Copyright 2004 Integrated Nano-Technologies little solutions for big problems Integrated Nano-Technologies

Copyright 2004 Integrated Nano-Technologies

little solutions for big problems little solutions for big problems

Integrated Nano-Technologies


AgendaAgenda

1. The Challenge2. DNA3. Applications4. What’s next


The ChallengeThe Challenge

Gain the ability to accurately & Gain the ability to accurately & reliably facilitate economically reliably facilitate economically

viable, bottom-up controlviable, bottom-up controland self-assembly of complex and self-assembly of complex

nano-structuresnano-structures


The Ideal Set of ToolsThe Ideal Set of Tools

• Information• Tools

To effectively build on any scaleyou must have:


Top-DownTop-Down

PlusPlus

Materials

Plan/Information Tools

Creates

Product


Bottom-UpBottom-Up

Tools

Materials with stored information

Plus

Creates

Self-AssembledProduct


The Ideal Nano MaterialThe Ideal Nano Material

• Can store information• Can be manipulated through:

– Cutting– Splicing– Copying– Duplicating

To effectively build complex structures, from the bottom-up, on the nano-scale, you must have materials that:


DNA & InformationDNA & Information

Cut/EditSplice/JoinCopyDuplicate

DNA is an information storage moleculeNature has provided a comprehensive tool set to manipulate DNA.


Building with DNABuilding with DNA

DNA can be used as a substrateMaterials can be added to change:

• Electrical Properties• Specific Dimensions• Rigidity


Coated DNA WiresCoated DNA Wires


DNA LithographyDNA LithographyProcedure for making nano-scale electronic components

Specifically synthesized DNA strand with tailed ends



Proteins applied to the ends, different proteins applied to the center



Unblocked section of DNA, coated



Center proteins removed



Unblocked section of DNA, coated



End blocking proteins removed, nano-scale component created


Complex DevicesComplex Devices

Using DNA Lithography, complex structures can be created

DNA Resistor

DNA Diode DNA Inductor DNA Transistor


Technion ResearchTechnion Research

• 2003 – Journal Science• Keren et al, publish the

creation of a DNA-Templated Field Effect Transistor (FET)


APPLICATIONSAPPLICATIONS


ApplicationsApplications

• BioSensors - Public Safety & Military

• Taggants - Forensic & anti countefeiting

• Catalysts – Industrial, automotive & hydrogen fuel cells

• Structures - Stronger, lighter materials

• Healthcare - Diagnostic devices & drug delivery systems

• Nano-Electronics – RFID Tags, smart materials

INT’s technology can be applied to


The Detection ChallengeThe Detection Challenge

The inability to detect and rapidly identify biowarfare agents and emerging diseases poses significant challenges.

System must be:PortableAccurateRapidLow costEasy to use


How BioDetect WorksHow BioDetect Works


INT’s BioDetectINT’s BioDetect








BioDetect ImagesBioDetect Images

Single Bridge Thousands of Bridges


Single Bridge DetectionSingle Bridge Detection

Probe Only Resistance:

2000 kΩ

Single Bridge Resistance:

1.8 kΩ


PrototypePrototype System Under Development System Under Development

• Prototype B. anthracis test developed.

• Demonstrated Proof of Concept with ECBC Biosensors Group Fall 2004. Written report pending.

• System demonstration expected Jan ’05 using a Generation I chip design, prototype micro-fluidics card, and prototype instrument.


Projected Accuracy & SensitivityProjected Accuracy & Sensitivity

GEN I GEN II

Tests 14/64 250

Detection# of spores

100 <10

Timeminutes

25 <5


BioDetect Military ApplicationsBioDetect Military Applications

Mobile Systems

UAVs

Perimeter Systems

Handheld Systems


BioDetect Public Safety ApplicationsBioDetect Public Safety Applications

Food/EnvironmentalSafety Clinical Diagnostics

Air Handlers/HVAC

First Responders


WHAT’S NEXT?WHAT’S NEXT?


What’s next?What’s next?

Radio Frequency TagsDrug Delivery SystemsArterial Plaque Removal DevicesEnhanced Catalytic ConvertersEnhanced Fuel CellsAnti-Counterfeit & Taggant Systems


little solutions for big problems little solutions for big problems

Integrated Nano-Technologies

Documents

Copyright 2004 Integrated Nano-Technologies little solutions for big problems Integrated Nano-Technologies