1

CPCRN Mission

To accelerate the adoption of evidence-based

cancer prevention and control in

communities.

2

CDC/NCI Interagency Collaboration

• Dissemination– Joint interest

• CDC/NCI (Application/Research)

– Complimentary strengths• Shared interest in cancer• Shared vision of CDC and NCI

– Cancer care in the United States needs to improve.

– Our investment in research needs to affect practice

3

Changes at NCI

• Welcome a new team leader– Russ Glasgow PhD

• Continue the same team– Cynthia Vinson– Michael Sanchez

• Continue the same emphasis– Turning your vision 900 to your work

• Measuring & understanding the dissemination process

4

What we expect of you

• Short term products– At least one all site project

• Progress in your own projects

– Active working groups to achieve the goals– Consider the SIP announcement

• FQHC, connection to Comprehensive Cancer• Use of existing cancer control resources (Planet)

• Intellectual power– Synthesis/integration/evaluation

• Progress in the measurement of dissemination• Expanded collaboration

– I’ll welcome you at NCI

5

I’m on to Other work

• Two big initiatives on the horizon– Multilevel interventions– Population Registries Opitmizing Screening

through Personalized Regimens (PROSPR)

Multilevel Interventions in Health Care: Building the Foundation for

Future Research

NCI Team

Stephen Taplin, MD MPH, Steve Clauser PhD

Rebecca Anhang Price PhD, Erica Breslau PhD, Veronica Chollette MS RN, Heather Edwards PhD, Irene Prabhu Das PhD

External ConsultantsArny Kaluzny PhDMartin Charns PhD, Maria Fernandez Phd, Mary Fennel PhD, Ernie Hawk MD, Tom Vogt MD, Jane Zapka ScD

Health care is a process affected by multiple contextual influences

We need to conduct research that evaluates these effects

• Traditional focus– Individual/family– Individual/physician– Effects of context on individual behavior

• Little examination of interactions among contextual influences

• Little examination of interventions that affect multiple levels (e.g. 3 or more)

Conference on the Horizon

• Multilevel Interventions in Health Care: Building the Foundation for Future Research– March 4-5, 2011, in Las Vegas, NV– Guided by an external consulting committee

• JNCI supplement– 11 Papers that grew out a June 2009 meeting

• Focus on factors affecting implementation– Contextual influences

Focus on Research Translation and Implementation

Discoveries(e.g. geneticrisk factor)

CandidateApplication(e.g. test)

Practice &Control

Programs in Communities

Reducing the Burden of Disease in

Communities

T1: Epi, Cohorts, Biobanks

Evidence basedGuideline/

Policy

T2: Clinical studies, RCTs

T3: Implementation Research

T4: OutcomesResearch

Adapted from Khoury et al; Gen Med 2007

Trials• Phase I• Phase II

• Phase III

• Phase IV

PROSPR

PROSPR Objectives

Primary Study the comparative effectiveness and outcomes of

existing and emerging cancer screening processes Breast Colon Cervical cancer.

Study the balance of benefits and harms of cancer screening across recognized cancer risk levels

Secondary Share data and conduct preliminary studies relevant

to future innovative research to optimize the screening process.

75 million over 5 years 9-12 sites, 1 statistical coordinating center

Natio

nal C

ance

r Ins

titut

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U.S. DEPARTMENTOF HEALTH AND HUMAN SERVICES

National Institutesof Health

Thanks

• It has been my pleasure and my privilege to work with you

• You are in good hands