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COURSE STRUCTURE
M. Sc. Chemistry
Session 2019-2021
Department of Chemistry
Babasaheb Bhimrao Ambedkar University
(A Central University)
Lucknow- 226 025
2
Annexure-II
Department of Chemistry
SEMESTER I
Subject
Code
Subject name Credit Marks
MCH-
CBCS-101
Elective-I
MCH-CBCS-101 (01): Chemistry in Life-I
MCH-CBCS-101 (02): Applied Chemistry-I
4 70 (End semester exam)
+30 (Internal exam)
MCH-102 Organic Chemistry-I 4 70 (End semester exam)
+30 (Internal exam)
MCH-103 Physical Chemistry-I 4 70 (End semester exam)
+30 (Internal exam)
MCH -104 Inorganic Chemistry-I 4 70 (End semester exam)
+30 (Internal exam)
MCH-105 Lab Course-I
8 70 (End semester exam)
+30 (Internal exam)
SEMESTER II
MCH-
CBCS-201
Elective-I
MCH-CBCS-201 (01): Chemistry in Life-II
MCH-CBCS-201 (02): Applied Chemistry-II
4 70 (End semester exam)
+30 (Internal exam)
MCH-202 Organic Chemistry-II 4 70 (End semester exam)
+30 (Internal exam)
MCH-203 Physical Chemistry-II 4 70 (End semester exam)
+30 (Internal exam)
MCH-204 Inorganic Chemistry-II 4 70 (End semester exam)
+30 (Internal exam)
MCH-205 Lab Course-II
8 70 (End semester exam)
+30 (Internal exam)
SEMESTER III
MCH-301 Supramolecular, Bioinorganic and Bioorganic
Chemistry
4 70 (End semester exam)
+30 (Internal exam)
MCH-302 Organic Chemistry-III 4 70 (End semester exam)
+30 (Internal exam)
MCH-303 Physical Chemistry-III 4 70 (End semester exam)
+30 (Internal exam)
MCH-304 Analytical Chemistry 4 70 (End semester exam)
+30 (Internal exam)
3
MCH-305 Lab Course-III
8 70 (End semester exam)
+30 (Internal exam)
SEMESTER IV
MCH-401 Compulsory Paper
Spectroscopic Techniques in Chemistry
4 70 (End semester exam)
+30 (Internal exam)
MCH-402 Elective-I
CH-401 (01): Medicinal Chemistry
CH-401(02): Polymer Chemistry
CH-401(03): Environmental Chemistry
4 70 (End semester exam)
+30 (Internal exam)
MCH-403 Elective-II
CH-402(01): Electrochemistry
CH-402 (02): Computers in Chemistry
CH-402(03): Material Chemistry
4 70 (End semester exam)
+30 (Internal exam)
MCH-404 Project 8 100 (Final)
MCH-405 Seminar 4 100 (Final)
(Dr. Jawahar Lal) (Dr. Shailesh Kumar)
(Invitee) (Invitee)
(Dr. Jyoti Pandey) (Dr. Anjani Tiwari)
(Invitee) (Invitee)
(Dr. Preeti Gupta) (Prof. Gajanan Pandey)
(Member) (Member)
(Prof. Kuldip Singh Dhindsa) (Prof. Kaman Singh)
(External Member) (Chairman)
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ANNEXURE II
SYLLABUS
SEMESTER I
MCH-CBCS-101 (01): CHEMISTRY IN LIFE-I 60hrs
Unit-I
Pharmaceutical and Drug Regulations
Regulatory aspects of pharmaceutical and bulk drug manufacture: DRA, FDA, CDSCO, IPR-
Patent, Patent approval process, Industrial Design, Trade mark, copyright, regularity aspects of
pharmaceutical & drug manufactures. Good manufacturing practices (GMP). Diagnostic and
therapeutic Radio pharmacy
Unit II
Drugs and Medicines- Similarity and differences, mode of Drug action, types of medicines;
Role of medicinal chemists- Journey of molecules from lab to market; Lipinski's Rule;
Current trends in Drug discovery-Drug Discovery Pipeline, Chiral Drugs: Importance & their
stereo electronic properties of drug molecus, Classification of drugs: on basis of
pharmacological activity, chemical structure, and origin, Methods of administration of drugs.
Modern Drugs for CNS, Clinical trials- Testing of new compound on human.
Unit-III
Green Chemistry
Introduction: Principles and Concepts of Green Chemistry, Prospects and future of Green
Chemistry, Twelve guiding principles of green chemistry, Green solvents, Green catalysis, Non-
conventional energy sources.
Unit IV
Polymer Chemistry
Basic concept: Classification of polymers (with suitable examples) based on origin, structure,
backbone, branching. Types of polymerization, Important thermoplastic and thermosetting
resins, Biomedical applications of polymers, Polymer supported reagents.
Recommended Books:
1. Drug Regulatory Affairs by V.Sai Kishore (Ikon Books)
2. Fundamentals in medicinal chemistry- G. Thomas. 2nd edition
3. Introduction to medical Chemistry, G. L. Patrick
4. Medicinal Chemistry- Ashutoshkar
5. Medicinal Chemistry- Sreeram and Yogeshwari
6. Medicinal Chemistry & Drug discovery- Burger (Volume 1-6)
7. Strategies for organic synthesis and Design -D. Lednicer
8. Burger’s Medicinal Chemistry vol. 1to6
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9. Green Chemistry: Theory and Practice. P.T. Anastas and J.C. Warner. Oxford University
Press.
10. Green Chemistry: Introductory Text. M. Lancaster Royal Society of Chemistry (London).
11. Introduction to Green Chemistry. M.A. Ryan and M.Tinnesand, American Chemical Society
(Washington).
12. Alternative Solvents for Green Chemistry. F.M. Kerton. Royal Society of Chemistry
(London).
13. Textbook of polymer science, F.W. Billmayer Jr. Wiley
14. Polymer Science, V.R. Gowarikar, N.V. Vishwanathan and J. Shreedhar, Wiley-Eastern
15. Introduction to Polymer Chemistry by Carraher Jr.
MCH-CBCS-101 (02): APPLIED CHEMISTRY-I 60hrs
Unit- 1
Surface active agents, Micelles, Advance Surface Chemistry
Surface active agent, classification of surface active agent, micellization, hydrophobic
interaction, critical micellar concentration (CMC), factors affecting the CMC of surfactant,
counter ion binding to micelles, thermodynamics of micellization – phase separation and moss
action models, solubilization, micro emulation, reverse micelles.
Gibbs adsorption isotherm, estimation of surface areas (BET equation), Surface film of liquids
electro- kinetic phenomenon), catalytic activity at surface. Chemical reactions on surfaces and
their mechanisms, various adsorption isotherms, Viz Freundlich, Langmuir, BET, Tempkin,
Radleich - Peterson, Dubini - Astakhov equation, Giles classification of adsorption isotherms.
Shapes. Activated carbon properties, adsorption capacity, iodine number, molasses number,
product density, mesh size, ash content, IUPAC classification of macro, meso and micro-porous
materials (pore size distribution), and industrial applications of adsorption.
Unit-2
Standard Protocols for Validation of Methods
Protocol for the design, conduct & interpretation of collaborative studies- 2005(IUPAC) AOAC
official 2002 methods of analysis, Appendix D: Guidelines for collaborative study procedure to
validate Characteristics of a method of analysis, ISO 5725 document.
Unit-3
Environmental Chemistry
The Atmosphere: Composition and structure of the atmosphere: troposphere, stratosphere,
mesosphere and thermosphere. Ozone layer and its role. Major air pollutants : CO, SO2, NO and
particulate matters –their origins and harmful effects, problems of ozone layer depletion, green
house effect, acid rain and photochemical smog, La Nino & El Nino. Air pollution episodes. Air
quality standard. Air pollution control measures: cyclone collector, electrostatic precipitator,
catalytic converter.
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The Hydrosphere: Environmental role of water, Water pollution control measures: waste water
treatment: chemical treatment and microbial treatment; water quality standards: DO. BOD, COD,
TDS and hardness parameters. Desalination of sea water: reverse osmosis, electro dialysis.
The Lithosphere: Water and air in soil, waste matters and pollutants in soil, waste classification,
treatment and disposal. Soil pollution and control measures.
Unit-4
Nanomaterial and Applied Green Chemistry
Nanomaterial, Role of size in nanomaterial, Semiconductor/Nanostructures/ nanowires/Nano
clusters/Carbon nanotubes: Synthesis & Application, Characterization techniques, Properties of
nanomaterial: optical, electronic, magnetic.
Need for Green Chemistry. Goals of Green Chemistry. Limitations/ Obstacles in the pursuit of
the goals of Green Chemistry, Strengthening/ development of analytical techniques to prevent
and minimize the generation of hazardous substances in chemical processes. Examples of Green
Synthesis/ Reactions and some real world cases, Green chemistry in sustainable development.
Recommended Books:
1. Physical Chemistry–P. W. Atkins, Oxford University press, VIIth edition, 2002
2. Physical Chemistry-K. L. Kapoor (Part-V)
3. Physical Chemistry- G. K. Vemulapalli, Prentice- Hall of India.
4. Environmental chemistry by A.K. De
5. Green Chemistry: Theory and Practice. P.T. Anastas and J.C. Warner. Oxford University
Press.
