COLLEGE OF PHARMACYRESEARCH AND SCHOLARSHIP REPORT

July 1, 2012 - June 30, 2013

Top: Christopher KaihoMiddle: Dr. Judith Potashkin, RaeAnn HirschyBottom: Dr. Eric Walters, Oscar Hernandez,

Amy McGlin, Najeah Ahmad

Cover: left Rita Huynh, right (foreground) Dr. Kevin Rynn, Alyssa Wenzel

The Inaugural Class of the Rosalind Franklin University of Medicine and Science’s

College of Pharmacy matriculated in the Fall of 2011. This is the first report

summarizing the College’s research and scholarship accomplishments, covering

the past academic year, July 1, 2012 - June 30, 2013.

In a very short period of time, the College has assembled an active and productive

group of scholars. The accomplishments that follow include the work of many

faculty and students. I am proud to catalog these accomplishments on the

following pages.

D. Eric Walters, Ph.D.

Associate Dean for Research

Introduction

Peer Reviewed Publications

M.L. Brackbill, Ateequr Rahman, J.S. Sandy, M.D. Stam, and A.F. Harralson. Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study. Intl. J. Endocrinol. 2012, Article ID 810926.

A. Hetzel, Gloria E. Meredith, D.J. Rademacher, and J.A. Rosenkranz. Effect of amphetamine place conditioning on excitatory synaptic events in the basolateral amygdala in vitro. Neuroscience 2012, 206:7-16.

Q. Huang, Rahul S. Deshmukh, S.S. Ericksen, Y. Tu, and G.D. Szklarz. Preferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism. Drug Metab. Dispos. 2012, 40(12):2324-2331.

M.T. Johnson, T.T. Yamanaka, D.R. Fraidenburg, and Sean P. Kane. Benzodiazepine misadventure in acute alcohol withdrawal: the transition from delirium tremens to ICU delirium. J. Anesth. 2013, 27(1):135-136.

Sean P. Kane, A.P. Bress, and E.P. Tesoro. Characterization of unbound phenytoin concentrations in neurointensive care unit patients using a revised Winter-Tozer equation. Ann. Pharmacother. 2013, 47(5):628-636.

A. Kiraly, Abbie Lyden, U. Periyanayagam, and P.S. Pang. Management of hemorrhage complicated by novel oral anticoagulants in the emergency department: case report from the northwestern emergency medicine residency. Am. J. Ther. 2013, 20(3):300-306.

X. Li, M.R. DeJoseph, J.H. Urban, A. Bahi, J.L. Dreyer, Gloria E. Meredith, K.A. Ford, C.R. Ferrario, J.A. Loweth, and M.E. Wolf. Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance. J Neurosci. 2013, 33(28):1130-1142.

D.S. Lieber, S.E. Calvo, Kristy Shanahan, N.G. Slate, S. Liu, S.G. Hershman, N.B. Gold, B.A. Chapman, D.R. Thorburn, G.T. Berry, J.D. Schmahmann, M.L. Borowsky, D.M. Mueller, K.B. Sims, and V.K. Mootha. Targeted exome sequencing of suspected mitochondrial disorders. Neurol. 2013, 80(19):1762-1770.

A.H. Metzger, Y.M. Hardy, C. Jarvis, S.C. Stoner, M. Pitlick, M.L. Hilaire, Scott Hanes, J. Burke, and N.M. Lodise. Essential Elements for a Pharmacy Practice Mentoring Program. Am. J. Pharm. Ed. 2013, 77(2):article 23.

J.E. McCutcheon, K.L. Conrad, S.B. Carr, K.A. Ford, D.S. McGehee, and Michaela Marinelli. Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults. J. Neurophysiol. 2012, 108(6):1620-1630.

Lama H. Nazer, R. Eljaber, D. Rimawi, and F.I. Hawari. Adverse drug events resulting in admission to the intensive care unit in oncology patients: Incidence, characteristics and associated cost. J. Oncol. Pharm. Pract. 2012, Epub ahead of print.

