions of the Royal Society – A 2011- : Clinical Orthopaedics and Related Research 2014- : PLOS ONE

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PARTICIPATION IN THE ORGANIZATION OF CONGRESSES - “Intensive course on Recent advances in orthopaedic biomechanics”, University of Bologna

and Ministry of Foreign Affairs, 4-11 May 1997: Conference Chairman. - 11th International Conference on Experimental Mechanics, Oxford 24-28 August 1998:

Scientific Committee and Session Chairman. - 15th “Danubia-Adria” on Experimental Methods in Solid Mechanics & IMEKO TC-15

Course, 30 September – 3 October 1998: Member of the Organizing Committee. - 12th Congress of the European Society of Biomechanics, Dublin 27-30 August 2000: Session

Chairman (“Musculoskeletal implant testing”); member of the Poster Committee. - Co-chairman of the symposium “Hip Biomechanics”, as part of the 13th Congress of the

European Society of Biomechanics, Wroclaw, 1-4 September 2002. - 13th Congress of the European Society of Biomechanics, Wroclaw, 1-4 September 2002:

Session Chairperson. - “2nd Youth Symposium on Experimental Solid Mechanics” IMEKO (TC 15), Milano

Marittima, 7-10 May 2003: Member of the Scientific Committee. - 32nd Congress of the Italian Society for Experimental Stress Analysis, Salerno, 3-6

September 2003: Session Chairman (Biomechanics) - 12th International Conference on Experimental Mechanics, Bari (29 August - 2 September

2004): Member of the Scientific Committee; Session Chairman (“Biomechanics”). - 16th Conference of the European Orthopaedic Research Society, 7-9 June 2006: Member of

the Scientific Committee; Session Chairman. - 5th World Congress of Biomechanics, Munich (29 July – 4 August 2006): Member of the

Scientific Committee; Track coordinator (“Implants for trauma and orthopedics” and “Biomechanical Analysis of retrieval implants”); Chairman of 3 sessions.

- 8th ASME-ESDA (Engineering Systems Design and Analysis), Turin (4-7 July 2006): Session Chairman (“Biomedical Devices in diagnosis and treatment”)

- 16th Congress of the European Society of Biomechanics, Lucerne 6-9 July 2008: Student Award Committee.

- 4th International Congress on Computational Bioengineering, (Bertinoro, 16-18 September 2009): Member of the Local Organizing Committee, Scientific Committee, Session Chairman (“Experimental validation of numerical models”)

- 17th Congress of the European Society of Biomechanics (Edinburgh, 5-8 July 2010): Chairperson of the session “Hip Arthroplasty”.

- 23rd Congress of the International Society of Biomechanics (Bruxelles, 3-7 July 2011): member of the Scientific Committee.

- 18th Congress of the European Society of Biomechanics (Bruxelles, 1-4 July 2012): member of the Scientific Committee.

- 3° Congresso Gruppo Nazionale Bioingegenria (Rome, 26-29 June 2012): member of the Scientific Committee.

- 2nd Meeting of the Italian Chapter of the European Society of Biomechanics (Rome, 29 June 2012): Organizing Committee.

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- 18th ESB congress (Lisbon 1-4 July 2012): member of the Scientific Committee, Member of the ESB Award Committee (Huiskes Medal for Biomechanics, and Student Mobility Award), chair of the session “Hip Biomechanics”.

- VPH 2012 (Integrative Approaches To Computational Biomedicine), London (18-20 September 2012): member of the scientific committee

- 19th ESB Congress (Patras, 25-28 August 2013): member of the Scientific Committee, Member of the ESB Award Committee, chair of the session “Spine Biomechanics”.

- 8th Combined Meeting of Orthopaedic Research Societies (CORS, Venice, 13-16 October 2013), Organizer of Symposium “Multiscale Biomechanical/Mechanobiological Models in Orthopedics: Systems to Organs to Tissues to Cells to Genes”.

- 26th Congress of the International Society for Technology in Arthroplasty (ISTA, Palm Beach, 16-19 October 2013): invited Faculty.