6. Green Chemistry: Introductory Text. M. Lancaster Royal Society of Chemistry (London).
7. Introduction to Green Chemistry. M.A. Ryan and M.Tinnesand, American Chemical Society
(Washington).
8. Alternative Solvents for Green Chemistry. F.M. Kerton. Royal Society of Chemistry
(London).
MCH-102: ORGANIC CHEMISTRY-I 60hrs
Unit-I
Nature of Bonding in Organic Molecules
Delocalized chemical bonding-conjugation, cross conjugation, resonance, hyperconjugation,
tautomerism. Reactive Intermediates-Generation, structure, stability and reactivity of
carbocations, carbanions, free radicals, carbenes,nitrenes and benzynes. Advanced treatment in
terms of detection techniques of reactive intermediates.
Aromaticity in benzenoid and non-benzenoid compounds, alternant and non-alternant
hydrocarbons, Huckel’s rule, energy of pi-molecular orbitals, annulenes, antiaromaticity,
homoaromaticity.
Unit-II
Stereochemistry
Concept of Chirality and molecular dissymmetry, R and S nomenclature, Geometrical isomerism
E and Z Nomenclature, Fischer projections, Sawhorse projections and Zig-zag notation and
interconversion, chirality without chiral centres: allenes, atropisomerism, prostereoisomerism,
prochiral relationship, homotopic, enantiotopic and diastereotopic atoms, groups and faces.
Stereospecific and stereoselective synthesis, asymmetric synthesis, enantioselective reaction
(Meerwein-Ponndorf-Verley reaction, Sharpless Epoxidation), Cram’s rule and Prelog’s rule,
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Racemic modifications and their resolution, enantiomeric excess (ee), Conformational analysis
of cyclohexanes and decalins, effect of conformation on reactivity, conformation of sugars.
Introduction to Circular Dichroism (CD) and Optical Rotatory Dispersion (ORD)
Unit-III
Reaction Mechanism: Structure and Reactivity
Energy consideration for reactivity, kinetics of reaction, kinetic and thermodynamic control,
Hammond’s postulate, intermediate vs transition state, Hammett equation, Curtin-Hammett
principle, Taft equation.
Methods of determination of reaction mechanism: a) product analysis; b) determination of
presence of intermediates; c) cross over experiment; d) isotopic labeling; e) stereochemical
evidence; f) kinetic evidence.
Unit-IV
(a) Aliphatic Nucleophilic Substitution
The SN2 , SN1 and mixed SN1 and SN2, SET mechanisms.
The neighboring group mechanism, Classical and nonclassical carbocations, common
carbocation rearrangements,The SNi mechanism. Nucleophilic substitution at an allylic, aliphatic
trigonal and vinylic carbon.
(b) Aromatic Nucleophilic Substitution
The SNAr, SN1, benzyne and SRN1 mechanisms.Reactivity-effect of substrate structure, leaving
group and attacking nucleophile. The von Richter, Sommelet-Hauser and Smiles rearrangements.
Recommended Books:
1. Stereochemistry by P. S. Kalsi (New Age International)
2. Stereochemistry of Carbon Compounds. (McGraw-Hill) E. L. Eliel
3. Organic Stereochemistry (McGraw-Hill) by Hallas.
4. Introduction to Stereochemistry (Benjumin)- K. Mislow
5. Stereochemistry of Organic Compounds- D. Nasipuri.
6. A Guide Book to Mechanism in Organic Chemistry (Orient-Longmens)-Peter Sykes
7. Reaction Mechanism in Organic Chemistry- S. M. Mukherji and S. P. Singh, revised by
S.P. Singh and Om Prakash, 2016 Edition.
8. Advanced Organic Chemistry-Reactions, Mechanism and Structure-J. March, (McGraw-
Hill).
9. Advanced Organic Chemistry, F.A. Carey and R., J. Sundber, Plenum.
10. Structure and Mechanism in Organic Chemistry-P.S. Kalsi
11. Organic Chemistry Vol. I. by I.L. Finar
12. Problems and Solutions by I.L. Finar
13. Modern Methods of Organic Synthesis by W Carruthers and I. Coldham
14. Organic Chemistry- R. T. Morrison and R. N. Boyd, (Prentice Hall)
15. Modern Organic Reactions (Benjamin) H. O. House.
16. Principle of Organic Synthesis-R. O. C. Norman and J. M. Coxon. (ELBS)
17. Basic Principles of Organic Chemistry (Benjamin) J. D. Roberts and M. C. Caserio.
18. Organic Chemistry (McGraw-Hill) Hendrikson, Cramand Hammond.
19. Modern Organic Synthesis: An Introduction, George S. Zweifel, Michael H. Nantz
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MCH -103: PHYSICAL CHEMISTRY-I 60hrs
Unit I
Chemical Dynamics
Theory for rate of reaction: collision, activated complex and unimolecular reaction i.e.
Lindemann, Thermodynamics of reaction rate. Reaction kinetics in solution, Salt effects: Primary
and secondary.
The fast reaction kinetics, Relaxation, NMR and flash photolysis methods. Oscillatory chemical
reaction, Belosov- Zhabotinsky reaction.
Photochemical reaction: Chain reaction involving H/Cl, H/Br reaction. Enzyme kinetics.
Unit II
Surface Chemistry
A. Adsorption
Laplace equation, Kelvin equation for vapor pressure of droplets, Gibbs adsorption isotherm,
Langmuir Adsorption Isotherm, Estimation of surface area by BET equation, surface film of
liquids (electro kinetic phenomenon),catalytic activity at surface.
B. Surface Active Agents and Micelles
Surface active agents, Classification of surface active agent, micellization, hydrophobic
interaction, critical micellar concentration (CMC), factors affecting the CMC of surfactant,
counter ion binding to micelles, thermodynamics of micellization – phase separation and mass
action models, solubilization, micro emulation, reverse micelles.
Unit III
Electrochemistry
Activity, activity coefficient, Debye-Huckel theory for electrolytic solution, determination of
activity and activity coefficient, ionic strength.
Electrochemistry of solution, Debye-Huckel – Onsager (DHO) treatment and its extension, ion
solvent interaction, Debye Huckel, B Jerum mode.
Thermodynamics of electrified interface equation, deviation of electrocapillarity,Lippmann
equation (surface excess), methods of determination, structure of electrified interfaces. Guoy
Chapman, Stern, Bockris, Devanathan method.
9
Unit IV
X-Ray and Electron Diffraction
Miller indices, Laue method, Bragg condition, Debye-Scherrer method of X-ray structural
analysis of crystals, index reflection. Structure of simple lattices and X-ray intensities, structure
factor and its relation to intensity and electron density, phase problem. Description of the
procedure for an X-ray structure analysis, absolute configuration of molecules, Ramchandran
plot.
Scattering intensity vs. scattering angle, Wierl equation, measurement technique, elucidation of
structure of simple gas phase molecule. Low energy electron diffraction and structure of
surfaces.
Recommended Books:
9. Thermodynamics for Chemists – S. Glasstone, D. Van Nostrand.
10. Principles of Electrochemistry-S. Glasstones
11. Modern Electrochemistry by K.N. Reddy
12. Thermodynamics A Core Course- R. C. Srivastava, S. K. Saha and A. K. Jain, Prentice-
Hall of India, IInd edition, 2004.
13. Chemical Kinetics- K. J. Laidler, Pearson Education, 2004
14. Physical Chemistry–P. W. Atkins, Oxford University press, VIIth edition, 2002
15. Physical Chemistry-K. L. Kapoor (Part-V)
16. Physical Chemistry- G. K. Vemulapalli, Prentice- Hall of India.
17. Basic Chemical Kinetics- G. L. Agarwal, Tata- Mc Graw Hill
18. Principles of Physical Chemistry–Marron and Pruton
19. Physical Chemistry– G. M. Barrow, Tata-McGraw Hill, Vth edition, 2003.
20. Chemical Kinetics by Keith Laidler, Harper and Row, 1995.
21. Chemical Kinetics: The Study of Reaction Rates in Solution by Kenneth A.Connors, VCH,
1990
22. Electrochemistry by Carl H. Hamann, Andrew Hamnett and Wolf Vielstich,
Wiley VCH, 1998.
23. Solid State Chemistry, A. R. West, paperback edition, Wiley (2007)
24. Solid State Chemistry, L. E. Moore and E. A. Smart, 3rd edition, Taylor and Francis
(2005)
17. Molecular Reaction Dynamics, R. D. Levine, Cambridge University Press, 2006
18. Catalysis: Concepts and Green Applications, G. Rothenberg,Wiley-VCH, 2008
19. Principles and Practice of Heterogeneous Catalysis, J. M. Thomas, W. J. Thomas,
Wiley, 2015
20. Advanced Polymer Chemistry: A Problem Solving Guide, M. Chanda, Marcel Dekker, 2000
21. Textbook of Polymer Science F. W. Billmeyer Jr., 3rd edition, John Wiley, 1991
22. Micelles, Theoretical and Applied Aspects by Moroi Y, Springer publication 1992
MCH-104: INORGANIC CHEMISTRY-I 60h
Unit-I
Stereochemistry and Bonding in Main Group Compounds
VSEPR theory & drawbacks, Bent rule, MO theory, Energy level diagram for F2, O2, CO, NO.
