Computational Drug Discovery Isoquinolines And Beta- and … · 2012-04-27 · (Ed.) Computational Drug Discovery and Design Contents ... A Guide to Understanding Ethics in Context

BiomedicineNews 9/2011

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L. Antkiewicz-Michaluk, Polish Academy of Sciences, Krakow, Poland; H. Rommelspacher, Charité-University Medicine, Berlin, Germany (Eds)

Isoquinolines And Beta-Carbolines As Neurotoxins And NeuroprotectantsNew Vistas In Parkinson‘s Disease Therapy

The specific topic, “Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotec-tants – New Perspectives In Parkinson`S Disease Therapy,” was chosen in light of accumulating neu-robiological evidence indicating that, in addition to exogenous neurotoxins (e.g.

Features 7 Contains up-to-date research 7 Written by field experts 7 In-depth look at a complex topic

Contents Two faces of 1,2,3,4-tetrahydroisoquinoline mode of action in the mammalian brain: is it an endo-genous neurotoxin or a neuromodulator?.- Iso-quinolines as a neurotoxins: action and molecular mechanism.- 1-Methyl-1,2,3,4-tetrahydroisoqui-noline – a potent neuroprotecting agent.- 1-Me-thyl-1,2,3,4-tetrahydroisoquinoline and addiction: experimental studies.- Beta-carbolines as neuro-toxins.- Neuroprotective β-carbolines: occurrence, formation and biodegradation.- Beta-carbolines and neuroprotection: inhibition of monoamine oxidase.- Beta-carbolines increase the efficiency of the respiratory chain in mitochondria.- Anti-oxidant properties of β-carbolines.- Restoration of neuronal functions in damaged dopamine neurons: in vitro and in vivo studies.- Prospects for new treatment options in neurodegenerative diseases.

Fields of interestsNeurosciences; Neurochemistry; Pharmacy

Target groupsProfessional/practitioner

Product CategoryContributed volume

Due January 2012

2012. III, 210 p. 31 illus., 1 in color. (Current Topics in Neurotoxicity, Volume 1) Hardcover7 $189.00ISBN 978-1-4614-1541-1

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R. Baron, University of Utah, Salt Lake City, UT, USA (Ed.)

Computational Drug Discovery and DesignContents A Molecular Dynamics Ensemble-Based Ap-proach for the Mapping of Druggable Binding Sites.-Analysis of Protein Binding Sites by Computational Solvent Mapping.-Evolutionary Trace for Prediction and Redesign of Protein Functional Sites.- Information Entropic Functions for Molecular Descriptor Profiling.-Expanding the Conformational Selection Paradigm in Protein-Ligand Docking.-Flexibility Analysis of Biomac-romolecules with Application to Computer-aided Drug Design.-On the Use of Molecular Dynamics Receptor Conformations for Virtual Screening.-Virtual Ligand Screening Against Comparative Protein Structure Models.-AMMOS Software: Method and Application.-Rosetta Ligand Docking with Flexible XML Protocols.-Normal Mode-Based Approaches in Receptor Ensem-ble Docking.-Application of Conformational Clustering in Protein-Ligand Docking.-How to Benchmark Methods for Structure-based Virtual Screening of Large Compound Libraries.-AG-GRESCAN: Method, Application, and Perspecti-ves for Drug Design.-ATTRACT and PTOOLS: Open Source Programs for Protein-protein Docking.-Prediction of Interacting Protein Resi-dues using Sequence and Structure Data.-MM-GB/SA Rescoring of Docking Poses.-A Case Study of Scoring and Rescoring in Peptide Docking.-The Solvated Interaction Energy (SIE) Method for Scoring Binding Affinities.-Linear Interaction Energy (LIE): Method and Applications in Drug Design.-Estimation of Conformational Entropy in Protein-Ligand Interactions: a Computational Perspective. [...]

Fields of interestPharmacology/Toxicology



Due January 2012

2012. 541 p. 137 illus., 41 in color. (Methods in Molecular Biology, Volume 819) Hardcover7 $159.00ISBN 978-1-61779-464-3

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Current Topics in NeurotoxicityT. Archer, R. M. Kostrzewa

www.springer.com/978-1-4614-1541-1


Biomedicine springer.com/NEWSonline

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P. Boddington, Oxford University, UK

Ethical Challenges in Genomics ResearchA Guide to Understanding Ethics in Context

New developments in science and technology have resulted in shifting ethical challenges in many areas including in genomics research. This book enables those who are involved in genomics re-search, whether as researcher, participant or policy maker, to understand the ethical issues currently developing in this field and to participate actively in these important debates. A clear account is given of how science and technology are outstrip-ping the capacity of previous ethical regulations to cope with current issues, together with practical illustrations of possible ways forward.

Features 7 Written by an experienced expert in the field 7 Provides a clear explanation of key ethical concepts 7 Enables the reader to understand and apply complex issues 7 An extensive glossary explains all relevant terms

Contents The ‘ethics job’.- Why ethics in genetics?- Why ethics in research?- The case of genomics research.- What ethics is, and how we are going to proceed.-Starting analysis in ethics: a practi-cal guide.- Research ethics and challenges from genomics: an overview of the issues.- Autonomy and its limits: the view from genetics.- The social and institutional context of ethics.- Respect for persons in research and in genetics.- Responsi-bilities of researchers in genomics.- Data sharing in genomics.- Glossary.- Abbreviations.- Index of text boxes.- Subject index.

Fields of interestsHuman Genetics; Theory of Medicine/Bioethics; Philosophy of Medicine

Target groupsResearch

Product CategoryMonograph

Due November 2011

2012. X, 200 p. Hardcover7 $189.00ISBN 978-3-642-23698-3

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C. Chen, University at Albany, NY, USA (Ed.)

Activation and Detoxification EnzymesFunctions and Implications

Humans are exposed to foreign compounds such as drugs, household products and environmental chemicals by swallowing or breathing. Also, food is considered a foreign compound. Such foreign compounds can be non-essential and non-func-tional to life, and commonly are referred to as xenobiotics. Some xenobiotics are not toxic; howe-ver, many of them are potentially toxic or become toxic after conversion to metabolic intermediates. A considerable number of foreign compounds belong to non-polar, lipophilic substances. Lipo-philic compounds are not soluble in water.

Features 7 Incorporates cutting-edge research 7 Fea-tures chapters written by renowned ex-perts 7 Contains helpful, full-color figures

Contents Overview.- Lipophilic Foreign Compounds.- Metabolic Conversion of Lipophilic Com-pounds.- Phase I Activation Enzymes.- Phase II Detoxification Enzymes.- Reactive Intermediate Formation.- Biomedical and Biochemical Effects.- Genetic Variations in Metabolizing Enzymes.- In-ducibility of Metabolizing Enzymes.- Induction and Inhibition Compounds.- Diets Rich in Enzy-me Modulators.- Induction of Enzymes for Health Benefits.- Sources of Foreign Compounds.- Cata-lytic Reactions of Activation Enzymes.- Catalytic Reactions of Detoxification Enzymes.- Diversified Classes of Enzyme Modulators.- Conclusion.- In-dex.

Fields of interestsHuman Physiology; Pharmacology/Toxicology; Health Promotion and Disease Prevention



Due December 2011

2012. X, 256 p. 41 illus., 2 in color. Hardcover7 $189.00ISBN 978-1-4614-1048-5

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H. Chen, LSU Health Sciences Center, Shreveport, LA, USA (Ed.)

Atlas of Genetic Diagnosis and CounselingContents Acardia.- Achondrogenesis.- Achondroplasia.- Adams-Oliver syndrome.- Agnathia.- Aicardi syndrome.- Alagille syndrome.- Albinism.- Alpha thalassemia-mental retardation (ATR-X) syndro-me.- Ambiguous genitalia.- Amniotic deformity, adhesions, mutilations (ADAM) syndrome.- Androgen insensitivity syndrome.- Angelman syndrome.- Apert syndrome.- Aplasia cutis congenita.- Arthrogryposis multiplex congeni-ta.- Asphyxiating thoracic dystrophy.- Ataxia telangiectasia.- Atelosteogenesis.- Autism.- Ban-nayan-Riley-Ruvalcaba syndrome.- Beckwith-Wiedemann syndrome.- [...]

Fields of interestsHuman Genetics; Cytogenetics; Molecular Medi-cine


Product CategoryReference work

Due February 2012

Print

2nd Edition. 2012. 1750 p. 2472 illus., 2018 in color. (In 2 volumes, not available seperately) 7 $699.00ISBN 978-1-4614-1036-2

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A. Chouker, Klinikum Großhadern, München, Germany (Ed.)

