" 0 ta0bP Elio"

MMHHCTEACTBO UPABOOXPANIMM PEC11YEZ.NDI YBEIGICTALI

NNW yipauene as arrps.qm Teem HiligrEefilirdI CRAM Kliffinneig TIMM

24Ar.

HIICTPYKIXHA 110 1TPHMEHEHI110 THOTPHA30JIHH THIOTRIAZOLIN

Toprosoe Ha3BaHHe npenapaTa: THoTpHa3o.aHH ,LteileTBylonxee BeweerBo (MHH): tiazotic acid. JleKapeTzennag 4)opma: Ta6neTKH. COCTaB: 1 Ta6Rema coxtep)KHT: aKmuerioe eettiecineo: M0p4)0JIHHHeBOrl Claim TIIa30THOR KHCITOTBI, B nepecqeTe Ha 100 %

BeatecTso, 200 mr, LITO 3KBHBaJleHTHO 133 mr Tila3OTHOrl KHCHOTIA;

acnomo2ame.ablible eeuiecmea: 'Taxman Kagrocbem,HEari, no)3HaoH, caxap-Hyapa, uezmono3a

mmKpoxpHcTaymiecKast, KaJIbLIHM cTeapaT. Onucaxue: Ta6neTKH 6enoro HRH HOlITH 6enoro LBeTa, Kpyrnok" opopivim c anocKoil

nortepxHocrmo, c 4)acKoti H pima& XapMaKOrepanewrineeKan rpyrma: Kap,mo.rioniqecKHe npenapaTm. Koa ATX: COlE B.

OapMaKOJI01-141MeCKHe CBOrICTBa

orDapMaxonormiecKid 34:04)eKT THa30THOR KHCJIOTM 06YCJIOBJIeH npoTHBoHmeMHtiecKHM,

mem6paHocTa6HHH3Hpyionwm, aHTHOKCHHaHTHEINI H HMMyHOMo,aptHpyi-outHm ,aeficTsHem. BoagetIcTsHe Hpenapara pearm3yeTcst 3a cqeT ycHsteHHA KomneHcaTopHoil aKTFIBaHHH aHa3po6Horo rinmarma H aKTHBaL11411 npoueccoB OKHCJIeHHA B 1/14KHe Kpe6ca C coxpaHeHHem

sHyTpHKrieromHoro 4)oHaa ATE. Harnreme B cTpyKType moneKyrim THa3OTHOcI KHCJIOTIDI THOM

cepbl, AAR KoTopoil xapaicrepHEJ OKHCJIHTe.TILHO-BOCCTaHOBIlTeMbHbIe CBOtICTBa, H TpeTHtmoro

a3oTa, KOTOpEgi CBA3bisaeT 1436bITOK HOHOB Bo,r(opo,aa, 06yerfamHBaeT aKTHBaHHIO

aHTHOKCH,HaHTHOPI clicTembI. CHAblibIe BOCCTaHOBIITeMbIlme CBORCTBa TH0111>H0rI rpynimi

BbI3BIBaIOT peaKLU410 C aKTHBHIAMH CDopmamH KHcnopo,aa H JIHHHgHbIMH pa,AHKanamH.

PeaKTHBaIIHR alITHPaHIIKaJILHLIX 1:14)epmeirroB — cynepoKcH21,4HcmyTa3m, KaTaJIa3LI H

rriTraTHoHnepoKcHaa3m — ripeaoTspamtaeT HHHHHa1t1410 aXTHBHMX 4)opm mcnopo,aa.

Bo3AdicTHHe THa3oTHoR KIICJIOTIA ripHBoAHT K TopmomeHmo npoLjeccoB OKHCJIeHH5I JIHI1H,210B B

HIIIeMH3Hp0BaHHBIX yqacmax mHoKap,aa, ymeHmHeruno qyBCTB14TeJlbHOCTII mHoKapAa K

KaTexaiamHHam, ripe,aoTspauxemllo uporpeccHBHoro yrHeTeHHsl coKpaTHTem,Hoil 037HKHHH

cepua, CTa6HJIH3aLIFIH H yMeHbiileHH/0 COOTBeTCTBeHHO 30HbI HeKpo3a H Huiemm mHoKapp.

