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RCPE GmbHRCPE GmbHMay 2010
K1 Competence Center - Initiated by the Federal Ministry of Economy, Family and Youth (BMWFJ) and the Federal Ministry of Transport, Innovation and Technology (BMVIT). Funded by FFG, Land Steiermark and Steirische Wirtschaftsförderung (SFG).
L
RCPE - KEY FACTS 1/2
Competence Centers are highly successful technology policy initiatives in Austria (currently 40+ centers with 1500+ researchers)Obj ti f C t C tObjectives of Competence Centers:
Cooperation between science and industryA hi i j i t t t i t l l hAchieving joint strategic top-level research Initiate new scientific and technological developments
Ne Competence Center la nched on the 1st of J l 2008New Competence Center launched on the 1st of July 2008: Research Center Pharmaceutical Engineering GmbH (RCPE) Total volume: approx €30 Mio ($42 Mio) for 7 yearsTotal volume: approx. €30 Mio ($42 Mio) for 7 yearsTimeframe: 7 years (extension possible)L t d i G A t iLocated in Graz, Austria
RCPE - KEY FACTS 2/2
RCPE is a non-profit limited liability company (GmbH)
100% owned by research institutions (Graz University of Technology: 65%, University of Graz: 20%, Joanneum Research: 15%)
RCPE projects are partially funded by the Austrian Research PromotionRCPE projects are partially funded by the Austrian Research Promotion Agency (national funding institution for applied industrial research in Austria) with 32.67% and by the province of Styria with 16.33%
Total public financing of 49%
min 26% cash5% i tifi
Joanneum Research: 15%
University of Graz: 20%min. 26% cash5% scientific
max. 20% in-kind
49% fundings
in kind
Graz University of Technology: 65%
Project funding overview Ownership structure
RCPE - KEY BENEFITS
RCPE provides independent R&D in the field of pharmaceutical i i b id i th b t i d i d t i l li tiengineering, bridging the gap between science and industrial applications
Defined IPRs provide maximum benefit for industrial partners
Long term cooperation with the RCPE possibleLong-term cooperation with the RCPE possible (funding period of 7+ years)
Diversity in research activities: small preparatory studies (literature review, initial measurements, proof of concept) up to extensive multi-year research programs are possible
Only 26% cash contribution required in joint research projectsOnly 26% cash contribution required in joint research projects
No time-consuming project application procedures; project work plan can be defined bilaterally and the project can be started immediately
RCPE can provide additional scientific partners if expertise is required
RCPE can provide additional industrial partners if industrial cooperation i d i d d/ f j t t h iis desired and/or for project cost-sharing
RCPE - TOPICS
We are interested to add YOU as Company or Scientific Partnerf ki t th th f ll i t ifor working together on the following topics:
Simulation toolsParticle technology (Coating, extrusion, melt extrusion, drying, etc.)Bioprocessing and bioreactorsPrinting of drugsPrinting of drugsProcess Analytical Technology (PAT)Continuous processingProtein manufactureMicroparticle synthesisQuality by Design (QbD)Quality by Design (QbD)
New areas and topics are welcome
RCPE - AREAS OF THE CENTER
AREA I –SELECTION OF CURRENT PROJECTSSELECTION OF CURRENT PROJECTS
MIXING & DISSOLUTION PROCESSES
MICROPARTICLES SYNTHESIS
VIRTUAL QUALITY-BY-DESIGN
AREA II –SELECTION OF CURRENT PROJECTS
PROTEIN PROPERTIES & AGGREGATION
SELECTION OF CURRENT PROJECTS
INTERACTION PACKAGING MATERIALS & PHARMACEUTICAL FORMULATIONSPHARMACEUTICAL FORMULATIONS
NANOPARTICLES
AREA III –SELECTION OF CURRENT PROJECTS
CONTINUOUS MANUFACTURING
SELECTION OF CURRENT PROJECTS
PRINTABLE FORMULATIONS
Carrier
API
CLEANROOMS
ONLINE MONITORING - PAT
SINGLE POINT OF CONTACT