Walsh diagram (triatomic and pentatomic).
Unit-II
Chemistry of Transition Elements-I
10
General characteristic properties of transition elements, crystal field theory: Splitting of energies
of orbitals under ocatahedral, tetrahedral and square planar environment, crystal field
stabilization energy, limitations of CFT.
Unit-III
Chemistry of Transition Elements-II
Heats of hydration, lattice energy, spectrochemical series, Jahn-Teller effect, stability of
coordination complexes and factors effecting stability, nephelauxetic effect, ligand field theory,
splitting of d orbital’s in low symmetry environments, molecular orbital theory as applied to
metal complexes, brief introduction to Angular Overlap Model.
Unit-IV
Chemistry of Transition Elements-III
Spectroscopic ground states, terms and symbols, selections rules, correlation, Orgel and
Tanabe-Sugano diagrams for transition metal complexes (d1-d9 states), Vibronic
transitions, calculation of 10 Dq, B and β parameters, Magnetic moments, Magnetic
properties of transition metal complexes, Inter-ion magnetic coupling, anomalous
magnetic moments, magnetic exchange coupling and spin crossover, comparison of
first transition series with 2nd and 3rd transition series.
Recommended Books:
1. Inorganic Chemistry - Principles, structure and reactivity, J. E. Huhey, Harper and Row.
2. Concise Inorganic Chemistry, J. D. Lee, Elbswith Chapman and Hall, London
3. Theoretical Inorganic Chemistry, M. C. Day and J. Selbin, Reinhold, EWAP
4. Advanced Inorganic Chemistry, F. A. Cotton, R. G. Wilkinson, John Wiley.
5. Modern Inorganic Chemistry, Willam L. Jooly.
6. Atomic Structure and Chemical bonding, Manas Chanda.
7. Chemistry of Elements, N. N. Greenwood and A. Earnshaw, Pergamon
8. Inorganic Electronic Spectroscopy, A. B. P. Lever, Elsevier.
9. Structural Inorganic Chemistry – A. F. Wells, 5th edition (1984).
10. Electrons and Chemical Bonding. (Section 2) H. B. Gray, W.A. Benjamin. London
(1965)
11. Physical Methods in Inorganic Chemistry, R. S. Drago, Affiliated East-West Press
(Section 1& 2) 2nd edition, Reinhold New York (1968)
MCH -105: LAB COURSE-I
a. Inorganic Chemistry
1. Quantitative separation and determination of pairs of metal ions using volumetric analysis.
2. Quantitative separation and determination of pairs of metal ions using gravimetric methods.
3. Qualitative and quantitative analysis of insolubles-oxides, sulphates and halides
4. Complexometric titrations.
5. Preparation, to purification and structural elucidation of some of the complexes from the
following by available phyco-chemical and spectral methods:
a. Mn(acac)3
b. [Co(Py)2Cl2]
c. [Ni(NH3)6 ]Cl2
d. Ni(dmg)2
11
e. [Cu(NH3)4 ]SO4.H2O
b. Organic Chemistry
1. Identification and separation of compounds of binary mixture by thin layer
chromatography.
2. One step synthesis of the following:
a. 3,5- dimethyl pyrazole from acetyl acetone
b. ortho- Benzoyl benzoic acid from phthalic anhydride
c. para- Nitrobenzoic acid from paranitrotoluene
d. Anthraquinone from anthracene
e. Benzhydrol from benzophenone
f. Chalcones from aromatic aldehydes
g. 1-Phenylazo-2-naphthol from aniline
3. Separation /Purification techniques -crystallization, distillation methods (atmospheric/
vacuum).
c. Physical Chemistry
1. Simultaneous determination of surface tension and viscosity with survismeter.
2. Verification of the limit of Beer-Lambert’s law using potassium permanganate solution.
3. Preparation of buffer solutions and determination of their pH values.
4. Potentiometric titration of phosphoric acid using NaOH and standard Potassium hydrogen
phthalate.
5. Determination of the primary salt effect on the kinetics of ionic reaction and testing of the
Bronsted relationship (iodide ion is oxidized by persulphate ion)
6. Determination of the degree of dissociation of weak electrolyte and to study the deviation
from ideal behaviour that occurs with a strong electrolyte.
7. Determination of pKa of an indicator.
8. Adsorption: study of surface tension – concentration – relationship for solutions (Gibbs
equation)
Recommended Books:
1. Inorganic Experiments, J. Derek Woolins, VCH
2. Findley’s Practical Physical Chemistry, revised B.P. Levitt, longmann
3. Vogels Text book of Practical Organic Chemistry, Pearson education.
4. Microscale Inorganic Chemistry, Z. Szafran, R. M. Pike and M. M. Singh, Wiley
5. Practical Inorganic Chemistry, G. Marr and B. W. Rockett, Van Nostrand
6. The Systematic Identification of Organic Compounds, R.L. Shriner and D.Y Curtin
7. Semimicro Qualitative Organic Analysis, N.D. Cheronis, J.B. Entrikin and E.M. Hodnett
8. Experimental Organic Chemistry, M.P. Doyie and W.S. Mungall
9. Small Scale Organic Preparation, P.J. Hill
10. Organometallic Synthesis, J. J. Fisch and R. B. King, Academic
11. Experimental Physical Chemistry, D.P. Shoemaker, C.W. Garland and J.W. Niber,
McGraw Hill Interscience
12
12. Experiments in Physical Chemistry, J.C. Ghosh, Bharti Bhawan
13. Synthesis and Characterization of Inorganic Compounds, W. L. Jolly, Prentice Hall
13
SEMESTER-II
MCH-CBCS-201 (01): CHEMISTRY IN LIFE-I 60hrs
Unit-I
Drug Design and Action:
Introduction to Drug Design- Different, Mode of Drug action, Drug receptors, types of receptors
-general introduction, Drug-Receptor Interaction, Drug action, Pharmacokinetics, and
pharmacodynamic properties of drugs, Biological factors affecting metabolism, Drug
metabolism, Prodrug concept, natural and synthetic compounds of medicinal importance.
Unit II
Industrial Chemicals
Explosives (Primary and Secondary Explosives). Corrosion, surface coating, refractories and
abrasives, lubricants, Cement, Paper Industry (Pulp and Pulping Process).
Unit-III
Bioinorganic Chemistry
Role of metal ions in biological processes, Oxygen uptake proteins-Myoglobin and
Haemoglobin. Metalloenzymes and metalloproteins: Introduction and role in biological
systems. Biological nitrogen fixation. PS-I, PS-II.
Unit IV
Biopolymers
Definition of Biopolymers and types of biopolymers, structure and isolation of biopolymers:
chitosan, alginates, and cellulose, modification of biopolymers, environmental impact of
biopolymers, latest development and applications of biopolymers.
Recommended Books:
1. Applied chemistry for Engineer by Diamont.
2. Industrial poisons and solvents by Jacobs.
3. Chemistry of engineering materials by Jain & Jain.
4. Engineering chemistry by B. K. Sharma.
5. P.S.Kalsi, J. P.Kalsi Bioorganic, Bioinorganic and Supramolecular Chemistry
6. Biopolymers: Biomedical and Environmental Applications by Susheel Kalia and Luc
Averous-Wiley Publications
14
MCH-CBCS-201 (02): APPLIED CHEMISTRY-II 60hrs
Unit-I
Water treatment and analysis: characteristics of water - alkalinity - hardness - unit of hardness,
Purification of water for drinking purpose - potability of water - clarification - coagulation -
contact & electro chemical coagulation - sterilization & disinfection of water - precipitation -
aeration - ozonisation - Chlorination.
Unit-II
Food Preservatives & additives: Definition - classification - Food Spoilage, Methods of
preservation - classification - Low and high temperature - preservatives examples - Dehydration
- osmotic pressure - food irradiation, Food additives– classification - their functions - chemical
substance, Packaging of foods - classification-Materials used for packaging.
Unit-III
Ecosystem and biodiversity: Ecosystem Concepts – structure – Functions and types of
ecosystem – Abiotic and biotic components – Energy flow and Energy dynamics of ecosystem –
Food chains – Food web – Tropic levels – Biogeochemical cycles (carbon, nitrogen and
phosporus) Biodiversity – magnitude and distribution of biodiversity – trends - biogeographical
classification of india – biodiversity at national, global and regional level.
Unit-IV
Clinical analysis of blood: Composition of blood,clinical analysis,trace elements in the
body.Estimation of blood chlolesterol,glucose,enzymes,RBC & WBC ,Blood gas analyser.
Recommended Books:
1. Industrial Chemistry (including chemical - engineering) - B.K. Sharma - Goel publishing house.
2. 2. Water pollution and management - C.K. Varashney - Wiley Eastern Ltd., Chennai - 20.