- 19th International Congress on Mechanics in Medicine and Biology, (ICMMB) Bologna 3-5 September 2014: Organizing Committee; chair of the “Biomechanical clinical applications” session

- 43rd Congress of the Italian Society for Stress Analysis (AIAS), Rimini9-12, September 2014: Organizing Committee; chair of the “Biomechanics” session

EVALUATOR FOR FUNDING BODIES 2006- : Ministry of University and Research (MIUR) 2008- : Expert for the European Commission (FP6, FP7, H2020) 2009- : Grantová agentura Ceské republiky (Czech Science Foundation) 2009 - : Wellcome Trust (United Kindgom) 2009- : Organisation for Health Research and Development (ZonMw, The Netherlands) 2011- : Cyprus Research Promotion Foundation 2011- : Medical Research Scotland. 2012- : Research Foundation Flanders (FWO, Belgium) 2014- : Fonds de la Recherche Scientifique-FNRS-Belgium 2014- : Swiss National Science Foundation (SNSF) 2014- : Norway Grants

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HONORS

STUDENTSHIPS AND FELLOWSHIPS July 1990: Studentship to attend the University of Utrecht (The Netherlands), sponsored by the University of Bologna.

1991: Fellowship of the Foundation “Cav. Masotti” for the best student of the Engineering Faculty, year 1990-1991. July-August 1991: Studentship to attend the University of Vilnius (Lituania), sponsored by the University of Bologna.

1991: Fellowship “Nuove Idee” for 5 selected University Students, sponsored by the bank Credito Romagnolo.

1991-1992: EU-funded Erasmus Scholarship to attend the “European Course in Biomedical Engineering”.

1993-1995: PhD Scholarship funded by the Italian Ministry of Education.

AWARDS The most prestigious award I received is the Clinical Biomechanics Award of the European Society of Biomechanics in 2002 with the paper “Ex-vivo and in vitro cement mantle fatigue damage around femoral stems: validation of a protocol to simulate real-life loading in hip replacement patients”

Other awards:

2013: The project “Strain gauge measurements in biomechanics” was awarded as 2nd best project by Hottinger Baldwin Messtechnique (HBM)

2013: The paper “Biomechanical investigation of augmentation in the lumbar vertebrae”, was selected as a finalist for the Clinical Biomechanics Award at the 19th Congress of the ESB (Patras).

2009: The paper “The material mapping strategy influences the accuracy of CT-based finite element models of bones: an evaluation against experimental measurements”, published in Medical Engineering & Physics 2007,29 has been awarded as Top 10 cited papers 2006-2008

2006: The paper “Improvement of experimental-numerical cross-validation in studies of the proximal femur” by M. Juszczyk, E. Schileo, F. Taddei, L. Cristofolini won the Honorable Mention Award at the Conference of Biomedical Engineering, Szklarska Poreba (Poland).

1999: EMBEC Student Competition Award for the best presentation: “Analysis of the fatigue behaviour of the cement locked uncemented (CLU) stem” by Monti L, Cristofolini L, Baleani

1997: Award for the best PhD thesis in Bioengineering sponsored by Lions Club Bressanone.

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1996: “Capocaccia” Award of the Italian Society for Experimental Stress Analysis (AIAS) “Capocaccia” for the paper “Experimental methods for the functional validation of hip prostheses: towards the standardization of load transfer investigations” presented at the 25th National Congress. 1994: Award of the Italian Society for Experimental Stress Analysis (AIAS) for the best Master Thesis in 1992-93.

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TEACHING

SUPPORT TO ACADEMIC TEACHING As a research Assistant in Experimental Mechanics, I contributed to several courses for the students in Mechanical Engineering, Electrical Engineering, Aerospace Engineering and Biomedical Engineering. This included:

1993-1998: Seminars and workshops to the Biomedical students within the degree in Electrical Engineering.

1994-1998: Seminars and workshops within the degree in Mechanical Engineering for the following courses: • Diagnostica Strutturale (Diagnosis of mechanical structures); • Analisi Sperimentale delle Tensioni (Experimental Stress analysis). • Principi e Metodi nella Progettazione Meccanica (Principles and methods of design of

mechanical components).

1997-1998: Seminars and workshops within the degree in Biomedical Engineering for the following course: • Comportamento Meccanico dei Materiali (Mechanics of materials and structures).

1999-2000: Seminars within the Specialization school for podologists for the following course: • Biomateriali (Biomaterials).

1994-1999: Member of the examination board for the following courses: • “Analisi Sperimentale delle Tensioni” • “Principi e Metodologie della Progettazione Meccanica” • “Costruzione di Macchine Automatiche” • “Meccanica dei Materiali”

1996-2000: Member of the examination board for the State Exam for the License in Engineering.

TEACHING FACULTY COURSES During the last 10 years I was in charge of several courses at the Engineering Faculty of the University of Bologna:

1998-: “Comportamento Meccanico dei Materiali” (Mechanics of materials and structures) to the Undergraduate students in Biomedical Engineering, University of Bologna.

2003-: “Meccanica dei Tessuti Biologici” (mechanics of living tissues) to the Graduate students in Biomedical Engineering, University of Bologna.