Stress Challenges and Immunity in SpaceFrom Mechanisms to Monitoring and Preventive Strategies

Contents Part I: Prelude: A personal view from above.-A view from the ESA Topical Team Stress and Im-munity. Part II: „Stress and Immunity“-research: a tight link between space and earth: What is Stress? The impact of everyday stressors on the immune system and health. Part III: Stress & Immune Allostasis in Space, from brain to immune res-ponses: Neurobiological mechanisms of stress and glucocorticoid effects on learning and memory: implications for stress disorders on earth and in space.- The autonomous nervous system.- Circadi-an rhythm and stress.- Endocannabinoids, “new-old” mediators of stress homeostasis.- Immune System, definitions and stress-sensitive func-tions.- Innate Immunity under conditions of space flight.-NK Cells assessments: a thirty year old History of Immune stress interaction in Space.- Adaptive Immunity and Spaceflight.-Stress, Hypoxia, and Immune Response.- Gravitational force – triggered stress in cells of the immune system.-Microbial Stress: Spaceflight-induced alterations in microbial virulence and infectious disease risks for the crew.- Stress, Spaceflight, and Latent Herpes Viruses Reactivation.- Stress and Radiation-responsiveness. Part IV: Preventive and Diagnostic Tool & Strategies: Conside-ration on minimal or non-invasive monitoring applications.- Psychological Monitoring.- Breath gas analyses.- Microbiological environment, com-plementary procedures.- Thermoregulation.- Flow Cytometry.- Radiation Sensitivity. [...]

Fields of interestsHuman Physiology; Medicine/Public Health, general; Immunology



Due October 2011

2012. X, 588 p. 74 illus., 50 in color. Hardcover7 $239.00ISBN 978-3-642-22271-9

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M. B. Teunissen, University of Amsterdam, The Netherlands (Ed.)

Intradermal ImmunizationThis volume of Current Topics in Microbiology and Immunology covers diverse topics related to intradermal immunization. The chapters high-light the effectiveness of intradermal immuniza-tion in experimental animal models or in clinical practice, all supporting the view that intradermal immunization is at least as good as other immu-nization routes. Keeping in mind that current vaccines are not specially designed for intradermal immunization, but show comparable efficiency even at reduced dosages, this underlines the great potential for the skin as a vaccination site. Hope-fully, the overview in this volume will encourage vaccine designers to focus on this promising im-munization route, and in addition, to inspire them to develop vaccines that are especially optimized for intradermal immunization.

Contents Preface.- Understanding the murine cutaneous dendritic cell network to improve intradermal vaccination strategies.- Insight into the immuno-biology of human skin and cutaneous dendritic cell subsets to perfection intradermal vaccination design.- Delivery systems for intradermal vacci-nation.- Targeting skin dendritic cells to improve intradermal immunization.- Intradermal Rabies vaccination: the evolution and future of pre- and post-exposure prophylaxis.- Intradermal vaccina-tion to protect against yellow fever and influenza.- The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanoma.- DNA vaccines and intradermal vaccination by DNA tattooing.- Subject index

Fields of interestsVaccine; Immunology; Dermatology



Due October 2011

2011. X, 250 p. 19 illus., 15 in color. (Current Topics in Microbiology and Immunology, Volume 351) Hardcover7 $189.00ISBN 978-3-642-23689-1

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P. Kozlowski, Louisiana State University Health Sciences, New Orleans, LA, USA (Ed.)

Mucosal VaccinesModern Concepts, Strategies, and Challenges

This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral patho-gen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immuni-zation route, which may offer a safer alternative to the nasal route for induction of broadly dissemi-nated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient inter-nalization of mucosally-applied vaccines.

Contents Preface.- Mucosal Delivery Routes for Optimal Immunization: Targeting Immunity to the Right Tissues.- Mucosal Immune Responses Induced by Transcutaneous Vaccines.- Advances in Mucosal Vaccine Development: M Cell-targeted Vaccines.-Microparticle and Nanoparticle Delivery Vehicles for Mucosal Vaccination.- Virus-Like Particles for Antigen Delivery at Mucosal Surfaces.- Plant-de-rived Antigens as Mucosal Vaccines.- Dry Powder Mucosal Vaccines: Critical Factors for Effective Manufacture and Delivery.- Mucosal Vaccines for Biodefense.-Mucosal Immunity and HIV Infection: Applications for Mucosal AIDS Vaccine Development.- Subject index

Fields of interestsVaccine; Immunology; Antibodies


Product CategoryHandbook

Due September 2011

2011. X, 200 p. 17 illus., 6 in color. (Current Topics in Microbiology and Immunology, Volume 354) Hardcover7 approx. $189.00ISBN 978-3-642-23692-1

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C. Murre, University of California, San Diego, CA, USA (Ed.)

Epigenetic Regulation of Lymphocyte DevelopmentThe studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.

Feature 7 ..

Fields of interestsImmunology; Gene Expression



Due October 2011

2012. X, 210 p. 18 illus., 13 in color. (Current Topics in Microbiology and Immunology, Volume 356) Hardcover7 approx. $189.00ISBN 978-3-642-24102-4

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T. J. Dougherty, Pfizer, Inc., Groton, CT, USA; M. J. Pucci, Achillion Pharmaceuticals, New Haven, CT, USA (Eds)

Antibiotic Discovery and DevelopmentThis volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experi-enced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nomi-nations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference.

Features 7 Chapters written by experts in their fields 7 Contains helpful, full-color illustra-tions 7 Features up-to-date research

Contents Introductory History of Antimicrobial Drugs.- Marketed Major Classes of Compounds.- The Rise of Antibiotic Resistance/Resistance Mechanisms to Major Classes.- Clinical Issues of Resistance: “Worst Offenders” List of Problematic Micro-bes.- Antibiotic Discovery.- Antibiotic Drug Development.- The Economics and Incentives of Antibiotic Drug Discovery.

Fields of interestsMedical Microbiology; Pharmacology/Toxicology; Physical Chemistry



Due December 2011

2012. XIV, 1251 p. 211 illus., 88 in color. Hardcover7 approx. $279.00ISBN 978-1-4614-1399-8

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V. Espina, L. A. Liotta, George Mason University, Manassas, VA USA (Eds)

Molecular ProfilingMethods and Protocols

Contents Tumor Staging and Grading: A Primer.-Clinical Trial Design in the Age of Molecular Profiling.-Personalized Medicine: Ethics for Clinical Trials.-Reduction of Preanalytical Variability in Specimen Procurement for Molecular Profiling.-The Human Side of Cancer Biobanking.-Intro-duction to Genomics.-Genomic Profiling: cDNA arrays and oligoarrays.-Genome wide methyla-tion profiling in archival formalin fixed paraffin embedded (FFPE) tissue samples.-An Overview of microRNA Methods: Expression Profiling and Target Identification.-Antibody Validation by Western Blotting.-Laser Capture Microdissection: ArcturusXT infra-red capture and UV cutting methods.-Antibody microarrays: Analysis of Cystic Fibrosis.-Tissue Microarrays As A Tool In The Discovery & Validation Of Predictive Biomarkers.-Reverse phase protein microarrays.-Serum Low Molecular Weight Protein Fractiona-tion for Biomarker Discovery.-Mass spectrome-try based biomarker discovery.-Mitochondrial Proteome: Toward The Detection and Profiling of Disease Associated Alterations.-Adult Neural Stem Cells: Isolation and Propagation.-Evanescent Wave Imaging: An Introduction to Total Internal Reflection Fluorescence Microscopy (TIRF).-Con-struction and Hyperspectral Imaging of Quantum Dot Lysate Arrays.-Microarray Data Analysis: Comparing Two Population Means.-Bioinforma-tics/Biostatistics: microarray analysis.-Structure-based functional design of drugs: from target to lead compound.-Personalized Medicine: Changing the Paradigm of Drug Development.-Grant Wri-ting Tips for the First Time Applicant.-Inventions and Patents: A practical tutorial. [...]

Fields of interestsMolecular Medicine; Pathology



Due December 2011

2012. XV, 522 p. 53 illus., 9 in color. (Methods in Molecular Biology, Volume 823) Hardcover7 $159.00ISBN 978-1-60327-215-5

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J. Fan, Illumina, Inc., San Diego, CA, USA (Ed.)

