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COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

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Page 1: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

COBRE Grant Writing Workshop

Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor

Lynn Snyder-Mackler

Page 2: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

2

Predoctoral Individual NRSA (F31)Predoctoral Individual MD/PhD NRSA

(F30)

Postdoctoral Institutional Training Grant (T32)Postdoctoral Individual NRSA (F32)

Small Grant (R03)

Research Project Grant (R01)

Independent Scientist Award (K02)

Senior Scientist Award (K05)

Stage of ResearchTraining / Career Awards

GRADUATE/MEDICALSTUDENT

POSTDOCTORAL

EARLY

MIDDLE

SENIOR

CA

RE

ER

Predoctoral Institutional Training Grant (T32)

NIH Pathway to Independence (PI) Award (K99/R00)Mentored Research Scientist Development Award (K01)Mentored Clinical Scientist Development Award (K08)Mentored Patient-Oriented RCDA (K23)Mentored Quantitative RCDA (K25)

Midcareer Investigator Award in Patient-Oriented Research (K24) Exploratory/Develop-

ment Grant (R21)

Training and Career Timetable

Pre-Bac Pre-Bac Institutional Training Grant (T34)

Page 3: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

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Mentored Quantitative

Research Career Development Award (K25)

Career Transition Award (K22)

Mentored Research Scientist

Development Award (K01)

PostdoctoralGraduate SchoolCollegeIndependentInvestigator

Mentored Clinical

Scientist Development Award (K08)

Mentored Patient-Oriented Research

Development Award (K23)

Pathway to Independence (PI) Award (K99/R00)

Mentored K Awards

Page 4: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

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Mentored Awards

• Support mechanisms that provide mentored research experiences to gain additional expertise in an area that will significantly enhance research capabilities or expertise in a new research area.

Page 5: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

F32 Ruth L. Kirschstein National Research Service Awards (NRSA) for

Individual Postdoctoral Fellows• Requirements: U.S. citizenship or permanent resident status,

doctorate awarded• Duration: Up to 3 years• Commitment: Full-time research fellowship• Provisions: ~$37K-$52K stipend, ~$8K institutional allowance,

60% up to $16K tuition• Research Career Awards (K)

http://grants.nih.gov/training/careerdevelopmentawards.htm

5

Page 6: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

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Mentored K Awards

• K01: Mentored Research Scientist Development Award

• K08: Mentored Clinical Scientist Development Award

• K22: Research Career Award for Transition to Independence

• K23: Mentored Patient-Oriented Research Development Award

• K25: Mentored Quantitative Research Development Award

• K99/R00: NIH Pathway to Independence (PI) Award

• K12: Institutional Mentored Research Scientist Development Program

Page 7: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

K01 Mentored Research Scientist Development Award

• Purpose: For individuals who wish to enhance their capacity for independent research.

• Requirements: U.S. citizenship or permanent resident status, doctorate awarded

• Duration: 3-5 years• Commitment: 75% effort• Provisions: Salary up to $75K, fringe benefits, other research

expenses up to $20K

7

Page 8: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

K08 Mentored Clinical Scientist Research Career Development Award

• Purpose: To support clinicians who need an intensive period of mentored research experience.

• Requirements: U.S. citizenship or permanent resident status, clinical doctorate awarded

• Duration: 3-5 years• Commitment: 75% effort (50% effort for physician surgeons)• Provisions: Salary up to $75K/$50K, fringe benefits, other research

expenses up to $20K

8

Page 9: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

ScientificReview:

Jun/July

Oct/Nov

Feb/Mar

CouncilReview:

October

January

May

Earliest AwardDate:

December

April

July

Receipt/DueDate:

Feb 12 (April 8)

Jun 12 (August 8)

Oct 12 (December 8 )

Timeline for K (F) Applications

9

Page 10: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

F and K sections and page limits

Section of ApplicationPage Limits *

(if different from FOA,FOA supersedes)

Introduction to Resubmission or Revision Application (when applicable)