3. Food Science - III Edition - B. Sri Lakshmi. New Age International Publisher, 2005.
4. Food Chemistry - Lilian Hoagland Meyer CBS Publishers & Distributors, 2004.
5. Food Science, Nutrition and Health - Brian.A.Fox, Allan G.Cameron Edward Arnold, London.
6. Fundamentals of ecology by M.C.Dash
7. A Text book of Environmental chemistry by W. Moore and F.A. Moore
8. Environmental Chemistry by Samir k. Banerji
9. A.I.Vogel-A text book of quantitative Inorganic analysis-ELBS,
10. F.D.Snell & F.M.Biffen-Commercial methods of analysis-D.B.Taraporavala & sons,
11. J.J.Elving and I.M.Kolthoff- Chemical analysis - A series of monographs on analytical
chemistry and its applications -- Inter Science- Vol I to VII.
15
MCH-202: ORGANIC CHEMISTRY-II 60hrs
Unit I
(a) Aliphatic Electrophilic Substitution
Bimolecular mechanisms-SE2 and SEi. The SE1 mechanism, electrophilic substitution
accompanied by double bond shifts. Effect of substrates, leaving group and the solvent polarity
on the reactivity.
(b) Aromatic Electrophilic Substitution
The arenium ion mechanism, orientation and reactivity. The ortho / para ratio, ipso attack,
orientation in other ring systems, quantitative treatment of reactivity in substrates and
electrophiles. Diazonium coupling, Vilsmeir reaction, Gatterman-Koch reaction.
Unit-II
(a) Addition to Carbon-Carbon Multiple Bonds
Mechanistic and stereochemical aspects of addition reactions involving electrophiles,
nucleophiles and free radicals, regio and chemoselectivity, orientation and reactivity.
Hydrogenation of double and triple bonds, Hydrogenation of aromatic rings. Hydroboration.
Michael reaction.
(b) Addition to Carbon-Hetero Multiple Bonds
Mechanism of metal hydride reduction of saturated and unsaturated carbonyl compounds, acids,
esters and nitriles. Addition of Grignard reagents, organozinc and organolithium reagents to
carbonyl and unsaturated carbonyl compounds.
Mechanism of condensation reactions involving enolates-Aldol, Knoevenagel, Claisen,
Mannich, Benzoin, Perkin and Stobbe reactions.
Unit-III
(a) Free Radical Reactions
Types of free radical reactions, free radical substitution mechanism, mechanism at an aromatic
substrate. Reactivity for aliphatic and aromatic substrates at a bridgehead.
Alicyclic halogenation (NBS), auto-oxidation, coupling of an alkynes and arylation of aromatic
compounds by diazonium salt. Sandemeyer reaction. Free radical rearrangement. Hunsdiecker
reaction.
(b) Elimination Reactions
The E2, E1 and E1cB mechanisms, orientation of the double bond, reactivity effects of substrate
structures, attacking base, the leaving group and the medium. Mechanism and orientation in the
pyrolytic elimination.
Unit-IV
Reactions and Rearrangements
Barbier- Wieland degradation, Dakin, Duff, Elbs persulphate, Nef, Pechmann, Tishchenko,
Ulmann, Vilsmeier reaction, Wittig reaction, Stork-enamine alkylation. Palladium catalyzed
reactions-Suzuki, Heck, Negishi coupling reactions.
16
Rearrangements- Pinacol-pinacolone, Wagner-Meerwein, Demjanov, Benzil-Benzylic,
Favorskii, Arndt-Eistert synthesis, Curtius, Schmidt, Baeyer-Villiger, Shapiro, Beckmann
reaction.
Recommended Books:
1. Organic Chemistry Vol. I. By I.L. Finar
2. Problems and Solutions by I.L. Finar
3. Reaction Mechanism in Organic Chemistry- S. M. Mukherji and S. P. Singh, revised by
S.P. Singh and Om Prakash, 2016 Edition.
4. Modern Methods of Organic Synthesis by Carruthers, W and Iain Coldham
5. Organic Chemistry- R. T. Morrison and R. N. Boyd, (Prentice Hall)
6. Modern Organic Reactions (Benjamin) H. O. House.
7. Principle of Organic Synthesis-R. O. C. Norman and J. M. Coxon. (ELBS)
8. Advanced Organic Chemistry (McGraw-Hill)- J. March
9. Basic Principles of Organic Chemistry (Benjamin) J. D. Roberts and M. C. Caserio.
10. A Guide Book to Mechanism in Organic Chemistry (Orient-Longmens)-Peter Sykes
11. Organic Chemistry (McGraw-Hill) Hendrikson, Cramand Hammond.
12. Modern Organic Synthesis: An Introduction, George S. Zweifel, Michael H. Nantz
MCH -203: PHYSICAL CHEMISTRY-II 60hrs
Unit I
Quantum Mechanics
Basic postulates of quantum mechanics, Schrodinger equation. Solution of the Schrodinger
equation model like particle in a box, the harmonic oscillator, the rigid rotor, the hydrogen atom.
Approximate Methods and Molecular Orbital Theory
The variation theorem, linear variation principle. Perturbation theory (first order and non-
degenerate) and their application
Huckel theory of conjugated system. Introduction to extended Huckel theory.
Symmetry and Group Theory: Determination of point group of a molecule, representations, the
great orthogonality theorem, character table, and construction of character tables for c2v and c3v
groups, symmetry adapted atomic basis sets, construction of molecular orbitals.
Unit II
Angular Momentum and Electronic Structure of Atom
Eigenfuctions for angular momentum, eigenvalues of angular momentum.
Russell-Saunders term and coupling schemes, Slater-Condon parameter, term separation energy
of pn configuration, term separation energy for the dn configuration, magnetic effects: spin orbit
coupling and Zeeman splitting.
17
Unit III
Classical Thermodynamics
Third law of thermodynamics, Nernst theorem, attainability of absolute zero, the thermodynamic
treatment of phase equilibria, thermodynamic properties of solutions, chemical potential,
chemical potential of real gases and fugacity, thermodynamic function of mixing,
thermodynamic treatment of ideal and non-ideal solutions, concept of activity, excess
thermodynamic functionsFree energy, chemical potential and entropy. Partial molar quantities
and their physical significance. Concepts of fugacity and determination of fugacity. Application
of phase rule to different component system.
Non Equilibrium Thermodynamics
Thermodynamic criteria for non – equilibrium condition, entropy production and entropy flow,
non equilibrium stationary states, phenomenological equation, microscopic reversibility and
Onager’s reciprocity relation, electrokinetic phenomena, diffusion, electric conduction,
irreversible thermodynamics for biological system, coupled reaction.
Unit IV
Statistical Thermodynamics:
Statistical ensembles. Basic postulates. Probability calculations. Behaviour of the density of
states. Equilibrium conditions and constraints. Reversible and irreversible processes. Distribution
of energy between systems in equilibrium. Canonical distribution and its simple applications.
Ensembles used as approximation. Quantum Statistics of ideal gases. Identical particles and
symmetry requirements. Quantum distribution functions. Maxwell-Boltzman, Photon,
BoseEinstein, and Fermi-Dirac statistics. Quantum statistics in the classical limit.
Recommended Books:
1. Elementary Quantum Chemistry by F. L. Pilar, Dover Publications, Inc. NY, 1990. 2nd Ed.
2. Molecular Quantum Mechanics by P. W. Atkins and R. S. Friedman, 3rd Ed., Oxford Univ.
Press, 1997.
3. Quantum Chemistry by Ira N. Levine, Prentice Hall,
4. Introduction to Quantum Chemistry by A. K. Chandra, Tata McGraw Hill.
5. Quantum Chemistry, I.R. Levine, Prentice Hall India (Ltd), 1995.
6. Quantum Chemistry, D. A. McQuarrie, Oxford University Press, 1983.
7. Lectures on Chemical Bonding and Quantum Chemistry, S. N. Datta, Prism Books, 1998.
8. “Thermodynamics and an Introduction to Thermostatistics”, Callen, H. B., John Wiley and
Sons. 1985
9. Kondepudi, D. and Prigogine, I. , “Modern Thermodynamics: From Heat Engines to
Dissipative Structures”, John Wiley & Sons. 1998
10. Molecular Driving Forces: Statistical Thermodynamics in Chemistry and Biology, K. A. Dill
and S. Bromberg, Garland Science, 2010.
11. Irreversible Thermodynamics, Theory and Applications, K. S. Forland, T. Forland and S.K.
Ratkje, John Wiley,1988.
18
12. Physical Chemistry, 3rd edition, G. W. Castellan, Narosa Publishing House, 1985
13. Physical Chemistry, R. S. Berry, S. A. Rice and J. Ross,John Wiley, 1980.
14. Chemical Thermodynamics, F. T. Wall, W. H. Freeman and Co., 1965.
15. Thermodynamics, G. N. Lewis, M. Randall, K.S. Pitzer and L. Brewer, McGraw Hill, 1961.
16. Statistical Thermodynamics, T. L. Hill, Addison Wesley, 1960.
17. Physical Chemistry - A Molecular Approach, D. A. McQuarrie and J. D. Simon, Viva
Books Pvt. Ltd. ( 1998 )
18. Symmetry and Spectroscopy of Molecules, K. Veera Reddy, New Age International Pvt.
Ltd. New Delhi (1999).