Next-Generation MicroRNA Expression Profiling TechnologyMethods and Protocols

Contents Controlling miRNA Regulation in Disease.- Int-roduction to miRNA Profiling Technologies and Cross-Platform Comparison.- Stem-Loop RT-qP-CR for MicroRNA Expression Profiling.- Poly(T) Adaptor RT-PCR.- MicroRNA In Situ Hybridi-zation.- Agilent MicroRNA Microarray Profiling System.- miRNA Gene Expression Profiling Using Illumina Universal BeadChips.- MicroRNA Expression Analysis Using the Affymetrix Plat-form.- Individualized miRNA Assay Panels Using Optically Encoded Beads.- Microfluidic Primer Extension Assay (MPEA).- MicroRNA Profiling Using µParaflo Microfluidic Array Technology.- MicroRNA Expression Analysis Using the Illu-mina MicroRNA-Seq Platform.- Next Generation Sequencing of miRNAs with Roche 454 GS-FLX Technology: Steps for a Successful Application.- Methods for Small RNA Preparation for Digital Gene Expression Profiling by Next-Generation Sequencing.- Profiling of Short RNAs Using Helicos Single-Molecule Sequencing.- deepBase: Annotation and Discovery of microRNAs and Other Non-Coding RNAs from Deep Sequencing Data.- PhenomiR: MicroRNAs in Human Diseases and Biological Processes.- miRNA Expression Profiling: From Reference Genes to Global Mean Normalization.- miRNA Data Analysis: Next-Gen Sequencing.- Integrated miRNA Expression Ana-lysis and Target Prediction.- miRNAs in Human Cancer.- Blood-Based miRNA Preparation for Non-Invasive Biomarker Development.

Fields of interestsHuman Genetics; Gene Expression



Due January 2012

2012. XIV, 410 p. 62 illus., 11 in color. (Methods in Molecular Biology, Volume 822) Hardcover7 $139.00ISBN 978-1-61779-426-1

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A. Fatatis, Drexel University College of Medicine, Philadelphia, PA, USA (Ed.)

Signaling Pathways and Molecular Mediators in MetastasisFeatures 7 Learning about metastatic dissemination of dif-ferent solid tumours from a single source 7 Con-tributors present their latest work in addition to literature review 7 Innovative objective of identifying common mediators of metastasis in different tumours

Contents Preface.-1. Introduction.I. Local invasion.-2. Re-activation of Epithelial Mesenchymal Transition in Invasive and Metastatic Cancer.-3. Biomechanical ECM Switches and Tumor Metastasis.-4. Moving aggressively: S100A4 and Tumor Invasion.- 5. Shift in TGF-b-induced signaling as culprit for local invasion and dissemination.-6. Role of Rac1-GEF and Dock180 in mediating tyrosine-kinase stimulated glioma invasion.- 7. Impact of tumor hypoxia, Src and Met signaling in the dissemina-tion of tumor cells.II. Homing and colonization at distant sites.-8. Cellular and Molecular Biology of Cancer Cell extravasation.- 9. Role of CXCL12 and CXCR4 in tumor biology and metasta-sis.-10. Transcription factors Stat5a/b and Stat3 in prostate cancer growth and metastases.-11. Survi-val and growth of early metastatic foci in the bone: Role of the alpha-receptor for Platelet-Derived Growth Factor.-12. Androgen receptor in regulati-on of prostate cancer progression and metastasis.- 13. Integrin signaling in angiogenesis and metasta-tic progression in the brain.-14. Tumor and host determinants of pulmonary metastasis in bladder cancer.-15. The Influence of metastatic breast can-cer on the bone microenvironment. Index.

Fields of interestsCancer Research; Oncology; Gene Function



Due December 2011

2012. XVIII, 404 p. 48 illus., 42 in color. Hardcover7 $189.00ISBN 978-94-007-2557-7

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D. Frank, Dana-Farber Cancer Institute, Boston, MA, USA (Ed.)

Signaling Pathways in Cancer Pathogenesis and TherapyIn recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angioge-nesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.

Features 7 Explores novel therapeutic strategies to inhibit signaling 7 Discusses current and next genera-tion antimitotic therapies in cancer 7 Features up-to-date research

Contents Signaling Pathways in Cancer: 21st Century Ap-proaches to Cancer Therapy.- Current And Next Generation Antimitotic Therapies In Cancer.- DNA Damage Checkpoint Signaling Pathways in Human Cancer.- Non-Receptor Tyrosine Kinases and their Roles in Cancer.- The Hedgehog Signa-ling Pathway in Cancer Pathogenesis and Thera-py.- Wnt Signaling in Cancer Pathogenesis and Therapeutics.- STAT Signaling in the Pathogenesis and Treatment of Cancer.- Protein Therapeutics in Oncology.- Index

Fields of interestsCancer Research; Pharmacology/Toxicology



Due December 2011

2012. VIII, 162 p. 13 illus., 10 in color. Hardcover7 $139.00ISBN 978-1-4614-1215-1

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A. D. Fryer, Oregon Health & Science University, Portland, OR, USA; A. Christopoulos, Monash University, VIC, Australia; N. M. Nathanson, University of Washington, WA, USA (Eds)

Muscarinic ReceptorsMuscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on musca-rinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investiga-tors and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues.

Features 7 Provides both a broad overview of muscarinic acetylcholine receptors and a detailed description of their molecular and cell biology and physiolo-gy, and current and potential future therapeutic applications of drugs targeted at the muscarinic system 7 Will be of interest to a wide range of researchers working in the areas of pharmacology, physiology, neuroscience, endocrinology, and re-ceptor biology, and to basic and clinical scientists working in both universities and the pharmaceu-tical/biotech industry 7 Written by leading authorities in the field

Fields of interestsPharmacology/Toxicology; Human Physiology; Cell Biology



Due November 2011

2012. VI, 660 p. 44 illus., 27 in color. (Handbook of Experimental Pharmacology, Volume 208) Hardcover7 approx. $459.00ISBN 978-3-642-23273-2

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M. Hayat, Kean University, Union, NJ, USA (Ed.)

Pediatric Cancer, Volume 1, NeuroblastomaDiagnosis, Therapy, and Prognosis

Contents Preface.-1. Introduction. I Diagnosis and biomar-kers.-2. Pediatric cns neuroblastoma: magnetic resonance imaging and spectroscopy.-3. Pediatric neuroblastoma-associated opsoclonus-myoclonus-ataxia syndrome: early diagnosis.-4. Neuroblas-toma mouse model.-5. Orbital metastasis in neuroblastoma patients.-6. Pediatric neuroblas-toma: molecular detection of minimal residual disease.-7. A comprehensive tissue microarray-based fish screen of alk gene in neuroblastomas. II Therapy.-8. Neuroblastoma: triptolide thera-py.-9. Neuroblastoma: ornithine decarboxylase and polyamines are novel targets for therapeutic intervention.-10. Neuroblastoma: antibody-based immunotherapy.-11. Targeting multidrug resistance in neuroblastoma.-12. Neuroblastoma: perspectives for the use of il-21 in immunothe-rapy.-13. Neuroblastoma: role of hypoxia and hypoxia inducible factors in tumor progressi-on.-14. Neuroblastoma: role of gata transcription factors.-15. Neuroblastoma: role of mycn/bmil pathway in neuroblastoma.-16. Neuroblastoma: role of clusterin as a tumor suppressor gene.-17. Refractory neuroblastoma cells: statins target atp binding cassette-transporters.-18. Neuroblas-toma: dosimetry for mibg therapies.-19. Advanced neuroblastoma: role of alk mutations.-20. Pediatric neuroblastoma: treatment with oral irinotecan and temozolomide. III Prognosis.-21. Genomic profiling of neuroblastoma tumors- prognostic impact of genomic aberrations.-22. Neuroblasto-ma patients: plasma growth factor mildkine as a prognostic growth factor.-23. Pediatric neuroblas-toma: role of tgfbi (keratoepithelin). [...]

Fields of interestsCancer Research; Pediatrics; Diagnostic Radiology



Due November 2011

2012. XXVI, 234 p. 24 illus. in color. (Pediatric Cancer, Volume 1) Hardcover7 $189.00ISBN 978-94-007-2417-4

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Pediatric CancerM. A. Hayat

Cancer still represents one of the leading causes of death in children. Tumors of the CNS account for 17% of childhood malignancies, with the highest incidence during the first 5 years of life. Some ty-pes of tumors are more common in children than in adults. The most common childhood tumors are neuroblastoma, medulloblastoma, low-grade astrocytomas, ependymomas, craniophayngiomas, and brain stem gliomas. The incidence rate of primary tumors of children between the ages 0 to 19 years is approximately 4 cases/100,000. The most commonly occurring childhood cancer is leukemia. It is estimated that 43,050 new cases of leukemia were diagnosed in the United States in 2010 with 21,840 deaths.