1

Specific Aims 1

Research Strategy 6

Respective Contributions 1

Selection of Sponsor and Institution 1

Responsible Conduct of Research 1

Applications for Concurrent Support (when applicable)

1

Goals for Fellowship Training and Career 1

Activities Planned Under This Award 1

Doctoral Dissertation and Other Research Experience

2

Sponsor(s) and Co-Sponsor(s) 6

Biographical Sketch 4

10

Section of ApplicationPage Limits *(if different from FOA,FOA supersedes)

Introduction to Resubmission or Revision Application (when applicable)

1

Specific Aims 1

First three items of Candidate Information (Candidate's Background, Career Goals and Objectives, and Career Development/Training Activities During Award Period and Research Strategy

12 pages (for all sections combined)

Training in the Responsible Conduct of Research

1

Mentoring Plan (Include only when required by the specific FOA, e.g., K24 and K05)

6

Statements by Mentor, Co-Mentors, Consultants, Contributors

6

Description of Institutional Environment 1

Institutional Commitment to Candidate’s Research Career Development

1

Biographical Sketch 4

Page 11: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Prepare the Application: read the instructions!!start early, seek internal reviewers

A. Candidate (grades, GREs, publications, pedigree)• US citizen or permanent resident• Doctoral degree (many ok)

B. Sponsor and Training Environment C. Research Proposal

g. Up to 3 yrsD. Training PotentialE. Vertebrate Animals, Human SubjectsF. You may have to resubmit…

Page 12: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

NIH Data Book – (http://report.nih.gov/ndb/index.aspx) Data provided by the Division of Information Services, Reporting Branch

Kirschstein-NRSA post-doctoral fellowships (F32s) Applications, awards, and success rates

Page 13: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

http://grants.nih.gov/training/data/tf_trends/sld006.htm

Postdoctoral trainees are funded by many Institutes

Page 14: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Assess your career situation and needs. Find out the opportunities for collaborating with a known laboratory and experienced mentor(s) and collaborators.

Asses the field and the competition; see which other projects in your field are being funded by NIH. Search the NIH database: Research Portfolio Online Reporting Tools (RePORT).

Evaluate yourself: What are your strengths and weaknesses? Can you capitalize on your expertise and fill in any gaps with collaborators or consultants?

Find out what resources and support your organization has and what additional support you will need.

Develop a Strategy

14

Page 15: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Is there an added value to your receiving a K award? Why not pursue research training through other mechanisms?

Give yourself plenty of time to write the application, probably three (to six) months.

Know your organization's key contacts and internal procedures for electronic application.

Begin the application by writing a one-sentence hypothesis for the proposed research project.

Call an Institute/Center (I/C) Program Officer for an opinion of your ideas. See if your ideas match any of the I/C's high-priority areas, reflected in I/C’s initiatives and concepts.

Develop a Strategy

15

Page 16: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Read NIH Guide notices.

Read the NIH Institute/Center Funding Opportunity Announcements.

Sign up for NIH's Electronic Application Listserv to Receive News and Updates.

See NIH's Electronic Submission Website.

As you plan your grant, watch for important policy and process changes.

Be wary of online information – always check when a page was last updated.

Stay Informed

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Page 17: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

The general rule of thumb for a K award is to start at least 3 months prior to the application due date.

Notify your referees early on and give them plenty of time to submit letters of reference.

At least a month before you want to apply, you'll need to get an NIH Commons account.

You will also need to know who is your organization's Authorized Organizational Representative (AOR). Your AOR is typically someone in your business office.

Only the AOR can submit your application to Grants.gov. Keep in mind that your organization is the “applicant.” You are the K candidate.

For info, see: http://era.nih.gov/ElectronicReceipt/process.htm

Start Early to Apply Electronically

17

Page 18: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Coordinate the application with your mentor’s schedule. Remember that a K application is a collaboration between you and your mentor.

As you write the research project, always keep in mind the impact on your career development plans and progression.

Make sure your planning and feedback are adequate by putting together your own review committee.

