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The effect of Uncariaand Tabebuiaextracts on molecular
epidemiological biomarkers in the patients with colorectal
cancer.
FERENC BUDN1, GOSTON EMBER2, RS PTER HORHTH2, LSZL ILLNYI2,
DE BLASIO ANTONIO1, TNDE GRACZA3, PL PERJSI, TAMS D!ID",
T#MEA !ARJAS1$%& IST!N EMBER1
Departments of 1Public Health and, 2Department of Surgery,3Mihly
Pekr Medical and ife
Science ibrary, !"nstitute of Pharmaceutical #hemistry, Medical
School, and
$aculty of Health Sciences, %ni&ersity of P'cs, H()*!3
P'cs+
"#oD #ancer "nformation -esearch $oundation, ./r/smarty str0 1,
H( 1 'b'ny,
Hungary
Correspondence to: [email protected]
Address: Szigeti str. 12, !"#2$ %&cs, ungar'
%hone: ()#!"2!*)#!)+$
a-: ()#!"2!*)#!)+*
e'/ords: gene e-pression, C0C, ras, p*), c!m'c, Uncaria,
Tabebuia
Short title: Effect ofUncariaand Tabebuia extracts on biomarkers
in patients with CRC.
1
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Abstract
T'( )*+-%(& (..()/ *. 0-)$4 /($/+(%/ $%& )*%0+5/-*% *.
0* )$44(&
6C*DTM /($7 8)*%/$-%-% %ncaria guianensis, %0 tomentosa $%&
abebuia
a&ellanedae9 *% (:5(00-*% *. c(myc, Ha(ras, 4cl(2, 5i(ras
$%& p3 ;(9 $%& )$)-%*?
(+
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E$4-( 0/&-(0 5*(& /'$/ /'( c(myc, Ha(ras, $%& p3
;(< *%)*=/+*
055(00* (%( (:5(00-*%0 )*4& ( 0(& $0 (4-$4( -*+$;(0 *.
)(/$-%
'$(+$/*4*-)$4 +$4-%$%)-(0, 0*4-& /+*0 8e0g0, )*4*()/$4 )$%)(
8CRC9, 4%,
$-% /+*0, (/)9 $%& .*44*@-% 0-&( (..()/0 *. )
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0))(00.4 055*/-( /'($5< -% /'( /($/+(%/ *. 5$/-(%/0 -%
)*4*()/$4 )$%)(,
$./(= /*(/'( /($/(& @-/' 0-)$4 (0()/-*% $%& )*%(%/-*%$4
)'(+*/'($5?> $%& CEA /+*+$;(0 @((
$40* (:$+-%(& $+*% /'(0( *4%/((0 C*D /($ )*%/$-%0 C$/0 C4$@
8U%)$-$
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a&ellanedae9, .*+
@'-)' 1 $4;$4*-& $%& ;-%*4$)-&?4
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Materials and Methods
Patients and treatments0I% /'-0 0/&< @(( 5$/-(%/0 @-/'
CRC 5(0(%/(&
T'(< @(( *5($/(& (/@((% 1 J$%$< 2 $%& 31 D()(+( 2
$/ /'(
C4-%-) *. S(9 T'(&-$%*0-0 *. */' *5 @(( -'/ $%& 4(./
0-&( )*4*% )$%)( $%& ()/$4
$&(%*)$)-%*+$, @-/' )4-%-)$4 0/$( I, II, III A./( (?0/$-%
(:$+-%$/-*%0
5$/-(%/0 %&(@(%/ /'( (0()/-*% -'/ $%& 4(./ 0-&(
'(+-)*4()/*+ 8-%&-)$/(& -% IU=+49 /+* +$;( 0(+ 4((40
@((
($4$/(& .*+ */-%( 4**& -%(0/-$/-*%0 8ELISA 9, 4**&
0$+54(0 @(( /$;(%
$/ /'( &$< *. /'( 0-)$4 /($/+(%/, $%& 1 @((;, 3,
+*%/'0 $%& 1
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7ntio8idant capacity and gene e8pression in&estigations0 T'(
$%/-*:-&$%/
)$5$)-/< *. 4**& @-/' &(*:
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Results
T'( +*4()4$ (5-&(+-*4*-)$4 -*+$;(0 @(( +($0(& $/ /'(
&$/( *. 0-)$4
/($/+(%/, /'(% $./( 1 @((;, 3, +*%/' $%& 1
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/($/+(%/ I% /@(4./' +*%/' $./( 0-)$4 /($/+(%/ /'(
$%/-*:-&$%/ )$5$)-/
