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A MESSAGE FROM THE CO-DIRECTORS Todd Lee, PharmD, PhD and Edith Nutescu PharmD, MS CTS, FCCP

The UIC Center for Pharmacoepidemiology and Pharmacoeconomic Research (CPR) is an interdisciplinary research unit of the UIC College of Pharmacy. One of the only centers of its kind, the mission of the CPR is to advance understanding of the impact of pharmacy and health care services, products, and policy by 1) conducting research in pharmacoeconomics, pharmacoepidemiology, and patient-centered outcomes; 2) translating and disseminating research; and 3) educating, training, and mentoring researchers. The faculty of the CPR are among the top researchers in the field of health services and pharmaceutical outcomes research - both nationally and internationally. (For more information see Section B.) Faculty have been recognized by serving in leadership positions in several national associations and committees and by several national and international awards. (For more information see Section E.) A primary goal of the CPR is to conduct ground-breaking research in pharmacoeconomics, pharmacoepidemiology, and patient-centered outcomes research in order to advance understanding of the impact of pharmacy and health care services, products, and policy. Research conducted by the Center is funded by a variety of sources, including pharmaceutical manufacturers, private research foundations, and by government agencies, including the National Institutes of Health, and the Agency for Healthcare Research and Quality. (For more information see Section C.) While conducting research and generating new knowledge are important, for such information to inform public policy and impact society it must be disseminated and used. Thus, the CPR actively seeks to translate and disseminates its research findings in scholarly publications and presentations at scientific meetings in order to inform health care policy and practice. (For more information see Section D.) By virtue of its position as a leading research center, the CPR seeks to educate, train, and mentor current and future scientists to expand the fields of pharmacoeconomics, pharmacoepidemiology, and patient-centered outcomes research by providing post-doctoral fellowships and other research training experiences. (For more information see Section F.) Calendar year 2014 was filled with many accomplishments for the CPR. We welcomed 3 new faculty members to the Center, Drs. Lisa Sharp, Greg Calip and Katie Suda, which increased our core faculty membership to 14. Center faculty had a very productive year, as funding levels increased while maintaining a high level of visibility through publications in peer-reviewed journals as well as presentations at national and international scientific meetings and academic societies. Total research funding increased substantially, with 15 new grants awarded and 42 grants that had continuation funding. Funding sources included the National Heart Lung and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Cancer Institute, the Agency for Healthcare Research and Quality, the Patient Centered Outcomes Research Institute, the Center for Disease Control and Prevention, the Food and Drug Administration, the American Cancer Society, the McKesson Foundation, and the Pew Charitable Trust, among others. CPR faculty published a total of 57 papers (6.3/FTE), presented 53 research papers at scientific meetings (5.9/FTE) and gave 23 invited seminars and presentations (2.6/FTE). The average H-index in 2014 for CPR faculty was 15.43 (range 3-28). The faculty collaborated with 20 and 21 internal (UIC) scientists and departments, and 121 and 77 external scientists and institutions, respectively. The Center also sponsored 17 seminars and the faculty mentored 12 graduate trainees (5 fellows, 2 K-awardees, and 5 graduate students who graduated in 2014).

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B. Faculty The total number of faculty in the CPR has been steadily increasing since the Center was founded in 2002 (Figure B1). In 2014 there were 14 faculty in the Center comprising 9 FTEs. Figure B1. Number of faculty and FTEs, 2002-2014

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CPR Faculty Members:

Carl V. Asche, PhD, MBA Carl Asche is Research Professor of Medicine and Director of the Center for Outcomes Research at the University of Illinois College of Medicine at Peoria, and Research Professor in the Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy. His research focuses on the use of comparative effectiveness and cost-effectiveness analysis in health care decision making. He is the author or co-author of over 75 papers in the medical literature and he is on the editorial board for Pharmacoeconomics. Dr. Asche joined CPR in 2013.

Gregory S. Calip, PharmD, MPH, PhD Gregory Calip is an Assistant Professor in the Department of Pharmacy Systems, Outcomes and Policy. He is an alumnus of the UIC College of Pharmacy where he completed his PharmD before pursuing his MPH in Biostatistics and Epidemiology at New York University and PhD in Epidemiology at the University of Washington. He completed additional training in cancer epidemiology and prevention as postdoctoral fellow at the Fred Hutchinson Cancer Research Center in Seattle. Dr. Calip’s primary research interests are related to the influences of commonly used medications and comorbidity on cancer risk and outcomes among cancer survivors. Dr. Calip was recently a recipient of the College’s Hans W. Vahlteich Research Scholar Award. Dr. Calip joined the Center in 2014.

Stephanie Y. Crawford, PhD, MPH Stephanie Crawford is an Associate Professor and Associate Head in the Department of Pharmacy Systems, Outcomes, and Policy. Dr. Crawford’s research interests include health services research for underserved populations, medication safety, adherence, and health disparities. Dr. Crawford has served on the FDA Advisory Committee on Drug Safety and Risk Management of the United States Pharmacopeia (USP) and has been elected Vice-Chair of the Committee for numerous years. Dr. Crawford has also served as an advisory board member for American Journal of Health-System Pharmacy and Hospital Pharmacy. She received her PhD at the University of Texas at Austin and MPH at UIC. Dr. Crawford joined the Center in 2013.

Robert J. DiDomenico, PharmD, FCCP Robert DiDomenico is a member of the CPR and Clinical Associate Professor in the Department of Pharmacy Practice. He received his PharmD and completed a Cardiovascular Pharmacotherapy Fellowship at UIC. Dr. DiDomenico is a clinical pharmacist specializing in cardiovascular pharmacotherapy in the acute care setting. He has authored more than 30 articles and book chapters on both clinical and outcomes-related topics in cardiovascular pharmacotherapy, with particular expertise in heart failure. In 2008 he received the ACCP Research Institute Investigator Development Award. Dr. DiDomenico has contributed to the efforts of the CPR since 2003.

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Todd A. Lee, PharmD, PhD - CENTER CO-DIRECTOR Todd Lee is Associate Professor in the Department of Pharmacy Systems, Outcomes, and Policy. He also has appointments in the Division of Epidemiology and Biostatistics in the UIC School of Public Health, and in the Section of Pulmonary, Critical Care, Sleep and Allergy at the College of Medicine. He joined the CPR in 2009. Dr. Lee received his PharmD from Drake University and PhD from the University of Washington. Dr. Lee’s research focus is patient outcomes related to the use of pharmaceuticals, with emphasis on medication safety and pharmacoeconomics. His therapeutic area of expertise is respiratory disease. He has received numerous awards, including the Bernie J. O’Brien New Investigator Award from ISPOR. Dr. Lee assumed co-directorship of CPR in 2013.

Edith A. Nutescu, PharmD, MS CTS, FCCP - CENTER CO-DIRECTOR Edith Nutescu is an Associate Professor in the Department of Pharmacy Systems, Outcomes, and Policy. She has been a member of the CPR since 2005. Dr. Nutescu received her BS from the Politechnical Institute of Bucharest, PharmD from UIC College of Pharmacy and MS in Clinical and Translational Science from UIC School of Public Health. Dr. Nutescu’s research focuses on comparative effectiveness, health services, and clinical and economic outcomes of various antithrombotic therapies and cardiovascular thrombosis. She is widely published in the medical and scientific literature and her work has been recognized by numerous awards, including the Distinguished Service Award from ASHP, the Clinical Practice Award from ACCP, and the Ruth L. Kirschstein National Research Award from NIH. Dr. Nutescu assumed co-directorship of CPR in 2013.

Simon Pickard, PhD - CENTER ASSISTANT DIRECTOR Simon Pickard is Associate Professor in the Departments of Pharmacy Systems, Outcomes, and Policy and the Department of Pharmacy Practice. He is also Assistant Director of the CPR and has been a member since it was founded in 2002. Dr. Pickard received his BS in Pharmacy and PhD from the University of Alberta. His research focus is on informing decision making in health care through the evaluation of economic, humanistic and clinical outcomes of health care interventions. He is internationally known for his work in health-related quality of life, and in particular he has been a leader in developing the EQ-5D. He has received numerous research awards, including several from the International Society for Quality of Life Research. In addition to his active research program he is currently the Director of Graduate Studies for the Department of Pharmacy Systems, Outcomes, and Policy.

Dima M. Qato, PharmD, MPH, PhD Dima Qato joined the CPR is 2012. Dr. Qato is an Assistant Professor in the Department of Pharmacy Systems, Outcomes, and Policy. Dr. Qato earned her PharmD from UIC, her MPH from the Johns Hopkins Bloomberg School of Public Health, and her PhD from the UIC School of Public Health. Dr. Qato’s primary research interests relate to access and use of medications in vulnerable populations. Dr. Qato uses population-based methods to understand patterns and determinants of medication use, with emphasis on aging, drug safety and disparities. In 2001, she was the recipient of the Schweitzer Fellowship and in 2002 she was granted the prestigious Fulbright Scholarship to study impediments to the appropriate use of medicines in Jordan.

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Glen T. Schumock, PharmD, MBA, PhD Glen Schumock is Head of the Department of Pharmacy Systems, Outcomes, and Policy and Professor in the Departments of Pharmacy Systems, Outcomes, and Policy. He is the founding director of CPR and faculty member since 2002. Dr. Schumock received a Bachelor in Pharmacy from Washington State University, a PharmD degree from the University of Washington, and an MBA and PhD (Epidemiology) from UIC. His research focuses on comparisons of the clinical effectiveness, safety, and costs of pharmaceuticals and of health care and pharmacy services, and was the PI of the Chicago-Area DEcIDE Center funded by AHRQ (through August 2012). Dr. Schumock has authored and edited over 100 articles and books, and he serves on the several journal editorial boards.

