AlzheimerAlzheimer’’s Diseases Disease--Update on Current Update on Current

ResearchResearchCherie Simpson, RN CNSCherie Simpson, RN CNS

Senior Adult Specialty Healthcare Senior Adult Specialty Healthcare and Researchand Research

New Twist on Current MedicinesNew Twist on Current Medicines

RivastigmineRivastigmine TransdermalTransdermal PatchPatchComparison of 23mg Comparison of 23mg DonepezilDonepezil SR to 10 mg IMSR to 10 mg IMMemantineMemantine

Delaying the progression of driving impairmentDelaying the progression of driving impairmentIn combination with Vitamin EIn combination with Vitamin ECompared to Compared to DonepezilDonepezil in early stagesin early stagesCommunicationCommunicationComprehensive, Individualized Management of AD Comprehensive, Individualized Management of AD and Caregiver Burdenand Caregiver Burden

New Twists New Twists

EstrogenEstrogen

TestosteroneTestosterone

LevadopaLevadopa

DHADHAIsoflavonesIsoflavonesAntioxidantsAntioxidants

Not Just Nutritional SupplementsNot Just Nutritional Supplements

Two In OneTwo In One

ZTZT--11

PRXPRX--03140314

LifeStyleLifeStyle

EXERCISE

Insulin/Glucose ConnectionInsulin/Glucose Connection

RosiglitazoneRosiglitazoneDD--pinitolpinitolSNIFF 120SNIFF 120

Altering or Preventing the DiseaseAltering or Preventing the Disease

VaccineVaccineWyeth/ElanWyeth/Elan (II, III soon)(II, III soon)Novartis/CytosNovartis/Cytos (I)(I)Merck (I)Merck (I)AffirisAffiris (I)(I)Institute of Molecular Institute of Molecular MedicineMedicine

Altering or Preventing the DiseaseAltering or Preventing the Disease

Selective AmyloidSelective Amyloid--beta lowering agents beta lowering agents ALAL--108108AntibioticsAntibioticsNonsteroidalNonsteroidalSimvastatinSimvastatinVitamin E and SeleniumVitamin E and Selenium

Future ResearchFuture Research--ItIt’’s On Goings On Going

SKSK--PCPC--B70M (II)B70M (II)HF0220 (II)HF0220 (II)GSK933776A (I)GSK933776A (I)PFPF--04360365 (I)04360365 (I)PAZPAZ--417, SAM315 (I)417, SAM315 (I)CTSCTS--2166 (going to II)2166 (going to II)

Treating the Behavioral and Treating the Behavioral and Psychological SymptomsPsychological Symptoms

DepressionDepression

ApathyApathy

AgitationAgitation

Disrupted sleepDisrupted sleep

Problems with Problems with Activities of Daily Activities of Daily LivingLiving

DepressionDepressionSertralineSertralineEscitalopramEscitalopramAntidepressant + Antidepressant + DonepezilDonepezil

ApathyApathyMethylphenidateMethylphenidate

Treating the Behavioral and Treating the Behavioral and Psychological SymptomsPsychological Symptoms

Treating the Behavioral and Treating the Behavioral and Psychological SymptomsPsychological Symptoms

AgitationAgitationMemantineMemantineAnitpsychotic/divalproexAnitpsychotic/divalproexDiscontinuation of antipsychoticDiscontinuation of antipsychoticPrazosinPrazosinBifeprunoxBifeprunox

Treating the Behavioral and Treating the Behavioral and Psychological SymptomsPsychological Symptoms

SleepSleep

BathingBathing

Other ResearchOther Research

REVEAL IIIREVEAL IIICouples CopingCouples CopingIntervention for AdultIntervention for Adult--Child CaregiversChild Caregivers

ResourcesResources

www.clinicaltrials.govwww.clinicaltrials.govSearch by Search by ““AlzheimerAlzheimer’’s Diseases Disease”” or by drug or by drug companycompany

www.alz.orgwww.alz.orgResearchResearch

www.alzforum.orgwww.alzforum.orgAlzheimerAlzheimer’’s Research Forums Research Forum