CR Rates After Induction II Course for Selected Risk Factors

Risk Factor CR (%) P Risk Factor CR % PAge* 0–2 yr 2–5 yr 6–15 yr >15 yr

81% 89% 87% 87%

0.124 Cytogenetics ** Low Risk Std Risk High Risk

96% 84%79%

<0.001

Initial WBC** <100k >100k

89% 76%

=0.001 Monosomy 7 Present Absent

75%86%

0.264

Flt3-ITD mutation* Present Absent

74%89%

<0.001 Flt3-ITD AR** High Low

71%90%

<0.001

WHO Pathology* Inv16 t(8;21) M0

97% 96% 67%

0.007 0.0050.029

WHO Pathology* M2 M7 All other types

79%76%

0.031 0.039

NS*As of March 2010 data cutoff; **As of June 2010 data cutoffAR=allelic ratio; CR=complete remission; Flt33/ITD=FMS-like tyrosine kinase 3 internal tandem duplication; Inv16=inversion 16; Std=standard; WBC=white blood cells

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