BOYTETRUONG D~I HQC DUQC HA NOI

se, 1f9G ITB-DHN

CONG HOA XA HOI cnu NGHIA VI:¢T NAMDQc l~p - Tl! do - H~nh phtic

Ha N6i, ngay~thang 10 ndm 2015

THONGBA.ONQi dung huong dftn on t~p cho dBi tU'Q11gdl! thi tuy~n sinh

dao tao trinh dQ th~c si dU'Q'chQc nam 2015 (dct 2)

Truong Dai hoc Duoc Ha NQi thong bao noi dung hirong d~n on t~p cho d6inrong du thi tuyen sinh dao tao trinh dQ thac si' duoc hoc nam 2015 (dot 2). Thi sinhdir thi 2 mon theo cac noi dung sau:

I. Mo n H6a hfru CO' (theo chuang trinh dqi hoc cua TruongDai h9C Duoc Ha N6i).1. Ph~n d~i CU'O'Dg

1) Hieu ling earn ling: Khai niem, phan loai, d~c diem, anh huang d~n luc acid-base, anh huang kha nang phan ling va chieu hu6ng phan ling cua hQ'Pchat htru ca.

2) Hieu ling lien hQ'P:Khai niem, phan loai, d~c diem, anh huang d~n lire acid-base, anh huang kha nang phan ling va chien hu6ng phan ling cua hQ'Pchat htru ca.

3) D6ng phan quang hoc: Khai niem, d6ng phan hiru tuyen, d6ng phan ta tuyen,h6n hQ'Pracemic.

4) Di~u kien dS phan ill hQ'P chat htru co c6 dong phan quang hoc. Cac chathoat quang c6 carbon b~t d6i xirng va khong c6 carbon b~t d6i xirng.

5) D6ng phan hinh hoc: Khai niem, cac dang dong phan hinh hoc c6 mot lienk~t doi va nhieu lien k~t doi trong phan nr.

6) D6ng phan cfru dang trong hQ'P ch~t hydrocarbon no, mach he: Khai niem,cfru dang d6i, cfru dang che khuat, c~u dang xen ke.

7) Co ch~ cua phan ling ccng hQ'Ptheo co ch~ g6c (AR) va phan ling th~ theo coch~ g6c (SR).

8) Co ch~ cua phan ling cong hQ'Pai di~n ill (AE) va phan ling cong hQ'Pai nhan

9) Co che cua phan ling tach loai don phan tir (EJ) va phan ling tach loai luongha "(E) ~....,: ..... --p an ill 2. ,,' " Y

10) Co ch~ cua phan ling th~ ai dien ttr (SE) 0 hQ'P chat thorn. Quy t~c th~ / rljf TRUuN(

Hollemann." , ;to, I HOI_ II! C~ che cua phan ling the ai nhan don phan nr (SN1) va phan ling the ai nhan [\0;' £) A .

luan~ ph~n ill ~SN2).\,2. Cac hoa chirc '~

1) H6a tinh cua alkan. ",~2) H6a tinh cua alken.3) H6a tinh cua alkyn.4) H6a tinh cua alkadien lien hQ'P.5) H6a tinh cua d~n ch~t halogen h6a cua hydrocarbon no, mach ho.6) H6a tinh cua hQ'Pchat co magiesi.7) H6a tinh cua alcol no rnach ho.

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8) H6a tinh cua ether oxyd cua hydrocarbon no, rnach ho.9) H6a tinh chung va hoa tinh phan biet cua amin b~c I, bac II, bac III thuoc day

hydrocarbon no, mach ho.10) H6a tinh cua acid monocarboxylic no, mach ho.ll) H6a tinh cua cac d~n chat cua acid monocarboxylic no, mach he.12) H6a tinh cua hydroxy acid no, mach ho.13) H6a tinh cua amino acid no, mach ho.14) H6a tinh cua h9P ch~t aldehyd, ceton.15) H6a tinh cua monosacarid.16) H6a tinh cua hydrocarbon 1 nhan thom.17) H6a tinh cua monophenol.18) H6a tinh cua monoamin thorn bac nhat.19) H6a tinh cua h9P ch~t diazoic.20) H6a tinh cua h9P chat azoic.21) H9P ch~t di vong nam canh co mot di t6: furan, thiophen, pyrol.22) H6a tinh cua pyridin.

3. Cac bili t~p1) Day chuyen hoa cua t~t ca cac h6a chirc hiru ca.2) So sanh hrc acid-base cua cac h9P chat hiru ca.3) So sanh kha nang phan ling cua cac hop chat hfru ca.4) D6ng phan: Hinh hoc, cfru dang, quang hoc.

Tai li~u on t~p1. BQ Y t~ - H6a hoc htru co - t~p I (2007), Nha xuat ban Y hoc,2. BQ Y t~ - H6a hoc htru co - t~p II (2007), Nha xu~t ban Y hoc.3. BQY t~ - Cau hoi trac nghiem H6a Hfru co (2012), Nha xuat ban Y hoc.4. Trfm QU6c Son, Tr§.n Thi Tiru - Danh phap hop chat hiru co (2010), Nha xuat

ban Giao due Viet Nam.

