"COVID19 update and the effectiveness of the

AstraZeneca vaccine"

Dr Ian Marr – MBBS FRACP FRCPA

Infectious Disease Physician and Microbiologist

COVID-19

https://apressnews.com/coronavirus-can-enter-body-through-eyes-scientists/

PLoS Pathog. 2020 Oct; 16(10): e1009037. Published online 2020 Oct30. doi: 10.1371/journal.ppat.1009037

Outcomes

Long COVID

Examples of long COVID

“My biggest takeaway from this

experience is that no matter how great of

shape you are in physically, no matter

what your age is, that you’re not immune

from things like this.”

“Miller…. said he was left shaken up by

shortness of breath and coughing when

he tried to sleep. He said he felt himself

“fatiguing faster” when he first tried

working out again in his home gym, but

that now he was training “full-on” again.”

Molecular suite – PC2

Open System: NAAT

• Master mix• Automated Vs Manual

District - sample prep

How does this improve?

• Vaccination

AstraZeneca

• What does 68% effective mean?

• What are the breakthrough infections?

• What are the protections to the Delta variant?

• What are all the differences in variants?

• Why are they talking about these variants?

Variants of concern

Variants of concern

Variants of concern

Vaccine facts

• No vaccine is 100% effective.

• Breakthrough cases occur for all vaccine preventable conditions.

• Breakthrough infections are mostly much milder

B and T cell immunity

https://www.nature.com/articles/s41577-020-00436-4

COVID-19 immunity

"got 99 problems but a vax ain't one“

- Stephen Harmon

1 month battle with COVID Died: Wednesday, July 21

Breakthrough deaths

Benefit of Vaccination

Vaccine induced immune thrombotic thrombocytopenia (VITT)/ Vaccine induced prothrombotic immune thrombocytopenia (VIPIT)

How to recognize this rare disorder

• Post adenovirus vectored vaccine (AZ / JJ) +/- Sputnik (4-30d)

• THROMBOCYTOPENIA (10 – 100microL)

• THROMBOSIS• Venous

• Arterial

• COAGULATION ABNORMALITY

• Measure D-dimer / Pf4 Ab / Plt

Treatment

• IVIG 1g/kg daily x 2d

• DOAC (Rivaroxaban) OR Fondaparinux

• Avoid heparin / clexane

• Avoid aspirin

Measuring risk

Breakthrough deaths

Questions

• Treatment?

• Spread?

• Protection?

• Testing?