Lisa K. Sharp, MA, PhD Lisa Sharp is a clinical health psychologist, an associate professor in the Department of Pharmacy Systems, Outcomes and Policy, and an IHRP Fellow. Dr. Sharp received her PhD from Northwestern University in Clinical Psychology, a post-doc in Health Psychology from University of Chicago, and a post-doc in Primary Care Health Psychology from Michigan State University. Her primary area of research targets the health of minorities and underserved populations in regards to understanding the direct and indirect effects of stress and depression on chronic illness and cancer, fostering patient participation and communication in the doctor-patient relationship, and ecological, social and psychological influences upon inflammatory processes. Dr. Sharp joined CPR in 2014.

Jo Ann Stubbings, MHCA Jo Ann Stubbings is a Clinical Associate Professor in the Department of Pharmacy Practice and in the Department of Pharmacy Systems, Outcomes, and Policy. She has been an active contributor to the Center since 2004. Ms. Stubbings received her BS in Pharmacy from Ohio State University and a Master of Health Care Administration from the University of Mississippi. Her research interests include Medicare Part D, pharmaceutical care business models, specialty pharmacy, marketing of pharmaceuticals and pharmacy services, and payment for pharmaceuticals and pharmacy services. Ms. Stubbings has received numerous teaching awards and is widely sought after for her expertise in medication payment policy issues

Katie J. Suda, PharmD, MS Katie Suda is a Research Health Scientist with the Center of Innovation for Complex Chronic Healthcare at the Department of Veterans Affairs (VA) and has a part-time appointment as a Research Associate Professor in the Department of Pharmacy Systems, Outcomes, and Policy. Dr. Suda received a Doctor of Pharmacy from Drake University in 1999 and a M.S. in epidemiology from the University of Tennessee Health Science Center. She completed a pharmacy practice residency at Baptist Memorial Health Care in Memphis, Tennessee and infectious diseases and outcomes research fellowship at UIC. Dr. Suda’s area of research is pharmacoepidemiology and infectious disease research in long-term populations at the VA. Dr. Suda joined CPR in 2014.

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Daniel R. Touchette, PharmD, MA, FCCP Daniel Touchette is Associate Professor in the Department of Pharmacy Systems, Outcomes, and Policy. Dr. Touchette is also the Network Director for the American College of Clinical Pharmacy Practice-Based Research Network (PBRN). He has been with the CPR since August 2005. Dr. Touchette received his BS in Pharmacy from the University of Manitoba, and his PharmD and Master of Economics degree from Wayne State University in Detroit. He also completed a fellowship in pharmacoeconomics and outcomes research at Wayne State. Dr. Touchette's research interests are in the broad areas of pharmacoeconomics and outcomes research. In particular he is interested in evaluation of clinical pharmacist and other healthcare practitioner activities, especially as it relates to improving medication adherence and reducing the adverse effects of medicines.

Surrey M. Walton, PhD - CENTER ASSISTANT DIRECTOR Dr. Walton is Associate Professor in the Department of Pharmacy Systems, Outcomes, and Policy and Assistant Director of the CPR. He also holds an adjunct appointment in the Department of Economics at UIC. He was a founding member of the CPR in 2002. Dr. Walton holds a BS in Economics from UCLA, and a Master and PhD degree in Economics from the University of Chicago, where he specialized in labor and health economics. He conducts quantitative research in health services evaluation, health economics, pharmacoeconomics, and health care labor markets.

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C. Research Total research funding (in dollars) increased substantially in 2014 ($2,347,130) compared to 2013 and exceeded funding levels reached in 2009 (Figure C1). Funding per FTE also increased markedly in 2014 ($260,792) compared to 2013 ($135,685). Figure C1a. Total funding, 2002-2014 Figure C1b: Funding per FTE and funding per award, 2002-2014

In 2014, foundations and pharmaceutical or private sources of funding each comprised 40% of grant funding to the CPR (Figure C2). Figure C2. Funding by source, 2002-2014

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Listed below are research grants and contracts active and awarded to CPR faculty in 2014. Those research grants and contracts awarded in 2014 are marked by an asterisk (*). Dollar amounts listed are the portion attributable to CPR investigators (total direct and indirect) for those grants where the PI is outside of the CPR. Title: Barriers to Appropriate Anticoagulation Therapy in Patients Undergoing Major Orthopedic Surgery Funding Source: Janssen Pharmaceuticals – Health Outcomes CPR Investigator: Nutescu EA (PI) Period: June 2009 to July 2015; Award: $131,336 Title: Pharmacomechanical Catheter Directed Thrombolysis for Acute Deep Vein Thrombosis Funding Source: National Institutes of Health/National Heart Lung and Blood Institute CPR Investigator: Nutescu EA (Co-I) Period: June 2010 to March 2015; Award: $335,000 Title: Comparative Effectiveness of Breast Imaging Modalities: A Natural Experiment Funding Source: Agency for Healthcare Research and Quality CPR Investigator: Schumock GT (Co-I) Period: September 2010 to August 2015; Award: $1,270,215 Title: Comparative Effectiveness of Management Strategies for Acute Lower Back Pain Funding Source: Agency for Healthcare Research Quality CPR Investigator: Asche CV (Co-I) Period: September 2010 to August 2014; Award: $1,642,640 Title: Health Promoters and Pharmacists in Diabetes Team Management Funding Source: NIH/NIDDK CPR Investigator: Sharp LK (Co-PI), Touchette DR (Co-I) Period: May 2011 to March 2016; Award: $405,359 Title: Pharmacare Innovation: a Research Proposal Funding Source: UIC College of Business Administration, CBA Rising the Research Profile Award CPR Investigator: Crawford SY (Co-I) Period: August 2011 to June 2014; Award: $500,000 Title: Moving Forward: A Weight Loss Program for African-American Breast Cancer Survivors Funding Source: NIH/NCI CPR Investigator: Sharp LK (Co-I) Period: September 2011 to July 2016; Award: $498,350 Title: Takeda-UIC 2-year Fellowship in Health Economics and Outcomes Research Funding Source: Takeda CPR Investigator: Pickard AS (PI) Period: July 2012 to June 2014; Award: $164,000

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Title: Implementation of Warfarin Pharmacogenetics at UI Health Funding Source: University of Illinois at Chicago Hospital & Health Sciences System Office of the Vice President for Health Affairs CPR Investigator: Nutescu EA (Co-PI) Period: August 2012 to August 2016; Award: $390,000 Title: Partnership for a Healthy Community: Peoria and Tazewell Counties of Illinois Community Transformation Project Funding Source: Center for Disease Control Small Community Transformation Grant CPR Investigator: Asche CV (Co-I) Period: October 2012 to September 2014; Award: $2,400,000 Title: Contemporary Pharmacy Practice Model for Clinical Thrombosis Management Funding Source: American Pharmacists Association Foundation CPR Investigator: Nutescu EA (Primary Mentor) Period: January 2013 to June 2014; Award: $1,000 Title: Patient-Centered Anticoagulation Self-Monitoring in Minority Patients Funding Source: National Institutes of Health/National Heart Lung and Blood Institute CPR Investigator: Nutescu EA (PI), Schumock GT, Sharp LK (Co-Mentors) Period: February 2013 to January 2017; Award: $526,567 Title: Emergency Patient Interdisciplinary Care (EPIC) Coordination for Frequent ER Visitors Funding Source: UIC University of Hospital and Health Sciences System CPR Investigator: Walton SM (Leadership Team) Period: April 2013 to March 2016; Award: $18,000 Title: Evaluation of Cranberry-Warfarin Drug-Interaction Funding Source: The Cranberry Institute CPR Investigator: Nutescu EA (PI) Period: April 2013 to December 2014; Award: $10,000 Title: Development of an NIH Pharmacogenomics Research Network Funding Source: University of Illinois at Chicago Office of the Vice Chancellor for Research CPR Investigator: DiDomenico RJ (Co-I) Period: May 2013 to April 2015; Award: $7,730 Title: Astellas-UIC Fellowship in Pharmacoepidemiology and Pharmacovigilance Funding Source: Astellas CPR Investigator: Lee TA (PI) Period: July 2013 to June 2015; Award: $184,953 Title: Takeda-UIC 2-year Fellowship in Health Economics and Outcomes Research Funding Source: Takeda CPR Investigator: Pickard AS (PI) Period: July 2013 to June 2015; Award: $164,000

