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Introduction
• The complement system is one of the major effector mechanisms of
humoral immunity
• Is an important effector mechanism of innate immunity.
• Jules Bordet 1919
• The complement system consists of serum and cell surface proteins
• Activation of complement involves the sequential proteolysis
• zymogens
The alternative
pathway
• The alternative-
pathway C3 and C5
convertases are both
stabilized by
properdin (factor P)