After you've settled on a project, draft a short description of your specific aims and discuss these with the committee.

Be sure to have the committee review the application after you're finished writing.

Before You Start Writing

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Page 19: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

The research component of a K application should be driven by strong hypotheses rather than advances in technology.

The hypothesis is the foundation, or the conceptual underpinning on which the entire project rests.

Generally applications should ask questions that prove or disprove a hypothesis rather than use a method to search for a problem or simply collect information.

However, sometimes applied research is also important to discover basic biology or develop or use a new technology.

You should develop a focused hypothesis that increases understanding of an important biologic process and is based on previous research.

Develop a Solid Hypothesis

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Page 20: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

A few Tips: Make sure your idea is not too broad. Your

hypothesis must be provable during your 3 to 5 year award with the level of resources you are requesting.

Your topic should fit NIH's public health mission. Tie your science to curing, treating, or preventing disease.

Show reviewers how your project fits in your field. Make this explicit.

Remember, methods are the means for performing your experiments. Your experimental results will prove or disprove your hypothesis.

If you have more than one hypothesis, choose the better one.

Develop a Solid Hypothesis

20

Page 21: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Make sure your hypothesis will generate aims and methods you can accomplish within the 3-5 years time and with the resources available.

After you have chosen your hypothesis, outline your specific aims:

List your aims and then all the experiments you will do to support each aim.

Keep in mind that your experiments support your aims, and your aims support your hypothesis.

Use graphics to plan experiments. Chart experiments with decision trees

showing alternative pathways should you get negative results.

Plan Your Application

21

Page 22: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

The Career (K) line budget is driven by NIH Institute and Center policies. As an applicant, you are restricted to what you can ask for.

Be aware that the NIH Institutes and Centers have varying salary and research cost scales!

A typical mentored K award to a new investigator provides partial salary and only modest research costs.

Ideally, your mentor(s) should be well-funded (NIH funding is preferred), and funding from the K is supplemental to his/her research funds.

Most independent K awards do not provide research costs. It is expected that you will have peer-reviewed research funding.

Request an Appropriate Budget

22

Page 23: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Stipends: Kirschstein-NRSA awards provide stipends

http://grants2.nih.gov/training/nrsa.htm. No departure from the published Kirschstein-NRSA stipend schedule may be negotiated between the institution and the fellow. For fellows sponsored by domestic non-federal

institutions, the stipend will be paid through the sponsoring institution.

Tuition and Fees: NIH will contribute to the combined cost of tuition

and fees at the rate in place at the time of award. For the most recent tuition/fees levels, see the following website: http://grants2.nih.gov/training/nrsa.htm.

Institutional Allowance: Fellows sponsored by nonfederal or nonprofit

institutions (domestic or foreign) will receive an institutional allowance to help defray fellowship expenses such as health insurance, research supplies, equipment, books, and travel to scientific meetings.

Request an Appropriate Budget

23

F-32

Page 24: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Sharpen the focus of your application. Beginning applicants, particularly at an early career stage, often overshoot their mark by proposing too much. Avoid an “over-ambitious” project or one that looks a lot like an R01 grant!

Your hypothesis should be provable and aims doable with the resources you are requesting.

Make sure the scale of your hypothesis and aims fits your request of time and resources.

Reviewers will quickly pick up on how well matched your research and career development objectives are.

Don't Propose Too Much

24

Page 25: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Write to Your Audience: Organize your application so the reviewers can

readily grasp and explain what you are proposing, and most importantly, why you should get a K award.

Be Persuasive: Tell reviewers why testing your hypothesis is

worth NIH's money, why you are the person to do it, and how your mentor(s) and institution can give you the support you'll need to get it done.

Balance the Technical and Non-technical: Keep the abstract, significance, and specific

aims non-technical, and get technical and detailed only in the methods section.