2009-2013: “Analisi sperimentale delle tensioni” (Experimental stress analysis) to the Graduate students in Mechanical Engineering, University of Bologna.

2010-: “Laboratorio di Meccanica dei Tessuti Biologici” (laboratory of mechanics of living tissues) to the Graduate students in Mechanical Engineering, University of Bologna.

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QUALITY OF ACADEMIC TEACHING

Quality of teaching at University of Bologna is regularly assessed by Osservatorio Statistico per la Qualità della Didattica (http://www3.unibo.it/qualita/). Questionnaires (20 multiple choice questions) are filled in anonymous by all students. The results I reported for the course I teach confirm my ability in planning, teaching, and motivating students, and my availability in providing supervision and tutoring: • Course “Comportamento Meccanico dei Materiali” (Mechanics of materials and structures)

for the Undergraduate students in Biomedical Engineering): this is considered a tough course (most students report that not enough credits are assigned to this topic in relation to the workload; only 50% of the students pass this exam during the first session). Despite this, in the last 5 years positive or very positive reports accounted for 60-80% of the total number of students (the average for undergraduate study in Bioengineering is: 45-60%). I believe this is due to the rigorous approach, coupled with the generous amount of examples and practical cases described.

• Course “Meccanica dei Tessuti Biologici” (Mechanics of living tissues) for the Graduate students in Biomedical Engineering: also this is considered a tough course (most students report that not enough credits are assigned to this topic in relation to the workload). Despite this, in the last 4 years positive or very positive reports accounted for 70-100% of the total number of students (the average for graduate study in Bioengineering is 50-75%). I believe this is due to the way I present this topic, integrating basic theory, laboratory experience, and state-of-the-art research.

OTHER TEACHING ACTIVITY: SEMINARS/LECTURE/COURSES IN ITALY

As part of my collaboration with other Italian Universities and Research Centres I provide additional teaching also outside the University of Bologna. This included: July 1995: Seminar “Calcolo probabilistico nell’esperimento e nella progettazione”, as part of the school Design for Quality, in Bertinoro. 7 October 1996: Seminar “Applications of the Design of Experiment to experimental mechanics”, to the PhD students in Mechanics of Materials, University of Parma. 12 May 1998: Seminar “Biomeccanica nelle applicazioni cliniche dei mezzi protesici”, to the Phd students in Biotechnology. 13 March 1999: lectures about the Design of the Experiment as part of the "Corso di perfezionamento sulle Macchine Automatiche per il Confezionamento e l'imballaggio", organized by the Union of Mnufacturers of Automatic Machines (UCIMA) 17 May 2004: lecture “Metodi sperimentali per la validazione funzionale di dispositivi” as part of the ECM course “Nuove tecnologie in Ortopedia” 27 November 2004: lecture “New device to measure implant stability of hip prostheses” as part of the ECM course “New technologies in orthopaedics” 25 November 2006: lecture “Fracture risk in hip resurfacing: a pre-clinical experimental-numerical method” as part of the ECM course “Total joint replacement”.

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OTHER TEACHING ACTIVITY: SEMINARS/LECTURES/COURSE ABROAD

International collaboration is extremely important both in research and in teaching. For this reason, I have a long track of teaching collaborations abroad, including: September 1994: Seminar “In-vitro testing of hip prostheses”, BSc Students in Biomedical Engineering, University College of London. October 1994: Invited lecture “Pre-clinical biomechanical validation of hip prostheses. A survey of the most common techniques”, Biomechanics '94 - 12th School of Biomechanics, Szklarska Poreba, Poland. 10 June 1996: seminar “In-vitro testing of orthopaedic implants”, Engineering Faculty, Technical University of Wroclaw. 15-21 July 1996: Seminar “The design of experiment in experimental mechanics”, School Design for Quality, sponsored by Italian Ministry for Foreign Affairs, for non-Italian students. 4-11 May 1997: organizer and lecturer of the “Intensive course on Recent advances in orthopaedic biomechanics”, promoted by the University of Bologna, sponsored by Italian Ministry for Foreign Affairs, for non-Italian students. 9-16 May 1999: Seminar “The role of D.O.E. in industrial design”, school Design for Quality, sponsored by Italian Ministry for Foreign Affairs, for non-Italian students. 10 June 1999: Seminar “Importance of Experimental design for sound quality design”, School Management of small and medium companies sponsored by Italian Ministry for Foreign Affairs, for non-Italian students. 5-7 September 2005: Crash-course (15 hours) “Mechanics of Living Tissues” Engineering Faculty, Technical University of Iceland, Reykjavik.

