Cracking the NRPS Code Nick Till Computational Biology Proteins without Genes Tyrocidine Vancomycin Nonribosomal Peptide Synthesis Taken without permission from J. Christopher Anderson A-domain Recognition Site Chem. And Biol. 1999, 6, A-domain Sequences Machine Learning Approach Information Content in 10-mers Prediction Results Conclusion Predictor works for about 50% of sequences picked at random IC Bar Charts show some explanation for some poor predictions A more intricate weighting function for the Hamming Distance could improve prediction power. Signatures Chem. And Biol. 1999, 6,