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CorporatePresentation
May 2020
ForwardLookingStatement
Thisdocumentandanyattachmentsareintendedforinformationpurposesonlyandshouldnotbeconstruedasonofferorsolicitationforthesaleofsecurities.Statements inthispresentationincludeforward-lookingstatementswithinthemeaningofcertainsecuritieslaws.Theseforward-lookingstatementsinclude,amongothers,statementswithrespecttoourobjectives,goalsandstrategiestoachievethoseobjectivesandgoals,aswellasstatementswithrespecttoourbeliefs,plans,objectives,expectations,anticipations,estimatesandintentions.Thewords “expected to” “illustrate” “has thepotential to” “willbe”, “evaluating” “plans” “canbe” “planning” “to predict” “potential” “may” “should” andwords and expressions of similar import, areintendedtoidentifyforward-lookingstatements.Resultsinearlystageclinicaltrialsmaynotbeindicativeoffullresultsorresultsfromlaterstageorlargerscaleclinicaltrialsanddonotensureregulatoryapproval.Youshouldnotputunduerelianceonthesestatementorthescientificdatapresentedasanumberofimportantfactors,manyofwhicharebeyondourcontrol,couldcauseouractualresultstodiffermaterially fromthebeliefs, plans, objectives, expectations, anticipations, estimates and intentions expressed in such forward-looking statements.We do not undertake to update any forward-looking statements,whetherwritten ororal,thatmaybemadefromtimetotimebyusoronourbehalf;suchstatementsspeakonlyasofthedatemade. The forward-looking statements included herein are expressly qualified in their entirety by thiscautionarylanguage.
MissionStatement
TeloGenomicsprovidesactionableinformationthatisrelevanttomedicalprofessionals in themanagementof cancer and cognitivedisease. It is adiagnostic company that applies innovative and minimally-invasiveanalysisofgenomicinstability,basedonthe3Dorganizationoftelomeres,toimprovequalityoflifeandreducetreatmentcost.
ExecutiveSummary
4
Genomicinstabilityiscriticalintheevolutionofprecisionmedicineforcancerandcognitivedisease
TeloView®uses3Danalyticsoftelomerestoanalyzegenomicinstabilityasadiseasepredictor
Focusingontherapidlyemergingfieldofminimallyinvasive/liquidbiopsy
Evaluatedover3,000patients,130+peer-reviewedpapers&$25millionnon-dilutivefunding
Opportunitiesindiagnostic/prognosticproducts,pharma&academicpartnerships
CollaborationwiththeMayoClinicfocusingonunmetclinicalneedsinmultiplemyeloma
TeloView®–ExtensivelyDevelopedPlatform
5
20+ diseaseswithidentifiable3D
telomeresignatures
3,000+ patientsevaluated
25+ confirmatoryclinical
studies
130+ peer-reviewedpapers
18 patentsinCanada,USA
&Europe
$25M+ innon-dilutiveR&D
funding
StrategicCollaboration–MayoClinic
6
Validation of TeloView® for two significant unmet prognostic needs in multiple myeloma (MM)
Study#1–ConfirmTeloView®canpredictpatientresponsetoinitialtherapyo Choosingeffectivetherapyimprovespatient’schancesofgoingintoremissionanddelaystheonsetofpainfulsymptoms
Study#2–ConfirmTeloView®canpredictthetransitionofSmolderingMM(aprecursortoMM)toactiveMM
o Identifyinghighriskpatientscanleadtoearliertreatment-delayingtheonsetofMM&itspainfulsymptoms
o Identifyinglowriskpatientscaneliminatecostlytreatmentandimprovequalityoflife
Theaddressablemarketforthetwounmetneedsisover$1.0billion
Technology–TeloView®(3DTelomereAnalysis)
7
DNAispackagedintochromosomes.AtthetipsofeachchromosomeareprotectiveregionsofDNAcalledtelomeres
The3Dorganizationoftelomereswithinagivencellishighlypredictiveofgenomicinstability
AMeasureofGenomicInstability
