2016 – 2017 Academic Year

Course: BIOL 336: Genetics Semester: Fall 2016

CRN: 12274

Instructor: Laura Harris, M.S., M.S., Ph.D. candidate

Campus/Location: Lansing Campus

Room Number: Laura’s Office 9th floor

Meeting Days and Times: Wednesday 10:30 am – 12:30pm

Course Start Date: September 6, 2016

Final Assessment Date: December 21, 2016

Last Day to withdraw without receiving an F: December 2, 2016

Instructor Contact Information:

Office Location: Lansing campusOffice Hours: All weekdays except Tuesdays12-1:30pm

Other times available by AppointmentPhone: 517-719-1729E-Mail: laura.harris@davenport.edu

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COLLEGE OF ARTS & SCIENCES2016 - 2017

Credit Hours: 4

Contact Hours: 4

Prerequisite: BIOL211/BIOL211L, and MATH135

Co-requisite: N/A

Course Description

This course presents an introduction to both classical and molecular genetics. Classic genetic concepts covered include Mendelian and Non-Mendelian patterns of inheritance, as well as linkage and chromosome mapping in eukaryotes and bacteria and bacteriophages. Molecular genetics topics include DNA structure, replication, mutation, and DNA repair; regulation of gene expression in both prokaryotes and eukaryotes; recombination and transposition at the molecular level. Genetic technologies including functional genomics, proteomics, bioinformatics, recombinant DNA, and biotechnology will be introduced and reinforced. Course content will facilitate student understanding of genetic analysis of individuals and populations. Special topics covered will include medical genetics and cancer and developmental genetics.

Learning Outcomes

Upon completion of this course students will be able to:

1. Relate the structure and function of the DNA molecule to its functional role in encoding genetic material

2. Extend the principles of inheritance as formulated by Mendel to multiple allelism, lethal alleles, gene interactions, and sex-linked transmission

3. Apply the Hardy-Weinberg Law in analyzing population genetics for gene frequency, sex linkage, equilibrium, and heterozygote frequency

4. Classify mutations in DNA and understand their direct effect on gene expression, inherited diseases and cancer

5. Explain how gene structure and expression impacts organism development6. Explain the relationship between genetic, physical, and cytogenetic maps7. Describe how information generated from genomic and proteomic bioinformatic

analysis can be used to discover practical knowledge about gene expression, relationships between species and human disease

8. Describe how various applications of recombinant DNA technology are utilized in genetic engineering and biotechnology

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Required Textbooks and Additional Materials

978-0134669762Concepts of Genetics 11/e by Klug:Bundle Components:-Hard Cover: Concepts of Genetics 11/e by Klug-Modified Mastering Genetics Valuepack Access Code-Student's Handbook and Solutions Manual for Concepts of Genetics, 11/E 

Davenport University has a print management system in which students are allotted a quota of free prints and copies based on enrolled credit hours.  Review the guidelines and FAQs on the DU website under Print Management.

DU Excellence System The Davenport University Excellence System consists of nine learning outcomes that demonstrate professional competencies necessary for graduates to engage in life-long learning and succeed in their chosen profession. These learning outcomes are reinforced throughout the curriculum of each academic program and are assessed at the course and program levels, where appropriate. The Excellence System covers:

Global and Intercultural Competence Civic and Social Responsibility Ethical Reasoning and Action Critical and Creative Thinking Analysis and Problem Solving Leadership and Teamwork Information and Technology Proficiency. Written Communication Professional Communication

Academic IntegrityDavenport University recognizes the principles of honesty and truth as fundamental to ethical business dealings and to a vibrant academic community of faculty and students. All members of an academic community shall be confident that each person's work has been responsibly and honorably acquired, developed and presented. The work that a student submits shall be a fair representation of his/her ability, knowledge and skill. The University expects students to respect and exhibit these principles as they form the basis of the quality of the institution and the quality of Davenport’s graduates.

As stated in the Student Code of Conduct, the University may discipline a student for academic dishonesty which is defined as any activity that tends to undermine the academic integrity of the institution. Academic dishonesty includes, but is not limited to: cheating, fabrication, facilitating academic dishonesty, interference, plagiarism, or

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violation of course rules. Definitions, procedures, and sanctions for these violations may be found under Student Code in the University catalog.

