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Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore www.ibe.a-star.edu.sg www.cerefy.com

Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

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Page 1: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Computer-assisted brain intervention: present and future

Computer-assisted brain intervention: present and future

Wieslaw L. Nowinski, DSc, PhDBiomedical Imaging Lab, Institute of Bioengineering, Singapore

www.ibe.a-star.edu.sg

www.cerefy.com

Page 2: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

- BIL R&D roadmapBIL R&D roadmap

- PresentPresent- stereotactic and functional neurosurgerystereotactic and functional neurosurgery

- interventional neuroradiologyinterventional neuroradiology

- skull base surgeryskull base surgery

- FutureFuture- surgical paradigm shiftssurgical paradigm shifts

- technical paradigm shifttechnical paradigm shift

- BIL contributionBIL contribution

- ConclusionConclusion

Page 3: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Biomedical Imaging Lab R&D roadmap

Neuroinformatics

Biomedical Imaging

Computer-assistedintervention

Medicaldevices

Biomedicalimaging tools

Human body models

Page 4: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Brain intervention applications

Stereotactic and functional neurosurgery

Interventional neuroradiology

Skull base surgery

Page 5: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Stereotactic and Stereotactic and functional neurosurgeryfunctional neurosurgery

Stereotactic and Stereotactic and functional neurosurgeryfunctional neurosurgery

Page 6: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Stereotactic and functional neurosurgery

frame placement

radiological imaging

computer planning

surgery proper neurophysiological localization therapeutic lesioning/DBS insertion

follow-up

Page 7: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Interventional Interventional neuroradiologyneuroradiologyInterventional Interventional neuroradiologyneuroradiology

Page 8: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Interventional neuroradiology

Drug delivery

Cerebral vasculature treatment

Tumor intervention

Page 9: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Skull base surgerySkull base surgerySkull base surgerySkull base surgery

Page 10: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Brain BenchBrain Bench

Page 11: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Future surgeryFuture surgery

““I never think of the futureI never think of the future

- it comes soon enough”- it comes soon enough”

Albert Einstein

Page 12: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Ignore it

Predict it continuously

Shape it discontinuously

Make it

Ways of Approaching the Future Ways of Approaching the Future Ways of Approaching the Future Ways of Approaching the Future

Page 13: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

BIL ContributionBIL ContributionBIL ContributionBIL Contribution

Surgeon-centric portal for stereotactic Surgeon-centric portal for stereotactic and functional neurosurgeryand functional neurosurgery

Do-it-yourself neurosurgeryDo-it-yourself neurosurgery

DoTellDoTell: operating room of the future : operating room of the future

Page 14: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Surgical paradigm shiftsSurgical paradigm shifts

Manufacturer-centric

Surgeon-centric

Patient-centric

Manufacturer-centric

Surgeon-centric

Patient-centric

Page 15: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

TechnicalTechnical paradigm shiftTechnicalTechnical paradigm shift

Device-centricDevice-centric

Environment-centricEnvironment-centric

Device-centricDevice-centric

Environment-centricEnvironment-centric

Page 16: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Surgeon-centric portal for stereotactic Surgeon-centric portal for stereotactic

and functional neurosurgeryand functional neurosurgery

Page 17: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Probabilistic functional atlas-based portal

Neurosurgeon - Neurosurgeon - data providerdata provider

Neurosurgeon - Neurosurgeon - data providerdata provider

Neurosurgeon - Neurosurgeon - data providerdata provider

Neurosurgeon - Neurosurgeon - useruser

Neurosurgeon - Neurosurgeon - useruser

Neurosurgeon - Neurosurgeon - useruser

SFN SFN PortalPortal

www.cerefy.com

Page 18: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

SFN-P client

SFN-P application

Local database

SFN-P server

Best contact database

Security server

Data provider database

User databaseSFN-P client

SFN-P application

Local database

Architecture of the Stereotactic and Functional Neurosurgery Portal (SFN-P)

Page 19: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

DoTellDoTell: operating room of : operating room of

the future the future

Page 20: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Leonardo da Vinci Leonardo da Vinci - Revolutionary staircase- Revolutionary staircase

Double helixDouble helix- Structure of DNA- Structure of DNA- Progress of mankind- Progress of mankind

Leonardo da Vinci Leonardo da Vinci - Revolutionary staircase- Revolutionary staircase

Double helixDouble helix- Structure of DNA- Structure of DNA- Progress of mankind- Progress of mankind

Inspiration - ChambordInspiration - Chambord

Page 21: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

DoTell is an intelligent device with:DoTell is an intelligent device with:

robotic capabilitiesrobotic capabilities

integratingintegrating information infrastructure, information infrastructure, knowledge-based decision support, imaging knowledge-based decision support, imaging systems, and therapeutic modalitiessystems, and therapeutic modalities

providing advice and actions providing advice and actions

What is DoTell?What is DoTell?

Page 22: Computer-assisted brain intervention: present and future Wieslaw L. Nowinski, DSc, PhD Biomedical Imaging Lab, Institute of Bioengineering, Singapore

Clinicians and researchers need to work

closely together to

build accurate body models

develop and validate realistic modeling techniques

develop and test surgical simulators

build a highly intelligent, autonomous OR

environment for surgery