YflyquieHHe peonoriptecKHK CBOrICTB KPOBH ocyniecuristeTcA 3a cqeT aKTFIBalalll 04)H6pHHoymmitecKoR cHcTemm. Yrirnuemie npoueccoB meTa6orm3ma mHoKarma, noBbnueHHe ero coKpanrremaok CHOCO6HOCTH, cnoco6cTBoBaHHe HopmaginaHHH cepHeimoro pHTma II03B0J151eT peKomeHAoBarb THa3OTHY10 KHCJIOTY AnSI netieHHsi 60JIBIIBIX C Pa3JIMIHEJMH 4)opmamH

HmemmxtecKoil 6o5te3HH cepatta. IlapannenE,Ho C upHmeHeHmem riperrapaTa B Kap,r(HosiorHH, THa3OTHY10 KHC.TIOTy ripmmeHmoT HpH

netieHHH 3a6ogeBaHHil Heqemx H ,apyrlix BHyrpeHmix opraHoB, yql4TitaBa51 ero BbICOKHe renaTonpoTeKTopHbie CBOrICTBa. flpenapaT npeztoTBpatHaeT pa3pyineHHe renaTounToB, cHyoKaeT

cTerieHb )1CHPOBOrI H1-14)HJILTPaHHH H pacripocTpaHeHme Hemposi06yristpHb1x Hexpo3oB HeqeHH, crioco6cTByeT ripoueccam perrapaTHBHorei pereHepaHHH reriaTouifros, HopmanH3yeT B HHX

yrgeso,aHmil, nHnlxAHbIH H IIHI McHTHBII3 o6MeHLI. YBeJIHTIHBaeT CKOpOCTb cHHTe3a H

BE,LaesieHH51 )Keirm, HopmanH3yeT ee XHMHtleCKIII1 COCTaB.

OapmaKoKtmorma

Hoene npHema BHYTpb npenapaT 6NcTpo BcacBmaeTcn, ero a6confoTHasi 61404(OCTYHHOCTI, COCTaB.TISICT 53 %. MaKcHmanbHaa KonteHTpaumn B nna3me KpoBH AocniraeTcsi *iepe3 1,6 tiaca nocne onHopa3oBoro npmema B3e 200 mr. flepao 110.11)/BbiBe,E(CHH51 COCTaB3131eT 1101-ITH 8 tiacos. floica3annsi K npnmenenino B KOMILTIeKCHOM netieHHH HILTeMHTIeCK011 60J1e3HH cep.ru cTeHoKapaHH, HHItapKTa mmoKapaa, nocTHH4)apKTHoro KapaHocKnepo3a; ceprtemHmx aPHTMHCI.

B KOMMIeKCHOM netieHHH xpolmgecKnx renaTHToB pa3JIHT-IH011 3THOJI0rHH, B TOM =merle anKoroni,Horo renaTHTa; uppo3a netieHH.

Cnoco6 npnmenennn H )103bI ripH CTa6H.ThHOrl cTeHoKaprum HarrpoKeHHn THOTpHa3OHHH Ha3Hamaior HO 200 Mr BHyTPE, 3 pa3a B CyTKH. Kypc netieHan - 8 HeaenE,.

flpH CTeHoKapzim noK051, HiHbapKTe MHoKapza, HOCTHHCDapKTHom KapaHocKnepo3e THOTPHa3OEHH Ha3HaTialoT no 200 mr BHYTPT, 3 pa3a B CYTKH Ha HPOTMKeHHH 20-30 ,r(Heil. UpH HapymeHHAx cepaeimoro pHTMa THOTPHa30.1114H Ha3Hatiarar no 200 Mr BHyrpi, HRH 110,a 5131DIK 3 pa3a B CYTKH. flpH 3a6oneBaHHAx netieHH THOTpHa30JIHH Ha3HamatoT no 200 Mr BHyrpE, 3 pa3a B CYTKH Ha npoTn)KeHHH 20-30 4Hert alliTeM,HOCTI) Kypca negeHun onpeaensieT BPavf HHZUBH,Ekya.11bH0 B 3aBHCHM0CTH OT TSDI(CCTH H TeLleHHA 3a6oneBaHHA.

