2018 sales data obtained from LePro PharmaCompass OPC Private Limited

Eliquis Revlimid Xarelto Imbruvica Lyrica Genvoya Tecfidera Ibrance Januvia Xtandi Triumeq Zytiga Mavyret Gilenya Advair Truvada Invega Sustenna Symbicort Spiriva Jardiance 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20(Apixaban) (Lenalidomide) (Rivaroxaban) (Ibrutinib) (Pregabalin) (Elvitegravir, Cobicistat, Emtricitabine, TAF) (Dimethyl Fumarate) (Palbociclib) (Sitagliptin) (Enzalutamide) (Abacavir, Dolutegravir, Lamivudine) (Abiraterone Acetate) (Glecaprevir, Pibrentasvir) (Fingolimod) (Salmeterol) (Emtricitabine, Tenofovir Disoproxil) (Paliperidone Palmitate) (Budesonide, Formoterol) (Tiotropium) (Empagliflozin)

$9.871 Billion $9.685 Billion $6.58 Billion $6.205 Billion $5.216 Billion $4.624 Billion $4.296 Billion $4.118 Billion $3.686 Billion $3.649 Billion $3.522 Billion $3.498 Billion $3.438 Billion $3.341 Billion $3.33 Billion $2.997 Billion $2.928 Billion $2.926 Billion $2.726 Billion $2.309 BillionCardiovascular Diseases Oncology Cardiovascular Diseases Oncology Neurological Disorders Infectious Diseases Neurological Disorders Oncology Diabetes Oncology Infectious Diseases Oncology Infectious Diseases Neurological Disorders Respiratory Disorders Infectious Diseases Neurological Disorders Respiratory Disorders Respiratory Disorders Diabetes

21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40Velcade Sprycel Janumet Lipitor Tivicay Jentadueto Alimta Pomalyst Afinitor Nexium Epclusa Symtuza Tasigna Aubagio Tagrisso Cialis Breo Ellipta Prograf Sensipar Xeljanz(Bortezomib) (Dasatinib) (Metformin, Sitagliptin) (Atorvastatin) (Dolutegravir) (Linagliptin) (Pemetrexed) (Pomalidomide) (Everolimus) (Esomeprazole) (Sofosbuvir, Velpatasvir) (Darunavir, Cobicistat) (Nilotinib) (Teriflunomide) (Osimertinib) (Tadalafil) (Fluticasone Furoate ) (Tacrolimus) (Cinacalcet) (Tofacitinib)

$2.283 Billion $2.275 Billion $2.228 Billion $2.207 Billion $2.18 Billion $2.154 Billion $2.133 Billion $2.04 Billion $2.02 Billion $2.400 Billion $1.966 Billion $1.955 Billion $1.874 Billion $1.861 Billion $1.86 Billion $1.852 Billion $1.847 Billion $1.785 Billion $1.774 Billion $1.773 BillionOncology Oncology Diabetes Cardiovascular Diseases Infectious Diseases Diabetes Oncology Oncology Oncology Gastrointestinal Disorders Infectious Diseases Infectious Diseases Oncology Neurological Disorders Oncology Sexual Health Respiratory Disorders Immunology Hormonal Disorders Immunology

41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60Pradaxa Latuda Plavix Otezla Odefsey Descovy Gleevec Farxiga Abilify Maintena Crestor Ventolin Mirena Family Brilinta Abraxane Myrbetriq Pulmicort Galvus Zetia Orkambi Keppra(Dabigatran Etexilate) (Lurasidone) (Clopidogrel) (Apremilast) (Emtricitabine, Rilpivirine, TAF) (Emtricitabine, TAF) (Imatinib) (Dapagliflozin) (Aripiprazole) (Rosuvastatin) (Albuterol) (Levonorgestrel) (Ticagrelor) (Paclitaxel Protein Bound) (Mirabegron) (Budesonide) (Vildagliptin) (Ezetimibe) (Lumacaftor, Ivacaftor) (Levetiracetam)

$1.679 Billion $1.648 Billion $1.627 Billion $1.608 Billion $1.598 Billion $1.581 Billion $1.561 Billion $1.514 Billion $1.491 Billion $1.433 Billion $1.377 Billion $1.342 Billion $1.321 Billion $1.292 Billion $1.287 Billion $1.286 Billion $1.284 Billion $1.271 Billion $1.262 Billion $1.254 BillionBlood Disorders Neurological Disorders Cardiovascular Diseases Dermatology Infectious Diseases Infectious Diseases Oncology Diabetes Neurological Disorders Cardiovascular Diseases Respiratory Disorders Sexual Health Cardiovascular Diseases Oncology Renal Disorders Respiratory Disorders Diabetes Cardiovascular Diseases Respiratory Disorders Neurological Disorders