J. Symersky, D. Osowski, D. Eric Walters, and D.M. Mueller. Oligomycin frames a common drug-binding site in the ATP synthase. Proc. Natl. Acad. Sci. USA 2012, 109(35):13961-13965.

J.J. Tong, B.C. Sohn, A. Lam, D. Eric Walters, B.M. Vertel, and L. Ebihara. Properties of two cataract associated mutations located in the N-terminus of Connexin 46. Amer. J. Physiol.: Cell Physiol. 2013, 304(9):C823-832.

D. Eric Walters. Team-based learning applied to a medicinal chemistry course. Med. Princ. Pract. 2013, 22(1):2-3.

X. Wang, M.E. Cahill, C.T. Werner, D.J. Christoffel, S.A. Golden, Z. Xie, J.A. Loweth, Michaela Marinelli, S.J. Russo, P. Penzes, and M.E. Wolf. Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization. J. Neurosci. 2013, 33(27):11012-11022.

W.C. Wong, K.A. Ford, N.E. Pagels, J.E. McCutcheon, and Michaela Marinelli. Adolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence. J. Neurosci. 2013, 33(11):4913-4922.

Y. Zhang, Gloria E. Meredith, N. Mendoza-Elias, D.J. Rademacher, K.-Y. Tseng, and K. Steece-Collier. Aberrant restoration of spines and their synapses in L-dopa-induced dyskinesia: Involvement of corticostriatal but not thalamostriatal synapses. J. Neurosci. 2013, 33(28):11655-11667.

John Vachansu, RaeAnn Hirschy, Alisa Joseph, Teklu Bahta

Books, Book Chapters, and Other Publications

L.B. Angelo. APHA’s Immunization Handbook. Second Edition. Washington, D.C. American Pharmacists Association. 2012.

Rahul Deshmukh. Modeling and simulation in drug discovery and development. J. Bioequiv. Bioavail. 2012, 4:xxvii-xxviii (Editorial).

M.L. Wagner and Jamie C. Holmes. Chapter 32, Parkinson’s Disease. In: M. Chisholm-Burns, T. Schwinghammer, B. Wells, P. Malone, and J. DiPiro (eds.), Pharmacotherapy Principles and Practice, Third Edition. McGraw-Hill; 2013:591-604.

Khyati Patel. New Drug Update: Lineclotide: A novel drug for constipation therapy. ACCP Ambulatory Care PRN Newsletter.

Kristy Shanahan and Lillian A. Mundt. Chapter 29, Body Fluid Analysis. In: M.L. Bishop, E.P. Fody, and L.E. Schoeff (eds.), Clinical Chemistry: Principles, Techniques, and Correlations, Seventh Edition. Philadelphia, PA:Lippincott Williams & Wilkins; 2013:604-624.

D. Eric Walters. The Sweetener Book. Lindenhurst, IL:Gale Walters Publishing. 2013.

R. Zane and Abbie Erickson [Lyden]. Management of the Obese Patient. In: R. Walls and M. Murphey (eds.), Manual of Emergency Airway Management. (4th ed). New York, NY: Lippincott Williams & Wilkins; 2012:410-417.

Teklu Bahta and D. Eric Walters. Linezolid Analogs. RFUMS Summer Research Poster Session. October 2012.

Courtney Chan, Aditi Thakkar, and Gloria E. Meredith. Structural plasticity in an animal model of levodopa- induced dyskinesia. RFUMS Summer Research Poster Session. October 2012.

Russell Dahl. Intracellular Calcium Handling as a Target for Major Diseases. RFUMS Department of Biochemistry and Biophysics seminar, Feb 2013.

Russell Dahl. Discovery of Clinical Candidates for HIV and Inflammation. RFUMS Department of Immunology seminar, Jan 2013.

Russell Dahl. Drug Discovery in the Ubiquitin Proteasome System. Mount Sinai School of Medicine, November 2012.

Russell Dahl. Emerging Drug Discovery Targets for Cancer and Neurodegeneration. DePaul University, October 2012.

Russell Dahl. Small Molecule Modulators of Protein Conjugation and Calcium Handling Targeting Cancer and Neurodegeneration” RFUMS Department of Cellular and Molecular Pharmacology seminar, September, 2012.