MCH-204: INORGANIC CHEMISTRY-II 60h
Unit-I
Kinetics and Mechanism of Substitution Reactions:
Nature of substitution reactions: prediction of reactivity of octahedral, tetrahedral and square-
planar complexes in terms of crystal field stabilization energy and structure preference energy;
rates of reactions; acid hydrolysis, base hydrolysis and anation reactions.
Unit-II
a) Organometallic Chemistry
Ligand hapticity, synthesis, structure and bonding organometallic compounds, organometllic
compounds in organic synthesis, homogeneous catalytic reactions (Hydrogenation,
hydroformylation, isomerisation and polymerisation), transition metal pie complexes.
b) Metal Carbonyls and Related Compounds:
Preparation, structure, and properties: bonding in metal carbonyls, variants of CO bridging,
vibrational spectra of metal carbonyls, principal reaction types of metal carbonyls.
Unit-III
Chemistry of Non-Aqueous Solvents
Classification of solvents, properties, levelling effect, type of reactions in solvents, chemistry of
liquid ammonia and liquid acetic acid with respect to properties, solubility and reactions.
Unit-IV
Inorganic Rings, Chains and Cages:
Chains: Catenation, heterocatenation, isopolyanions and heteropoly anions;
Rings: Borazines, Phosphazenes;
Cages: Cage compounds having phosphorus, oxygen, nitrogen and sulphur:
Boranes,Carboranes.
Recommended books:
1. Inorganic Chemistry- Principles, structure and reactivity, J. H. Huheey, Harper and Row
Publisher, Inc. New York (1972)
2. Concise Inorganic Chemistry, J. D. Lee, Elbs with Chapman and Hall, London
19
3. Theoretical Inorganic Chemistry, M.C. Day and J. Selbin, Reinhold, EWAP
4. Organometallic Chemistry, T. S. Swain and D. S. T. Black.
5. Structure and Properties of Materials, JohnWulff,Volume–4, Electronic properties, Wiley
Eastern
6. Advanced Inorganic Chemistry- F. A. Cotton, R. G. Wilkinson.
7. Modern Inorganic Chemistry- Willam L. Jooly.
8. Organometallic Chemistry- P. L. Pauson.
9. Chemistry in non–aqueous solvents, H. S. Sisler, Reinhold Publishing Corporation, USA, 4th
edition (1965)
10. Inorganic Chemistry- Gary L. Miessler and Donald A. Tarr.
MCH -205: LAB COURSE-II
a. Inorganic/Analytical Chemistry
1. Preparation of selected coordination complexes and their characterization by physical,
magnetic and spectral techniques.
2. Volumetric analysis: redox, complexometric and precipitation titrations.
3. Column Chromatography: separation of mixture of ortho and para-Nitroanilines or of
given sample.
4. Determination of Pb/Cd by AAS.
b. Organic Chemistry
1. Two step preparation, separation, purification and characterization (UV/IR
spectroscopy) of following compounds:
i. Sym-tribromobenzene from aniline.
ii. para -Nitroaniline from acetanilide.
iii. Benzanilide from benzophenone.
iv. para –Amino benzene sulphanamide from acetanilide
v. Anthraquinone from phthalic anhydride.
vi. Preparation of Benzilic acid from Benzoin
c. Physical Chemistry
1. To determine the adsorption isotherm of acetic acid from aqueous solution by charcoal.
a. Freundlich adsorption isotherm
b. Langmuir adsorption isotherm
c. BET adsorption isotherm
2. Determination of the specific rotation of sucrose & tartaric acid.
3. Determine the cell constant of a given conductivity cell at a given temp.
4. Determine the equivalent conductance of a strong electrolyte at several concentration at a
given temperature and test the validity if Onseger’s equation .
5. Determination of the rate constant for the oxidation of iodide ions by hygrogen peroxide
studying the kinetics as an iodine clock reaction.
20
6. Electrochemistry: Determination of solubility and solubility product of sparingly soluble
salts (PbSO4, BaSO4) conductometrically, Potentiometry, pHmetry:
7. To study the quenching of fluorescence of organic dye(s).
Recommended Books:
1. Inorganic experiments, J. Derek Woolins, VCH
2. Microscale Inorganic Chemistry, Z. Szafran, R. M. Pike and M. M. Singh, Wiley
3. Practical Inorganic Chemistry, G. Marr and B. W. Rockett, Van Nostrand
4. Systematic identification of organic compounds, R.L. Shriner and D.Y Curtin
5. Semimicro qualitative organic analysis, N.D. Cheronis, J.B. Entrikin and E.M. Hodnett
6. Experimental organic chemistry, M.P. Doyie and W.S. Mungall
7. Small scale organic preparation, P.J. Hill
8. Organometallic synthesis, J. J. Fisch and R. B. King, Academic
9. Experimental physical chemistry, D.P. Shoemaker, C.W. Garland and J.W. Niber,
McGraw Hill Interscience
10. Findley’s Practical Physical Chemistry, revised B.P. Levitt, longmann
11. Vogels, text book of Practical Organic Chemistry, Pearson education.
12. Experiments in physical chemistry, J.C. Ghosh, Bharti Bhawan
SEMESTER-III
MCH-301: SUPRAMOLECULAR, BIOINORGANIC AND BIOORGANIC CHEMISTRY
60hrs
Unit-I
Definition of supramolecular chemistry. Nature of binding interactions in supramolecular
structures. Synthesis and structure of crown ethers, lariat ethers, podands, cryptands, spherands,
calixarenes, cyclodextrins, cyclophanes, cryptophanes, carcerands and hemicarcerands.
Unit-II
Bioinorganic Chemistry: Role of metal ions in biological processes, structure and properties of
metalloproteins in electron transport processes-cytochromes, ferrodoxins and iron sulphur
proteins, Biological nitrogen fixation, PS-I, PS-II, Oxygen uptake proteins.
Unit-III
Molecules of Life-Carbohydrates- polysaccharides, lipids, cell membranes, nucleic acid.
Amino acids and proteins, Ramachandran plot, protein folding: DNA/RNA structures, various
forms (a, b, c, z) of DNA.
Metabolism and Energetics: Glycolysis , citric acid cycle , oxidative phosphorylation.
Unit-IV
Metalloenzymes: Hydrolytic and redox enzymes: Carbonic anhydrase and superoxide dismutase
Oxygen uptake Proteins: Hemerythrin and hemocyanin
21
Molecular Recognition: Molecular organization, Chiral recognition and role of sugar in
biological recognition
Recommended books
1. Lehn, J. M. Supramolecular Chemistry: Concepts & Perspectives Wiley-VCH (1995).
2. Balzani, V. Photochemistry of Coordination Compounds Academic Press (1970).
3. Desiraju, G. R., Ed. Perspectives in Supramolecular Chemistry, Vol. 2: Crystal
Engineering and Molecular Recognition Wiley: Chichester (1995).
4. Atwood, J. L. & Steed, J. W. Supramolecular Chemistry: A Concise Introduction John
Wiley & Sons (2000).
5. P.S.Kalsi, J. P.Kalsi Bioorganic, Bioinorganic and Supramolecular Chemistry
6. L. Stryer, Biochemistry, 5th Edition, (2002) Freeman &Co. New York
7. D.L. Nelson and M.M. Cox, Lehninger Principles of Biochemistry 3rd Edition ((2002)
McMillan North Publication
8. D. Voet, J. G. Voet, Biochemistry 3rd Edition (2004), Wiley International Publication.
9. I. Bertini, H. B. Gray, S. J. Lippard, J.S. Valentine, 1st South Asian Edn., (1998) Viva
Books Pvt. Limited, New Delhi M. B. Smith, Organic Synthesis, (1998) Mc Graw Hill Inc,
New York
MCH -302: ORGANIC CHEMISTRY-III 60hrs
Unit I
Organic Photochemistry
Photochemistry of alkenes and related compounds- Isomerization, Di-π-methane rearrangement
and cycloadditions.
Photochemistry of aromatic compounds-Ring isomerization and cyclization reactions.
Photochemistry of carbonyl compounds-Norrish type-I and type-II cleavage, photoenolization,
Paterno-Buchi reaction, photodimerisation of α, β- unsaturated ketones, rearrangement of enones
and dienones, Photo-Fries rearrangement, Barton reaction
Unit II
Pericyclic Reactions
Classification of pericyclic reactions, Woodward- Hoffmann correlation diagrams. FMO and
PMO approach, Frontier orbitals of ethylene 1,3 butadiene, 1,3,5 hexatriene and allyl system,
Electrocyclic reactions- conrotatory and disrotatory motion, 4n, 4n+2 and allyl systems.
Cycloadditions – antarafacial and suprafacial addition, 4n and 4n+2 systems, 2+2 addition of
ketenes, 1,3, dipolar cycloadditions. Sigmatropic rearrangements.
Unit-III
(a) Oxidations: Metal based and non-metal based oxidations of alcohols to carbonyls
(aluminium, DMSO, hypervalent iodine and TEMPO based reagents), alkenes to epoxides
alkenes to diols, Prevost reaction and Woodward modification, selenium based allylic
oxidation, ketones to ester/lactones.
