Upload
annabelle-curtis
View
223
Download
3
Tags:
Embed Size (px)
Citation preview
CODIS – Combined DNA Index System
CODIS STRs and ProbabilitySTR African
AmericanAmerican Caucasian
D351358 0.097 0.080
VWA 0.074 0.068
FGA 0.036 0.041
TH01 0.114 0.080
TPOX 0.091 0.207
CFS1PO 0.079 0.128
D5S818 0.121 0.166
D13S317 0.139 0.081
D7S820 0.087 0.067
D8S1179 0.080 0.069
D21S11 0.042 0.041
D18S51 0.032 0.032
D16S539 0.076 0.091
1/X = value
1/X = 0.097
SOLVE FOR X
X = 1/0.097 = 10.3
This means the DNA matches one in 10.3 people
Think about class evidence…how do we narrow down the pool of
possible suspects?
Where is DNA found?
DNA is contained in blood, semen, skin cells, tissue, organs, muscle, brain cells, bone, teeth, hair, saliva, mucus, perspiration, fingernails, urine, feces, etc.
http://www.dna.gov/basics/
THIS IS NUCLEAR DNA!
Two types of DNA
Analysis of mtDNA is done when RFLP and STR cannot be used on NUCLEAR DNA
1. Nuclear DNA (inside nucleus)
2. Mitochondrial DNA (mtDNA)
Nuclear DNA
Nuclear DNA:Found in nucleus of cellsContains 23 chromosome pairsEach parent contributes half
Mitochondrial DNA
Mitochondria are found in all cells of the body
Provides 90% of energy our bodies need to function
Contain bits of DNA passed down through generations
Hundreds of thousands of mitochondria per cell!!
What are the benefits? What are the limitations?
Nuclear vs. Mitochondrial DNA
Mitochondrial DNA
Used in identifying remainsGenerous amount present in bonesShows maternal lineage matches (will be
identical if related through the mother)
In the NEWS: Sandringham http://www.metro.co.uk/news/886331-sandringham-murder-body-could-be-
missing-teenager-say-police http://www.telegraph.co.uk/news/uknews/crime/8998481/Sandringham-body
-identification-will-take-further-three-days.html
Last March
Royalty-obsessed Robert James Moore found dead
TOD ~ up to 3 yrs
Missing Persons: Dung Beetle Biologist