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AbbVie: A Leading Global Biopharmaceutical Company

TRADITIONAL PHARMA

BIOTECH

The expertise, financial stability and resources to effectively commercialize products

The focus, culture and innovative spirit to achieve breakthrough science

FOCUSED

PASSIONATE

REMARKABLE IMPACT

ABBVIE

A GLOBAL BIOPHARMACEUTICAL

COMPANY

BIOTECH TRADITIONAL PHARMA

AbbVie established independently from Abbott Laboratories in January 2013 A publically traded company (NYSE ticker ABBV)

AbbVie: Corporate Overview Sales: $19.96B (YE 2014)

Experience: Biopharmaceutical organization with leading scientific experience People: 28,000+ employees Global understanding: 30 commercial products in 170+ countries

>120+ years of pharmaceutical development and manufacturing Offer both specialized and standard type manufacturing

Plants: 12 State-of the-art global manufacturing facilities

North America & Europe (Singapore under construction)

Reliability: Exceptional Quality, Regulatory and Delivery track record

Long term Vision: Investing in success

Therapeutic Areas of Focus: Immunology, Kidney Disease, Liver Disease, Neuroscience and Oncology

AbbVie Contract Manufacturing Organization (CMO) Toll Manufacturing

Embedded CMO business unit built on a strong foundation and broad manufacturing capabilities.

Commitment. o Sales: > $500MM/year o > 25 years of CMO experience o Global Operation o Top 10 CMO globally on revenue basis

Markets served: o Pharmaceuticals o Nutraceuticals o Food additive o Chemical applications

Key CMO Differentiator: Broad Service Menu and Deep Technical Depth

Capabilities. Development & Manufacturing: - Biologics (Monoclonal Antibody) - APIs (Small Molecule) - Classical Microbial Fermentation - Drug Product - Hot Melt Extrusion (HME) Service Consolidation - Potent (API and Drug Product) with top performing CMO - Prefilled Syringes - Controlled Drug (DEA) - Packaging

Performance. Industry Recognized Reliability. - 2011-2014 CMO Life Sciences Leadership Award - Ranked within the top 3% of CMOs globally

AbbVie Contract Manufacturing / Toll Manufacturing Commitment. Capabilities. Performance.

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AbbVie Manufacturing Sites Commitment. Capabilities. Performance.

Drug Product Lake County, IL USA Barceloneta, Puerto Rico Campoverde, Italy Ludwigshafen, Germany Sligo, Ireland Cork, Ireland Wyandotte, MI USA

Fermentation (Classical) North Chicago, IL USA

Biologics (Monoclonal Antibodies )

Worcester, MA USA Barceloneta, Puerto Rico

APIs Campoverde, Italy Sligo, Ireland North Chicago, IL USA Wyandotte, MI USA

AbbVie Contract Manufacturing Commitment. Capabilities. Performance.

AbbVie Client Management Commitment. Capabilities. Performance.

Proposal Stage: Evaluate existing Process Description

Perform Facility Fit Evaluation: compare process and process parameters to existing equipment, capacities, capabilities to identify:

– Existing equipment that can be used as is

– Equipment that needs to be modified prior to use

– Equipment that needs to be purchased

– Unit operations that need to be optimized to fit facility

– New raw materials – EH&S evaluation

Create detailed project plan and budget

Program execution: Manage the successful implementation of

projects into manufacturing

Achieve Contract Commitments

Provide effective communication between Customer and AbbVie

Develop Project Plan and Schedule

Form Commercial Project Team

Facilitate Team Meetings

Transfer detailed project information and data

Track progress, action items and project milestones

Transition to Account Management after Commercial Launch

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Class A Certification (2007/2011/2014) based on Oliver Wight Manufacturing Philosophy

KPIs in place to monitor business processes

Master Production Schedule conformance

Supply Plan Achievement

Data Accuracy

New Product Introduction Milestone Achievement

Perfect Index

Right First Time

EHS Index

Customer Service

Days on Hand

Commitment. Capabilities. Performance.

Business Processes established New Product Introduction

Master Production Scheduling

Material Ordering and Inventory Management

Monthly Management Reporting System Continuous Improvement Tools Utilized Kaizen RCPS – Root Cause Problem Solving 5S Six Sigma Total Productive Maintenance Program

Dedicated Internal Business Excellence Organization

AbbVie Continuous Improvement

Operational Excellence

• Perfect Index

• Safety Performance

• Operational Excellence

• Maintenance Excellence (MEP)

• Quality Index

• Scheduling Index

• Zero Loss Time and OSHA driven by focused improvement plans

Customer Satisfaction

• No backorder to patients

• Achieving customer service levels > 98% . On time and in full order fulfillment

• Flawless Execution of Launches

• Equipment investment

• Quarterly Business Reviews

• Cost Improvement Programs (CIP)

Assurance of Supply

• Regulatory and customer inspections

• Zero High Impact Complaints

• Zero Product Actions

• Monthly management and customer reviews of deliveries

Commitment. Capabilities. Performance. Performance

AbbVie CMO

Benefits to our Partners Dedicated CMO with Broad Service Menu and Deep Technical Depth, impact on:

Time Cost Resource

Diverse Manufacturing Network for ease in global launch and supply Reliable supplier with superior quality record WE INVITE YOU TO DRAW ON ABBVIE’s CMO EXPERIENCE visit us at ChemSpec booth # A01 or at www.abbviecontractmfg.com

AbbVie CMO – Q & A Session