A Few Tips as You Write

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Page 26: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Make Life Easy for Reviewers:

Write clearly and concisely

Guide the reviewers with graphics as

much as possible

Label all materials clearly

Edit and proof

Know These Review Problems and

Solutions:

Write a compelling argument for why

your career will be enhanced by

receiving a K award

Write to the non-expert in the field

A Few Tips as You Write

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Page 27: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Candidate Qualifications, Career Goals,

Training Plans

Statements by the Mentor, co-Mentors,

Collaborators, and Consultants

Institution Environment and Commitment

to the Candidate

Specific Aims

Research Strategy

Write a Compelling Application

27

Page 28: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Writing a competitive mentored K award grant application

• Main sections of the grant application– Candidate (Sections 2 – 4)*– Instruction in the Responsible Conduct of

Research (Section 5: limited to 1 page)– Statements by Mentors, Co-Mentors, and

Collaborators (Section 7; limited to 6 pages)– Description of Institutional Environment (Section 8;

limited to 1 page)– Institutional Commitment to Candidate’s Research

Career Development (Section 9: limited to 1 page)– Specific Aims (Section 10: limited to 1 page)– Research Strategy (Section 11)*

*Sections 2 – 4 plus Section 11 are limited to 12 pages

Page 29: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Biographical Sketch:

Personal Statement: Your research

experience and other qualifications

for this K award.

Research Support: Your/colleagues

accomplishments attesting to

qualifications of the research team.

Don’t confuse this with “Other

Support.”

Candidate’s Background:

Coordinate with information in the

Biographical Sketch, e.g., research

and/or clinical training experience

that has prepared you for the K.

Candidate’s Qualifications

29

Page 30: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Career Goals and Objectives:

Tell the reviewers about your

scientific history, and how the K

award fits into you research career

development plans.

If you have changed research

direction, discuss reasons for the

change, and be sure to justify how it

will help you to develop your research

career.

You should always provide a career

development timeline, including plans

to apply for subsequent grant

support.

30

Candidate’s Career Goals

Page 31: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Career Development/Training During Award:

Make sure to fully explain any new or

enhanced research skills you will gain

as a result of the K.

Stress activities that will enhance

your research career, e.g., courses,

techniques.

Describe any additional, non-research

activities in which you expect to

participate. Explain how the activity is

related to your research and career

development plans.

31

Candidate’s Career Plans

Page 32: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Training in Responsible Conduct of Research:

Document any prior participation in

RCR training and/or propose plans to

receive additional instruction.

Discuss the five components outlined

in the NIH Policy: Format, Subject

Matter, Faculty Participation,

Duration, and Frequency.

Is the plan appropriate for your career

stage, and will it enhance your

understanding of ethical issues

related to research?

32

Responsible Conduct of Research

Page 33: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Statements by Mentor(s), Consultant(s):

Each mentor must explain how he/she

will contribute to the development of

the candidate's research career.

Discuss the research And Also other

activities, e.g., seminars, scientific

meetings, training in RCR,

publications and presentations.

Document the sources and amounts of

anticipated support for the

candidate’s research project.

33

Mentor(s), Collaborators, Consultants

Page 34: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Statements by Mentors, Co-Mentors,

and Collaborators

• Assemble a complementary team

– Choose a primary mentor who is a senior investigator with a track-record of NIH funding

• Your primary mentor should be at your home institution.

– Include co-mentors who will complement the primary mentor’s strengths.

– Avoid including co-mentors from institutions outside the region.

• If you do include someone from outside the region, call them a scientific or technical advisor rather than a co-mentor.

Page 35: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Statements by Mentors, Co-Mentors, and Collaborators

(Cont’d)

– Each member of your “team” must play a role in your training or research plan.

– Establish a relatively small (3-5) mentoring committee.

– This section is limited to 6 pages.• Each member of your team must submit a signed

letter.• The primary mentor’s letter should be at least 2

pages, leaving only 4 pages for all other members; hence, the total number of mentors/advisors on your team should not exceed 5.

Page 36: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Statements by Mentors, Co-Mentors,

and Collaborators

• Evaluation criteria for primary mentor:– Appropriateness of mentor’s research qualifications in the area

of this application.– Quality and extent of mentor’s role in providing guidance and

advice to candidate.– Previous experience in fostering the development of more

junior researchers.– History of productivity and support.– Adequacy of support for the research project.