Rahul Deshmukh. Optimization of Drug-Like Properties: An Integrated Drug Discovery Approach. Haim and Jane Nagirner Weinstein Symposium Series, RFUMS.

Rahul Deshmukh. Applied Pharmaceutical Analysis India, March 3-6, 2013, Hyderabad, India.

Rahul Deshmukh. 5th International Symposium on DMPK, March 7-10, 2013, Mohali, India.

Sarah S. Garber and Marc Abel. Incorporating IPE into the PharmD Curriculum. Collaborating Across Borders IV, Vancouver, Canada, June 2013.

Sarah S. Garber, Marc Abel, David Harrison, and Gary Oltmans. Developing Assessment Tools at a New College of Pharmacy. American Association of Colleges of Pharmacy Annual Conference, Kissimmee FL, July 2012.

Dorin Govargiz, Thomas Kim, and Lisa Michener. Assessment of Student Performance in an Objective Structured Clinical Exam (OSCE) involving first-year Pharmacy Students in Simulated Patient Counseling, Copresenter with P2 Students. RFUMS Summer Research Poster Session. October 2012.

Do’Monique Gribble and D. Eric Walters. Developing Potential Scaffolds for The HIV Protease Inhibitor Darunavir that will Increase Binding to the HIV Protease Enzyme and Resist Mutations. RFUMS Summer Research Poster Session. October 2012.

Abstracts and Presentations

RaeAnn Hirschy and Judith Potashkin. Shared Molecular Networks in Parkinson’s disease and Diabetes. RFUMS Summer Research Poster Session. October 2012.

Rita Huynh and D. Eric Walters. Development of Polyketides as ATP Synthase Inhibitors. RFUMS Summer Research Poster Session. October 2012.

Alisa Joseph, Jennifer Obasohan, and Michaela Marinelli. Adolescents are insensitive to punishment- induced suppression of cocaine self-administration. RFUMS Summer Research Poster Session. October 2012.

Sean P. Kane. Maximizing Outcome by Minimizing Sedation: Emerging Evidence in Mechanically Ventilated Patients. Continuing Education presentation.

Sean P. Kane. Is that Crystal Violet You’re Wearing? A Review of Gram Positive Resistance and Antibiotic Treatment. Continuing Education presentation.

Sean P. Kane. Managing the balance between patient comfort and oversedation. Continuing Education presentation.

Rafeda Khan, Kevin Morris, and Ateequr Rahman. The Impact of an Interprofessional Care Model on Professional Practitioners and Resultant Outcomes for Senior Patients with Diabetes. RFUMS Summer Research Poster Session. October 2012.

Abbie Lyden. Career Pathways, Health Professions: Introduction to Pharmacy. DePaul University.

Abbie Lyden. Pharmacotherapy for Physician Assistants: Ophthalmology. Northwestern University.

Gloria E. Meredith, Y. Zhang, and K. Steece-Collier. Structural plasticity of medium spiny neurons: Dopamine-induced changes. Dopamine 2013 Congress, Alghero, Italy.

Gloria E. Meredith. The importance of circuit rewiring in amphetamine-associated contextual learning. Dopamine 2013 Congress, Alghero, Italy

Lisa Michener. Educational Excellence Symposium-Creating a Culture of Educational Excellence: Introductory Collaborative Learning Bridge Project. RFUMS Master Teachers Guild Poster Session, August 2012.

Lisa Michener, Gloria E. Meredith, Marc A. Abel, P. Eder, and Sarah Garber. Introductory Collaborative Learning Bridge (ICLB): A curricular Innovation. AACP Annual Meeting.

Khyati Patel. Comparing change in hemoglobin A1C of patients in pharmacist managed telehealth clinic versus in-person clinic. ACCP Annual Meeting, October 2012.

D.J. Rademacher, J.A. Rosenkranz, A. Hetzel, N. Mendoza-Elias, and Gloria E. Meredith. Amphetamine- associated contextual learning produces a constellation of structural plastic changes of synapses in basolateral amygdala circuitry. Society for Neuroscience Abs.