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Title: Text Messaging to Support Medication Adherence Funding Source: University of Illinois at Chicago Center for Clinical and Translational Science CPR Investigator: Sharp LK (PI) Period: August 2013 to July 2015; Award: $30,000 Title: BCR-ABL1 Mutations Conferring Treatment Resistance to Tyrosine Kinase Inhibitors Among Patients with Chronic Myeloid Leukemia Funding Source: ARIAD Pharmaceuticals, Inc. CPR Investigator: Pickard AS (PI), Lee TA (Co-I) Period: August 2013 to August 2014; Award: $35,454 Title: Control Systems for Artificial Pancreas Use During and After Exercise Funding Source: NIDDK CPR Investigator: Sharp LK (Co-I) Period: August 2013 to July 2018; Award: $433,170 Title: PATient Navigator to rEduce Readmissions (PArTNER) Funding Source: Patient-Centered Outcomes Research Institute CPR Investigator: Pickard AS (Co-I), DiDomenico RJ (Co-I) Period: August 2013 to July 2016; Award: $37,500 Title: Fault-Tolerant Control Systems for Artificial Pancreas Funding Source: NIDDK CPR Investigator: Sharp LK (Co-I) Period: August 2013 to July 2018; Award: $344,306 Title: The Cost Effectiveness of School-Based Supervised Asthma Therapy Funding Source: NHLBI CPR Investigator: Lee TA (Co-I) Period: August 2013 to April 2017; Award: $60,000 Title: Beliefs and Attitudes Towards Antipsychotic Use in Patients with Schizophrenia and Bipolar Disorder Funding Source: Sunovion Pharmaceuticals CPR Investigator: Touchette DT (PI) Period: September 2013 to August 2016; Award: $354,304 Title: Bringing Care to Patients: Patient-Centered Medical Home for Kidney Disease Funding Source: Patient-Centered Outcomes Research Institute CPR Investigator: Sharp LK (Co-I) Period: October 2013 to September 2015; Award: $199,833 Title: ACIP Pneumococcal Immunization Recommendations for Adults with Immune Compromising Conditions – a Scientific Survey of Clinical Practice Guideline Implementation Funding Source: Pfizer Inc. CPR Investigator: Touchette DT (PI) Period: November 2013 to November 2014; Award: $130,298

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Title: Medication Therapy Management Clinic: The Impact on Clinical Parameters and Resource Utilization Funding Source: American College of Clinical Pharmacy Ambulatory Care PRN CPR Investigator: Touchette DT (Mentor and Co-I) Period: November 2013 to October 2014; Award: $2,000 Title: Analytic Methods to Assess the Robustness of Drug Safety Monitoring Results* Funding Source: FDA CPR Investigator: Lee TA (Co-I) Period: January 2014 to March 2015; Award: $18,112 Title: Development of a HRQL Data Archive* Funding Source: EuroQol Group CPR Investigator: Pickard AS (PI) Period: January 2014 to June 2015; Award: $28,220 Title: Family, Nutrition, Physical Activity (FNPA) Tool Practice Intervention* Funding Source: American Cancer Society Population and Science Grant CPR Investigator: Asche CV (Co-I) Period: January 2014 to December 2015; Award: $249,541 Title: NDI Plus Linkage to the Mini-sentinel Distributed Data Network* Funding Source: FDA CPR Investigator: Lee TA (Co-I) Period: January 2014 to June 2015; Award: $46,572 Title: Training Health Insurance Enrollees for Implementation of the ACA in Illinois* Funding Source: DOI Interagency Contract CPR Investigator: Walton SM (Co-I) Period: April 2014 to March 2015; Award: $1,069,482 Title: David J. Riback 2014 Summer Research Fellowship for Project Titled: Impact of a Pharmacist Guided Pharmacogenetics Service on Predictions of Warfarin Stable Dose* Funding Source: University of Illinois at Chicago College of Pharmacy CPR Investigator: Nutescu EA (Primary Mentor) Period: May 2014 to August 2014; Award: $6,000 Title: David J. Riback 2014 Summer Research Fellowhsip for Project Titled: Factors that influence Adoption of Anticoagulation Self-Monitoring in a Minority Population* Funding Source: University of Illinois at Chicago College of Pharmacy CPR Investigator: Nutescu EA (Primary Mentor) Period: May 2014 to August 2014; Award: $6,000 Title: Understanding the Relationship between Health Behaviors, Attitudes and Perceptions of HRQL using the EQ-5D* Funding Source: EuroQol Group CPR Investigator: Pickard AS (PI) Period: June 2014 to June 2015; Award: $26,560

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Title: Takeda Pharmaceuticals International and UIC 1-year Fellowship in Medication Adherence* Funding Source: Takeda Pharmaceuticals CPR Investigator: Touchette DT (PI) Period: July 2014 to June 2015; Award: $73,374 Title: Takeda Pharmaceuticals International and UIC 2-year Fellowship in Medication Adherence* Funding Source: Takeda Pharmaceuticals CPR Investigator: Touchette DT (PI) Period: July 2014 to June 2016; Award: $147,515 Title: Takeda-UIC 2-year fellowship in Health Economics and Outcomes Research* Funding Source: Takeda Pharmaceuticals CPR Investigator: Pickard AS (PI) Period: July 2014 to June 2016; Award: $161,000 Title: Mobilizing for Patient Adherence to Cancer Therapies (mPACT)* Funding Source: McKesson Foundation, Mobilizing for Health® Program CPR Investigator: Crawford SY (PI) Period: August 2014 to September 2015; Award: $250,000 Title: EHR-Based Medication Complete Communication Strategy to Promote Safe Opioid Use* Funding Source: Northwestern CPR Investigator: Walton SM (subcontract PI) Period: September 2014 to August 2017; Award: $89,559 Title: National Assessment of State Oversight of Drug Compounding* Funding Source: Pew Charitable Trust CPR Investigator: Pickard AS (PI) Period: November 2014 to November 2015; Award: $137,213 Title: The Effect of Taxane Chemotherapy on Balance in Breast Cancer Patients* Funding Source: Illinois Cancer Care Foundation CPR Investigator: Asche CV (Co-I) Period: December 2014 to December 2016; Award: $37,982

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D. Dissemination Dissemination activities remain an important component of the activities of the CPR faculty. This effort includes peer-reviewed journal publications, research abstract presentations, and invited presentations. (Figure D1). CPR faculty published a total of 57 publications in 2014, or an average of 6.3/FTE. Research papers totaled 53 in 2014 (or an average of 5.9/FTE) and invited presentations were at 23 (or 2.6/FTE). Figure D1. Dissemination activities, 2002-2014

Figure D2. Dissemination activities per FTE, 2002-2014

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Listed below are all of the individual publications, research papers presented, and invited presentations made by CPR faculty in 2014.

Publications Adimadhyam S, Schumock GT, Walton SM, Joo M, McKell J, Lee TA. Risk of arrhythmias associated with ipratropium bromide in children, adolescents and young adults with asthma: a nested case-control study. Pharmacotherapy. 2014;34(4):315-323. Asche CV, Hippler SE, Eurich DT. Review of models used in economic analyses of new oral treatments for type 2 diabetes mellitus. Pharmacoeconomics. 2014;32(1):15-27. Biondi EA, Mischler M, Jerardi KE, Statile A, French J, Evans R, Lee V, Chen C, Asche CV, Ren J, Shah SS. Blood Culture Time to Positivity in Febrile Infants with Bacteremia. JAMA Pediatrics. 2014;168(9):844-92. Calip GS, Malone KE, Gralow JR, Stergachis A, Hubbard RA, Boudreau DM: Metabolic syndrome and outcomes following early-stage breast cancer. Breast Cancer Research and Treatment. 2014;148(2):363-77. Cannon J, Lee TA, Clark N, Setlak P, Grim S. The risk of seizures among the carbapenems: a meta-analysis. Journal of Antimicrobial Chemotherapy. 2014;69(8):2043-2055. Carbone L, Chin AS, Lee TA, Burns SP, Svircev JN, Hoenig HM, Bailey L, Weaver FM. Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury. American Journal of Physical Medicine and Rehabilitation. 2014;95(6):1015-1020. Cavallari LH, Nutescu EA. Warfarin pharmacogenetics: to genotype or not to genotype, that is the question. Clinical Pharmacology and Therapeutics. 2014;96(1):22-4. Christison AL, Daley BM, Asche CV, Ren J, Aldag JC, Ariza AJ, Lowry KW. Pairing motivational interviewing (MI) with a nutrition and physical activity assessment and counseling tool in pediatric clinical practice: a pilot study. Childhood Obesity. 2014;10(5):432-41. Clay E, Khemiri A, Zah V, Aballea S, Ruby J, Asche CV. Persistence and Healthcare Utilization Associated with the Use of Buprenorphine/Naloxone Film and Tablet Formulation Therapy in Adults with Opioid Dependence. Journal of Medical Economics. 2014;17(9):626-36. Coleman CI, Limone BL, Bookhart BK, Mody SH, Nutescu EA. Cost-effectiveness analysis of extended duration anticoagulation with rivaroxaban to prevent recurrent venous thromboembolism. Thrombosis Research. 2014;133(5):743-9. Daniels CC, Shelton CM, Bass PJ, Wang WC, Suda KJ. Limb swelling in a pediatric sickle cell patient after revaccination with the 23-valent pneumococcal polysaccharide vaccine. International Journal of Clinical Pharmacy. 2014;36(2):261-263.

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DiDomenico RJ, Bress AP, Na-Thalang K, Tsao YY, Groo VL, Deyo KL, Patel SR, Bishop JR, Bauman JL. Use of a Simplified Nomogram to Individualize Digoxin Dosing versus Standard Dosing in Patients with Heart Failure. Pharmacotherapy. 2014;34(11):1121-31. Dilokthornsakul P, Chaiyakunapruk N, Nimpitakpong P, Jeanperrapong N, Jampachaisri K, Lee TA. Understanding medication oversupply and its predictors in the outpatient departments in Thailand. BMC Health Services Research. 2014;14:408. Dilokthornsakul P, Chaiyakunapruk N, Schumock GT, Lee TA. Calendar time-specific propensity score analysis for observational data: a case study estimating the effectiveness of inhaled long-acting beta-agonist on asthma exacerbations. Pharmacoepidemiology and Drug Safety. 2014;23(2):152-164. Dorsch MP, Lose J, DiDomenico RJ. The effect of cardiology pharmacy credentialing on process of care measures and outcomes in myocardial infarction and heart failure. Pharmacotherapy. 2014;34(8):803-8.