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B. Gutkin, DEC-ENS, Paris, France; S. H. Ahmed, University of Bordeaux, France (Eds)

Computational Neuroscience of Drug AddictionContents Foreword: P Dayan.- Part 1 – Pharmacological-based models of addiction.- Chapter 1. Simple deterministic mathematical Model of maintai-ned drug delf-Administration behavior and its pharmacological applications. V.L. Tsibulsky* and A.B. Norman.- Chapter 2. Intermittent Adapta-tion : A mathematical model of drug tolerance, dependence and addiction. A. Peper .- Chapter 3. Control theory and addictive behavior. D. New-lin, P.A. Regalia, T.I. Seidman, G. Bobashev.- Part 2 – Neurocomputational models of addiction.- Chapter 4. Circuit models of addiction: receptors and neural dynamics in nicotine self-administra-tion. M. Graupner and B. Gutkin.- Chapter 5. N Dual-system learning models and drugs of abuse. N.D. Daw and D.A. Simon.- Chapter 6. Modeling decision-making systems in addiction. Z. Kurth-Nelson and A. D. Redish.- Chapter 7. Computatio-nal models of incentive-sensitization in addiction: Dynamic limbic transformation of learning into motivation. J. Zhang, K. C. Berridge, and J. W. Aldridge.- Chapter 8. Understanding addiction as a pathological state of multiple decision making processes: a neurocomputational perspective. M. Keramati, A. Dezfouli and P. Piray.- Part 3 – Eco-nomic-based models of addiction.- Chapter 9. Po-licies and priors. K Friston.- Chapter 10. Toward a Computationally Unified Behavioral-Economic Model of Addiction. E.T. Mueller, L.P. Carter and W.K. Bickel.- Chapter 11. Simulating Patterns of Heroin Addiction within the Social Context of a Local Heroin Market. L. Hoffer, G. Bobashev and R. J Morris.

Fields of interestsNeurosciences; Computer Appl. in Life Sciences



Due December 2011

2012. XIV, 342 p. 91 illus., 28 in color. (Springer Series in Computational Neuroscience, Volume 10) Hardcover7 $209.00ISBN 978-1-4614-0750-8

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M. Hayat, Kean University, Union, NJ, USA (Ed.)

Stem Cells and Cancer Stem Cells,Volume 3Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 3

Contents PREFACE.-1. Introduction.-2. Diversity oriented fluorescence library approach for stem cell probe development.-3. Isolation of mesenchymal stem cells from umbilical cord (method).-4. Mesenchy-mal stem cell isolation and expansion methodo-logy.-5. Hair follicle stem cells.- 6. Rat embryonic cortical neural stem cells: role of hypoxia on cell proliferation and differentiation.-7. Human cord blood-derived hematopoietic stem and proge-nitor cells: from biology to medicine.-8. Pro-teomic characterization of mesenchymal stem cell-like populations derived from various tissue types.-9. The roles of nanog during early embryonic development and primordial germ cell migration.-10. Human embryonic stem cells in serum-free media: growth and metabolism. I. MOLECULAR GENETICS.-11. Evolutionary dynamics of mutations in hematopoietic stem cells and beyond.-12. Isolated corneal epithelial stem cells derived from limbal biopsies: use of lectin as a marker for identifying transient amplifying cells.-13. Stem cell distribution and mgmt expres-sion in glioblastoma: role of intratumoral hypoxic gradient.- 14. Initiation of human tumourigenesis: upregulation of foxm1 transcription factor. II THERAPY.-15. Role of cancer stem cells of breast, colon, and melanoma tumors in the response to antitumor therapy.-16.Ccell-based regenera-tive therapies: role of major histocompatibility complex-1 antigen.-17. Mesenchymal stem cells for cellular therapies.-18. Radiation burns and mesenchymal stem cell therapy. [...]

Fields of interestsCancer Research; Oncology; Stem Cells



Due November 2011

2012. XXXVIII, 386 p. 56 illus. in color. (Stem Cells and Cancer Stem Cells, Volume 3) Hardcover7 $209.00ISBN 978-94-007-2414-3

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M. Hayes, Teagasc, Dublin, Ireland (Ed.)

Marine Bioactive CompoundsSources, Characterization and Applications

Features 7 Identifies and discusses the best sources of sus-tainable marine bioactive compounds known to date 7 Discusses how bioactive compounds alter biological activity to provide therapeutic benefits to humans and animals 7 Discusses market opportunities for the identification and commer-cialization of new marine bioactive compounds

Contents 1. Taxonomy of Marine Macroalgae Used as Sources of Bioactive Compounds.- 2. Extraction and Characterization of Bioactive Compounds with Health Benefits from Marine Resources: Macro- and Microalgae Cyanobacteria and Inver-tebrates.- 3. Marine Bioactive Peptides and Protein Hydrolysates: Generation, Isolation Procedures and Biological and Chemical Characterizations.- 4. Chitin, Chitosan and Their Derivatives from Marine Rest-Raw Materials: Potential Food and Pharmaceutical Applications.- 5. Industry Potenti-al of Marine Bioactive Components: Downstream Processing and Vehicles for Efficient Delivery in situ.- 6. Extraction and Characterization of Bioactive Carbohydrates with Health Benefits from Marine Resources: Macro- and Microalgae, Cyanobacteria and Invertebrates.- 7. Medicinal Chemistry and Ligand Profiling for Evaluation of Promising Marine Bioactive Molecules.- 8. Marine-Derived Functional Foods: Claims and Current Legislation.

Fields of interestsPharmaceutical Sciences/Technology; Bioorganic Chemistry; Pharmacy



Due December 2011

2012. XIV, 232 p. 34 illus., 8 in color. Hardcover7 $209.00ISBN 978-1-4614-1246-5

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8

J. Jasmin, P. G. Frank, M. P. Lisanti, Thomas Jefferson University, Philadelphia, PA, USA (Eds)

Caveolins and CaveolaeRoles in Signaling and Disease Mechanisms

Caveolae are 50-100 nm flask-shaped invagina-tions of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts.

Features 7 Discusses pleiotropic functions of caveolae and caveolin proteins 7 Presents the role and function of caveolae and caveolins in cell signaling and human disease mechanisms 7 Focuses on selected topics

Contents Lipid Rafts, Caveolae and GPI-Linked Proteins.- Caveolae and the Regulation of Endocytosis.- Ca-veolin-1: Role in Cell Signaling.- Regulation of eNOS in Caveolae.- Recent Developments in the Interactions Between Caveolin and Pathogens.- Caveolin-1 and Breast Cancer: A New Clinical Perspective.- Caveolin-1 and Prostate Cancer Pro-gression.- Caveolins and Caveolae, Roles in Insulin Signalling and Diabetes.- Atherosclerosis, Caveolae and Caveolin-1.- Caveolins and Heart Diseases.- Caveolins and Lung Function.

Fields of interestBiomedicine general



Due November 2011

2012. XX, 184 p. 27 illus., 1 in color. (Advances in Experimental Medicine and Biology, Volume 729) Hardcover7 approx. $139.00ISBN 978-1-4614-1221-2

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M. Kaufmann, Private Universität Witten/Herdecke gGmbH, Germany; C. Klinger, Private Universität Witten/Herdecke gGmbH, Witten, Germany (Eds)

Functional GenomicsMethods and Protocols

Contents Prediction of Protein Tertiary Structures using MUFOLD.-Prediction of Protein Functions.-Genome Wide Screens for Expressed Hypothetical Proteins.-Self Custom-Made SFP Arrays for Non-Model Organisms.-Construction and Analysis of Full-length and Normalized cDNA Libraries from Citrus.-Assembling Linear DNA Templates for in vitro Transcription and Translation.-Automated Computational Analysis of Genome-wide DNA Methylation Profiling Data from HELP-tagging Assays.-Detection of RNA Editing Events in Hu-man Cells using High- Throughput Sequencing.-Comparative Study of Differential Gene Ex-pression in Closely Related Bacterial Species by Comparative Hybridization.-Whole Genome RT-qPCR MicroRNA Expression Profiling.-Using Quantitative Real-Time Reverse Transcriptase Polymerase Chain Reaction to Validate Gene Regulation by PTTG.-FRET-Based Real-Time DNA Microarrays.- 2-D Gel Electrophoresis: Constructing 2D-Gel Proteome Reference Maps.-The use of Antigen Microarrays in Antibody Profiling.-Limited Proteolysis in Proteomics using Protease-immobilized Microreactors.-Mass Spec-trometry for Protein Quantification in Biomarker Discovery.-High-throughput Microtitre Plate-based Assay for DNA Topoisomerases.-Microscale Thermophoresis as a Sensitive Method to Quantify Protein - Nucleic Acid Interactions in Solution.-Bioluminescence Resonance Energy Transfer: an Emerging Tool for the Detection of Protein-prote-in Interaction in Living Cells.-LuMPIS – Lucife-rase-based MBP-pull-down Protein Interaction Screening System. [...]

