8/8/2019 COPD Pathophysiology
1/1
COPD
ASTHMA CHRONIC BRONCHITIS EMPHYSEMA
Allergens H. influenza Cigarette Antialpha antitrypsin D.
(dust, pollens, molds Diplococcus Pneumoniae SmokingCigarettes,
smoke,etc.)
Inflammation of the BronchiBreakdowns of elastin
Activates IgeBradykinin, Histamine, destruction ofProstaglandin
alveolar wall
septa
Mast cells & Basophils Inc. capillary PermeabilityInc. Dead
space
Dec.pulmonary bed
Release Histamine, Leukotrienes, Fluid/ Cell Exudation
Prostaglandin, Cytokines, SerotoninInc. CO2 Inc.blood
flowEdema of mucous membrane
Inflammation of bronchial airway hypercapnea Inc.RBC
Inc. activity of Goblet Cells
Vasodilation Hypersecretion of mucous additional expansion of
the thorax
Bronchoconstriction Plugged airway
Dec. intrathoracicpressure
Dec. O2 lungs
Decreased Oxygen Blood circulation
hypox
ia
whee
zes
cyanos
is
Persis
ted
Cough
Barrel
chest
pinkis
h