Elliott WV, Suda KJ, Hamilton LA, Curry KY, Byrd DC. Impact of eliminated assignments on students’ performance in and evaluation of a drug information and literature evaluation cours. Currents in Pharmacy Teaching and Learning. 2014;4(6):483-487. Finch NA, Guarascio AJ, Suda KJ. Guillain-Barre Syndrome in an elderly male following influenza vaccination. Journal of the American Pharmacists Association. 2014;54(2):188-192. Garg N, Rolle AJ, Lee TA, Prasad B. Home-based diagnosis of obstructive sleep apnea in an urban population. Journal of Clinical Sleep Medicine. 2014;10(8):879-885. Hanson RL, Habibi M, Khamo N, Abdou S, Stubbings JA. Integrated clinical and specialty pharmacy practice model for management of patients with multiple sclerosis. American Journal of Health-System Pharmacists. 2014;71;463-469. Howard-Thompson A, Cartmell B, Suda KJ. Toxic Epidermal necrolysis reaction associated with the use of moxifloxacin. International Journal of Antimicrobial Agents. 2014;44:178-179. Jordan N, Sohn MW, Bartle B, Valenstein M, Lee Y, Lee TA. Association between chronic illness complexity and receipt of evidence-based depression care. Medical Care. 2014;52(Suppl 3):S126-S131.

Justo JA, Gauthier TP, Scheetz MH, Chahine EB, Bookstaver PB, Gallagher JC, Hermsen ED, DePestel DD, Ernst EJ, Jacobs DM, Esterly JS, Suda KJ, Olsen KM, Abbo LM, MacDougall C. Knowledge and attitudes of doctor of pharmacy students regarding the appropriate use of antimicrobials. Clinical Infectious Diseases. 2014;59(Suppl 3):S162-S169. Kaatz S, Fu AC, AbuDagga A, LaMori J, Bookhart BK, Damaraju CV, Tan H, Schein J, Nutescu EA. Association between anticoagulant treatment duration and risk of venous thromboembolism recurrence and bleeding in clinical practice. Thrombosis Research. 2014;134(4):807-13.

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Krabbe PF, Devlin NJ, Stolk EA, Shah KK, Oppe M, van Hout B, Quik EH, Pickard AS, Xie F. Multinational evidence of the applicability and robustness of discretechoice modeling for deriving EQ-5D-5L health-state values. Medical Care. 2014;52(11):935-43. Laliberté F, Nutescu EA, Lefebvre P, Rondeau-Leclaire J, Bookhart BK, LaMori JC, Damaraju CV, Schein J, Kaatz S. Risk factors associated with myocardial infarction in venous thromboembolism patients. Current Medical Research and Opinion. 2014;30(1):27-35. Lee WJ, Lee TA, Pickard AS, Caskey RN, Schumock GT. Drugs associated with adverse events in children and adolescents. Pharmacotherapy. 2014; 34(9): 918-926. Lee YM, Eggen J, Soni V, Drozda K, Nutescu EA, Cavallari LH. Warfarin dose requirements in a patient with the CYP2C9*14 allele. Pharmacogenomics. 2014;15(7):909-914. Lin FJ, Pickard AS, Krishnan JK, Joo MJ, Au DH, Carson SS, Gillespie S, Henderson AG, Lindenauer PK, McBurnie MA, Mularski RA, Naurekas ET, Vollmer WM, Lee TA; CONCERT Consortium. Measuring health-related quality of life in chronic obstructive pulmonary disease: properties of the EQ-5D-5L and PROMIS-43 short form. BMC Medical Research Methodology. 2014;14:78. Liu FX, Ghaffari A, Dhatt H, Kumar V, Balsera C, Wallace E, Khairullah Q, Lesher B, Gao X, Henderson H, LaFleur P, Delgado EM, Alvarez MM, Hartley J, McClernon M, Walton SM, Guest S. Economic evaluation of urgent-start peritoneal dialysis versus urgent-start hemodialysis in the United States. Medicine. 2014;93(28):e293. Liu FX, Walton SM, Leipold R, Isbell D, Golper TA. Financial Implications to Medicare from Changing the Dialysis Modality Mix Under the Bundled Prospective Payment System. Peritoneal Dialysis International. 2014;34:749-757. Marler JL, Curry KY, Suda KJ. Assessing the quality of database search strategies utilized by meta-analyses that evaluate infectious disease drug therapy. Therapeutic Innovation and Regulatory Science. 2014;48:336-340. Mathur S, Singh N, Suda KJ. Association of risk perception and information provided on the labels of over-the-counter drugs: Role of race, education, age and income. Epidemiology, Biostatistics and Public Health. 2014;11(3):9159. McConeghy KW, Bress A, Qato DM, Wing C, Nutescu EA. Evaluation of Dabigatran Bleeding Adverse Reaction Reports in the FDA Adverse Event Reporting System during the First Year of Approval. Pharmacotherapy. 2014;34(6):561-9. Nicoll KG, Ramser KL, Campbell JD, Suda KJ, Lee MD, Wood GC, Sumter R, Hamann GL. Sustainability of improved glycemic control after diabetes self-management education. Diabetes Spectrum. 2014;27(3):207-211.

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Nutescu EA, Engle JP, Bathija S, Grim SA, Chan J, Mucksavage JJ, Ohler KH, Tesoro EP, Thielke JJ, Shapiro NL, Donnelly AJ, Garofalo J, DiDomenico RJ. Balance of Academic Responsibilities of Clinical Track Pharmacy Faculty in the United States: A Survey of Select American College of Clinical Pharmacy Practice and Research Network Members. Pharmacotherapy. 2014;34(12):1239-49. Owens GM, Fine C, Harrington DW, Jacobson AK, Merli GJ, Nutescu EA, Schaecher KL, Vance J, Villanueva T, Waldo AL. Improving transitions of care for patients with thromboembolic disease. Am J Manag Care. 2014;20(4 Suppl):S81-91. Patel V, Lin FJ, Ojo O, Rao S, Yu S, Zhan L, Touchette DR. Cost-utility analysis of genotype-guided antiplatelet therapy in patients with moderate-to-high risk acute coronary syndrome and planned percutaneous coronary intervention. Pharmacy Practice. 2014;12(3):438. Prentice JC, Conlin PR, Gellad WF, Edelman D, Lee TA, Pizer SD. Capitalizing on prescribing pattern variation to compare medications for type 2 diabetes. Value Health. 2014;17(8):854-862. Prieto-Centurion V, Markos MA, Ramey NI, Gussin HA, Nyenhuis SM, Joo MJ, Prasad B, Bracken N, Didomenico RJ, Godwin PO, Jaffe HA, Kalhan R, Pickard AS, et.al. Interventions to Reduce Rehospitalizations Following Chronic Obstructive Pulmonary Disease Exacerbations: A Systematic Review. Annals of the American Thoracic Society. 2014;11(3):417-24. Prieto-Centurion V, Rolle AJ, Au DH, Carson SS, Henderson AG, Lee TA, Lindenauer PK, McBurnie MA, Mularski RA, Naureckas ET, Vollmer WM, Joese BJ, Krishnan JA, CONCERT Consortium. Multicenter study comparing case definitions used to identify patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 2014;190(9):989-995. Qato DM, Daviglus ML, Wilder J, Lee TA, Qato D, Lambert B. ‘Pharmacy deserts’ are prevalent in Chicago’s predominantly minority communities, raising medication access concerns. Health Affairs (Millwood). 2014;33(11):1958-1965. Recht M, Neufeld EJ, Sharma VR, Solem CT, Pickard AS, Gut RZ, Cooper DL. Impact of Acute Bleeding on Daily Activities of Patients with Congenital Hemophilia with Inhibitors and Their Caregivers and Families: Observations from the Dosing Observational Study in Hemophilia (DOSE). Value in Health. 2014;17(6):744-8. Ren J, Ning Z, Kirkness CS, Asche CV, Wang H. Risk of Using Logistic Regression to Illustrate Exposure- Response Relationship of Infectious Diseases. BMC Infectious Disease. 2014;14; 540. Reynolds T, Cameron M, Conway M, Ising A, Lau EHY, Olson J, Pavlin, Storm B, Suda KJ, Corley C. Using Social Media for Biosurveillance: Gap between Research and Action. Online Journal of Public Health Informatics. 2014;6(1):e112. Seal B, Sullivan SD, Ramsey S, Asche CV, Shermock K, Sarma S, Zagadailov EA, Farrelly E, Eaddy M. Comparing Hospital-based Resource Utilization and Costs for Prostate Cancer Patients With and Without Bone Metastases. Appl Health Econ Health Policy. 2014;12(5):547-57.

