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4 Controlled release morphine is less expensive than morphine solution After taking into account both acquisition and administration costs at a Canadian hospital, it was found that the daily cost of treatment with controlled release morphine tablets ('MS Contin') 120 mg/day was about half that of oral morphine solution 120 mg/day. This result was based on 12-hourJy and 4-hourly dosing regimens for the tablets and solution, respectively, and the lower cost for controlled release morphine tablets would be applicable up to a daily dose of 500 mg/day. Even though the acquisition costs for the controlled release tablets were greater than those for morphine solution, this was more than offset by the greater costs associated with ancillary supplies and administration of morphine solution 6 times/day compared with twice-daily administration of morphine tablets. Previous studies have shown that controlled release morphine tablets given twice-daily to patients with severe cancer pain are as efficacious as morphine solution administered 6 times a day. A separate analysis showed that the costs of providing analgesia via a continous SC morphine infusion 60 mg/day were greater than those for oral morphine administration. Goughnour SR. Cost considerations of analgesic therapy: an analysis of the effects of dosing frequency and route of administration. Postgraduate Medical Journal 67 (Suppl. 2): 87-91. 1991 " ,. 28 Sep 1991 INPHARMA® ISSN 0156.2703/91/0928·0004/0S01.00/0 e Adi, IIIt"IIl1tiolllll Ltd

Controlled release morphine is less expensive than morphine solution

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Controlled release morphine is less expensive than morphine solution

After taking into account both acquisition and administration costs at a Canadian hospital, it was found that the daily cost of treatment with controlled release morphine tablets ('MS Contin') 120 mg/day was about half that of oral morphine solution 120 mg/day. This result was based on 12-hourJy and 4-hourly dosing regimens for the tablets and solution, respectively, and the lower cost for controlled release morphine tablets would be applicable up to a daily dose of 500 mg/day. Even though the acquisition costs for the controlled release tablets were greater than those for morphine solution, this was more than offset by the greater costs associated with ancillary supplies and administration of morphine solution 6 times/day compared with twice-daily administration of morphine tablets. Previous studies have shown that controlled release morphine tablets given twice-daily to patients with severe cancer pain are as efficacious as morphine solution administered 6 times a day.

A separate analysis showed that the costs of providing analgesia via a continous SC morphine infusion 60 mg/day were greater than those for oral morphine administration. Goughnour SR. Cost considerations of analgesic therapy: an analysis of the effects of dosing frequency and route of administration. Postgraduate Medical Journal 67 (Suppl. 2): 87-91. 1991 " ,.

28 Sep 1991 INPHARMA® ISSN 0156.2703/91/0928·0004/0S01.00/0 e Adi, IIIt"IIl1tiolllll Ltd