Usingfluorescentmarkersandhighresolutionmicroscopes,thelocationofeachtelomerewithinacellnucleuscanbevisualizedanddigitallyanalyzed
TeloView®&GenomicInstability
8
TeloView®Single-cellAnalysis
- Basedontheassessmentof6uniquetelomereparameters- Cellsareanalyzedindividuallyusing3D-TelomereFISH*:
o Representstheoverallgenomicinstabilityprofileofthepatiento Canstratifypatientsbyprogression&theheterogeneityofcancers
- Predictsresponsetotherapy&guidesprecisionmedicinetreatmentsolutions- Requiresnomorethan100cellsanddoesnotrequireDNAamplification
First-in-class diagnostic/prognostic tool used to analyze genomic instability
Heterogeneityofcancer
- Tumorsmayhavegroupsofcellsthatcontributedifferentlytotheaggressivenessofcancers- Preciseprofilingofatumorshouldaccountforitsdistinctgroupsofcancercellsandrarecellsinguidingtreatment
*FISH FluorescentInSitu
Hybridization
Labelingoftelomereswithfluorescenttagscanbevisualizedandimagedin3Dusingamicroscope.Thefluorescentsignalscanthenbequantifiedtomeasurekeyfeaturesoftelomeres
TeloView®–WorkflowOutline
9
Personalized TeloView® Lab Report
TeloView®Analysis
ImageProcessing
3D Image Acquisition
3D – Telomere immuno-FISH
Sample Accession
4 5 6 1 3 2
Samples(fromblood,urine,etc.)areinspectedandassignedanID
Specificlabelingoftelomeresanddiseasespecificproteinswithfluorescenttags
Selectionofindividualtargetcells;AdaptimageformatforTeloView®analysis
1.#ofTelomeres2.Telomerelengths3.Telomereaggregates4.a:cRatio5.Nuclearvolume6.Positioninnucleus
Personalizedresultsthatinformandguidetreatment
Acquiresconsecutiveimagesatconsecutivefocalplanesacrossthedepthofthesampletobuildone3Dimage
PrecisionMedicine
- Thetailoringoftherapiesforgroupsofstratifiedpatientsbasedongenomic,life-style&environmentalfactors
- Itleadstoimprovedclinicaloutcomes&qualityoflifeforpatientsandreducescostsinthelong-term
-
GenomicInstability
- Adefiningfeatureandcauseofcancer&otherdiseases- Isanincreasedtendencyofgenomicmutationsduringcelldivision
Adetailedanalysisofgenomicinstabilitycanbeusedtostratifypatientsbyprogressionoftheirdisease&guidetreatment*
Industry–PrecisionMedicine&GenomicInstability
10
*MaiS.Thethree-dimensionalcancernucleus.GenesChromosomesCancer.2019;58:462–473.https://doi.org/10.1002/gcc.22720
MinimallyInvasive/LiquidBiopsyvTissueBiopsy*
11
MinimallyInvasive/LiquidBiopsyo Doesnotrequiresurgeryo Usesliquids,hair,skin,etc.o Capturescirculatingtumorcells(CTC’s)o Faster,cheaper&painlesscomparedtosurgeryo Repeatableformonitoringo Providesgenomicanalysisofthenatureofcancers
Tissuebiopsyo Requiresinvasivesurgeryo Expensive($15000–$45,000)o Painful&hardtorepeato Riskofcomplicationso Sideeffectso Providesusefulgenomicinformation
*Marrugo-RamírezJ,MirMandSamitierJ.Blood-BasedCancerBiomarkersinLiquidBiopsy:APromisingNon-InvasiveAlternativetoTissueBiopsy.Int.J.Mol.Sci.2018,19,2877
LiquidBiopsyIndustry
12
• Liquid-biopsyplatformsareattractingintenseinvestorinterest*• Pharmacompanies&VC’sinvestedover$1.2Bnin2018**
NextGenerationSequencing(NGS)o Prevalentinliquidbiopsyo Allowshighspeedandlowcostgenomicsequencingo RequiresisolationofDNAcellsfollowedbyamplification(theproductionofmultiplecopies
oftargetedsequencesofDNA)o Requireslargerstudiestocompensateforchallengingsignal-to-noiseratioo Risksmissingthepotentialheterogeneityofthecancer
*SheridanC.InvestorskeepthefaithincancerliquidbiopsiesNATUREBIOTECHNOLOGY|VOL37|SEPTEMBER2019|969–977**https://www.prnewswire.com/news-releases/liquid-biopsy-poised-to-revolutionize-prognosis-and-early-detection-300757046.html