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Schumock GT, Li EC, Suda KJ, Matusiak LM, Hunkler RJ, Vermeulen LC, Hoffman JM. National trends in prescription drug expenditures and projections for 2014. American Journal of Health-System Pharmacy. 2014;71:482-99. Seltzer ED, Stolley MR, Sharp, LK. Social networking sites usage among childhood cancer survivors -- a potential tool for research recruitment? Journal of Cancer Survivorship. 2014;8(3):349-354. Sohn MW, Oh EH, Budiman-Mak E, Lee TA, Stone NJ, Pearce WB. Reply [letter]. Journal of Vascular Surgery. 2014; 59(3): 876. Stubbings JA. Health systems are capable of handling a REMS. P&T. 2014; 39(5). Suda KJ, Hicks LA, Roberts RM, Hunkler RM, Taylor TH. Trends and seasonal variation in outpatient antibiotic prescription rates in the United States, 2006-2010. Antimicrobial Agents and Chemotherapy. 2014; 58(5):2763-2766. Suda KJ, Regen SM, Lee TA, Easterling JL, Hunklwer RJ, Danziger LH. Outpatient influenza antiviral prescription trends with influenza-like illness in the USA, 2008-2010. International Journal of Antimicrobial Agents. 2014;43(3):279-283. Suda KJ, Sterling JM, Guirguis AB, Mathur SK. Academic performance after implementation of a blended learning approach to a drug information and literature evaluation course. Currents in Pharmacy Teaching and Learning. 2014;6(3):367-372. Sumino K, O’Brian K, Bartle B, Au DH, Castro M, Lee TA. Coexisting chronic conditions associated with mortality and morbidity in adult patients with asthma. Journal of Asthma. 2014; 51(3) 306-314. Touchette DR, Doleresco F, Suda KJ, Perez A, Turner S, Jalundhwala Y, Hoffman J. Economic evaluations of clinical pharmacy services: 2006-2010. Pharmacotherapy. 2014;34(8):771-793. Walton SM, Rash C, Lambert BL, Galanter WL. A Case Study in Generic Drug Use: Should There Be Risk Adjustment in Incentive Payments. Journal of Managed Care Pharmacy. 2014;20(11):1093-1099. Walton SM, Schumock GT. Should off-label drugs be included as comparators in pharmacoeconomic studies? PharmacoEconomics. 2014; On-line (October 1): 32(11):1035-1037. Zueger PM, Schultz NM, Lee TA. Cost effectiveness of liraglutide in type II diabetes: a systematic review. Pharmacoeconomics. 2014;32(11):1079-1091.

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Research Presentations (*denotes trainees) Ahmed L, Kshatriya S, Shah A, Vatanka P, Goliak K, Touchette D. Assessment of a community pharmacy-based education program and pharmacist intervention to optimize insulin delivery. Poster Presentation: American Pharmacists Association 2014 Annual Meeting, Orlando, FL. March 2014. Almon L, Suda KJ, Butler J, Hamilton L. Globalization of phase III and phase IV antiretroviral clinical trials in HIV infected adults and senior patients. Poster Presentation: American Society of Health-System Pharmacists Midyear Clinical Meeting, Anaheim, CA. December 2014. Asche CV, Vozenilek J, Bland A. Economic Evaluation Guidelines for Medical Simulation Outcomes Researchers. Oral Presentation: 14th International Meeting on Simulation in Healthcare, San Francisco, CA. January 25-29, 2014. Asche CV, Ren J, Hippler SE. Evaluation of medical quality based on readmissions within 30 days among beneficiaries in central Illinois. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research, Montreal, QC, Canada. May 31-June 4, 2014. Asche CV, Eurich DT, Hippler SE. Review of models used in economic analyses of new oral treatments for type 2 diabetes mellitus. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research, Montreal, QC, Canada. May 31-June 4, 2014. Awé C, Gaither CA, Crawford SY, Tieman J. Perceptions of pharmacy students’ stress and stressors: a comparative analysis across two multi-campus universities. Poster Presentation: American Association of Colleges of Pharmacy Annual Meeting, Grapevine, TX. Jul 27, 2014. Bland A, Vozenilek J, Asche CV. Simulation's Value Proposition: An analysis of the economic, quality and patient safety factors. Oral Presentation: American College of Physician Executives, Chicago, IL. April 25-29, 2014. Bussey H, Nutescu EA. Assessment of a New Method of Warfarin Management vs the New Oral Anticoagulants and Conventional Warfarin Management in Atrial Fibrillation. Poster Presentation: American College of Chest Physicians, Chest Annual Meeting, Austin, TX. October 25-30, 2014. Calip GS, Boudreau DM. Characteristics associated with nonadherence to medications for hypertension, dyslipidemias, and diabetes among breast cancer survivors. Oral Presentation & Poster Discussion Session: 37th Annual San Antonio Breast Cancer Symposium, San Antonio, TX. Dec 2014. Abstract published in: Cancer Res 2014 Dec; 74(s1): PD4-6. Cheng WH*, Rash C*, Patel P*, Gratie D*, Bathija S, Pickard AS, Berbaum M, Hellenbart E, McDowell M*, Khan M, Shapiro N, Galanter W, Stamos T, Nutescu EA. Impact of Target Specific Oral Anticoagulants On Quality of Life. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research 19th Annual International Meeting, Montreal, QC, Canada. May 31-June 4, 2014. Abstract published in: Value in Health 2014:17 (3):A120-A121;PCV107. Winner of the Best Poster Finalist Award.

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Cheng WH*, Manzoor BS*, Cavallari L, Sharp L, Gerber B, Fitzgibbon MI, Schumock GT, Nutescu EA. Quality of Pharmacist-Managed Anticoagulation Therapy In Long-Term Ambulatory Settings: A Systematic Review. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research 19th Annual International Meeting, Montreal, QC, Canada. May 31-June 4, 2014. Abstract published in: Value in Health 2014:17(3):A126-A127;PHS10. [Also presented at UIC College of Pharmacy Research Day, Chicago, IL. March 7, 2014]. Christison A, Lowry K, Haddock S, Asche CV, Robin R, Gutnick D, Kirkness C. Brief Action Planning Paired with Obesigenic Screening in Pediatric Primary Care Clinics: Description of Methods and Design. Poster Presentation: 2014 American Academy of Pediatrics National Conference, San Diego, CA. October 11-14, 2014. Costa D, King MT, Aaronson N, Brazier JE, Cella D, Grimison P, Janda M, McTaggart-Cowan H, Pickard AS, Arbuckle R. The development of cancer-specific multi-attribute utility instruments from the EORTC QLQ-C30 and FACT-G. Oral Presentation: International Society for Quality of Life Research, 21th Annual Conference, Berlin, Germany. October 15-18, 2014. Abstract published in: Qual Life Res (2014) 23:29. Crawford SY, Touchette DR, Sharp LK, Shaw JW, Provenzano A, Papa A, Harkins T. Opportunities and challenges in providing face-to-face and telephonic MTM services to a commercially-insured population. Poster Presentation: Academy of Managed Care Pharmacy, AMCP 2014 Nexus, Boston, MA. Oct 9, 2014. Abstract awarded gold medal. Drozda K*, Patel SR, Nutescu EA, Cavallari LH. Addition of CYP2C9*5,*6,*8,*11 and rs12777823 genotypes into an existing warfarin dosing algorithm improves algorithm performance for African Americans. Poster Presentation: American College of Clinical Pharmacy Annual Meeting, Austin, TX. October 12-15, 2014. Abstract published in: Pharmacotherapy 2014;34(10):e220:168. Drozda K*, Wong S*, Patel S, Nutescu EA, Cavallari LH. Effects of African-specific genetic variation on performance of warfarin pharmacogenetic dosing algorithms. Poster Presentation: Annual Meeting of the American Society of Clinical Pharmacology and Therapeutics, Atlanta, GA. March 18, 2014. Abstract published in: Clin Pharmacol Ther 2014;95(Suppl 1):S11 (#PT-012). Dr. Drozda was selected for an ASCPT Presidential Trainee Award in recognition of this abstract. Evans CT, Ramanathan S, Spadoni S, Sabzwari R, Patel U, Krankoski K, Suda KJ. Comparing Bacteria Isolated from Patients with Spinal Cord Injury Versus All Patients. Poster Presentation: Infectious Disease Society of America, Philadelphia, PA. October 2014. Gannon M*, Abdou S, Stubbings JA. Efficiency and costs of a prior authorization service for specialty medications at an academic health system. Poster Presentation: Academy of Managed Care Pharmacy, AMCP Nexus 2014, Boston, MA. October 14, 2014. Golicki D, Janssen B, Pickard AS. Responsiveness of the EQ-5D-5L with stroke. Poster Presentation: International Society for Quality of Life Research, 21st Annual Conference, Berlin, Germany. October 15-18, 2014. Abstract published in: Qual Life Res (2014) 2:71. Gratie D*, Cheng WH*, Drozda K*, Duarte J, Lee J, Galanter WL, Garofalo J, Krishnan JA, Cavallari L, Nutescu EA. Poster Presentation: Impact of a pharmacist guided pharmacogenetics service on prediction of warfarin stable dose. American College of Clinical Pharmacy Annual Meeting, Austin, TX. October 12-15, 2014. Abstract published in: Pharmacotherapy 2014;34(10):e289:415. Winner of the Best Student Research Poster Award.

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Hamilton LA, Heidel RE, McDonough S, Franks A, Suda KJ. Assessing the Utility of Social Media in Pharmacy Education. Poster Presentation: American Association of Colleges of Pharmacy Annual Meeting, Dallas, TX. July 2014.