A minor violation occurs the first time the student has a breach of academic integrity and typically involves an assignment or activity that does not represent a significant part of the course grade. For example, the student knowingly and intentionally cheats on a weekly assignment; copies a source without proper citation; etc.

A major violation occurs as a first violation on an assignment or activity that is a significant part of the course grade, such as an exam or major paper, or as the result of a second minor violation. Students are expected to review the complete Academic Integrity policy in the University catalog under Academic Policies and Procedures.

The University utilizes Turnitin.com plagiarism detection software. All papers will be submitted to Turnitin.com where they will be compared against the entire Internet and against a database of previously submitted student papers.

Non-Discrimination Policy -Equal Opportunity EducationDavenport University maintains a policy of non-discrimination regarding students on the basis of race, color, religion, national origin, sex, weight, height, marital status, physical or mental limitations and/or disability in the administration of its admissions policies, educational policies, scholarships and loan programs and other University administered programs. In addition, the University does not discriminate regarding extra-curricular activities or employment practices. The University has a policy prohibiting unlawful discrimination or sexual harassment. Incidents of discriminatory harassment must be reported to the campus leader or his/her designee. For more information see www.davenport.edu/respect.

Anti-Harassment Policy Davenport University supports a culturally diverse academic community and is committed to maintaining a positive environment that fosters respect among those represented in the University community. The policy of Davenport University is to provide an environment free from sexual harassment and acts of harassment on the basis of age, color, disability, familial status, height, marital status, national origin, political affiliation, race, religion, sex/gender, sexual orientation, veteran status and weight. Such harassment does harm to those who experience it and destroys the environment of mutual respect and tolerance that must prevail if Davenport University is to fulfill its mission. Therefore, prohibited harassment will not be tolerated at the University. For additional information or to report an issue contact the Executive Director of Risk Management/Senior Title IX Coordinator.

ADA StatementStudents with disabilities may request accommodations as provided within federal law. In order for the University to adequately review each case, requests should be made to the Student Access Coordinator prior to the start of the semester. Requests made after the start of the semester should be completed as early in the semester as possible to prevent delays in accommodation. Students may contact their advisor or go to the

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Davenport University website for the name of the Student Access Coordinator for the location where they attend.

Military AssistanceDavenport University recognizes the extraordinary contributions of the members of our armed services. Service members and their dependents should check the military page of the DU website for educational benefits. Davenport University is committed to ensuring continuity of study for every Active Duty, Reserve, and Guard service member who is prohibited from completing a semester as planned due to reassignment, long term training/schools or deployments. Service members should work with their DU military specialist and instructors prior to these events in order to ensure proper preparation and handling of DU financial records and academic coursework so that academic re-integration is as seamless as possible upon return.

Student Responsibilities Students are bound by all policies of Davenport University and should familiarize themselves with these through reading the catalog and student handbook. Students should review the DU website under Refund Policies for tuition reimbursement rules and procedures.

All students must complete the final assessment for the course, such as the final exam, project, or presentation. Students who do not complete the final assessment will receive a grade of F.

Students are expected to be adequately prepared for each class session. It is reasonable to expect at least two hours of outside study for every hour spent in the classroom (inseat or online).

Students are expected to assist in maintaining a classroom environment that is conducive to learning. Free discussion, inquiry, and expression are encouraged. Behavior that interferes with the instructor’s ability to conduct the class or the ability of students to benefit from that instruction is not acceptable.

Alternative Delivery StatementAlternative delivery formats require considerably more student time outside of class and maintain the same level of assignments and academic rigor as the traditional classroom format. “Blended inseat w/online” is an example of an alternative delivery format.

Scheduled Class Meeting TimesThe State dictates minimal contact hour requirements that are rigidly upheld by the University. Some of that instructional time is used for tests. The University's expectation is that classes will meet for the entire assigned time.

Attendance Requirement

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Regular attendance and active participation are essential elements in the learning process. Therefore, Davenport has implemented an Attendance Practice for all courses as follows:

Courses 199 and below - attendance is taken up to the last day to withdraw with a “W” grade

Courses 200 and above - attendance is taken the first two weeks of the semester/session

For in-seat classes, attendance is taken on a daily basis starting the first class meeting. An absence is defined as missing more than one-half of a class period. Any unexcused absence will start the process for administrative withdrawal from the course.