(b) Reductions Catalytic hydrogenation (Heterogeneous: Palladium/Rhodium; Homogeneous:
Wilkinson), Hydride transfer reagents (i) NaBH4 triacetoxyborohydride, L-selectride, K-
22
selectride, Luche reduction; LiAlH4, DIBAL-H, and Red-Al; Trialkylsilanes, Meerwein-
Pondorff-Verley reduction
Unit –IV
(a) Synthetic design
Reterosynthetic analysis, Reactivity Umpolung, functional group interconversion, donor acceptor
disconnection in the carbon-carbon single bond formation. Domino reactions, olefin metathesis.
(b) Green Chemistry
Introduction to Principles and concepts of green chemistry.
Approaches for green synthesis:
a. Green starting materials
b. Green reagents
c. Green solvents and reaction conditions
d. Green catalysis
Future trends in Green Chemistry.
Recommended books:
1. Fundamental of Photochemistry, K. K. Rohatgi-Mukherjee, New Age International (P)
Ltd., New Delhi, 1986.
2. Modern Molecular Photochemistry of Organic Molecules, N. J. Turro, V. Ramamurthy,
J. C. Scaiano, University Science, Books, CA, 2010.
3. Photochemical Synthesis, I. Ninomiya, T. Naito, Academic Press, New York, 1989.
4. Reaction Mechanism in Organic Chemistry- S. M. Mukherji and S. P. Singh, revised by
S.P. Singh and Om Prakash, 2016 Edition.
5. Pericyclic Reactions-A Mechanistic and Problem Solving Approach- Sunil Kumar Vinod
Kumar S.P. Singh, Academic Press
6. Principle of organic synthesis- R. O. C. Norman and J. M. Coxon. (ELBS)
7. Advanced organic chemistry (Mc Graw- Hill) J. March.
8. Jagdamba Singh and L D S Yadav, Advanced Organic Chemistry / Organic Synthesis,
Pragati Prakashan, 2011.
9. I. Fleming, Pericyclic Reactions, Oxford University Press, Oxford (1999).
10. Modern organic synthesis: An Introduction, George S. Zweifel, Michael H. Nantz
11. Green Chemistry: Theory and Practice. P.T. Anastas and J.C. Warner. Oxford University
Press.
12. Green Chemistry: Introductory Text. M. Lancaster Royal Society of Chemistry (London).
13. Introduction to Green Chemistry. M.A. Ryan and M.Tinnesand, American Chemical
Society (Washington).
14. Alternative Solvents for Green Chemistry. F.M. Kerton. Royal Society of Chemistry
(London).
15. Recoverable and Recyclable Catalysts. M. Benaglia. Wiley.
23
16. Handbook of Green Chemistry & Technology. J. Clark and D. CHquarrie. Blackwell
Publishing.
17. Eco-Friendly Synthesis of Fine Chemicals. R.Ballini. Royal Society of Chemistry
(London)
MCH -303: PHYSICAL CHEMISTRY-III 60hrs
Unit I
Solid State Reactions and Crystal Defects
Kinetics of solid state reactions
Perfect and imperfect crystals, intrinsic and extrinsic defects – point defects, line and plane
defects and their thermodynamics ( Schottky and Frenkel defect formation), colour centers, non-
stoichiometry in solids.
Electronic Properties and Band Theory
Metals, insulators and semiconductors, electronic structure of solids band theory, band structure
of metals, insulators and semiconductors.
Intrinsic and extrinsic semiconductors, doping semiconductors, p-n junctions, super conductors.
Optical Properties – Optical reflectance, photoconduction photoelectric effects.
Unit II
Magnetic and Electric Properties
Classification of materials: Quantum theory of paramagnetics cooperative phenomena-magnetic
domains, hysteresis.
Electrically conducting solids, organic charge transfer complex, organic metals, new
superconductors
Unit III
Photophysical Processes and Photochemical Reactions
Electron transfer reactions, Photoconduction, Chemiluminiscence, Atom sensitized reactions,
sensitization and quenching, Photosensitization, Stern – Volmer equation. Photosynthesis,
Photomorphogenesis and Photochemistry of vision.
Interaction of electromagnetic radiation with matter, types of excitations, fate of excited
molecule, quantum yield, transfer of excitation energy.
Phosphorescence and the triplet state, Delayed Fluorescence, Energy level diagrams, Intersystem
crossing (Jablonski diagram), Franck –Condon Principle, Physical properties of excited
molecules, Light emission and chemical reaction from excited states, Radiationless
deactivation of excited states.
Biopolymers and their Molecular Weights
Evaluation of size, shape, molecular weight and extent of hydration of biopolymers by various
experimental techniques.
24
Unit IV
Biophysical Chemistry
Biological Cell and Its Function
Biological cell, structure and functions of proteins, enzymes, DNA and RNA in living systems.
Helix coil transition.
Cell Membrane and Transport of Ions
Structure and functions of cell membrane, ion transport through cell membrane, irreversible
thermodynamic treatment of membrane transport.
Recommended books:
1. Solid State Chemistry, L. E. Moore and E. A. Smart, 3rd edition, Taylor and Francis
(2005)
2. Solid State Physics, N. W. Ashcroft and N. D. Mermin, Harcourt College Publishers
(1976)
3. Solid State Chemistry, A. R. West, paperback edition, Wiley (2007)
4. P. L. Houston, Chemical Kinetics and Reaction Dynamics, Dover, 2006
5. 2. J. I. Steinfeld, J. S. Francisco, and W. L. Hase,Chemical Kinetics and Dynamics, 2nd
Edition, Prentice Hall, 1998
6. Nelson DL and Cox MM; Lehninger principles of biochemistry, Sixth edition, WH
Freeman and company, 2012
7. Berg JM, Tymoczko JL and Stryer L; Biochemistry, Seventh edition, WH Freeman
and company, 2011
8. Voet D and Voet JG; Biochemistry, Fourth edition, John Wiley and Sons, 2011
9. Pelczar MJ, Chan ECS and Krieg NR; Microbiology, Tata McGraw-Hill, Fifth
edition,2008 (37Th reprint)
10. R. J. Simond, Chemistry of Biomolecules, Royal Society of Chemistry, U.K. London,
1992.
11. C. Kittel, Introduction to Solid State Physics, 6th edition, Wiley, 1991.
12. A. R. West, Solid State Chemistry and Its Applications, Wiley, 1989.
13. P. A. Cox, Electronic Structure and Chemistry of Solids, Oxford University Press, 1991.
14. A. W. Adamson, Physical Chemistry of Surfaces, Wiley, 1990.
15. H. V. Keer, Principles of the Solid State, Wiley Eastern, 1993.
16. D. K. Chakrabarty, Solid State Chemistry, New Age International, 1996.
17. A. Zangwill, Physics at Surfaces, Oxford University Press, 1988.
18. K. K. Rohatagi-Mukherjee, Fundamentals of Photochemistry, Wiley Eastern, 1978.
19. M. S. Wrighton, Inorganic and Organometallic Photochemistry, ACS Pub.,1978.
20. V. Balzani and V. Carasiti, Photochemistry of Co-ordination compounds, Academic
Press,1970.
25
MCH -304: ANALYTICAL CHEMISTRY 60hrs
Unit I
Separation Methods-I
General principle, Classification of chromatographic methods: adsorption chromatography,
partition chromatography, size exclusion chromatography, ion exchange chromatography,
affinity chromatography. Nature of partition forces. Chromatographic behaviour of components.
Distribution Coefficient, Rf value, Retardation, Retention, Capacity factor, Separation factor,
Column efficiency and resolution. Van Deemter equation. Thin layer chromatography: Solvents
used in methods of detection.
Unit II
Separation Methods-II
Column chromatography: Adsorption and partition methods. Nature of column materials.
Gas Chromatography: Principle and Instrumentation, general components of a gas
chromatography, mobile systems, sample injection system, GC detectors.
HPLC: Principle and Instrumentation, general components of a high performance liquid
chromatography, solvent delivery systems, sample injection system, HPLC detectors.
Hyphenated techniques: LC-MS.
Unit-III
Solution Equilibria
General treatment of equilibria in aqueous medium involving monoprotic weak acid and weak
base, and salts of weak acids and weak bases. Calculation of pH, Constructing titration curves
from charge balance and mass balance equations, acid-base titrations, redox titration,
complexometric titrations, precipitation titrations.
Unit IV
Thermal Analysis
Thermogravimetric analysis (TGA), Differential Thermal Analysis (DTA), and Differential
scanning calorimetry (DSC): Principles, techniques and applications of thermometric titration
methods
Recommended books:
1. Modern Methods of Chemical Analysis, R. L. Pecsok, L. D. Shields, T. Cairns and L.C. Mc
William, 2nd Edition (1976), John Wiley, New York.
2. Analytical Chemistry, G. D. Christian, 5th Edition (1994), John Wiley & Sons, New York.
3. Analytical Chemistry - An Introduction, D. A. Skoog, D.M. West, F.J. Holler, S.R. Crouch,
7th Edition (2000), Saunders College Publishing, Philadelphia, London.