Hamilton LA, Suda KJ, Heidel RE, McDonough S, Franks A. The Role of Online Learning in Pharmacy Education. Poster Presentation: American Association of Colleges of Pharmacy Annual Meeting, Dallas, TX. July 2014. Hsu G, Paolella G, Wirth SM, Cuellar Puri S, Venepalli N, Crawford SY, Boyd AD. Mobilizing for patient adherence to cancer therapies (mPACT). Oral Presentation: Consumer Health Informatics in the Midwest (CHIM) Meeting, Fort Wayne, IN. Oct 25, 2014. Jalundhwala YJ*, Manzoor BS*, Patel HD*, Cheng WH*, Patel PA, Touchette D. Cost-effectiveness of pharmacotherapies for treatment naïve hepatitis C genotype 1 patients: A payer's perspective. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research 19th Annual International Meeting, Montreal, QC, Canada. June 4, 2014. Jiang R*, Ursan I*, Pickard EM, Lee TA, Ng D, Pickard AS. Emergence of BCR-ABL1 Kinase Domain Mutations Associated with Newly Diagnosed Chronic Myeloid Leukemia: A Meta-Analysis of Clinical Trials of Tyrosine Kinase Inhibitors. Poster Presentation: Academy of Managed Care Pharmacy, 26th Annual Meeting & Expo, Tampa, FL. April 1-4, 2014. Judeh I*, Khamo N, Abdou S, and Stubbings JA. Workflow platform for a health system based specialty pharmacy. Poster Presentation: 49th American Society of Health System Pharmacists, Anaheim, CA. December 9, 2014. Kim K*, Ardati A, Cavallari LH, DiDomenico RJ, Touchette DR. Cost-Effectiveness of genotype and phenotype driven P2Y12 antagonist selection in the patients with acute coronary syndrome: A model based approach. Oral & Poster Presentation: American College of Cardiology 63rd Annual Scientific Session & Expo, Washington, DC. March 2014. Abstract published in: Journal of the American College of Cardiology 01/2014 63(12):A24. Kim K*, Lee TA, Schumock GT. Potential confounding by indication in the association between leukotriene-modifying agent use and suicide attempts in patients with asthma. Poster Presentation: UIC College of Pharmacy Research Day, Chicago, IL. March 7, 2014. Lee WJ*, Lee TA, Pickard SA, Shoaibi A, Schumock GT. Feasibility of alternative methods for health outcomes of interest algorithm validation. Poster Presentation: 30th Anniversary International Conference on Pharmacoepidemiology & Therapeutic Risk Management, Taipei, Taiwan. October 27, 2014. Lee YM*, Drozda K*, Hoop J, Duarte JD, Cavallari LH, Nutescu EA. Barriers to implementing pharmacogenetic testing in an urban population. Poster Presentation: American College of Clinical Pharmacy Annual Meeting, Austin, TX. October 12-15, 2014. Abstract published in: Pharmacotherapy 2014;34(10):e252:287. Levy J, Nutescu EA, Meyer J. Post Hoc Analysis of Desirudin Versus Enoxaparin for Thromboprophylaxis in High-Risk Patients Undergoing Elective Hip Replacement Surgery. Poster Presentation: American Society of Hematology 56th Annual Meeting and Exposition, San Francisco, CA. December, 6-9 2014. Abstract published in: Blood 2014:124(12):5086.

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Lin FJ, Lee TA, Joo M, Pickard AS. Inhaled anticholinergic medications and risk of urinary retention. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research Asia Pacific Conference, Beijing, China. Sept 6-8, 2014. Norman R, King MT, Costa D, Aaronson N, Cella D, Fayers P, Kemmler G, Pickard AS, Street D, Velikova G, Young T, Viney R on behalf of the MAUCa Consortium. Importance vs severity in the development of utility-based measures of health. Oral Presentation: International Society for Quality of Life Research, 21th Annual Conference, Berlin, Germany. October 15-18, 2014. Norman R, King MT, Costa D, Aaronson N, Cella D, Fayers P, Kemmler G, Pickard AS, Street D, Velikova G, Young T, Viney R on behalf of the MAUCa Consortium. Valuing a utility instrument derived from the EORTC QLQ-C30 (QLU-C10D): feasibility and respondent preference for presentation of 10 domains in a discrete choice experiment (DCE). Oral Presentation: International Society for Quality of Life Research, 21th Annual Conference, Berlin, Germany. October 15-18, 2014. Abstract published in: Qual Life Res (2014) 23:29. Nutescu EA, Song X, Bookhart B, Shi N, Raut M, Damaraju CV, Schein J, Kaatz S. Mortality Rates Among Patients With Venous Thromboembolism on Anticoagulant Therapy. Poster Presentation: American Heart Association’s 2014 Scientific Sessions, Chicago, IL. November 15-19, 2014. Abstract published in: Circulation 2014;130:A16875. Nutescu EA, Duarte J, Cheng WH*, Sarangpur S*, Gor D*, Manzoor BS*, Galanter N, Drozda K*, Galanter W, Stamos T, Peace D, Garofalo J, Bauman J, Krishnan J, Cavallari LH. Novel Genotype Guided Personalized Warfarin Service Improves Outcomes in an Ethnically Diverse Population. Poster Presentation: American Heart Association’s 2014 Scientific Sessions, Chicago, IL. November 15-19, 2014. Abstract published in: Circulation 2014;130:A16119. Patel V*, Walton S, Galanter W, Lee T, Schumock GT, Nutescu EA. The validity of algorithms for identifying suspected and confirmed heparin-induced thrombocytopenia. Poster Presentation: UIC College of Pharmacy Research Day, Chicago, IL. March 7, 2014. Pickard AS, Lee TA, Mody S, Durkin M. A Comparison of Dosing Patterns and Pharmacy Costs of Three Commonly Prescribed Oral Long-Acting Opioids: Tapentadol ER, Oxycodone CR, and Oxymorphone ER. Poster Presentation: Academy of Managed Care Pharmacy, 26th Annual Meeting & Expo, Tampa, FL. April 1-4, 2014. Ren J, Asche CV, Kirkness CS. Risk on using logistic regression to illustrate exposure-response relationship of infectious disease. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research, Montreal, QC, Canada. May 31-June 4, 2014. Sarangpur S*, Sharp L, Gerber B, Schumock GT, Fitzgibbon ML, Cavallari LH, Bathija S, Nutescu EA. The Impact of Missed Clinic Appointments on the Quality of Anticoagulation Control In an Inner-City Underserved Minority Population. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research 19th Annual International Meeting, Montreal, QC, Canada. May 31-June 4, 2014. Abstract published in: Value in Health 2014:17(3):A151;PHS152. Seal BS, Xia F, Germino R, Rietschel P, Zagadailov E, Asche CV, D'Souza A, Morland K, Eaddy M. An evaluation of national treatment trends in pancreatic cancer. E-abstract Presentation: 2014 American Society of Clinical Oncology Annual Meeting, Chicago, IL. May 30 – June 3, 2014.

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Seal BS, Sagadailov E, Farrelly E, Asche CV, Germino R, Rietschel P, Eaddy M, Stafkey-Mailey D. Evaluating costs and utilization of prostate cancer patients with bone metastases in the outpatient hospital setting. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research, Montreal, QC, Canada. May 31- June 4, 2014. Seal BS, Xia F, Rietschel P, Germino R, Asche CV, D'Souza AO, Morland K, Eaddy M. Treatment patterns and cost of care for patients with pancreatic cancer. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research, Montreal, QC, Canada. May 31-June 4, 2014. Seal BS, Xia F, Stafkey-Mailey, Asche CV, Zagadailov E, Eaddy M. Treatment patterns and cost of care for patients with gastrointestinal stromal tumor (GIST) treated with Imatinib. Poster Presentation: International Society for Pharmacoeconomics and Outcomes Research, Montreal, QC, Canada. May 31-June 4, 2014. Stafkey-Mailey D, Seal BS, Xia F, Rietschel P, Germino R, Asche CV, Zagadailov E, Eaddy M. An evaluation of national treatment trends and survival in GIST. E-abstract Presentation: 2014 American Society of Clinical Oncology Annual Meeting, Chicago, IL. May 30 - June 3, 2014. Stubbings, JA. Managing Growth in a Health-System Based Specialty Pharmacy: Strategies for Access and Payment. Oral Presentation: 49th American Society of Health System Pharmacists, Anaheim, CA. December 10, 2014. Suda KJ, Reynolds T, Akkina J, Halasz S, Burkom H. Where do you find interesting biosurveillance publications? Poster Presentation: International Society of Disease Surveillance, Philadelphia, PA. December 2014. Valenzuela RM, Gonia LM, Taylor AJ, Wankel K, Cooley KL, Parry VL, Asche CV. Demographic and clinical characteristics of Multiple Sclerosis (MS) patients treated at the Illinois Neurological Institute (INI) MS Center. Poster Presentation: OSF 2014 Annual Research Symposium, Peoria, IL. May 6, 2014. Yousif DJ*, Stubbings JA, and Martin MT. Patient satisfaction with health-system based specialty pharmacy services compared with usual care. Poster Presentation: 49th American Society of Health System Pharmacists, Anaheim, CA. December 9, 2014. Zah V, Prado M, Chowdbury T, Asche CV. Workshop Abstract. From Traditional Databases to Big Data ¬ Has the Future Arrived? Oral Presentation: International Health Economics Association, Dublin, Ireland. July 12-16, 2014. Zhong Y, Kamalakar R, Asche CV, Seal B. Evaluate algorithms for identifying treatment patterns for patients with metastatic colorectal cancer using administrative claims data. Poster Presentation: American Society of Clinical Oncology Quality Care Symposium, Boston, MA. October 17-18, 2014. Zhong Y, Kamalakar R, Asche CV, Seal B. Treatment patterns of patients with metastatic colorectal cancer in a large national U.S. claims-based data. Poster Presentation: American Society of Clinical Oncology Quality Care Symposium, Boston, MA. October 17-18, 2014.