Fields of interestHuman Genetics



Due December 2011

2nd ed. 2012. XVIII, 437 p. 73 illus., 12 in color. (Methods in Molecular Biology, Volume 815) Hardcover7 $139.00ISBN 978-1-61779-423-0

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A. A. Khan, King Saud University, Riyadh, Saudi Arabia (Ed.)

Bacteria and CancerBacterial infections cause substantial morbidity and mortality in cancer patients. These infections always remained enigmatic due to initial reluc-tance of cancer researchers in understanding their etiologic potential. Etiological association of bac-teria with cancer gained credibility after discovery of carcinogenic potential of Helicobacter pylori.

Features 7 Extensive coverage of negative and positive associations between bacteria and cancer 7 Sim-plification of complicated associations with illustrations and figures 7 Contains idea for utilization of bacteriological knowledge in cancer research 7 Focus on recent advances in bacteria and cancer biology

Contents Epidemiological indication about bacterial infec-tions associated with cancer.-2. Gastric cancer and Helicobacter pylori.-3. Streptococcus bovis and colorectal cancer.-4 Chlamydial diseases: A cross-road between chronic infection and development of cancer.-5. Salmonella typhi and gall bladder cancer.-6. Ocular adnexal lymphoma of MALT type and its association with Chlamydophila psittaci infection.-7. Possible strategies of bacterial involvement in cancer development.-8. Bacteria as a therapeutic approach in cancer therapy.-9. Tar-geting cancer with Amino-acid auxotroph Salmo-nella typhimurium A1-R.-10. Bacterial asparagi-nase: A potential therapeutic agent for treatment of acute lymphoblastic leukemia.-11. Can Bacteria evolve anticancer phenotype?-12. Management of bacterial complications in cancer patients. Index.

Fields of interestsCancer Research; Medical Microbiology; Onco-logy



Due December 2011

2012. XV, 285 p. 26 illus., 14 in color. Hardcover7 $189.00ISBN 978-94-007-2584-3

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9

C. Knapp, V. Madden, University of Florida, Gainesville, FL, USA; S. Fowler-Kerry, University of Saskatchewan, Saskatoon, SK, Canada (Eds)

Pediatric Palliative Care: Global PerspectivesFeatures 7 Description of pediatric palliative care in 23 countries 7 Program development and imple-mentation 7 Pediatric palliative care policies and legislation 7 Barriers and enablers of pediatric palliative care 7 Description of children who need pediatric palliative care

Contents Aknowledgement.-1.Pediatric Palliative Care: Overview. I. Africa.-2. Pediatric Palliative Care in Malawi .- 3. Pediatric Palliative Care in South Af-rica.-4. Pediatric Palliative Care in Uganda.-5. Pe-diatric Palliative Care in Zimbabwe. II. Asia.-6. Pe-diatric Palliative Care in Armenia.-7. Pediatric Palliative Care in India.-8. Pediatric Palliative Care in Malaysia.-9. Pediatric Palliative Care in the Middle East.-10. Pediatric Palliative Care in Saudi Arabia.-11. Pediatric Palliative Care in Singapo-re.-12. Pediatric Palliative Care in Thailand.III. Europe.-13. Pediatric Palliative Care in Germa-ny.-14. Pediatric Palliative Care in Ireland.-15. Pe-diatric Palliative Care in Poland.-16. Pediatric Palliative Care in the UK. IV. North America.-17 Pediatric Palliative Care in Canada.-18. Pediatric Palliative Care in Costa Rica.-19. Pediatric Palliati-ve Care in Mexico.-20. Pediatric Palliative Care in the United States of America. V. Oceania.-21. Pe-diatric Palliative Care in Australia and New Zea-land. VI. South America.-22. Pediatric Palliative Care in Argentina.-23. Pediatric Palliative Care in Brazil.-24. Pediatric Palliative Care in Chile. VII. Conclusion.-25. Pediatric Palliative Care: A New and Emerging Paradigm. Index.

Fields of interestsBiomedicine general; Maternal and Child Health; Pediatrics



Due December 2011

2012. XXXVI, 464 p. 64 illus. in color. Hardcover7 $209.00ISBN 978-94-007-2569-0

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R. Lever, University of London, UK; B. Mulloy, NIBSC, Potters Bar, Hertfordshire, UK; C. P. Page, Sackler Institute of Pulmonary Pharmacology, London, UK (Eds)

Heparin - A Century of ProgressHeparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, under-standing of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like mate-rials from both natural and synthetic sources.

Features 7 Written by leading experts in the field 7 With numerous illustrations 7 A valuable reference work on the occasion of the upcoming centenary of heparin

Contents Part 1. Introduction.- Part 2. Unfractionated and Low Molecular Weight Heparins.- Part 3. Clinical Use of Heparin and LMWH.- Part 4. Non An-ticoagulant Indictions for Heparin and Related Compounds.- Part 5. Heparin-like Entities.

Fields of interestsPharmacology/Toxicology; Molecular Medicine; Pharmaceutical Sciences/Technology



Due November 2011

2012. VI, 480 p. 79 illus., 34 in color. (Handbook of Experimental Pharmacology, Volume 207) Hardcover7 $419.00ISBN 978-3-642-23055-4

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C. López-Larrea, Hospital Universitario Central de Asturias, Oviedo, Spain (Ed.)

Self and NonselfIn 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine.

Features 7 Covers different aspects of the emergence of immune systems in the evolution of life 7 Focu-ses on the origin of the immune response during the development of multicellularity 7 Presents an integrated view of self and nonself recognition systems in the context of evolution

Contents The Origin of the Bacterial Immune Respon-se.- The Evolution of Self During the Transition to Multicellularity.- Glyconectin Glycans as the Self-Assembling Nano-Molecular-Velcrosystem Mediating Self-Nonself Recognition and Adhesion Implicated in Evolution of Multicellularity.- Neg-lected Biological Features in Cnidarians Self-Nonself Recognition.- Intracellular Inflammatory Sensors For Foreign Invaders and Substances of Self-Origin.- Nonself Perception in Plant Inna-te Immunity.- How Did Flowering Plants Learn to Avoid Blind Date Mistakes? Self-Incompatibility in Plants and Comparisons with Nonself Rejection in the Immune Response.- Signaling Pathways that Regulate Life and Cell Death: Evolution of Apoptosis in the Context of Self-Defense.- Sensing Necrotic Cells.- Sensing Endoplasmic Reticulum Stress.- Autophagy and Self-Defense.- Viruses and Host Evolution: Virus-Mediated Self Identity.- The Evolution of Adaptive Immunity.- Epigenetic Code and Self-Identity.- Viral Immunomodula-tory Proteins: Usurping Host Genes as a Survival Strategy.- The Emergence of the Major Histocom-patilibility Complex.- MHC Signaling During Social Communication.

Fields of interestsImmunology; Biomedicine general



Due January 2012

2012. XXII, 318 p. 35 illus., 22 in color. (Advances in Experimental Medicine and Biology, Volume 738) Hardcover7 approx. $209.00ISBN 978-1-4614-1679-1

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10

A. Lorence, Arkansas State University, Jonesboro, AR, USA (Ed.)

Recombinant Gene ExpressionContents Using Folding Promoting Agents in Recombinant Protein Production: A Review.-Routine Iden-tity Confirmation of Recombinant Proteins by MALDI-TOF Mass Spectrometry.-A Matter of Packaging: Influence of Nucleosome Positioning on Heterologous Gene Expression.-Tools of the Trade: Developing Antibody-Based Detection Ca-pabilities for Recombinant Proteins.-Heat-shock Protein Fusion Vectors for Improved Expression of Soluble Recombinant Proteins in Escherichia coli.-The use of a Flagellar Export Signal for the Secretion of Recombinant Proteins in Salmonella.-Optimization of Purification Protocols Based on the Step-by-step Monitoring of the Protein Aggregates in the Soluble Fractions.-Heterologous Protein Expression by Lactococcus lactis.-An Ex-tended Suite of Genetic Tools for Use in Bacteria of the Halomonadaceae: An Overview.-Regulated Recombinant Protein Production in the Antarctic Bacterium Pseudoalteromonas haloplanktis TAC125.-A Novel Strategy for the Construction of Genomic Mutants of the Antarctic Bacterium Pseudoalteromonas haloplanktis TAC125.-A New Bacterial Co-expression System for Over-ex-pressing Soluble Protein and Validating Protein-protein Interaction.-Heterologous High-level Gene Expression in the Photosynthetic Bacterium Rhodobacter capsulatus.-Plasmid DNA Produc-tion for Therapeutic Applications.-Recombinant Protein Production in the Eukaryotic Protozoan Parasite Leishmania tarentolae: A Review.-Ex-pression of Multi-subunit Proteins in Leishmania tarentolae.-Recombinant Protein Production in Yeasts.-Yeasts as Tool for Heterologous Gene Expression. [...]