For online classes, attendance is defined as participating in at least one graded academic activity each week. Postings not related to the graded discussion topics, emails, or course assignments may be disqualified for attendance purposes. Any unexcused absence will start the process for administrative withdrawal from the course.

Students are to notify the instructor of a planned absence a minimum of 24 hours prior to the course meeting time. Any unexcused absence will initiate the withdrawal process and merely notifying the instructor does not guarantee that the absence alert will be cleared. For complete details and ramifications, students are expected to read the full Attendance Practice available on the DU website.

Standardized Grade ScaleThe following grading scale is a University standard for courses in this area of study:

A 100 – 93 C+ 79 – 77A- 92 – 90 C 76 – 73B+ 89 – 87 C- 72 – 70B 86 – 83 D+ 69 – 67B- 82 – 80 D 66 – 63

F 62 – 0

All BIOL prefixed courses taken as requirements in the Nursing programs require a C+ or better grade for successful completion.

Research ApprovalDavenport University’s Institutional Review Board is a committee mandated by Federal laws to protect the rights and welfare of the human subjects participating in research activities. Compliance is monitored by the Office of Human Research Protection of the U.S. Department of Health and Human Services. DU’s IRB must review and approve all proposed academic research at DU or by DU faculty, staff or students that involve

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certain criteria to ensure that the research meets these governmental standards for the safety and protection of any human subjects involved in the research.

NOTE: If your research involves surveys, questionnaires, focus-groups, or other methods involving people, you will need to have your study approved by the Davenport University Institutional Review Board. Review materials on the DU IRB website.

MISSED EXAMS: There will be ONE make-up exam allowed. It is highly recommended you do not miss an exam! Dates are already scheduled and are on the course schedule. Makeup exams may differ from missed exams in content or format or both. LATE ASSIGNMENTS: Late assignments will not be accepted without acceptable documentation of a medical emergency or other unavoidable acceptable circumstance; instructor reserves the right to assign an alternative assignment for missed exams in content or format, or both in the event, the answers to the assignment have already been reviewed in the course. Late assignments receive a10% deduction for each day they are late. Assignments more than 4 days late will not be accepted. Technological issues are not considered valid grounds for late assignment submission. In the event of University server outage, students should submit assignments to the instructor and when systems are restored, submit those assignments according to syllabus instructions. Unless an Incomplete grade has been granted, learner assignments submitted after the last day of class will not be accepted.

QUOTATIONS: All quotes (word-for-word from a source) must adhere to APA formatting and referencing guidelines. All works which are comprised of more than 20% quotes, whether properly referenced or not, must be revised so that students express significant original thought in each work submitted for credit. Late penalties will be implemented in such cases.

PROFESSIONAL BEHAVIOR IN BIOL 336:Students must abide by the college's code of student conduct. Tape recording lectures without the faculty member's consent is prohibited. Please do not use computers or any other electronic devices during class unless permission for usage has been granted by the instructor. The use of cell phones or pagers, and text messaging during class is prohibited. Food and drinks are not allowed in classrooms.

Since the purpose of a college education is in large part to prepare you for life as an educated citizen and for a professional career, part of your assessment in this course will be based on the development of your professional attitude and behavior.

Unprofessional behavior includes, but is not limited to, the following:1. Speaking in class without raising your hand and waiting to be called upon.2. Coming to class late and being disruptive.3. Leaving class early and being disruptive.3. Making comments and asking questions that are inappropriate.

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4. Attempting to coerce the instructor to change established policies.5. Listening to voicemail messages or text messaging during the lecture.6. Having your cell phone ring during lecture.

Please remember that all cell phones must be silenced and put away before class begins!

Breakdown of Points for BIOL336

Exams (3 @125 points each)   375 ptsChapter Homework Assignments (10 @25pts each) 250 ptsResearch Paper 200 ptsComprehensive Final Exam (Mandatory) 175 pts__________________ _______________ _________ Total        1000 pts.  

Grade is determined by adding all points earned for all assignments and applying the total to the grading scale. 