• TeloView®doesnotuseNGSorDNAamplification,earlystudieshaveshownTeloView®maybeequivalentorbetterinprofilingprostatecancerbyitsaggressiveness*
*DrachenbergD,AweJ,PozzoA,SaranchukJandMaiS.AdvancingRiskAssessmentofIntermediateRiskProstateCancerPatients.Cancers2019,11,855;doi:10.3390/cancers11060855
CompaniesofInterest
13
• AdaptiveBiotechnologiesCorp.(Nasdaq:ADPTNGS)Raised$300million,IPOJune2019
• GuardantHealth(Nasdaq:GHNGS)Raised$240million,IPOOctober2018
• Grail,Inc.(PrivateNGS)Raised$1.5billionsince2016
• Biocept,Inc.(Nasdaq:BIOCNGS)Raised$10million,December2019
• LifeLength(PrivateTelomeres)Simple2Danalysis
TeloView®–MultipleMyeloma(MM)
14
• Telo’sleadapplicationisadiagnostic/prognostictoolforunmetneedsacrossthespectrumofMM
• MMisacancerofwhitebloodcells:o Occursinplasmacells-atypeofwhitebloodcellthatgrowsinbonemarrowo Symptomsincludebonepain/fractures,anemia,fatigue,recurrentinfections&kidney
problemso Over140,000casesofMMintheUSin2020*o Anincurablediseasethatcanbemoderatedthroughtreatment&hasa52%survival
rateover5years*
• StandarddiagnosisforMMarebloodtestsandinvasivebonemarrowbiopsyandlimitedgenomictestingavailable
*https://seer.cancer.gov/statfacts/html/mulmy.html
MultipleMyeloma–DiseaseProgression
15
Initiation Progression
Clonalplasmacells
Post-germinalcentralBcell
MGUS SmolderingMultipleMyeloma
MultipleMyeloma
Plasmacellleukemia
Clonal,malignantplasmacells
• Normalmatureplasmacells
• Highlycomplicatedandaggressiveformofmyeloma
• Symptomaticfullstageofthedisease
• Abnormalmyelomacellsaccumulatedinthebonemarrow
• AsymptomatichigherriskprecursorofMM
• HigherlevelsofMproteins
• Elevatedplasmainbonemarrow
• AsymptomaticlowriskprecursorofMM
• Mildlyelevatedantibodies(calledMproteins)
MultipleMyeloma–DiseaseProgression
16
TeloView®hasthepotentialtoguidediseasemanagementinmultipleareas
Initiation Progression
Post–germinalcentralBcell
MGUS
Clonalplasmacells
SmolderingMultipleMyeloma
MultipleMyeloma
Plasmacellleukemia
Clonal,malignantplasmacells
TELO-MM#2 TELO-MM#1
MayoCollaboration#1–MultipleMyeloma
17
MMistreatedwithcombinationtherapy,thereareover40differentcombinationsavailable,gettingtherightinitialtherapyiscritical:
o Itcandelaysymptoms,bringonremissionandreducecostso Patientsbuildupresistancetotherapyandcanchangecombinationsmultipletimeso Typesoftreatmentincludes;chemotherapy,immunotherapy,proteasomeinhibitors,stemcell
therapyandradiationo Annualcostoftherapyis$126-256ko Thereareover32,000newcasesofMMayearintheUS*o Addressablemarketforguidinginitialtherapyisover32,000testsperyear
AretrospectivestudydesignedtoshowsignificantdifferencesbetweenMMpatientswhofailedinitialtherapyfromthosewhoremainedinremission
InitialResponsetoTherapyinMM
*https://seer.cancer.gov/statfacts/html/mulmy.html
MayoCollaboration#2–MultipleMyeloma
18
AretrospectivestudydesignedtoshowsignificantdifferencesbetweenstableSMMpatientsvs.progressingSMMpatients
TransitionofSMMtoActiveMM
• SMMisaprecursortoactiveMM:o Standardofcarehasbeentomonitorbutnottreat,butischangingtoearlier
treatmentofhighriskpatientso Currentdiagnosisisasimplebloodtestandinvasivebonemarrowbiopsyo Thereareover250,000peoplewithSMMintheUS*o 13-14%SMMpatientstransitiontoactiveMMeachyear*
• TeloView®isnon-invasive,itcanbeusedover2timesperyearinregularmonitoring• Addressablemarketisover500,000testsperyear
TherearecurrentlynoteststhataccuratelypredictwhowilltransitionfromSMMtoactiveMM
*RavindranA,BartleyAC,HoltonSJ.Prevalence,incidenceandsurvivalofsmolderingmultiplemyelomaintheUnitedStates.BloodCancerJournal(2016)6,e486;publishedonline21October2016
MultipleMyeloma–RepresentativePublications
19