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Invited Presentations Asche, CV. “Evaluation of Medical Quality Based on Readmissions within 30 Days.” Grand Rounds, Department of Surgery, Order of Saint Francis Medical Center, Peoria, IL. 2014. Asche, CV. “Review of Models Used in Economic Analyses of New Oral Treatments of Type 2 Diabetes Mellitus.” 2014 Mount Hood Challenge Conference, Stanford University, Stanford, CA. June 2014. Asche, CV. “Big Data for Big Questions.” Real World Evidence & Data Partnerships Summit, Bethesda, MD. October 2014. Asche, CV. “Big Data for Big Questions.” GLG Life Sciences Research Webcast. 2014. Crawford, SY. “Medication Therapy Management programs for commercially-insured populations – opportunities, barriers, and lessons learned.” Heath Outcomes Research Seminar Series, University of Illinois at Chicago, Center for Clinical and Translational Science, Chicago, IL. February 2014. Crawford, SY. “Quantitative research designs – strengths and weaknesses.” Summer Program in Clinical and Translational Research Methods, University of Illinois at Chicago, Center for Clinical and Translational Science, Chicago, IL. July 2014. Crawford, SY. “Life and death in a prescription bottle.” UIC Summer College Lecture Day, University of Illinois at Chicago, Chicago, IL. June 2014. Crawford, SY. “Survey design and evaluation.” Chicago State University, College of Pharmacy, All-College Retreat, Chicago, IL. January 2014. DiDomenico, RJ. “Hypertensive Emergencies.” Panelist: 2014 American College of Cardiology Scientific Sessions, Washington, DC. March 2014. Nutescu, EA. “Models of Systematic Anticoagulation Care in the US.” American College of Cardiology Anticoagulation Consortium, Washington, DC. September 2014. Pickard, AS. “Incorporating Patient-Reported Outcome Measures in Reimbursement Decision-Making: Measuring and Valuing Health.” 25th Annual Meeting, Canadian Agency for Drug and Technologies in Health (CADTH), Gatineau, QC, Canada. April 2014. Pickard, AS. “Mapping health utilities: where does this road lead?” International Society for Pharmacoeconomics and Outcomes Research, Chicago-Regional Chapter Webinar. October 2014. Schumock, GT. “National Trends in Prescription Drug Expenditures and Projections: How to Apply to Your Institution.” MedAssets Midwest Regional Pharmacy Meeting at Advocate-Lutheran General Hospital, Park Ridge, IL. September 2014. Schumock, GT. “Exploring Medication Safety in Children.” China Medical University, Taichung, Taiwan. October 2014.

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Schumock, GT. “Exploring Medication Safety in Children.” National Taiwan University, Taipei, Taiwan. October 2014. Schumock, GT. “Exploring Medication Safety in Children.” Taipei Medical University, Taipei, Taiwan. October 2014. Sharp, LK. “Approaches to Supporting Diabetes Self-Management in Underserved Populations.” 7th Annual Diabetes Symposium of Wisconsin, Medical College of Wisconsin, Division of Endocrinology, Metabolism, and Clinical Nutrition , Milwaukee, WI. May 2014. Sharp, LK. “Rationale and implementation of a community health worker and clinical pharmacist medical home to support adherence in chronic disease.” Pulmonary, Critical Care, Sleep & Allergy Research Conference Series, University of Illinois at Chicago, Chicago, IL. January 2014. Stubbings, JA. “Managing Growth in a Health-System Based Specialty Pharmacy: Strategies for Access and Payment.” 49th American Society of Health System Pharmacists, Anaheim, CA. December 2014. Suda, KJ. “Biostatistics and Clinical Study Design.” Loyola University, College of Medicine, Chicago, IL. August 2014. Touchette, DT. “Impacting adherence to medications.” Takeda Pharmaceutical SMART Program, Deerfield, IL. February 2014. Walton, SM. “Show me the Money: Methods in Economic Evaluation.” Achieving Excellence in Clinical Research: Scientific, Ethical and Operational Considerations Conference, Advocate Childrens Hospital, Chicago, IL. September 2014. Walton, SM. “Cost Effectiveness of Pilot Programs within the Centers for Population Heath and Health Disparities.” HOSS Seminar, University of Illinois at Chicago, Chicago, IL. January 2014.

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E. Faculty Recognition

Editorial Boards American Journal of Health-System Pharmacy, Co-Field Editors: Schumock GT, Crawford SY. Annals of Pharmacotherapy, Editorial Board Member: Nutescu EA. Anticoagulation Forum, Centers for Excellence On-Line Resource, Editorial Board Member: Nutescu EA. Clinical Care Reports, Associate Editor: Calip GS. ClotCare - OnLine Resource for Health-Care Professionals, Editorial Board Member: Nutescu EA. Current Medical Opinion and Research, Editorial Board Member: Asche CV. ISRN –Stroke, Editorial Board Member: Pickard, AS. Journal of Comparative Effectiveness Research, Associate Editor: Schumock GT. Journal of the American Pharmacists Association, Editorial Advisory Board Member: Calip GS, Crawford SY. Medical Decision Making, Editorial Board Member: Pickard AS. Open Journal of Pharmacoeconomics, Editorial Advisory Board Member: Pickard AS. Pharmacoeconomics, Editorial Board Members: Asche CV, Schumock GT. Pharmacotherapy, Editorial Board Members: Nutescu EA, Schumock GT. Quality of Life Research, Associate Editor: Pickard AS. Quality of Life Research, International Advisory Board Member: Pickard AS. Reviews on Recent Clinical Trials, Associate Editor: Nutescu EA. The Open Antimicrobial Agents Journal, Editorial Board Member: Asche CV. Thrombosis, Editorial Board Member: Nutescu EA.

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Professional Association Service American Association of Colleges of Pharmacy: Social and Administrative Sciences Membership Survey Analysis/Assessment Committee Chair: Crawford SY; Membership Committee Chair: Suda KJ. American Cancer Association: Regional Leadership Board Member: Asche CV. American College of Cardiology: Anticoagulation Consortium Member: Nutescu EA. American College of Clinical Pharmacy: Board of Regents Member: Nutescu EA; Pharmacotherapy Board of Directors Chair: Nutescu EA; Clinical Practice Affairs Committee Appointed Member: Nutescu EA. American Society of Health-System Pharmacists: Section of Home, Ambulatory, and Chronic Care Practitioners - Cognitive Services Reimbursement Resources Advisory Group Member: Nutescu EA. Anticoagulation Forum: Board of Directors Member: Nutescu EA. Centers for Medicare and Medicaid Services: Medicare Provider Feedback Group Member: Stubbings JA. Chicago Department of Public Health: Advisory Board Member: Qato DM. Chicago Asthma Consortium: Board of Directors Member: Sharp LK. EuroQol Group: Executive Committee Deputy Chair: Pickard AS; Data Archive Working Group Deputy Chair: Pickard AS. Guidelines and Economists Network International: Board Member: Asche CV. Illinois Council of Health-System Pharmacists: Government Affairs Committee Member: Stubbings JA. Illinois Department of Human Services: Clinical Care Advisory Group: Pickard SA. Institute of Health Metric Evaluation: Global Burden of Disease Expert Panel Member: Qato DM. International Health Economics Association: Strategic 2020 Planning Committee Member: Asche, CV; 10th World Congress of Health Economics Scientific Committee: Asche CV. International Society of Disease Surveillance: Biosurveillance Papers of the Year Selection Committee Member: Suda KJ; Trainee Abstract of the Year Selection Committee Member: Suda KJ. International Society of Pharmacoeconomics and Outcomes Research: Classification of Databases Working Group, Co-Chair: Asche CV; Chicago Regional Chapter Board of Directors: Asche CV; Chicago Regional Chapter Board, Director of Communications: Asche CV; 20th Annual International Meeting Research Review Committee Co-Chair: Asche CV; Bernie J. O’Brien New Investigator Award Committee Member: Lee TA; National Council of Faculty Advisors for Student Chapters Member: Pickard AS; UIC Student Chapter Advisor: Pickard AS.

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National Blood Clot Alliance: Medical and Scientific Advisory Board Member: Nutescu EA. National Center for Quality Assurance: Respiratory Measurement Advisory Panel Member: Lee TA. University Health System Consortium: Specialty Pharmacy Task Force Member: Stubbings JA. United States Food and Drug Administration: Joint Meeting of the Arthritis Advisory Committee and Drug Safety and Risk Management Advisory Committee member: Crawford SY. United States National Institutes of Health: National Center for Research Resources, National Consortium of Clinical and Translational Sciences Award Institutions, Comparative Effectiveness Research Key Function Committee Member: Schumock GT. United States Pharmacopeia: Pronunciation Project Expert Panel Member: Crawford SY; Nomenclature, Safety, and Labeling Expert Committee Vice Chair: Crawford SY; NSL/PSD Teaspoon Consensus Joint Subcommittee Member: Crawford SY. United States Department of Veterans Affairs: SCI/D QUERI Executive Committee Member: Suda KJ; SCI/D QUERI Infection Prevention and Management Committee Member: Suda KJ; Cross-QUERI Resource Center for Improving Prescribing Practices Steering Committee Member: Suda KJ.