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80Benicar Vimpat Harvoni Opsumit Atripla Biktarvy Promacta Tafinlar + Mekinist Isentress Celebrex Norvasc Exjade Chantix Sutent Esbriet Faslodex Entresto Co-Diovan Kyprolis Kalydeco(Olmesartan Medoxomil) (Lacosamide) (Ledipasvir, Sofosbuvir) (Macitentan) (Efavirenz, Emtricitabine, TDF) (Bictegravir, Emtricitabine, TAF) (Eltrombopag) (Dabrafenib, Trametinib) (Raltegravir) (Celecoxib) (Amlodipine) (Deferasirox) (Varenicline) (Sunitinib) (Pirfenidone) (Fulvestrant) (Sacubitril, Valsartan) (Hydrochlorothiazide, Valsartan) (Carfilzomib) (Ivacaftor)

$1.242 Billion $1.241 Billion $1.222 Billion $1.215 Billion $1.206 Billion $1.184 Billion $1.174 Billion $1.155 Billion $1.14 Billion $1.129 Billion $1.111 Billion $1.099 Billion $1.084 Billion $1.049 Billion $1.041 Billion $1.028 Billion $1.028 Billion $1.023 Billion $1.012 Billion $1.008 BillionCardiovascular Diseases Neurological Disorders Infectious Diseases Cardiovascular Diseases Infectious Diseases Infectious Diseases Oncology Oncology Infectious Diseases Anti-Inflammatory Cardiovascular Diseases Oncology Neurological Disorders Oncology Autoimmune Disorders Oncology Cardiovascular Diseases Cardiovascular Diseases Oncology Respiratory Disorders

81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100Exforge Jakavi Letairis Bridion Doliprane Nuvaring Lupron Rexulti Vesicare Lixiana Invokamet Lamictal Lynparza Premarin Family Votrient Brintellix Edurant Samsca Nexavar Flovent(Amlodipine, Valsartan) (Ruxolitinib) (Ambrisentan) (Sugammadex) (Acetaminophen) (Ethinyl Estradiol, Etonogestrel) (Leuprolide) (Brexpiprazole) (Solifenacin) (Edoxaban) (Canagliflozin, Metformin) (Lamotrigine) (Olaparib) (Conjugated Estrogens) (Pazopanib) (Vortioxetine) (Rilpivirine) (Tolvaptan) (Sorafenib) (Fluticasone Propionate)

$1.002 Billion $977 Million $943 Million $917 Million $911 Million $902 Million $892 Million $884 Million $884 Million $881 Million $881 Million $865 Million $834 Million $832 Million $828 Million $826 Million $816 Million $810 Million $805 Million $791 MillionCardiovascular Diseases Oncology Cardiovascular Diseases Neurological Disorders Anti-Inflammatory Sexual Health Oncology Neurological Disorders Renal Disorders Blood Disorders Diabetes Neurological Disorders Oncology Sexual Health Oncology Neurological Disorders Infectious Diseases Cardiovascular Diseases Oncology Respiratory Disorders

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120Synthroid Symdeko Avodart Augmentin Ranexa Zoladex Baraclude Noxafil Risperdal Consta Aprovel Adempas YAZ Tarceva Toprol Cymbalta Singulair Glucobay Nexplanon Viagra Adalat(Levothyroxine) (Tezacaftor, Ivacaftor) (Dutasteride) (Amoxicillin, Clavulanate) (Ranolazine) (Goserelin) (Entecavir) (Posaconazole) (Risperidone) (Irbesartan, Hydrochlorothiazide) (Riociguat) (Drospirenone, Ethinyl Estradiol) (Erlotinib) (Metoprolol) (Duloxetine) (Montelukast) (Acarbose) (Etonogestrel) (Sildenafil) (Nifedipine)

$776 Million $769 Million $761 Million $758 Million $758 Million $752 Million $744 Million $742 Million $737 Million $737 Million $731 Million $722 Million $714 Million $712 Million $708 Million $708 Million $704 Million $703 Million $692 Million $690 MillionHormonal Disorders Genetic Disorders Renal Disorders Anti-Bacterial Cardiovascular Diseases Oncology Infectious Diseases Anti-Fungal Neurological Disorders Cardiovascular Diseases Cardiovascular Diseases Sexual Health Oncology Cardiovascular Diseases Neurological Disorders Respiratory Disorders Diabetes Sexual Health Sexual Health Cardiovascular Diseases

121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140Nexgard Ganfort Cellcept Concerta Uptravi Complera Azilva Stribild Alecensa Bendeka Anoro Ellipta Aspirin Cardio Vidaza Lenvima Dexilant Emend Sulperazon Allegra Bystolic Ambisome(Afoxolaner) (Bimatoprost) (Mycophenolate Mofetil) (Methylphenidate) (Selexipag) (Rilpivirine, Emtricitabine, TDF) (Azilsartan) (Cobicistat, Elvitegravir, Emtricitabine, TDF) (Alectinib) (Bendamustine) (Umeclidinium, Vilanterol) (Acetylsalicylic Acid) (Azacitidine) (Lenvatinib) (Dexlansoprazole) (Aprepitant) (Cefoperazone, Sulbactam) (Fexofenadine) (Nebivolol) (Amphotericin B)