Summary#22016studyconductedon10patientsex-vivo
• Tested3MMdrugsunderdevelopmentforefficacy• SuccessfullyshowedthatTeloView®couldpredictpatientresponsetoeachdrug
- Thefollowingkeysummariesarefrompeerreviewedpublications(2013-2019)- Included158patientswithMM,SMMorMGUS&providedthecatalystfortheMayoCollaboration
Summary#12013studyincluded86patients
• Establishedproofofconcept• Canbeconductedwithliquidbiopsy• Stratifiespatientsbydistinct3Dtelomereprofilesforstageofthedisease
Summary#32019studyincluded62patients
• UsedTeloView®tostratifypatientsbydistinct3Dtelomereprofile• Successfullystratified&groupedpatientsbetweenMGUS&activeMM
0 1,000 2,000 3,000 4,000 5,000 6,000 7,000 8,000
List
Pric
e ($
USD
) GenomicTesting=PremiumPricing
20
Commercialization
21
There are several potential paths to revenues: • Licenseorsaledirectlytopharmaceuticalcompaniesforresearchorasa
companiondiagnostic• Licenseorsalewithdiagnosticlaboratorycompaniesorestablisheddiagnostic
companies• DirectsalesthroughasinglespecializedCLIAlaboratoryasaLabDevelopedTest
(LDT)• Directsaleswithaninvitrodiagnostictest(IVT)underFDAapprovalasanew
product
TeloView®informsonarangeofcancersandneurologicaldiseases
22
Multiple MyelomaHodgkin’s LymphomaMyelodysplastic Syndrome/Acute Myeloid LeukemiaChronic Myeloid Leukemia
Prostate CancerAlzheimer’s Disease Lung Cancer (NSCLC)
Breast CancerMelanomaCutaneous LymphomaPancreatic CancerThyroid CancerHead and Neck CancerOral CancerEsophageal Cancer
TeloView®
Gastrointestinal CancerRhabdomyosarcomaEpendymomaCholangiocarcinomaGlioblastomaOligodendrogliomaNeuroblastoma
TELOLeadership
23
SabineMai,PhD,DirectorandChair,Clinical&ScientificAdvisoryBoardProfessor,UniversityofManitoba,TIER-ICanadaResearchChairfromTheCanadianInstituteofHealthResearch.Aworldleaderin3Dmicroscopy,telomeresbiology,genomicinstabilityandcancer.
SherifLouis,PhD,PMP,ChiefExecutiveOfficerAnexperiencedbusinessleaderandaccomplishedscientistwithstrongtrackrecordinthebiotechnologyindustryfocusedontechnologydevelopmentandcommercialization.
GuidoBaechler,Chairman25yearsofexperienceworkingwithemergingtechnologiesinlifesciences/medicaldiagnostics.ServedasPresident&ChiefExecutiveOfficerofSingulex.PriortoSingulex,heldexecutiveleadershippositionsatbothRocheDiagnosticsandRocheMolecularDiagnostics.
Clinical&ScientificAdvisoryBoard
24
Sabine Mai, PhD – Chair, Clinical & Scientific Advisory Board
Kenneth C. Anderson, MD – Harvard & Dana-Farber Cancer Institute (USA)
Laurence Klotz, MD – Sunnybrook Hospital (Canada) Hans Knecht, MD – McGill & The Jewish General Hospital (Canada)
Darrel Drachenberg, MD – CancerCare Manitoba (Canada)
Pubco&Capitalization
25
SharesIssued:
52-WeekRange:
RecentPrice:(01/05/20)
MarketCap:
PrivatePlacement:(11/25/2019)
ProjectBurnRate:
41.2m
$0.30-$0.10
$0.145
$6m
$1.74m
<$100k/mo.
InvestmentSummary
26
• TeloView®isafirst-in-classprognostic/diagnostictoolusedtoanalyzegenomicinstabilityasapredictorofdiseaseandguidetreatment
• Uniquespaceintherapidlyemergingfieldofminimallyinvasive/liquidbiopsy• CollaborationwiththeMayoClinic,focusingonunmetclinicalneedsinmultiple
myeloma(MM),usingTeloView®topredict:o EfficacyofinitialtherapyinMMo TransitionfromsmolderingMMtoactiveMMo Addressablemarketfortheseindicationsisover$1.0billion
• Over130+peer-reviewedpapersevaluatingover3,000patientsand20+diseases• Opportunitiesindiagnostic/prognosticproducts,pharmaceuticalpartnershipsand
academiccollaborations
ContactInformation
27
MaRSDiscoveryDistrict101CollegeSt.,Suite200Toronto,Ontario,Canada
E:[email protected]:416.673.8487