Compounds for Pest Control and Methods for Their Use – Patents

Patents based on joint CDC OSU research on natural biocides from forest resources to control arthropodsCompounds considered food grade due to citrus connectionConsidered safer for environment and people by CDCKills mosquitoes, ticks, fleasRepellent longer lasting than DeetField trials – Earle Naval Weapons Station, N.J.Formulations – Legacy BioDesign, Loveland, COSource Agricultural / Forestry ByproductsPossible synthesis from Douglas-fir needle compound

Mosquito Diseases

MalariaDengueYellow feverWest Nile virusSt. Louis encephalitis

Tick Diseases

Lyme

Granulocytic ehrlichiosis

Rocky Mountain spotted fever

Human babesiosis

Pesticide Concerns

Environmental contaminationRisk to non-target speciesIncreased health risk with wide area sprayingEndocrine disruptions

Neurological damageCancers

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10 min 1 hr 2 hr 3 hr 4 hr

Time

Nu

mb

er

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pe

led

Deet

IR3535

Lemon

Picaridin

Nootkatone

Human Finger Tick Repellent AssayAll Compounds are Tech Grade & tested at 2.5% AI in ETOH

* Avg # of ticks repelled over 5 trials/time point

Targeted Products

Insecticides – Area sprays mosquitoes, ticks, fleasPersonal repellents mosquitoes, ticks, fleasShampoos treatments head liceTravel sprays airport sales bed bugs Salmon safe agricultural pesticides -- organic? wine grape pests

Key Compounds

Nootkatone High value $4,000/Kg used in foods , cosmetics from grapefruit, syn. ValenceneNootkatol food grade can be produced from

valenceneValencene from orange/citrus oils byproduct of orange juice

production used to make nootkatone

Companies of InterestFirmenich - Switzerland essential oil/

cosmetics nootkatone/nootkatol production

patentMCI Miritz Citrus Ingredients GmbH - Germany Miritz is a pioneer in citrus specialties Armour - Israel Current producer of nootkatoneIndena - Italy ( Seattle office ) Natural products, nutraceuticals,

Taxol

Patent coverageResource countries

PatentUS, Canada, Australia, Germany, France,

Italy, Greece ResourceUS, Brazil, China, Israel (?),North Africa