Ateequr Rahman. Methodology and Design for Scholarship of Teaching and Learning. Haim and Jane Nagirner Weinstein Symposium Series, RFUMS.

Kevin Rynn, Sarah S. Garber, Marc S. Abel, K. Stegh, R. Allen, Janeen Winnike, Gloria E. Meredith. An Introductory Boot Camp to Community Pharmacy Services for Non-Practicing Faculty. American Association of Colleges of Pharmacy, Annual Meeting, July 2012, Orlando, Florida.

Kristy Shanahan and D.M. Mueller. A yeast model study of a human ATP synthase nuclear gene variant. Research Poster Day, Capt. James A. Lovell Federal Health Care Center, January 24, 2013.

S.K. Tappert, Sarah S. Garber, W. Rheault, and J. Stoecker. Institutionalizing Interprofessional Education at a Health Professions University. Collaborating Across Borders IV, Vancouver, Canada, June 2013.

D. Eric Walters. Adventures in computer aided drug design. Carroll University, February, 2013.

D. Eric Walters. Applications of computational chemistry in drug discovery. Concordia University Wisconsin, February, 2013.

D. Eric Walters. The computational chemistry toolbox. DePaul University, March, 2013.

D. Eric Walters. Computer aided drug design. Purdue University, April, 2013.

Alyssa Wenzel and David Harrison. Structural identification of SUMO by means of crystallization. RFUMS Summer Research Poster Session. October 2012.

Grants

Russell Dahl and Ruben Parra. Halogen Bonding for the Rational Design of Novel Anticancer Kinase Inhibitors. DePaul-RFUMS Research Pilot Grant. $100,000, 9/1/2013 - 6/30/2014.

Arun K. Ghosh, PI. Design & synthesis of nonpeptide protease inhibitors. D. Eric Walters, Co-investigator. NIH/GMS, 4/1/96 - 8/31/16.

K. Steece-Collier, PI. Profiles of maladaptive plasticity: impact on graft and levodopa efficacy, Gloria E. Meredith, Co-Investigator. P50 NS058830-01A1 Morris K. Udall Parkinson’s Center of Excellence. NIH/ NINDS (STEECE-COLLIER, PI project 1), 8/1/09 – 07/31/14

Kevin Rynn, S. Kent, Gloria Meredith, Tina Zook, K. Hankewych, Scott Hanes, S. Patel, Sarah Garber. National Association of Chain Drug Stores (NACDS) Community PREP Grant. $50,000 / 3 years.

Alyssa Wenzel, Teklu Bahta, Dorin Govargiz, Kevin Morris, Rita Huynh, Rafeda Khan Soumyabrata Munshi

Teklu Bahta Alisa Joseph, Jennifer Obasohan

Monday, October 1, 2012Dr. Patrick Woster, Medical University of South CarolinaSmall Molecule Inhibitors of the Histone Demethylase LSD1 as Epigenetic Modulators

Monday, December 3, 2012Dr. Rahul Deshmukh, Rosalind Franklin UniversityOptimization of Drug-Like Properties: An Integrated Drug Discovery Approach

Monday, January 7, 2013Dr. Iqbal Atcha, Wal-MartThe Diamond Factor

Monday, February 25, 2013Dr. James Surmeier, Northwestern UniversityDeterminants of neuronal vulnerability in Parkinson’s disease: What the roadmap tells us

Monday, March 11, 2013Dr. Tim Esbenshade, Abbott LaboratoriesDrug Discovery Challenges of a GPCR Target: Development of Histamine H3 Antagonists

Monday, March 25, 2013Dr. David Rogers, University of TennesseeOvercoming Limitations of Antifungal Drug Therapy From ClinicalPharmacy to Molecular Mycology

Monday, April 15, 2013 Dr. Ateequr Rahman, Rosalind Franklin UniversityMethodology and Design for Scholarship of Teaching and Learning

Monday, May 13, 2013Dr. Christopher Cunningham, Concordia University WisconsinOpioid analgesics and chronic pain: New leads for avoiding analgesic tolerance

The Haim and Jane Nagirner Weinstein Centennial Symposium Series, 2012-2013

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