Fields of interestsHuman Genetics; Gene Expression



Due January 2012

3rd Edition. 2011. X, 748 p. 105 illus., 1 in color. (Methods in Molecular Biology, Volume 824) Hardcover7 $159.00ISBN 978-1-61779-432-2

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D. W. McCandless, Rosalind Franklin University, Chicago, IL, USA

EpilepsyAnimal and Human Correlations

The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized.

Features 7 This volume examines features of animal and human studies related to both simple and complex partial seizures. 7 Typical as well as atypical sei-zures are described whenever possible, studies in primates receive careful attention. 7 Rather than offering an inclusive survey of every published study relating to epilepsy in animals and humans, the book offers judiciously selected material with clear correlative relevance.

Contents Prologue: World Health Concerns, Incidence, Costs, etc.- Section 1 Animal Partial.- Chapter 1: Simple Partial.- Chapter 2: Complex Partial.- Section 2 Animal Generalized.- Chapter 3: Tonic Clonic.- Chapter 4: Tonic.-Chapter 5: Ato-nic.- Chapter 6: Myoclonic.-Chapter 7: Absence .- Section 3 Animal.- Chapter 8: Unclassified-Mixed.- Chapter 9: Nocturnal.- Section 4 Human Partial.- Chapter 10: Simple Partial.-Chapter 11: Simple complex.- Section 5 Human Genera-lized.- Chapter 12: Tonic Clonic.- Chapter 13: To-nic.- Chapter 14: Atonic.- Chapter 15: Myoconic.- Chapter 16: Absence.- Section 6 Human.- Chapter 17: Unclassified-Mixed.- Chapter 18: Nocturnal.- Section 7 Miscellaneous.- Chapter 19: Pediatric Considerations.- Chapter 20 : Surgery.- Chapter 21: Status Epilepticus.- Chapter 22: Epilogue

Fields of interestsNeurosciences; Neurology; Neurochemistry



Due October 2011

2011. 700 p. 63 illus., 4 in color. Hardcover7 $239.00ISBN 978-1-4614-0108-7

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I. Mercier, J. Jasmin, M. P. Lisanti, Thomas Jefferson University, Philadelphia, PA, USA (Eds)

Caveolins in Cancer Pathogenesis, Prevention and TherapyCaveolins are important structural proteins of Caveolae, small invaginations of the membrane. They have been shown to play an important role in the pathogenesis of multiple cancers. In this volume, we will mainly focus on the importance of Caveolin-1 in breast, prostate, lung, skin, colon, pancreatic and brain cancers with also a mention of the novel role of Caveolin-3 in breast cancer.

Features 7 Explores the relationship between Caveolins and prostate cancer 7 Describes the role of Caveolins in tumor angiogenesis 7 Studies the novel role of Caveolin-3 in breast cancer

Contents Preface.- Local and Distant Effects of Caveolin-1 on Prostate Cancer Progression.- Caveolin-1 in Colon Cancer: the Flexible Connection to Wnt Signaling.- Caveolin-1 and Pancreatic Ductal Ade-nocarcinoma.- Caveolin-1 in Brain Tumors.- The Role of Caveolin-1 in Skin Cancer.- Caveolins and Tumor Angiogenesis.- Caveolin-1 and Breast Can-cer.- Caveolin-1 and Cancer-Associated Stromal Fibroblasts.- Index

Fields of interestsCancer Research; Pharmacology/Toxicology



Due December 2011

2011. XII, 134 p. 12 illus., 11 in color. (Current Cancer Research) Hardcover7 $139.00ISBN 978-1-4614-1000-3

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11

K. B. Michels, Harvard Medical School, Boston, MA, USA (Ed.)

Epigenetic EpidemiologyThe exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance.

Features 7 First book in this new, emerging field 7 State of the art on human evidence in epigene-tics 7 Helps to digest rapid growing information on epigenetics in humans 7 A guide how to design a study on epigenetics in humans 7 As-sists in interpreting and understanding epigenetic evidence in humans

Contents Introduction.-1. The Human Epigeno-me.-2. Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology.-3. Laboratory methods in epige-netic epidemiology.-4. Biostatistical methods in epigenetic epidemiology.-5. Epigenome changes during development.-6. The role of epigene-tics in the developmental origins of health and disease.-7. Epigenetics and assisted reproductive technology.-8. Imprinting disorders of early childhood.-9. The utility of twins for epigenetic analysis.-10. Changes in the epigenetic profile with age.-11. Influence of environmental factors on the epigenome.-12. Epigenetic epidemiology of cancer.-13. Epigenetic epidemiology of infectious diseases.-14. Epigenetic epidemiology of inflam-mation and rheumatoid arthritis.-15. Asthma epigenetics: Emergence of a new paradigm? -16. Epigenetic epidemiology of autism and other neurodevelopmental disorders.-17. Epigenetic epi-demiology of psychiatric disorders.-18. Epigenetic epidemiology of type 1 diabetes.-19. Epigenetic epidemiology of obesity, type 2 diabetes, and metabolic disorders.-20. Epigenetic epidemiology of atherosclerosis. Index.

Fields of interestsCancer Research; Epidemiology; Human Genetics



Due November 2011

2012. XII, 445 p. 39 illus., 31 in color. Hardcover7 $209.00ISBN 978-94-007-2494-5

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R. Milner, The Scripps Research Institute, La Jolla, CA, USA (Ed.)

AstrocytesMethods and Protocols

Contents Astrocytes: Multi-talented Stars of the Central Nervous System.-Neurogenic Astrocytes and their Glycoconjugates: not just “Glue” Any-more.- Heterogeneity of Astrocytic Form and Function.-Preparation of Mixed Glial Cultures from Postnatal Rat Brain.-Generation of Primary Astrocyte Cultures Devoid of Contaminating Microglia.-Derivation of Microglia-free Astrocyte Cultures from Neural Stem Cells.-Isolation and Culture of Spinal Cord Astrocytes.-Isolation and Culture of Astrocytes from the Retina and Optic Nerve.-Primary Cultures of Astrocytes from Fetal Bovine Brain.-Isolation and Cultivation of Porcine Astrocyte.- Isolation and Culture of Human Astrocytes.-Cell Culturing of C. elegans Glial Cells for the Assessment of Cytosolic Ca2+ Dynamics.-Astrocyte Polarization and Wound Healing in Culture:Studying Cell Adhesion Molecules.-An in Vitro Trauma Model to Study Rodent and Human Astrocyte Reactivity.-Use of Gel Zymography to Examine Matrix Metalloproteinase (gelati-nase) Expression in Brain Tissue or in Primary Glial Cultures.-ELISA Methodology to Quantify Astrocyte Production of Cytokines/Chemokines In Vitro.-Induction of Nitric Oxide Synthase-2 Expression and Measurement of Nitric Oxide Production in Enriched Primary Cortical Ast-rocyte Cultures.-Examining Potassium Channel Function in Astrocytes.-Connexin Based Chan-nels in Astrocytes: How to Study their Properties.-Isotope-based Quantitation of Uptake, Release and Metabolism of Glutamate and Glucose in Cultured Astrocytes.-An in Vitro Model of Reactive Astrog-liosis and its Effect on Neuronal Growth. [...]

Fields of interestsNeurosciences; Human Physiology



Due December 2011

2012. XVIII, 672 p. 113 illus., 51 in color. (Methods in Molecular Biology, Volume 814) Hardcover7 $159.00ISBN 978-1-61779-451-3

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G. Molineux, Amgen Inc., Thousand Oaks, CA, USA; M. Foote, Westlake Village, CA, USA; T. Arvedson, Amgen Inc., Thousand Oaks, CA, USA (Eds)

Twenty Years of G-CSFClinical and Nonclinical Discoveries

Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulo-cyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neu-tropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting. This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recom-binant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.

Features 7 Many of the authors are the original inves-tigators of recombinant human G-CSF 7 Key researchers provide their outlook for the next 20 years 7 Describes oncological and non-oncolo-gical applications

Contents Basic Science.- Use of rHuG-CSF in the Oncology Setting.- Use of rHuG-CSF in Non-Oncology Set-ting.- Safety and Economics.- The Next 20 Years.

Fields of interestsPharmacology/Toxicology; Cancer Research; Immunology



Due November 2011

2012. XV, 562 p. 49 illus., 8 in color. (Milestones in Drug Therapy) Hardcover7 $239.00ISBN 978-3-0348-0217-8

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12

M. Negrello, Okinawa Institute of Science and Technology, Japan

Invariants of BehaviorConstancy and Variability in Neural Systems

The study of the brain and behavior is illuminated with the discovery of invariances. Experimental brain research uncovers constancies amidst varia-tion, with respect to interventions and transforma-tions prescribed by experimental paradigms. Place cells, mirror neurons, event related potentials and areas differentially active in fMRI, all illustrate the pervasive role of invariances in neural systems in relation to their function.