SUPERVISOR OF UNDERGRADUATE AND GRADUATE THESES

Since 1996 I supervised students in Mechanical Engineering, Electrical Engineering and Biomedical Engineering in their final project: • Over 70 students for the old-style laurea (5-years degree), • Over 50 students for the laurea (3-years degree, equivalent to a Bachelor) • Over 40 students for the laurea magistrale (2-years degree, equivalent to a Master)

SUPERVISION OF DOCTORATE STUDIES

Since 2004 I am a member of the Board of the Dottorato di Ricerca Bioingegneria (PhD program in Biomedical Engineering) at the University of Bologna. Since 2006 I am the secretary of the Dottorato di Ricerca Bioingegneria. Also, I am responsible of the international contacts (including recruitment of foreign candidates and periods abroad of Italian candidates).

I supervised a total of 19 PhD students in Biomedical Engineering at University of Bologna, on topics related to musculoskeletal biomechanics and orthopaedics.

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SUPERVISION OF THE EXCHANGE OF STUDENTS

Since 1997 I supervised several students during their experience abroad: • 15 students of the University of Bologna (Mechanical, Electrical and Biomedical

Engineering) during their projects at foreign Universities and Industries (Berlin, Linköping, Patras, Tuttlingen, Leeds, Surrey, Uganda, Cluj-Napoca, Reykjavik, Nijmegen)

• 25 foreign students (Erasmus, Leonardo and other bilateral agreements), from Germany (Erlanghen, Wilhelmshaven, Berlin), Ireland (Dublin), Sweden (Lund), USA (Pittsburgh), Venezuela (Caracas), Iceland (Reykjavik), Poland (Wroclaw, Technical University of Gliwice, Silesia), the Netherlands that joined the Engineering Faculty of the University of Bologna for 3-12 months

• I advised 12 foreign students for their final project (Linköping, Reykjavik, Dublin, Caracas).

I am in charge of the following Erasmus exchange with: • Since 2008: Università di Rejkyavik, School of Science and Engineering; • Since 2010: Institut Supérieur d'Ingénieurs de Franche-Comté, Besançon • 2011-2015: Radboud University Nijmegen.

SUPERVISION OF FOREIGN PHD STUDENTS

I have been invited to: • Co-supervise the PhD student of the Department of Fine Mechanics, University F.A of Setif,

Algeria for the thesis: “Mechanical behaviour of human hip prosthesis” (Candidate: Nabila Ihaddadene. Supervisor: Bouzid Said. Defence: 2006)

• Co-supervise a PhD student of the university of Oxford, Dept. of Engineering Science for the thesis: “Finite Element Analysis of the Human Tibia” (Candidate: Hans Gray. Supervisor: Amy Zavatsky, Harinderjit Gill. Defence: 2007)

• Serve as an opponent for the PhD Thesis at Trondheim University Hospital, Norway: “Experimental evaluation of new concepts in hip arthroplasty” (Candidate: Tina S. Wik. Supervisor: Arild Aamodt. Defence: 2011).

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PREPARATION OF TEXTBOOKS AND HANDOUTS

Since 1998 I collaborated to the preparation of textbooks and handouts for students of Mechanical Engineering, Electrical Engineering, and Biomedical Engineering. This included: • A section dedicated to the Design and Analysis of the Experiment (DOE) for the course in

“Analisi Sperimentale delle Tensioni” (experimental stress analysis) and “Diagnostica strutturale” (structural diagnosis);

• A section dedicated to the Experimental Biomechanics for the course in “Analisi Sperimentale delle Tensioni” (experimental stress analysis);

• A section dedicated to the organization of lab simulations and experiments as part of the course “Bioingegneria II” (advanced bioengineering);

• Preparation of handouts for the course “Comportamento Meccanico dei Materiali” (mechanics of materials and structures);

• Preparation of a textbook for the course “Meccanica dei Tessuti Biologici” (mechanics of living tissues);

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OTHER ACADEMIC ACTIVITIES

FACULTY BOARDS

I am a member of the following Boards of the School of Engineering and Architecture, University of Bologna: • Board for the assessment of stages and student traineeships of undergraduates in Biomedical

Engineering • Board for the assessment of stages and student traineeships of graduates in Biomedical

Engineering • Board for individual study careers of undergraduates in Biomedical Engineering • Board for individual study careers of graduates in Biomedical Engineering

Bologna, 15th May 2016

Documents

CURRICULUM VITÆ of LUCA CRISTOFOLINI - …...• Consensus development in collaboration with other research centers and international organizations. Development of instrumentation