4. Analytical Chemistry: Principles, J. H. Kennedy, 2nd Edition (1990), Saunders Holt, London.
5. Principal of Instrumental Analysis, D. Skoog and D. West
6. Analytical Chemistry, G. D. Christian
7. Instrumental Methods of Inorganic Analysis (ELBS): A. I. Vogel
26
8. Introduction to Chromatography, Bobbit
9. Instrumental Methods of Analysis (CBS), H. H. Willard, L. L. Mirrit, J. A. Dean
10. Instrumental Methods of Analysis, Chatwal and Anand
11. Chemical Instrumentation: A Systematic Approach, H. A. Strobel
MCH -305: LAB COURSE-III
a. Organic Chemistry
1a. Extraction of Natural Products:
i. Citric acid from lemon.
ii. Lactose and casein from milk
iii. Caffeine from tea leaves.
1b. Synthesis and purification of organic compounds using column chromatography in the
following reactions:
1. Grignard Reaction (Under inert atmosphere)
2. Cross coupling reaction using organometallic reagent.
3. Protection/deprotection of amine and alcohols
4. Multicomponent/Domino reactions
1c. Green Techniques-Transformation using sonicator/microwave synthesizer.
b. Polymer/Inorganic Chemistry
1. Molecular weight determination by viscocity method
2. Determination of molecular weight of polymers by osmotic pressure method,
3. Calculation of Physico-chemical properties of a biomolecules by computational
software
4. Preparation, purification and structural elucidation of following complexes by
available phyco-chemical and spectral methods.
a. Chloropentaaminecobalt (III) chloride.
b. Bis (cyclopentadienyl) iron (II), Ferrocene.
c. Fe-Phenanthroline complex
5. Supramolecules catalysed reactions using cyclodextin/crown ethers.
Recommended Books:
1. Experimental physical chemistry, D.P. Shoemaker, C.W. Garland and J.W. Niber,
McGraw Hill Interscience
2. Findley’s practical physical chemistry, revised B.P. Levitt, longmann
3. Vogels, text book of practical organic chemistry, pearson education.
4. Experiments in physical chemistry, J.C. Ghosh, Bharti Bhawan
5. D. G. Hundiwale, V. D. Athawale, U. R. Kapadi, V. V. Gite, Experiments in Polymer
Science, New Age International Pvt. Ltd., New Delhi, 2009.
6. F. J. Davis, Polymer Chemistry-Practical Approach in Chemistry, Oxford University
Press, Oxford, 2004.
7. Quantitative organic analysis, Vogel’s.
27
SEMESTER-IV
MCH -401: Spectroscopic Techniques in Chemistry
Unit I
UV-Visible spectroscopy: Basics of photometry, Lambert beer’s law, Woodward-Fisher rule
and applications.
Infra-red spectroscopy: Applications of FTIR in structural determination.
Raman Spectroscopy: Theory, Instrumentation and Applications of Raman Spectroscopy.
Unit II
NMR Spectroscopy
1H NMR: Instrumentation, Magnetic and non-magnetic nuclei, Larmor frequency, absorption of
radiofrequency, chemical shift and its measurement, factors influencing chemical shift,
deshielding, anisotropic effect, spin-spin coupling, factors influencing coupling constant, AB,
AX and ABX systems, simplification of second order spectrum, selective decoupling, NOE
effects, restricted rotation (DMF, DMA), cyclohexane ring inversion, chemical shift reagents for
stereochemical assignments. . 13C NMR: Introduction, chemical shifts, Off-resonance coupled and decoupled spectra. Two
dimensional NMR spectroscopy.
Spectral Interpretation of compounds based on NMR spectroscopy.
UNIT II
Mossbauer spectroscopy
Basic principles, Instrumentation, Selection rules, recoilless emission and absorption, hyperfine
interaction, chemical isomer shift, magnetic hyperfine and quadruple interaction. Application to
Fe and Sn complexes.
Unit IV
Mass Spectrometry
Basic principles, ionization techniques, isotope abundance, molecular ion, fragmentation
processes of organic molecules, McLafferty rearrangement, deduction of structure using mass
spectral fragmentation, FAB-Mass, high resolution MS, soft ionization methods, EI-MS and
MALDI-MS.
Recommended books:
1. Skoog, D. A.; Holler, F. J.; Nieman, T. A. Principles of Instrumental Analysis, 5th Ed.,
Thomson Brooks/Cole, 1998.
28
2. Strobel, H. A.; Heineman, W. R. Chemical Instrumentation: A Systematic Approach, 3rd
Ed., John Wiley and Sons, 1989.
3. Willard, H. H.; Merritt, Jr., L. L.; Dean, J. A.; Settle, Jr., F. A. Instrumental Methods of
Analysis,7th Ed., Wadsworth, 1988.
4. Rubinson, K. A.; Rubinson, J. F. Contemporary Instrumental Analysis , 1st Ed., Prentice
Hall,2000.
5. Rouessac, F.; Rouessac, A. Chemical Analysis: Modern Instrumentation Methods and
Techniques, 4th Ed., John Wiley and Sons, 1998.
6. Settle, F. A. Handbook of Instrumental Techniques for Analytical Chemistry, 1st Ed.,
Prentice Hall, 1997.
7. Kaur, H. Instrumental Methods of Chemical Analysis, 1st Ed., Pragati Prakashan, 2001.
8. Ewing, G. W. Instrumental Methods of Chemical Analysis, 5th Ed., Mcgraw-Hill, 1985.
9. Banwell, C.N. and McCash, E.L.M.,“Fundamentals of Molecular Spectroscopy”, 4th Ed.
McGraw-Hill N. Y. 1999
10. Slichter, C.P., “ Principles of Magnetic Resonance”, Springer Verlag. 1981
11. Graybeal, J.D., “Molecular Spectroscopy”, McGraw-Hill. 1988
12. Atkins, P. and Paula, J.de, “Physical Chemistry”, 7th Ed., Oxford Univ. Press. 2003
13. Drago, R.S., “Physical Methods in Inorganic Chemistry”, Reinhold Publishing Corp.,
East West Press Ltd.
14. Instrumental Methods of Analysis- Willard, Merrit, Deanand Settle.
15. Spectroscopic Identification of Organic Compounds- R. M. Silverstein and G. C.
Bassler
16. Absorption Spectroscopy of Organic Molecules- V. M. Parikh
17. Applications of Spectroscopic Techniques in Organic Chemistry- P. S. Kalsi
Elective Papers:
MCH -402(01): MEDICINAL CHEMISTRY
Unit I
Introduction to Medicinal Chemistry
Role of Medicinal Chemists, Medicines, Current trends in Drug discovery, Drug Discovery
Pipeline, Clinical trials, Leads and analogues: desirable properties, Sources of leads and drugs.
Procedures followed in drug design, Classification of drugs: on basis of pharmacological
activity, chemical structure, and origin, Methods of administration of drugs.
Unit II
Drug Design and Action
29
Development of new drugs, concept of lead, Compound and lead modification, Lipinski rule,
concepts of prodrugs, Drug receptor interactions, PK and PD properties of drugs, and Drug
metabolism, Therapeutic Index, Drug-response relationship (Agonist and Antagonists),
Tachyphylaxis, structure-activity relationship (SAR) factors affecting bioactivity, Isosterism and
bio-isosterism, Drug Designing: Methods of variation, Theories of drug activity (Clark’s
occupancy theory, The Rate theory, The two-state model, Concept of drug receptors elementary
treatment of drug receptor interactions, Receptors, and their properties, types of receptors.
Unit III
Pharmacokinetics and Pharmacodynamics Properties of Drugs
Introduction to drug absorption, distribution, elimination using pharCHokinetics important
pharCHokinetics parameters in defining drug disposition and in therapeutics, drug metabolism,
biotransformation significance of drugs medicinal chemistry.
Unit IV
Synthesis and Action of Drugs
Based on structure or pharCHological basis with examples; Mode of action and synthesis of
cardiac glycosides, local antiinfective drugs, antineoplastic agents, psychoactive drugs,
antibiotics.
Recommended books:
1. Fundamentals in medicinal chemistry- G. Thomas. 2nd edition
2. Introduction to medical Chemistry, G. L. Patrick
3. Medicinal Chemistry- Ashutoshkar
4. Medicinal Chemistry- Sreeram and Yogeshwari
5. Medicinal Chemistry & Drug discovery- Burger (Volume 1-6)
6. Strategies for organic synthesis and Design -D. Lednicer
7. Burger’s Medicinal Chemistry vol. 1to6
MCH -402(02) : POLYMER CHEMISTRY 60hrs
Unit I
Basics of Polymers
Importance of polymers. Basic concepts: Monomers repeat units, degree of polymerization.
Linear, branched and network polymers. Classification of polymers. Step Growth
Polymerization: Theory of reactivity of large monomeric molecules, ring formation vs. chain
formation.
Polymerization: Chain Reaction, Free radical, Cationic, Anionic and living polymers.
Coordination and co-polymerization. Polymerization conditions and polymer reactions.
Unit II
Polymer Characterization
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Polydispersion-average molecular weight concept. Number, weight and viscosity average
molecular weights. Polydispersity and molecular weight distribution. The practical significance
of molecular weight. Measurement of molecular weights. Light scattering, osmotic,
ultracentrifugation viscosity and end group analysis methods.