Features 7 Studies the possible space of variations in structure and dynamics that maintain a given behavioral function unchanged; what are, in other words, the invariants of a given behavior 7 Inva-riances are introduced first generally, then in the study of neural systems 7 The role of empirical invariances in explanation of behavioral function is discussed and exemplified

Contents 1 Invariants of Behavior: Constancy and Variabi-lity in Neural Systems and Behavior.- Summary.- Acknowledgements.- Foreword.- Part I Invariants of Behavior.- 2 Introduction.- 3 Invariances in Theory.- 4 Empirical Assessments of Invariance.- 5 Modeling and Invariance.- 6 Dynamical Sys-tems and Convergence.- 7 Neurons, Models and Invariants.- Part II Neurodynamics of Embodied Behavior.- 8 Neurodynamics and Evolutionary Robotics.- 9 Attractor Landscapes in Active Tra-cking.- Appendix: Learning.- Appendix: Related Work.- References.- 10 Convergent Evolution of Behavioral Function.- 11 Neural Communication: Messages between Modules.

Fields of interestsNeurosciences; Computation by Abstract Devices; Neurobiology

Target groupsGraduate


Available

2011. XIX, 251 p. 65 illus., 45 in color. (Springer Series in Cognitive and Neural Systems, Volume) Hardcover7 $209.00ISBN 978-1-4419-8803-4

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F. Nijkamp, Utrecht University, The Netherlands; M. J. Parnham, University Hospital for Infectious Diseases, Zagreb, Croatia (Eds)

Principles of Immunopharmacology

Contents Introduction: Altering the chain of command in host defence.- Immunity: Hematopoiesis and lymphocyte development: an introduction.- T cell subsets and T cell-mediated immunity.-Antibody diversity and B lymphocyte-mediated immunity.- Dendritic cells.- Cytokines.- Innate immunity - phagocytes, natural killer cells and the complement system.- Inflammatory mediators and intracellular signalling.- Immune response in human pathology: Infections caused by bacteria, viruses, fungi, and parasites.- Immune respon-se in human pathology: Hypersensitivity and autoimmunity.- Cancer immunity.- Neuroimmu-noendocrinology.- Immunodiagnosis: Antibody detection.- Immunoassays.- Flow cytometry.- Microarrays.- Immunotherapeutics: Vaccines.- Plasma-derived immunoglobulins.- Anti-allergic drugs.- Drugs for the treatment of airway disease.- Perspectives of immunotherapy in the manage-ment of asthma and other allergic conditions.- Im-munostimulants in cancer therapy.- Anti-infective activity of immunomodulators.- Immunopharma-cology of probiotics and prebiotics.- Mild plant and dietary immunomodulators.- Influence of antibacterial drugs on the immune system.- Cy-totoxic drugs.- Immunosuppressives in trans-plant rejection.- Corticosteroids.- Non-steroidal anti-inflammatory drugs.- Disease-modifying antirheumatic drugs.- Immunotoxicology.- Ap-pendices.- Glossary.- Index.

Fields of interestsImmunology; Pharmacology/Toxicology; Cell Biology


Product CategoryGraduate/Advanced undergraduate textbook

Due August 2011

3rd, revised and extended ed. 2011. XXXI, 728 p. 162 illus., 37 in color. Softcover7 approx. $129.00ISBN 978-3-0346-0135-1

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M. Pardon, University of Nottingham, UK; M. Bondi, University of California San Diego, La Jolla, CA, USA (Eds)

Behavioral Neurobiology of AgingThis volume discusses the current state of research findings related to healthy brain aging by integ-rating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.

Features 7 This volume provides topics that will be useful to researchers, clinicians and students interested in the current knowledge and research chal-lenges in neurobiological perspectives in aging as well as future research directions in aging research 7 Written by leading authorities in this field 7 With numerous illustrations

Contents From the contents: Preface.- Part 1. Epidemiologic perspective in aging.- Part 2. Cognitive and emo-tional perspectives in aging.- Part 3. Reproductive aging.- Part 4. Medical and psychiatric factors in aging.- Part 5. Modifiers of brain aging.

Fields of interestsNeurosciences; Behavioural Sciences; Geriatrics/Gerontology



Due January 2012

2012. Approx. 300 p. (Current Topics in Behavioral Neurosciences, Volume 10)7 approx. $209.00ISBN 978-3-642-23874-1

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13

J. M. Parry, E. M. Parry, Lyndhurst, UK (Eds)

Genetic ToxicologyPrinciples and Methods

The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types.

Features 7 Covers the scientific basis, the methodolo-gies, and the applications of the methods in clear detail 7 Features step-by-step, laboratory ready protocols 7 Includes expert tips and implemen-tation advice to ensure successful results

Contents The Application of Structure Activity Relation-ships to the Prediction of the Mutagenic Activity of Chemicals.- Bacterial Mutagenicity Assays: Test Methods.- The Mouse Lymphoma Assay.- Mam-malian Cell HPRT Gene Mutation Assay: Test Methods.- The In Vitro Mammalian Chromosome Aberration Test.- The Interpretation and Analysis of Cytogenetic Data.- The In Vitro Micronucleus Assay.- The In Vitro and In Vivo Comet Assays.- Assessment of DNA Interstrand Crosslinks (ICLs) Using the Modified Alkaline Comet Assay.- 32P-Postlabelling for the Sensitive Detection of DNA Adducts.- Methods for the Detection of DNA Ad-ducts.- The GADD45a-GFP GreenScreen HC As-say.- Real Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR): Technical Considera-tions for Gene Expression Analysis.- Cytogenetic In Vivo Assays in Somatic Cells.- Cytogenetic Methods in Human Biomonitoring: Principles and Uses.- The Measurement of Induced Genetic Change in Mammalian Germ Cells.- Transgenic Animal Mutation Models: A Review of the Models and How They Function.- Analysis of Genotoxici-ty Data in a Regulatory Context.

Fields of interestsPharmacology/Toxicology; Human Genetics



Due December 2011

2012. XIV, 355 p. 112 illus., 46 in color. (Methods in Molecular Biology, Volume 817) Hardcover7 $139.00ISBN 978-1-61779-420-9

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G. P. Quinn, S. T. Vadaparampil, University of South Florida, Tampa, Fl, USA (Eds)

Reproductive Health and Cancer in Adolescents and Young AdultsFeatures 7 Summarizes the latest research in this field 7 Each chapter written by expert in the field 7 Covers broad array of reproductive health issues 7 Unique population of AYA (adolescent and young adult) 7 Each chapter has vignette and list of recommendation for providers

Contents Forward.-Acknowledgements.-Introduc-tion.-1. Principles of Cancer Treatment: Impact on Reproduction.-2. Fertility Preservation Options for Females.-3. Fertility Preservation Options for Males.-4. Contraception During Cancer Treat-ment in Young Persons.-5. Sexual Health During Cancer Treatment.-6. The Exceptional Needs of Breast Cancer Patients.-7. Pregnancy and Cancer.-8. Preimplantation Genetic Diagnosis for Hereditary Cancers.-9. Non-Traditional Family Building Options.-10. Parenting with Cancer I: Developmental Perspective, Communication, and Coping.-11. Parenting with Cancer II: Parenting at Different Stages of Illness.-12. Pediatric Patients and Reproductive Health.- 13. Institutional Ap-proaches to Implementing Fertility Preservation for Cancer Patients.- 14. Patient Provider Com-munication and Reproductive Health.-15. Ethical Issues in Fertility.-16. Legal Issues Associated with Fertility Preservation.-Appendix.Table 2: Assisted Reproductive Technologies estimated cost. Table 3: Fertility Preservation Options for Females. Table 4: Fertility Preservation Options for Males. Index.

Fields of interestsCancer Research; Oncology; Reproductive Medi-cine



Due November 2011

2012. XII, 300 p. 1 illus. (Advances in Experimental Medicine and Biology, Volume 732) Hardcover7 $209.00ISBN 978-94-007-2491-4

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A. L. Ronco, IUCLAEH, Maldonado, Uruguay; E. De Stéfani, Universidad de la República, Montevideo, Uruguay

Nutritional Epidemiology of Breast CancerThe book is the first one published exclusively on the field of nutritional epidemiology of breast cancer. It summarizes the currently existing knowledge, with an updated and comprehensive international bibliography (~ 1.000 references). The authors also performed a review on the epide-miological studies on nutrition and breast cancer carried out in Uruguay between 1994 and 2011, which allowed exploring and identifying the main risk and protective factors for the disease in this high-risk country.

