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Copyright 2004 © Mattioli Engineering All rights reserved
Transdermal Delivery Transdermal Delivery TechnologyTechnology
Limits of existing Technology
Traditional Ionthophoresis Ineffective for high weight molecules Changes the pH of ionic drug solutions Electrolytic effect at the electrodes Electrolysis of the ionic solution
Microdermabrasion Low delivery rate Effects limited to the skin surface
Electroporation High peak currents High risk of skin damage Adverse effects
Limits of existing Technology
Ultrasounds Ineffective for high weight molecules
Microcurrents Very Low delivery rate Not validated for medical application
Topical Application (Patches) Low delivery rate Adverse effects
Mattioli Engineering’s Solution
Mattioli Engineering removes the limits…
combines the advantages of the existing technologies
to create the Transderm® Ionto system
Mattioli Engineering’s Solution
How does Transderm Ionto System works:How does Transderm Ionto System works:
1st Step: Ultrapeel® Microdermabrasion
2nd Step: Transderm® Ionto systemUsing Dermoelectroporation® Technology
DERMOELECTROPORATION®
DERMOELECTROPORATION® means:
Dermo = From preventive MicroDERMDERMaabrasion.
Electroporation = From the shape of the electrical pulses of -low current - max 5mA- delivered on the dermis after microdermabrasion.
DERMOELECTROPORATION®
DERMOELECTROPORATION® features:
“Electroporation-like” pulsed IONTOPHORESISIONTOPHORESIS with safe, current-limited, pulsed waveforms (low current - max 5mA)
RETURN ELECTRODE around the ionic drug solution delivery electrode and not separated as in traditional Ionthophoresis systems.
DERMOELECTROPORATION®
Results of DERMOELECTROPORATION®
Ionic solution of low-weight moleculesEquivalent to classic Iontophoresis, but without direct currentEquivalent to classic Iontophoresis, but without direct current
Transdermal delivery of:
Ionic solution of high-weight molecules““Electroporation-like” Transdermal delivery prior Microdermabrasion requiredElectroporation-like” Transdermal delivery prior Microdermabrasion required
Advantages of Transdermal Deliveryof Low-Weight Molecules
Positive and negative ions of the drug are transdermally delivered at the same time
No electrolytic reactions at the electrodes No change of ionic drug solution pH No electrolysis of ionic drug solution Less skin irritation Possibility for prior microdermabrasion to enhance
transdermal delivery
European Clinical tests demonstrate advantages of Dermoelectroporation® Vs. Iontophoresis for transdermal delivery of radioactive Lidocaine
Advantages of Transdermal Deliveryof High-Weight Molecules
No skin damage due to low limited-current pulses
No change in pH due to symmetrical pulse administration
No adverse effects reported
European Clinical tests demonstrate enhanced delivery of collagen
and a five-fold increase in transdermal delivery of Eparine
using Dermoelectroporation® Vs. application on the skin
Advantages of Dermoelectroporation®
TRANSDERM® IONTOTRANSDERM® IONTO
Copyright 2004 © Mattioli Engineering All rights reserved
TRANSDERMTRANSDERM®® IONTOIONTO
New FDA 510K New FDA 510K approval approval on on Vibration FeaturesVibration Features
EUROPEAN EXPERIENCES
Biostimulation & Biorestoration
Clinical Test from Dr. Bacci – Plastic cosmetic surgery specialist-Arezzo
FOR EDUCTIONAL PURPOSES ONLY
Mattioli Engineering © All rights reserved – Do not distribute – For internal use only Biorestoration
Carnitine
Collagen
Lidocaine
Rehabilitation
Dermoelectroporation and Cellulite
Clinical Test from Dr. Cavallini –Plastic surgery specialist-MILAN
FOR EDUCTIONAL PURPOSES ONLY
Mattioli Engineering © All rights reserved – Do not distribute – For internal use only
The European ExperienceCollagen
FOR EDUCTIONAL PURPOSES ONLY
Mattioli Engineering © All rights reserved – Do not distribute – For internal use only
The European Experience -Lidocaine
FOR EDUCTIONAL PURPOSES ONLY
Mattioli Engineering © All rights reserved – Do not distribute – For internal use only
FOR EDUCTIONAL PURPOSES ONLY
Mattioli Engineering © All rights reserved – Do not distribute – For internal use only
“Efficacy of Dermoelecroporation treatment on Inflammatory – degenerative pathologies of human locomotive apparatus”
Observation Study carried out at:S.C. Riabilitazione OrtopedicaOspedale “Eugenio Morelli” di SondaloAzienda Ospedaliera della Valtellina e della Valchiavenna
Project Responsible : Dr. Paolo BuselliPhysical and rehabilitative therapy specialist
S.C.-Struttura Complessa RIABILITAZIONE ORTOPEDICA