flo6ognme AerICTIMBI flpenapar, KaK npaBHno, XOPOLUO nepeHocHTcn. Y 603MHTAX C noBbnueHHoil HHAHBILayalliaHOg 1-1YBCTBHTeJILHOCTIal0 pe,aKo moryr B03HHKaTB: co cmopoubz KOO1C1,1 U nooKoolcuoii mennamKu: 3y21, rHnepemHA KO)KH, cum), KpanHBHHua, aHrHoHeBporwiecKHA OTeK. flpH npmeme B KomnneKcHori Tepankm, npeHmyLLxecTsenHO y nanHeirroB noxcHnoro BO3paCTa, onHcaHbi OT,Ekenblibie cnriaki: Hapytuenust co cmopoubz UMMy1-11-10ii cucmembz: aHackinaKTHT-iecual LUOK; Heepo.nozuttecKue paccmpolicmaa: ronoBoKppKeHmn, alym B ymax; oice.gyaotmo-Kuutetmble paccmpolicmea: nposnmetifin nmcnencwiecKHx smneHHA cyxocTI, BO pTy, TOHTHOTa, pBoTa; B3YTM )KHBOTa; uapyweuuR co cmopoubi oblXaMeRb11017 CUMICA4b1, opeauoe opyouou KnemKu u cpeoocmeubsi: o,abnima, yaymbe; othque paccmpoitcm6a: nHxopa,aKa, o6inan cna6ocTb. B nepHo nocTperHcTpanHoHHoro Hatfuno,ReHun oTmer-ranncb TaK)Ke peaKLIHH, CB513b KOTOPETX C npmemom npenapaTa THoTpHa3onHH He AoKa3aHa: co cmopoubi cepaequo-cocyoucmoii cucmeivibi: apTepHam,Hasf rHnepTeH3HA, TaxmKapana.

IlpoTnnonoica3anna 110BbialeHHa51 IlyBCTBHTeMbHOCTb K THa3OTHOH. KHCII0Te H K npyrHm KomnoHeHTam npenapaTa. HOT-legHa51 HeAOCTaTOT-IHOCTb.

Jlewapernennme n3anmorlericirnnn THOTPHa30JIHH, KaK KapnHonpoTeKropHmil npenapaT, MO)KHO npHmeHATT. B KOM6HHaHHH C 6a3HCHI,IMH cpeacTsamm Teparnai HmemHgecKog 6one3HH cepana. KaK renaTonpoTeKropHoe cpeacTso moweT cogeTamcn c Ha3HatieHHem TPa)(HIAHOHHIDIX MCTQaOB netreHHA renaTHTOB.

Oco6ble yKa3aima Hp14,1467-ientle e ne10110o 6epebtetillOCMUU1111Kopimenuct opydwo. 3C14)eKTHBHOCTID H 6e3011aCHOCTB nplimeHeHHA npenapaTa B nepHoz 6epeMeHHOCTH HAM KOpMJIeHHArpyAmo He Hay-Yam ic& Rem. OnLiTa ripmvieHeHHA npenapaTa AeTSIM HeAocTaTotmo. Cnocorotiocnib 611207111b na ocopocnib peaniuu npu ynpamenuu ctemompaucnopmom unu paoome C opyoumu )vtexanuamamu. Ha gaHHEAil MOMeHT coo6inemisi OTCyTCTBy10T, 0,414aK0 eneAyeT rIPITHBaTla BO3MONGIOCTb pa3BHTHSI rOJI0B0Kpy>KeIiklA.

IlepoompoBKa flpH nepe1o3HpoBxe B motie 110BbILIMeTC51 KoHLtefrrpausi HarpHA 14 KaJ1H51. B TaK14X CJIrlaSIX npenapaT Heo6xoaHmo OTMeHHTb. Jler-leHHe cHmirromarwiecKoe.

'opMa BE.mycKa Ta6JleTKH no 200 Mr N2 10 B 6JTHCTepe, 9 6JIHCTepOB B na(nce.

YCIOBH51 xpalielma XpaHHTE. B Op111-14HaSIBH0r4. ynaKoBice, npM TemnepaType He BIDIUle 25°C. XpaHHTE. B HeAoeTynHom ,71.1151AeTeil Mee-re.

CpoK FO,EHIOCTH 2 ma.