Features 7 Original and Innovative approaches 7 Chal-lenging proposals 7 Information completeness

Contents Preface.-1. general epidemiology of breast cancer in the world .-I. Current knowledge.-2. Energy and related factors.-3. Foods.-4. Nutrients.-5. Vi-tamins and bioactive substances.-6. Alcohol and other beverages.-7. Dietary patterns.-8. Polyunsa-turated fatty acids.-9. Insulin resistance, meta-bolic syndrome and breast cancer the research in Uruguay.-10. Methodology.- 11. The role of foods.-12. The role of nutrients and other subs-tance.-13. The role of anthropometry.-14. Foods and nutrients for secondary prevention: risk classification through artificial intelligence.-II. Future perspectives.-15. Primary prevention: the new challenges.-16. Basic guidelines for breast health.-17. Prevention after diagnosis.-18. Nu-tritional strategy from populations to individu-als.-19. The breast cancer risk profile.Index.

Fields of interestsCancer Research; Nutrition; Epidemiology



Due November 2011

2012. V, 262 p. 46 illus., 33 in color. Hardcover7 $189.00ISBN 978-94-007-2396-2

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14

M. G. Rossmann, Purdue University, West Lafayette, IN, USA; V. B. Rao, Catholic University of America, Washington, D.C., USA (Eds)

Viral Molecular MachinesThis book will contain a series of solicited chap-ters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chap-ters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will exami-ne in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion.

Features 7 Written by leaders in their respective fields 7 Uses the best examples from bacte-riophages and animal viruses, many causing infectious diseases of public health impor-tance 7 Conveys state of the art knowledge of the topic generated by combining X-ray crystal-lography, high resolution electron microscopy, molecular genetics, biochemistry, and single molecule biophysics

Contents Viruses: Sophistiated Biological Machines.- F1-Atpase: A Prototypical Molecular Motor.- Recon-structing Virus Structures From Nanometer To Near-Atomic Resolutions With Cryo-Electron Mi-croscropy And Tomography.- Principles Of Virus Structural Organization.- Viral Entry Machines.- Genome Replication Machines.- Capsid Assembly And Maturation.- Genome Packaging Machines.

Fields of interestsVirology; Microbiology; Infectious Diseases



Due December 2011

2012 2012. XII, 722 p. 221 illus., 192 in color. (Advances in Experimental Medicine and Biology, Volume 726) Hardcover7 $279.00ISBN 978-1-4614-0979-3

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J. Siepmann, University Lille Nord de France, Lille, France; R. A. Siegel, University of Minnesota, Minneapolis, MN, USA; M. J. Rathbone, Griffith University, Southport, QLD, Australia (Eds)

Fundamentals and Applications of Controlled Release Drug DeliveryFeatures 7 Text easy to understand 7 Book is generously supplemented with diagrams 7 Covers among others mechanisms and modeling of drug delivery, overview of applied therapeutics, and concepts of temporal, spatial and chronotherapeutic approa-ches to drug delivery

Contents The Need for Drugs and Drug Delivery Sys-tems.- Overview of Controlled Release Mecha-nisms.- Hydrophobic Polymers of Pharmaceutical Significance.- Hydrogels.- Biodegradable Polymers in Drug Delivery Systems.- Diffusion Controlled Drug Delivery Systems.- Swelling Controlled Drug Delivery Systems.- Degradable Polymeric Carriers for Parenteral Controlled Drug Delivery Systems.- Porous Systems.- Targeted Delivery Using Biode-gradable polymeric Nanoparticles.- Liposomes in Drug Delivery.- Receptor Mediated Delivery Systems for Cancer Therapeutics.- Biological Rhythms, Drug Delivery, and Chronotherapeu-tics.- Site Specific Controlled Release for Cardio-vascular Disease – Translational Direction.- Drug Delivery Systems to Fight Cancer.- Applications of Vaccine Delivery in Infectious Diseases.- Tis-sue Engineering in Drug Delivery.- The Shaping of Controlled Release Drug Product Development by Emerging Trends in the Commercial, Regulatory and Political Macro-Environment

Fields of interestsPharmacology/Toxicology; Biochemistry, general; Pharmacy



Due November 2011

2012. VIII, 776 p. 147 illus., 42 in color. (Advances in Delivery Science and Technology) Hardcover7 $239.00ISBN 978-1-4614-0880-2

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Y. Takayama, National Institute of Livestock and Grassland Science, Tsukuba, Japan

Lactoferrin and its Role in Wound HealingLactoferrin is an iron-binding glycoprotein belon-ging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fib-roblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Pro-tein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing.

Features 7 Provides the recent advances in molecular me-chanisms of wound healing 7 Provides in-depth information on roles of lactoferrin as a signaling molecule 7 Presents the scientific background on use of lactoferrin as a wound healing agent

Contents 1. Molecular regulation of wound healing, - 2. Role of hyaluronan in wound healing, - 3. Lactoferrin structure, function and genetics, - 4. Lactoferrin as a signaling mediator, - 5. Effects of lactoferrin on skin wound healing

Fields of interestsBiomedicine general; Human Physiology; Cell Biology



Due November 2011

2012. XV, 122 p. 12 illus., 1 in color. Hardcover7 $139.00ISBN 978-94-007-2466-2

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J. R. Turner, Quintiles, Durham, NC, USA

Key Statistical Concepts in Clinical Trials for PharmaThis book discusses key statistical concepts that facilitate the inferential analysis of data collected from a group of individuals participating in a pharmaceutical clinical trial, the estimation of their clinical significance in the general popu-lation of individuals likely to be prescribed the drug if approved, and the related decision-making that occurs at both the public health level (by regulatory agencies when deciding whether or not to approve a new drug for marketing) and the individual patient level (by physicians and their patients when deciding whether or not the patient should be prescribed a drug that is on the market). These concepts include drug safety and efficacy, statistical significance, clinical significance, and benefit-risk balance.

Feature 7 Discusses key statistical concepts

Fields of interestsBiomedicine general; Pharmaceutical Sciences/Technology


Product Category

Due November 2011

2012. II, 50 p. 1 illus. in color. (SpringerBriefs in Pharmaceutical Science & Drug Development) Softcover7 $69.95ISBN 978-1-4614-1661-6

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R. O. Williams III, A. B. Watts, University of Texas, Austin, TX, USA; D. A. Miller, Hoffmann-La Roche, Inc., Nutley, NJ, USA (Eds)

Formulating Poorly Water Soluble DrugsThis volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds.

Features 7 Highlights the most recent advancements reported in the literature on technologies to im-prove the dissolution and bioavailability of poorly water soluble drugs 7 Provides a comprehensive discussion of new technologies developed and recently reported 7 Very useful to scientists in the chemical industry and agricultural industry

Contents Route-Specific Challenges in Delivery of Poorly Water Soluble Drugs.- Optimizing the Formula-tion of Poorly Water Soluble Drugs.- Solid-State Techniques for Improving Solubility.- Mechanical Particle Size Reduction Techniques.- Solubilized Formulations.- Injectable Formulations of Poorly Water Soluble Drugs.- Design and Development of Self-Emulsifying Lipid Formulations for Impro-ving Oral Bioavailability of Poorly Water-Soluble and Lipophilic Drugs.- Structured Development Approach for Amorphous Systems.- Melt Extru-sion.- Spray Drying Technology.- Pharmaceutical Cryogenic Technologies.- Precipitation Techno-logies for Nanoparticle Production.- Emerging Technologies to Increase the Bioavailability of Poorly Water Soluble Drugs.- Regulatory Conside-rations for Development and Commercialization of Poorly Water Soluble Drugs.

Fields of interestPharmaceutical Sciences/Technology



Due December 2011

2012. XIV, 731 p. 187 illus., 52 in color. (AAPS Advances in the Pharmaceutical Sciences Series, Volume 3) Hardcover7 $239.00ISBN 978-1-4614-1143-7

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SpringerBriefs in Pharmaceutical Science & Drug DevelopmentSpringerBriefs in Pharmaceutical Science & Drug Development present concise summaries of cutting-edge research and its applications in the fields of the pharmaceutical and biotechnology industries. Featuring compact volumes of 50 to 125 pages, the series covers a range of content from professional to academic. Typical topics might include: • A timely report of state-of-the art analytical techniques • A bridge between new research results, as published in journal articles, and a contextual literature review • A snapshot of a hot or emerging topic • An in-depth case study or clinical example • Practical information and background to allow researchers to transition into new areas SpringerBriefs in Pharmaceutical Science & Drug Development will allow authors to present their ideas and findings to their scientific and research communities quickly and will allow readers to absorb them with minimal time invest-ment. Both solicited and unsolicited manuscripts are considered for publication in this series.



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