Unit III
Structure and Properties
Morphology and order in crystalline polymers-configurations of polymer chains. Crystal
structures of polymers. Morphology of crystalline polymers, strain-induced morphology,
crystallization and melting. Polymer structure and physical properties-crystalline melting point
Tm, entropy and heat of fusion. The glass transition temperature, Tg. Relationship between Tm
and Tg, properties requirements and polymer utilization.
Unit IV
Polymer Processing
Processing techniques: Calendering, die casting, rotational casting, film casting, injection
moulding, blow moulding, extrusion moulding,thermoforming, foaming and reinforcing.
Speciality polymers: Fire retarding polymers and electrically conducting polymers.
Biomedical polymers – contact lens, dental, artificial heart, kidney, skin and blood cells
polymers.
Recommended books:
1. Textbook of polymer science, F.W. Billmayer Jr. Wiley
2. Polymer Science, V.R. Gowarikar, N.V. Vishwanathan and J. Shreedhar, Wiley-Eastern
3. Introduction to Polymer Chemistry by Carraher Jr.
4. Functional monomers and polymers, K. Takemoto, Y. Inaki and R.M. Ottanbrite
5. Contemporary polymer chemistry, H. R. Alcock and F.W. Lambe, Pretice Hall
6. Physics and chemistry of polymers, J.M. G. Cowie, Blackie Academic and professional
7. Principles of polymerization,G. Odien, 3rd edition (1991) John-Wiley, Singapore
8. Principles of Polymer Science, P. Bahadur and N. V. Sastry, Narosa Publication House,
New Delhi (220)
MAC-402 (03): Environmental Chemistry 60h
Unit I
Environment
Scope and significance, Chemical and photochemical reactions in the atmosphere, Classification
of environmental pollutants (air, water, noise and soil), sampling, monitoring, Chemical
toxicology: Biochemical effects of metals, Bio-warfare agents.
Unit II
Air and Noise Pollution
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Air pollutants, Green House Effect, carbon dioxide and other Green House gases, control
measures, ozone depletion problem, El Nino phenomenon, Asian brown cloud, acid rain,
particulates, remedial control measures.
Noise classification and noise pollution hazards.
Unit III
Water Pollution
Classification of water pollutants. Wastewater: Constituents, BOD, COD measurements,
municipal waste water, industrial wastewater and storm water, Arsenic contamination in ground
water, Fluorosis, principle of wastewater treatment, treatment processes-physical, chemical and
biological processes.
Unit IV
Solid Wastes
Characterization of solid waste, solid waste disposal and management, recycling, land filling,
Ocean dumping, Sludge treatment, solid waste disposal, Hazardous Wastes: Identifying
hazardous, methods of identification, waste listed as hazardous waste.
Recommended books:
1. Environmental chemistry by A.K. De
2. Rogers Manual of Industrial Chemistry, Vol. 1. Ed. By C. C. Furnas (Nastrand).
3. Outline of Chemical Technology by Dryden (Ed. And revised by Gopal Rao and Sitting)
(Affiliated East-West Press.)
4. Standard Methods for the Examination of water and waste water-American Public Health
Association.
MCH -403 (01): Electrochemistry 60hrs
Unit I
Electrokinetic Phenomenon
Electrokinetic Effects, Electrokinetic potential/Zeta potentials,Determination of zeta potential,
influence of ions on electrokinetic phenomena, Electro-Osmosis, Streaming potential,
Sedimentation potential. Theoretical and quantitative treatment of electrokinetic
phenomena, Electrophonetic Mobility and Bound hydrogen ion.
Unit II
Bio-Electrochemistry
Threshold phenomena, Donnan Membrane Equilibrium, Membrane Potential, Application of
Donnan Membrance Equilibrium, Hodges-Huxely Equation, Core conductor model. Quantum
Aspects of Charge transfer at electrode-solution interfaces, quantization of charge transfer
tunneling. Semiconductor Interfaces: Theory of double layer semiconductor solution interfaces,
Limiting current in semiconductor electrode.
Unit III
Polarography and Voltametry
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Electrode polorization, Theories of overvoltage, Importance of overvoltage, Principle of
polarography, variations of the conventional polarographic methods, Pulse Polarography,
Oscillographic polarography, Tensammetry, AC polarography, square wave polarography,
Anodic stripping and cyclic voltametry, Qualitative and quantitative application of polarography,
Determination of stoichiometry and formation constants of complexes. Amperometric titrations
and advantages.
Unit IV
Solid State Electrochemistry
Solid Fuel Cells and Solid state batteries, General principles of semiconductivity and
semiconductors, Temperature dependence of electrical resistances, Coherent Length,
Piezoelectric effect, Piezoelectric and pyroelectric materials, Conducting polymers,
Fullerenes-Doped conductors. Brief idea of Electrochemistry of molten electrolytes and
nonaqueous solvents.
Recommended Books
1. Meites, L., “Polarographic Techniques”, 3rd Ed., Interscience publishers, N.Y. 1990
2. Lund and Baizer, “Organic Electrochemistry”, Marcel Dekker, New York. 2000
3. Bard, A.J. and Faulkner, L.R., “Electrochemical Methods-Fundamentals and
Applications”, John Wiley. 2000
4. Sane, R.T. and Joshi, A.P., “Electroanalytical Chemistry: Theory and Applications”,
Quest Publications. 1999
5. D. K. Chakrabarty, Adsorption and catalysis by solids, Wiley Eastern, 1990.
6. F. P. Kane and G. B. Larrabee (Eds.), Characterisation of solid surfaces, Plenum, 1978.
7. W. Adamson, Physical Chemistry of Surfaces, 3rd edition, Wiley Interscience, 1976.
8. A. Clark, The Theory of Adsorption and Catalysis, Academic Press, 1970.
9. An Introduction To Electrochemistry : Samuel Glasstone
MAC-403 (02) : Computers in Chemistry 60h
Unit I
Approximate Methods
The variation theorem, linear variation principle. Perturbation theory (first order and non-
degenerate).Applications of variation method and perturbation theory to the Helium atom.
(Ground and excited state)
Hartree-Fock Theory
Introduction to extended Huckel theory, Slater-Condon rules, Hartree-Fock equation, Koopmans
and Brilouintheories, Roothan equation, Gaussian basis sets.
Unit II
Configuration interaction and MC-SCF
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Introduction to CI; full and truncated CI theories, size consistency. Introductory treatment of
coupled cluster and MC-SCF methods.
Unit III
Semi-Empirical Theories
A review of the Huckel, EHT and PPP treatments, ZDO approximation, detailed treatment of
CNDO and INDO theories. A discussion of electronic energies and properties.
Computer experiments using quantum chemistry- software packages such as
GAUSSIAN.GAMESS/ MOPAC/ AM1 and modelling software e.g. MM2/ AMBER/ CHARM.
Unit IV
Density Functional Theory
Derivation of Hohnberg-Kohn theorem, kohn-Sham formulation, N- and V- representabilities,
review of the performance of the existing local (e.g. Slater Xa and other methods) and non-local
functional, treatment of chemical concepts with the density functional theory.
Recommended books:
1. Modern quantum chemistry, N.S. Ostlund and A. Szabo, McGraw Hill
2. Methods of molecular quantum mechanics, R. McWeeny and B. T. Sutclife, Academic
Press
3. Density functional theory of atoms and molecules, R.G. Parr and W. Yang, Oxford
4. Exploring chemistry with electron structure methods, J. B. Foresman and E. Frish,
Gaussian Inc.
5. Semi-empirical MO theory, J. Pople and D. L. Beveridge
6. Modern Quantum Mechanics, Sakurai, J. J., Pearson Education ,1994
MAC-403 (03): Materials Chemistry 60h
Unit I
Inorganic Materials
Design and synthesis of inorganic materials, requirements and constraints, combination
properties of composites, functional materials, active materials; solid state reactions for synthesis
of inorganic materials: ceramic methods, precursor method and sol-gel synthesis, physical and
chemical vapour depositions; carbides, nitrides, structural and functional ceramics,
intermetallics; intrinsic and extrinsic properties: electrical, optical and magnetic properties;
ceramic superconductors, magnetic ceramics, Nanomaterials.
Unit II
Organic Materials
Molecular electronics: molecular materials for electronics and molecular scale electronics:
Molecular properties, molecular arrangement and molecular interactions, piezoelectric and
pyroelectric organic materials; molecular magnets based on transition metal complexes and
34
organic ferromagnets, organic non-linear optical materials: photochromic organic materials and
their classes; conducting polymers: polyacetylene, polypyrrole, polyaniline and polythiophene;
conductive change transfer materials: TTFTCNQ, metal–dithiolate systems, fullerenes.
Recommended Books:
1. P.J. Vander Put, Inorganic Chemistry of Materials, Plenum Press, New York, 1998.
2. M.C. Petty, M.R. Bryce and D. Bloor, Editors An Introduction to Molecular Electronics,
Edward Arnold, London 1995.
(Dr. Jawahar Lal) (Dr. Shailesh Kumar)
(Invitee) (Invitee)
(Dr. Jyoti Pandey) (Dr. Anjani Tiwari)
(Invitee) (Invitee)
(Dr. Preeti Gupta) (Prof. Gajanan Pandey)
(Member) (Member)
(Prof. Kuldip Singh Dhindsa) (Prof. Kaman Singh)
(External Member) (Chairman)