YCJI0B1151 oTnycica 113 arrreK Ho penenTy.

Ha3Balifle H wee npoll3BoA13Tena LIAO «ICHeBme4mpenapam. YKpaHHa, 01032, r. KHeB, y.n. CaxcaraHcKoro, 139.

"MA'QULLANGAN" O'ZIEUSTON RESPUBLIKASI

$001LIQUI &MASH VAZ/RLICI 1 Dori viaitaltai va ablIty to sitattai

naserat qilish Soak bookannagi

09 20 J. m

itkPillcHOMA THOTPHA30J114H THIOTRIAZOLIN

lipenapaTimnr caB,Ao HOMH: THOTpHa30JIHH Talent) 3Tywill mozwa (XOM): tiazotic acid. „loin mamma: Ta6.11encanap TR:action: 1 Ta6neTxa Kytinnarnnapim caKnaftw: Oaan mooaa: THa3OT KHCJI0TaCHHH mop:Donnell TY3H 100% moznara Karrra xlico6nauralwa — 200 mr, 133 mr THMOT KncRoTacnra 3KBHBaJleHT; epdamtiu modoctnap: KapTolilKa Kpaxmann, 110BHZ0H, KaHA KyKyHH, MHKpOKpHCTaILTI Karmunii creaparn. Tatpmlni: OK eKH ,ge51pJIH OK paimm, CHJITIHK 103aJIH, AymanoK 1.11a1C13114, cpacKa Ba plleKaTI14 Ta6menarlap. (IclapmalcoTepanewrific rypyxn: KapAnonornK BoonTanap. ATX KOMI: COlEB.

CoapmaKonormc xycycnarnapn THa3OT KHCJI0TaCHHHHT 4)apmaKOR0111K camapacm FunemmAra Kaptun, mem6panann 6apKapOpflaLIITHpyar-IH, aHTHOKCH,RaHT Ba HMMyHOM0,72(yJIAHH51 Tabciwn 6HJIaH 6or.ranc. lipenaparmnir Tascnpn ana3po6 TJIHKOJIH3HH KOMIIeHCaTOp dmomnannuannn xygaiimpnnin Ba Kpe6c uHxnHua ATO xpKatipa HT-UCH 3axnpacknm caKnannum 6HJIaH OKCHAJIaHHIll )Kapadanapkin 4:monnammpHum xileo6Hra amanra THa30T KHCTIOTaCHHH monexynacHHHHr TapicH6HBa oKcHanaman-KatiTaparnau xycycmanapH xapaicrep.Tm 6pu-aH

oni-HHryrypr THOJIHHHHT Ha opTinKma BO,LI0p0,a, HOHIlapHHH 601710BLIH ytmamim a3OTHHHT mamsywinrit, aHTI40KCanaHT TH3HMHHH (1)a0.1131a11.1111.11131-111 Ta'bMHHJIarlfaH. THOJI rypyxymmir Krum Kaitrapywm xycyckurrnapH KHCJI0p0,aHHHT (Dam maKrmapH Ba JIHHHA paTancamapx &Irian peaK111,151H14 ilaKiwaxm. AHTHpaaHKall cloepmenTmap — cynepoKauwncmyra3a, KaTana3a Ba rzyrarnonnepoKmaa3am4 KatiTa cba0JIJIaLTIHIEH KHCJI0p0AHHHT (lmon LIMKTIJIapHHH Kriatinnunin OJI,E(HHH onaw4. THa30T KHCJI0TaCHHHHT Ta'BCHpH mHoicap,amuir inuemnara riparan coxartapnna JIHIIHAJIapHHHT OKCHATIaHHIII wapadmapinin Topmoanannumra, MHOKapAHHHT KaTexonammumpra Ce3yallaHJIHTHHH Kalviatimunra, }opium-if KncKapyagaminK 4:MOJIHSITHHH KriarlH6 6opystm cycatimumm OJIAHH14 onHawa, Typrynnammimra Ba myBoclanc Hexpoa PIOTHHH Ba MHOKapAHHHT HILICMHSICHHH xamarmumra orm6 KenarkH. KOHHHHT peonormc xycycHATHapmm 5IXIIIHJIaHHIIIH (1)H6pHHO.TIHTHK TH3HMHHH NHco6Hra amanra OIHHpHJIa,L(14. MHoxawma mera6oim3m Hcapaermapmm 51XLIIHJIaHHIIIH, yinnir KncKapyBLiamanK KO6HJIH5ITHHH 0111HDTH, lopaic pHTMHHH Hopmarmanmamra epzam 6epumH, lopax Hmemmc xacarummumr TypHH maKimapH 6ynraH 6emopiapHH AaBoriam yliyH THOTpHa30IIIIHHH 6yKTHIIIHMKOHHHH 6eparw. IlpenapaTnn Kapzwonornswa *maul 6nnan napannen Karma, yrimir ioKopn renaronpoTeKTop xycycnsmiapnim KHco6ra 031116, THa3OT KHCJI0TaCkl xa4rap KacarnmKnapn Ba 60IIIKa HIIKH KacaunnKnapfm AaBonanwa Kpuranaum. Hpenapar renarounTaapiin naptlariamunknin OJIAHHH onafm, 611114 H4145H,TpaHH51 ztapawacmin Ba wnraplipnir mapKa3ml3 no6ysisfp HeKpO3IIHH Tapicannui Aapawacmm Kamatrnpann, renarounTnapnmir penapaTHB perenepannacm )Kapabanapnra epzam 6epa,an, y.naRaa. ofccnn, yrneso,a, JIHHHA Ba nnrmenT anmanninymni nopmannaurrnpazn. CatopOHHHT CHHTe3H Ba unKaparinin Te3J1HrHHH oampaAH, yHI4Hr KHMEBHCI rapicH6HHH HopmaanaurrHpaAH.