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Awards

Asche CV. UIC College of Medicine – Peoria 2014 Outstanding Researcher Award. November 2014. Crawford SY. American Pharmacists Association Wiederholt Prize for Best Published Paper Award for Economic, Social and Administrative Sciences (co-recipient). March 2014. Crawford SY. United States Pharmacopeia Award for Outstanding Contribution to the Standards-setting Process presented to USP Nomenclature, Safety, and Labeling Expert Committee (Co-Recipient as Committee Vice-Chair). September 2014. Qato DM. Palestinian American Research Center 2014-15 Fellow. February 2014. Qato DM. American Public Health Association 2014 James G. Zimmer New Investigator Award Honorable Mention. November 2014. Schumock GT. American Society of Health-System Pharmacists Foundation Award for Sustained Contribution to the Literature. December 2014. Touchette DR and Schumock GT. American Pharmacists Association – Academy of Pharmaceutical Research and Science Clinical Research Paper Award. March 2014. Touchette DR. University of Illinois at Chicago and Takeda Pharmaceutical Company Professorship in Medication Adherence. March 2014.

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F. Training As a leading research center, the CPR seeks to promote the advancement of research in pharmacoepidemiology, pharmacoeconomics, and pharmaceutical comparative effectiveness by providing post-doctoral research training fellowships and other experiences. Fellowships Fellowships have been offered by the CPR for more than a decade and past CPR fellows/trainees have gone on to successful careers in the pharmaceutical industry, academia, managed care, and consulting sectors. The CPR had 6 fellows in various stages in their programs in 2014. Table E1. CPR fellow program graduates

Fellow Year/s Program Sponsor

Grace Shin 1999-2001 Pharmacia

Bhakti Arondekar 2000-2002 Pharmacia

Melissa Butler 2001-2003 Pfizer

Nima Patel (now Shori) (PGY2) 2001-2002 VA/TAP

Hayley Park 2002-2004 Walgreens

Juan Blackburn 2003-2005 UIC

Shiraz Gupta 2005-2007 TAP

Vikrant Vats 2005-2008 UIC/Walgreens

Alexandra Perez (now Rivera) 2006-2008 UIC

Robert Wittenberg 2007-2008 Takeda

Caitlyn Wilke (now Solem) 2007-2010 Novo Nordisk

Yoojung Yang 2008-2011 UIC/Takeda

Charisse DeLeon 2008-2009 Takeda

Firas Dabbous 2009-2010 Takeda

Funda Tiryaki 2009-2011 UIC

Rima Tawk 2010-2012 Takeda

Jennifer Samp 2011-2013 Takeda

Hari Patel (current) 2012-2014 Takeda

Patrick Zueger (current) 2013-2015 Astellas

Iulia Ursan (current) 2013-2015 Takeda

Varun Kumar (current) 2014-2016 Takeda

Ernest Law (current) 2014-2016 Takeda

Shan Xing (current) 2014-2016 Takeda

K-Award Trainees

Faculty of the CPR are involved as mentors for individuals participating in both individual and institutional K-award programs. There have been four trainees at UIC, as shown in the table below. In addition, CPR faculty have served as primary mentors for individual K-awards – some of these through 2014. Table E2. K-award trainees

Trainee Year/s Sponsor Primary Mentor

Min Joo, MD 2009-2014 NHLBI Todd Lee

Rahul Khare, MD 2010-2015 AHRQ Todd Lee

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Graduate Training CPR faculty serve as advisors or thesis/dissertation committee chairs/members for students enrolled in Master or PhD programs on campus. In 2014, five students completed programs where a CPR faculty member served as their major advisor. Table E3. MS/PhD program graduates with CPR faculty advisors

Graduate Year Completed

Degree Major Advisor

Sudhir Sanugale 2001 MS Surrey Walton

Yu (Nancy) Ko 2003 MS Swu-Jane Lin

Bhakti Arondekar 2004 PhD Surrey Walton

Mehul Dalal 2006 PhD Simon Pickard

Chaitanya Sarawate 2003 MS Surrey Walton

Shih-Ying (Audrey) Hung 2005 MS Simon Pickard

Xue Grace Chiou 2009 MS Surrey Walton

Nasreen Khan 2006 PhD Swu-Jane Lin

Zhixiao (Jason) Wang 2006 PhD Surrey Walton

Eunmi Jung 2007 MS Simon Pickard

Xiaoyan (Charlene) Ying 2007 MS Surrey Walton

Caitlyn Wilke (now Solem) 2007 MS Simon Pickard

Hongjun Yin 2006 PhD Swu-Jane Lin

Hsiang-Wen (Margaret) Lin 2008 PhD Simon Pickard

Alexandra Perez (now Rivera) 2009 MS Surrey Walton

Shengsheng Yu 2009 MS James Shaw

Yash J. Jalundhwala 2010 MS James Shaw

Xiaoqing (Frank) Liu 2010 PhD Surrey Walton

Caitlyn Wilke (now Solem) 2010 PhD Simon Pickard

Yoojung Yang 2010 MS Glen Schumock

Xiaochen Luo 2011 MS James Shaw

Sruthi Adimadhyam 2012 MS Glen Schumock

Jennifer Samp 2012 MS Simon Pickard

Sacheeta Bathija 2013 MS Surrey Walton/Edith Nutescu

Fang-Ju (Irene) Lin 2013 PhD Simon Pickard

Wei-Han (Wendy) Cheng 2014 MS Walton

Anurag Mohan 2014 MS Crawford

Kun Peng 2014 MS Lee

Shishir Sarangpur 2014 MS Nutescu

Shradda Shinde 2014 MS Schumock

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Seminars The CPR seeks to advance understanding of pharmaceutical outcomes research by sponsoring seminars, webinars, and other learning opportunities. Table E5 provides a list of such CPR sponsored programs in 2014. Table E4. Seminars sponsored by CPR in 2014

Date Series Speaker Name Institution Title

01/16/2014 HOSS Surrey Walton, PhD UIC Costs of Pilot Programs within the Centers for Population Health and Health Disparities: A Case for Allied Health?

01/23/2014 ISPOR Steve Albert, PhD University of Pittsburgh Economic Drivers in Fall Prevention

01/28/2014 ISPOR Jonathan Karnon, PhD & James Stahl, MDCM, MPH

University of Adelaide & Harvard University, respectively

Modeling Using Discrete Event Simulation

2/20/2014 HOSS Stephanie Crawford, PhD, MPH

UIC Medication Therapy Management Programs for Commercially-Insured Populations – Opportunities, Barriers, and Lessons Learned

2/26/2014 ISPOR Gurkipal Singh, PhD Stanford University Database Research: Can you Believe Your Own Findings?

03/06/2014 PD Al Edwards, PharmD UIC Drug Safety: The FDA Perspective

03/20/2014 HOSS Lindsey Leininger, PhD

UIC Using Self-Report Health Measures to Predict High-Need Cases among Medicaid-Eligible Adults

04/02/2014 ISPOR Frank Corvino, PHD Genesis Life Sciences Constructing health Economics Models Based on PK/PD Profile

04/04/2014 ISPOR Mark Roberts, MD, MPP

University of Pittsburgh Conceptualizing a Model

04/17/2014 HOSS Dan Touchette UIC Introduction to Practice-Based Research and the American College of Clinical Pharmacy’s Research Network

09/18/2014 HOSS Margie Snyder Purdue Medication Therapy Management Services: For who and how?

09/23/2014 ISPOR Josephine Mauskopf, PhD, MHA, MA & Daniel Mullins, PhD

RTI Health Solutions & University of Maryland, respectively

Principles of Good Practice for Budget Impact Analysis

10/09/2014 PD David Mott University of Wisconsin Studying the Role of the Community Pharmacists in Falls Prevention for Older Adults

10/16/2014 HOSS Kevin McConeghy, PharmD, MS

UIC The Impact of Pharmacy Based Immunization Regulations on Influenza Vaccination in the U.S.

10/23/2014 ISPOR Marc Berger, MD & Bradley Martin, PharmD, PhD

Pfizer & University of Arkansas, respectively

Tools for Assessing Evidence for Health Care Decisions I: Assessing Prospective and Retrospective Observational Studies

11/20/2014 HOSS Rachel Caskey UIC Barriers to Acceptance and Utilization of the HPV Vaccine

11/20/2014 ISPOR J. Jaime Caro Evidera Tools for Assessing Evidence for Health Care Decisions II: Assessing Modeling Studies

HOSS = Health Outcomes Seminar Series. This is jointly sponsored by CPR and the UIC Center for Clinical and Translational Sciences (CCTS) PD = Professional Development Series. Jointly sponsored by CPR, ISPOR-Student Chapter, and Office of Professional Development ISPOR Webinars = Participation in this webinar series is made available through CPR and ISPOR Regional and Student Chapters

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2014 CPR Annual Report

Editors: Todd Lee, PharmD, PhD, Edith Nutescu, PharmD, MS CTS, Simon Pickard, PhD, Surrey Walton, PhD Design: Chris Gummert Photography: Joshua Clark