II. Mon tfch hop ki~n thtrc H6a dutrc - DU'(}'c Iy (thea chuang trinh dai hoc cua TruongD¢ hQCDuocHa N(JI).

1. Dai cuong v~ duoc dQng hQC va tac dung ciia thubc,1.1. DU'(}'c dQng hoc

- H~p thu thuoc: Cac dirong dua thuoc vao co thS va S\I h~p thu cua thuoc;thong s6 diroc dong hoc cua qua trinh h~p thu (dien tich duoi dirong cong, sinh khadung cua thuoc).

- Phan b6: Lien k~t cua ihu6c voi protein huyet nrong, phan b6 thuoc d~n cac t6chirc, thong s6 diroc dong hoc cua qua trinh phan b6 (thS tich phan b6).

- Chuyen h6a: Anh huang cua chuyen h6a d~n tac dung sinh hoc va dQc tinhcua thuoc; earn ling va ire ch~ enzyme chuyen h6a thuoc.

- Thai tnr: Thai trir thuoc qua than; thong s6 duoc dong hoc cua qua trinh thaitnr thuoc (dQ thanh lQC va thai gian ban thai).1.2. Tac dung ciia thudc

- Cac kieu tac dung cua thuoc- Co ch~ tac dung cua thuoc

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- Cac y~u t6 anh huong d~n tac dung cua thuoc (tuong tac thuoc, tre em, nguoicao tuoi, ngiroi mang thai, thai ky cho con bu),

- Phan irng b~t loi cua thuoc: Dinh nghia, phan loai.2. Nh6m thudc va cac thudc Cl}th~2.1. D~c di~m chung ciia nhom thuoc (n~u c6)*

- Dac di~m c~u t<;10chung,- Phan loai,- Tinh chat li, hoa h9C,- Co ch~ tac dung,- Tac dung,- Chi dinh.

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2.2. Thuoc cl} the- Ten quoc t~, ten khac (neu co)- Nguon g6c,- Tinh ch~t ly hoa va irng dung trong pha ch~, kiem nghiem, bao quan,- Diroc dong h9C (neu co),- Tac dung va co ch~ tac dung,- Chi dinh dieu tri,- Tac dung khong mong muon,- Chong chi dinh,- Tuong tac thuoc (neu co),.- Dang bao che va biet duoc thirong gap.

2.3. Danh muc cac nh6m thuBc va thudc cu th~. .TT ChU'O'Dg

I. ? Ghi chuThuoc cu the

(s6 thuoc)1 Thuoc gay me, gay te Thiopental, Lidocain 2

Thuoc an than, gay ngu2 - Nhorn barbiturat* Pheno barbital

2- Nhom benzodiazepin * Diazepam

3 Thuoc giam dau trung irong Morphin, Codein 2

4Thuoc giam dau va thuoc giarn dau, ha sot, Aspirin, Paracetamol,

3chong viern khong steroid* Diclofenac.5 Vitamin Vitamin A, B 1, B6, C 46 Thuoc tim mach ...

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- Thu6c ire ch~ enzym chuyen" Captopril..•J

- Thu6c chen kenh calci nhomNifedipin, Felodipin 6

NP'Idihydropyridin * ./

~}I- Thu6c gian mach Nitroglycerin -:-:;:",.v'

- Thu6c loi tieu:+ Thu6c loi ti~u quai Furosemid+ Thu6c loi tieu thiazid* Hydroclorothiazid

Clorpheniramin,7 Cac thuoc khang HI * Promethazin, Cetirizin, 4

Loratadin

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TT Chuong Thu6c ct.Ith~ Ghi chu(s6 thuoc)

Thu6c dieu tri viern loet da day, ta trang:8 - Cac thuoc khang H2

Cimetidin3

- Cac thuoc ire ch§ bom proton*Omeprazol, Lansoprazol

Hormon va cac chat nrong tv- Hormon sinh due Estradiol, Progesteron

9- Hormon vo thuong than" Hydrocortison, Prednisolon

6- Thu6c dieu tri dai thao duong typ 2:+Nhorn sulfonylurea* Gliclazid+Nhom biguanid MetforminThu6c khang sinh va thuoc khang khuan- Khang sinh penicilin* Penicilin G, Amoxicilin-Khang sinh cephalosporin* Cephalexin, Cefuroxim,

10 Cefotaxim- Khang sinh aminosid* Streptomycin, Gentamicin- Khang sinh macrolid* Erythromycin 10- Nhom quinolon* Acid nalidixic, CiprofloxacinCac thuoc dieu tri nam va benh do ky sinhtrung- Thuoc dieu tri nam: Fluconazol, Amphotericin B

11 - Thu6c di~u tri benh do ky sinh trung: 6+ Thuoc di~u tri giun, san A1bendazo1+ Thu6c di~u tri s6t ret Quinin, Cloroquin,+ Thuoc di~u tri 1y.amip va Trichomonas Metronidazol

12 Thuoc diSu tri 1ao Isoniazid, Rifampicin 2Tong so 15 nhorn thuoc (cac nh6m thuoc c6 dau *) va SO thuoc cu the. * la cac nh6mthuoc trong muc 2.1.

Tai lifU on t~p1. Li thuyet Hoa Diroc I, NXB Y hoc, 20072. Li thuyet H6a Duoc II, NXB Y hoc, 20073. Diroc u I, NXB Y hoc, 20074. Duoc u II, NXB Y hoc, 2007

NO'i nhlj.n:- Website;- Luu: VT, SDH.

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