(DapmaKomuieTmcacn Mira Ka6y.rf Kauai-man cynr ripenapaT Te3 cypnriann, y11141-1r TYJIHK 6140KHpaOHHIEJIIIIII 53% HH TallIKHE Knnann. KOH naa3mackmarn KonnenTpaminnra 200 Mr ,a03aHa 6Hp MapTa Ka6yri KaramraBgali epir 1,6 coarnali KegHH 3pmnaLm. 5Ipnm inncapnyanu Awn nesipun 8 coamn TallIKHJI

KYJITIaHHJIHIIIH 10pax HinemnK Kaca.Tmnrkmn: creBorcapAnsf, Is.moKapA nmimplan, mul)apKT,aan Kenai FI4

Kapnnocxnepowm; topic apnTmmsmapkam maxmyaBM,I,RaBoaamna KYJmaxami. KenH6 4H1041.11F1 Typnwia 6y.arail cypymcann rennin...up-in, my xcymzanan armorosum renammn, wnrap 11HppO3HH14 maxcmyaBml AaBonamila KY-nnaHann.

Icy.a.nam ycy.rm Ba Ao3a.napn 3y'pmcinu cTenoicapAnsicnna THOTpHa3OHHH cyrxa,aa 3 mapTa 200 mr Am" Kura 6popirnann. AaBOJIaLII Kypcn 8 xaclyraim TaUEKHn KHJIaHH.

Ty'pmckn Ba THITH xonmarn cTeHoKapnmckma, mnoicapn micloapKTnaa, mutlapKT,zon Kethunn KawmocKnepo3,4a THOTpHa3OHHHHH 20-30 Kyn ,gaBornma cymana 3 mapTa 200 mr Aax wira 6y1opnria,An. 10paK pHTMHHH 6y3HJIHLUJIapHita THOTplIa3OHHHHH cyrica,aa 3 mapTa 200 Mr Am." wira dICH THJI ocTnra 6yropma)m. )KHrap KacammKaapnaa THOTpl4a3OHHHH11 QaaTza cyncana 4 mapTa 200 mr „Ran nqra 20-30 KyH ,itaBowma 6yfopnna,m4. gaBorfam Kypanumr naBomnrumrkam Kacamanumnr ornp.rnifn Ba Keimumra Kapa6, 1.11144JOKOp MaXCHti paBnama 6erirmaiinn.