CustomerCustomer
One stop shop for…RCPE connects customers to…
Research Projects
Funded and Contractual
Graz University of Technology, University of Graz, Joanneum Research, …
Research Facilities
j
K1
Research
ServicesIndustrial Partners
K1 Services
OUR PARTNERS 01.07.08
OUR PARTNERS TODAY
RCPE Analytics
FT‐NIR/MIRPerkinElmer
Raman PerkinElmer
FT‐IR Bruker VERTEX
React IR ASI ReactIR 1000
SWAXS Hecus S3‐Micro
Helos SympatecLaser diffraction
QicPic SympatecSize and shapePerkinElmer
Spectrum 400PerkinElmer
RamanStation 400Bruker VERTEX ASI ReactIR 1000 Hecus S3 Micro Laser diffraction
size analysisSize and shape image analysis
HPLCHP‐Agilent 1090
GC PerkinElmer
DTALyotherm
DSCShimadzu DSC‐50
EVK HeliosNIR Imaging
ZetasizerMalvern
Krüss EasydropContact angle
Clarus500 NanoZS measurement
RheometerAnton Paar Physica
MicroscopeLeica DM4000
PIV cameraMotionScope M3
Freeman FT4Powder rheometer
Friability TestingCopley
Kern MLS_NMoisture analyzer
Pfrengle´s trickle test
MCR 300 DFC290 camera AS 400 DIN/ISO 4324
RCPE Process Equipment
Extrusion System Batch Fluid Bed System Compaction SimulatorLaboratory Tablet PressExtrusion SystemZSK 18
Coperion
Batch Fluid Bed System GPC G1
Glatt Process Technology
Compaction SimulatorSTYLCAM 200R
MedelPharm
Laboratory Tablet Press102i
Fette Compacting
SIMULATION TOOLS
Multiphase flow
CFD (Computational Fluid Dynamics)
Particle flow
DEM (Discrete Element Method)CFD (Computational Fluid Dynamics) DEM (Discrete Element Method)
Spray drying/ granulation Spray and coating Bubbly flowsBlending Coating
Software: EDEM, RPDMixing
Molecular dynamicsMD (Molecular Dynamics)MD (Molecular Dynamics)
Room flow
Softwares: FIRE OpenFOAM Software: MOESoftwares: FIRE, OpenFOAM Software: MOE
OVERALL RCPE BUDGET AND FUNDING
16,7 Mio.€f ffor four years
Scientific
Partners 46%
Partners
5%
16 33%
Province of Styria
Funding 54%
16,33%
54%
32,67%,
IPRS AND FUNDING MODEL
Defined IPRsFull IPR to industry partners
Gratuitous non exclusive timely unlimited non transferableDefined IPRs(Intellectual Properties Rights)
Gratuitous, non-exclusive, timely unlimited non-transferable right of use to RCPE
Exploitation and utilization rights to RCPE after 12-24 months
Project Financing (Example)
Details must be singularly clarified in cooperation contract
P j t V l € 500 000Project Volume € 500.000,-
Funding 49% € 245.000,-
Inkind University 5% € 25.000,-
min. 26% cash5% scientific
max. 20% in kind
Cash Industry 26% min. € 130.000,-
Inkind Industry 20% max. € 100.000,-49% fundings
in-kind
3 Industry Partners:Cash per each industry partner € 43.333,-
Inkind per each partner € 33 333 -
2 Industry Partners:Cash per each industry partner € 65.000,-
Inkind per each partner € 50 000 - Inkind per each partner € 33.333,Inkind per each partner € 50.000,
SUCCESS STORY
RCPE was founded on 1st of July 2008app. 65 employees3 new Scientific Partners and 18 new Industrial Partners4 patents
A t f l i l t f d i h ti l d tA system for analyzing a granulate for producing a pharmaceutical productA system and method for manufacturing a medicationMethods and compositions for biologically controlling microbial growth on l i tclean room equipment
Synthetical Nucleic-Acid-ParticleWorking Group at Rutgers University in New Jersey, USA established (since 15th of April 2009, three employees)One new Business Unit (RCPS) has been launched
THE PROCESS ENGINEERING CENTER
Office building with state-of-the-art laboratory facilitiesStart of construction: 2009Scheduled for completion: 2011Footprint: 1000 m² / 7 stories + basementp
CONTACT
Prof. Dr. Johannes KhinastScientific Director
Contacts:e‐mail: [email protected].: +43/316/873/7978
Dr. Thomas K. KleinBusiness Director
Inffeldgasse 21a/II A‐8010 Graz
Business Director
Contacts:e‐mail: [email protected] : +43/316/873/9700tel.: +43/316/873/9700