TENTATIVE SCHEDULE: instructor reserves the right to make adjustments to this syllabus as needed

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Week Date Lecture Topic Assignments1 9/9/16 Introduction

Lecture Chapter 1 Introduction to GeneticsLecture Chapter 2 Mitosis and Meiosis (review)

2 9/16/16 Lecture Chapter 3 Mendelian GeneticsLecture Chapter 4 Extensions of Mendelian GeneticsHomework: Chapters 3 and 4 DUE

3 9/23/16 Lecture Chapter 5 Chromosome Mapping in EukaryotesHomework: Chapters 5 and 6 DUEResearch Topic DUE

4 9/30/16 Exam 1 (Chapters 1 through 5)Lecture Chapter 6 Genetic Analysis and Mapping in Bacteria

5 10/7/16 Lecture Chapter 7 Sex Determination and Sex ChromosomesLecture Chapter 8 Chromosomal MutationsHomework: Chapters 7 and 8 DUEResearch Outline DUE

6 10/14/16 Lecture Chapter 9 Extranuclear InheritanceLecture Chapter 10 DNA Structure and AnalysisHomework: Chapters 9 and 10 DUE

7 10/21/16 Lecture Chapter 11 DNA ReplicationLecture Chapter 12 DNA Organization in ChromsomesHomework: Chapters 11 and 12 DUEResearch Bibliography DUE

8 10/28/16 Exam 2 (Chapters 6 through 12)Lecture Chapter 13 The Genetic Code and Transcription

9 11/4/16 Lecture Chapter 14 Translation and ProteinsHomework: Chapters 13 and 14 DUE

10 11/11/16 Lecture Chapter 15 Gene Mutation, DNA Repair and Transposition Homework: Chapters 15 and 17 DUE

11 11/18/16 Lecture Chapter 17 Regulation of Gene Expression in EukaryotesHomework: Chapters 19 and 20 DUE

Thanksgiving Break (11/25/16)12 12/2/16 Exam 3 (Chapters 13 through 17)

Lecture Chapter 19 Cancer and the Cell CycleLecture Chapter 20 Recombinant DNA TechnologyResearch Annotated Bibliography DUE

13 12/9/16 Lecture Chapter 25 Population GeneticsHomework: Chapter 25 DUE

14 12/16/16 Lecture Chapter 21 Genomics, Bioinformatics, and ProteomicsLecture Chapter 22 BioengineeringHomework: Chapters 21 and 22 DUEResearch Paper DUE

15 12/21/16 Research Presentation DUEComprehensive Final Exam

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Genetics and Society Research Paper and Presentation

Introduces &/or Reinforces Excellence System OutcomesCivic & social responsibility, Ethical reasoning & action, Critical & creative thinking, Analysis & problem Solving, and Written communication.

Guidelines: Students will complete a group research paper on a genetic disease (e.g., Huntington Disease, Sickle Cell Anemia) or related special topic (e.g., genetically modified foods, prenatal genetic screening, epigenetics, DNA forensics, gene therapy, etc.). The assignment will require multiple deadlines to assure that students do not procrastinate and that they are getting timely feedback throughout the research and writing process. A 15-minute PowerPoint presentation will be presented during the last period of the semester.

Point Allocation:Topic: 10 pointsDetailed Outline: 30 points

Introduction with thesis statement Topic sentences for each paragraph Section headings as needed for organization clarity Conclusion with main points to summarize References NOT needed Work evaluated on completeness

Bibliography with at least 10 resources: 1point/resource based on APA format and source credibilityAnnotated Bibliography: 50 points

Work evaluated on completeness of summarization of resource (5pts/resource) Inclusion of proper grammar and spelling

Completed Paper: 50 points Inclusion of proper grammar, spelling, and APA format (title page, header, proper

font style and effect, spacing, margins, in-text citations with proper format, etc.): 10 points

Inclusion of feedback from prior submissions: 20 points Inclusion of introduction and conclusion: 20 points

Completed Presentation: 50 points

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Genetics and Society Research Presentation Grading Rubric

Criteria (15 points) Score CommentsContent

Same as research paper Includes introduction and conclusion Includes references

Criteria (5 points/each) Score CommentsEngaged entire audience/used effective body language

Poise in speech and answering questions Body language, particularly eye contact,

slouching, lack of movement NOT reading from paper

Use of effective visual, tactile or auditory aids including appropriate graphics

White space must be fully utilized Clear headings used at the top of each slide Graphics are clear and do not overlap with text Easy to read color contrasts

Text is limited to approximately five lines with approximately five words per bulleted item.Slide transitions are logical and maintain the flow throughout the presentation.Appropriate font sizes are used.Proper spelling and rules of grammar, usage, and punctuationAppropriate length (15 minutes)

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