Howya Twbcupaapu

IlpenapaT, onaTna, 50C11114 yanammippulaAn. lacopm maxcnil ce3yaqammrn 63/".araB 6emopmpAa iceinnarnslap Kamnaii-Kam Nomiapim 103 6epHIIIH MyMKHH:

mepu as mepu ocmu KnetiamKacu momouuoan: KHLIMEIIeuE, Tepu rnnepemnszcn, TomMa, manna'', ammespoTmc Max(myamiii naBonam Tapm4614,aa ica6yn KnmniraFmaa, mime cca Kexca &unarm nanneffump,aa azoxpma xonarnap KenTnpnnraB: ummyn m1.13W1/11 momomuaan 6y3unuianap: aBactinnaKinx moK; tieepanozwc 6y3u.nuumap: 601.1.1 Anal-mum, KyaoKnapAa IHOBKHH; maboa—utialc 6y3unuutnapu: Ancneriemc xypminuniapki - OF133 Kypnam, KYHTHJI atimmm, wpm Aam 6ymunn; naOac musumu, 197Kpal: NaOacu as Kfrc opanusu absagapu momonitoati 6y3unuttaap: xmcnpam, 6Y-THHHILI;

ymymuli 6y3u.nuutnap: HCHTMa, ymymnii NOJICH3JIHK. IloeTperncTpannon Ky3aTyBnap AaBpn,aa IllyHH111-,4eK THOTp133.3011HHHH Na6ya KHnHEEE 61111aH 60FJIHICHHTH pic6oTnanraB peammmap xy3aTkumail: lopax-iyou momup MU3WW11 momonuaaki: aprepnan rlinepTeH3nA, TaxincapAna.

Kjuumm mywom 6yamaraH xoxiaraap Taa3OT KHCJI0TaCH Ba npenaparmuir 6onnca Komnoliewrgapnra loicopn ce3yBLiammx. Byripax ernmmoBxnumula Kynzaui mymmm 3Mac.

Aoppumpinifir y3apo Ta'bellpH THOTpHa30JIHHH14 KapnnonpoTeicTop BOCHTa ckalmTn,aa lopaic HIlleMHK xacan.114Knap H

Aanonauma 6a3Hc BocnTanapn 6n.riaB maxcmya,aa Ky'rufam mymxkm.

•

3

renaTonpoTeKTop BOCHTa cmtlaTH,ga npenapaTHH renammapHH affballaBnit gasogam ycynn &max 6Hpra *maw MyMKHH.

Maxcyc Kypcarmaaap A'ontuRaoop.aux as 3.341131M oaepuda lifilimauutuu. flpenapaTHH Nomn.nagopmix exil 3MH3141.11 AaHpHila *nn= camapa,RopiiHrH Ba xaaDeHankirll ypraHammaraH. Eanazap. flpenapaTHH 6aaariapAa Kynnaux TaApH6acH eTapmH ?Mac. Acmompaucnopm 6ouuyapuui elcu 6ouvca mexamomiap 6unan uuulauida peaKyuR me3nu2uaa mabcup iyu.nuut xycycusimu. AilHH narrraa xa6apnap Apc, 6npoic 6om afinaHmEH pHBOWBaHMITH MyMKHHJIEFHHH xilco6ra ORME Kepax. rIpenapaT 6orranap ononmailgHraH )1cori,aa calviaHcHH Ba 51p01(.11HJIHK myazaTH syTraci KYJIJIaHHJIMaCHH.

A03aH14 oumpn6 1060pHJIIIIIIII Ao3a oumpH6 Hp6opHrtraHHaa CHRAHKaa HaTpHil Ba KaJIHRHHHF KOHLIeHTpaHHACH oniabm. ByHaag xo.u.napaa npenapaTHH 6eKop wilful Kepax. Anon= CHMBTOMaTHIC

ilimapaallm malcJlH 200 Mr ,r(aH 10 Ta6.meTica 6.TnicTepaa. 9 6.nHcTepaaH KyTHAa.

CaKaaxn mapoHTH Opunman ypamH,aa, 25°C AaH mi(opH 6pmaraH Napoparaa.

ApOIVIIIJIHK myaaaTH 2 rum.

,lopllxoHaaap,u(aH 6epHm TapTH6H PeuenT 6p1Htia.

Hmaa6 IniKapyrom "KneHmemapenapar" )1CA)C YKpaHHa, 01032, KHeB in., CaKearallexHil K5 .139.