$689 Million $684 Million $676 Million $663 Million $663 Million $653 Million $647 Million $644 Million $643 Million $642 Million $633 Million $629 Million $617 Million $617 Million $617 Million $615 Million $613 Million $588 Million $586 Million $571 MillionParasitic Infections Ophthalmology Immunology Neurological Disorders Cardiovascular Diseases Infectious Diseases Cardiovascular Diseases Infectious Diseases Oncology Oncology Respiratory Disorders Cardiovascular Diseases Oncology Oncology Gastrointestinal Disorders Oncology Renal Disorders Respiratory Disorders Cardiovascular Diseases Infectious Diseases

141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160Pantoprazole Invanz Combigan Tracleer Inomax Kombiglyze Lo Loestrin Ninlaro Xalkori Iressa Takecab Travoprost Group Depakine Vytorin Nesina Vraylar Amitiza Tamiflu Neupro Jevtana(Pantoprazole) (Ertapenem) (Brimonidine, Timolol) (Bosentan) (Nitric Oxide) (Saxagliptin, Metoprolol) (Norethindrone Acetate, Ethinyl Estradiol) (Ixazomib) (Crizotinib) (Gefitinib) (Vonoprazan) (Travoprost) (Valproate) (Ezetimibe, Simvastatin) (Alogliptin) (Cariprazine) (Lubiprostone) (Oseltamivir) (Rotigotine) (Cabazitaxel)

$569 Million $554 Million $551 Million $546 Million $543 Million $543 Million $528 Million $526 Million $524 Million $518 Million $518 Million $517 Million $511 Million $497 Million $496 Million $487 Million $479 Million $478 Million $478 Million $477 MillionGastrointestinal Disorders Anti-Bacterial Ophthalmology Cardiovascular Diseases Respiratory Disorders Diabetes Sexual Health Oncology Oncology Oncology Gastrointestinal Disorders Ophthalmology Neurological Disorders Cardiovascular Diseases Diabetes Neurological Disorders Gastrointestinal Disorders Anti-Viral Neurological Disorders Oncology

161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180Onfi Zyprexa Uloric Androgel Sandimmune Zepatier Ultibro Breezhaler Vasostrict Hyzaar Frontline Strattera Memary Voltaren Kuvan Xeloda Duodopa Reyataz Flomax Medrol Decapeptyl(Clobazam) (Olanzapine) (Febuxostat) (Testosterone) (Dexmethylphenidate) (Elbasvir, Grazoprevir) (Indacaterol, Glycopyrronium) (Vasopressin) (Losartan, Hydrochlorothiazide) (Fipronil) (Atomoxetine) (Memantine) (Diclofenac) (Sapropterin) (Capecitabine) (Carbidopa, Levodopa) (Atazanavir) (Tamsulosin) (Methylprednisolone) (Triptorelin)

$475 Million $471 Million $471 Million $469 Million $463 Million $455 Million $454 Million $454 Million $453 Million $451 Million $451 Million $450 Million $445 Million $434 Million $431 Million $430 Million $427 Million $427 Million $426 Million $421 MillionNeurological Disorders Neurological Disorders Autoimmune Disorders Hormonal Disorders Neurological Disorders Infectious Diseases Respiratory Disorders Renal Disorders Cardiovascular Diseases Parasitic Infections Neurological Disorders Neurological Disorders Anti-Inflammatory Renal Disorders Oncology Neurological Disorders Infectious Diseases Renal Disorders Immunology Hormonal Disorders

181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200Seroquel Vosevi Multaq Canasa Vfend Sevoflurane Injectafer Amaryl Incruse Ellipta Nasonex Bosulif Cubicin Halaven Ambien Aricept Stivarga Viibryd Atozet Tenelia Madopar(Quetiapine) (Sofosbuvir, Velpatasvir, Voxilaprevir) (Dronedarone) (Mesalazine) (Voriconazole) (Sevoflurane) (Ferric Carboxymaltose) (Glimepiride) (Umeclidinium) (Mometasone Furoate) (Bosutinib) (Daptomycin) (Eribulin) (Zolpidem) (Donepezil) (Regorafenib) (Vilazodone) (Ezetimibe, Atorvastatin) (Teneligliptin) (Levodopa, Benserazide)

$404 Million $396 Million $396 Million $394 Million $393 Million $391 Million $387 Million $379 Million $378 Million $376 Million $375 Million $367 Million $365 Million $363 Million $357 Million $356 Million $350 Million $347 Million $347 Million $344 MillionNeurological Disorders Infectious Diseases Cardiovascular Diseases Gastrointestinal Disorders Anti-Fungal CNS And Anesthesia Blood Disorders Diabetes Respiratory Disorders Respiratory Disorders Oncology Anti-Bacterial Oncology Neurological Disorders Neurological Disorders Oncology Neurological Disorders Cardiovascular Diseases Diabetes Neurological Disorders

Key Oncology Neurological Disorders Diabetes Cardiovascular Diseases Infectious Diseases Respiratory Disorders Immunology Blood Disorders Sexual Health Miscellaneous

Top 200 Small Molecule Pharmaceuticals by Retail Sales in 2018Compiled and Produced by the Njarðarson Group (The University of Arizona)