Page 37: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Letters of Collaboration

• The letter from the primary mentor is key. It should cover the following areas:– His or her qualifications in the research area proposed

by the candidate.– Previous experience as a research supervisor. – The nature and extent of supervision that will occur

during the award period. • Include an evaluation component that describes how your

mentors will assess your progress (e.g., quarterly meetings).

• Include specific milestones during the K award (e.g., completion of coursework, submission of manuscripts).

– What resources, if any, they will make available to you in support of your training and/or research.

Page 38: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Letters of Collaboration

• Any of the following issues could also be addressed, which are the criteria by which the candidate will be evaluated:– Potential for conducting research – Evidence of originality– Adequacy of scientific background – Quality of research endeavors or publications

to date – Commitment to patient-oriented research – Need for further research experience and

training

Page 39: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Primary mentor’s letter

• The primary mentor’s letter can also “re-frame” any potential weaknesses in the application.– Examples:

• Productivity of candidate (e.g., few publications).• Feasibility of conducting research plan with resources

of K award.• Limited mentoring experience of primary mentor. • Limited resources of primary mentor (e.g., no current

R01 funding.• Co-mentor(s) not at UD.• Scientific overlap with primary mentor.

Page 40: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Letters of Collaboration

• Letters from co-mentors, scientific advisors, and others can be much shorter.

• Be sure to include description of the role of the co-mentor/scientific advisor.

• Make sure that letters are consistent with text in grant application (re: frequency of meetings, etc.).

Page 41: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Letters of Recommendation• 3 - 5 letters are required. • They should be from senior investigators

who have competed successfully for NIH funding and have been involved in the training of junior investigators.

• Can be from any period in your career (e.g., graduate school, medical (professional) school, residency).

• Cannot be from your primary mentor or co-mentors.

Page 42: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Letters of Recommendation

• Letters should address the candidate’s potential for a research career.– Potential for conducting research – Evidence of originality– Adequacy of scientific background – Quality of research endeavors or publications

to date – Commitment to patient-oriented research – Need for further research experience and

training

Page 43: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Statements by Mentor(s), Consultant(s):

Provide details on the candidate's

anticipated teaching load, clinical

responsibilities, etc.

It is critical to discuss plans for

transitioning the candidate to the

independent investigator stage by the

end of the K award period.

Mentor(s) must provide details for

any previous experience as a mentor,

types (e.g., graduate students,

Postdocs), numbers, and career

outcomes.

43

Mentor(s), Collaborators, Consultants

Page 44: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Description of Institutional Environment:

The sponsoring institution must

document a strong, well-established

research program related to the

candidate's areas of interest.

The statement should include the

names of the mentor(s) and other

relevant faculty.

The statement should provide details

of facilities and resources available

for the candidate.

Any opportunities for intellectual

interactions, e.g., journal clubs,

seminars, and presentations?

44

Institution’s Research Environment

Page 45: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Institutional Commitment to the Candidate:

The institution must document its

commitment to the candidate’s career

development independent of the K

award!

The institution must agree to provide

adequate time and support to the

candidate for the period of K.

Provide documentation for the

institution's commitment to the

development and advancement of the

candidate during the period of the K

award.

45

Institution’s Commitment

Page 46: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Institutional Commitment to the Candidate:

The institution must provide the

candidate with appropriate office and

laboratory space, equipment, and

other resources and facilities (e.g.,

access to clinical and/or other

research populations) to carry out the

proposed research.

The institution must provide

appropriate time and support for any

proposed mentor(s) and/or other staff

consistent with the career

development plan.

46

Institution’s Commitment

Page 47: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Institutional Commitment to the Candidate:

The institution must document its

commitment to the candidate’s career

development independent of the K

award!

The institution must agree to provide

adequate time and support to the

candidate for the period of K.

Provide documentation for the

institution's commitment to the

development and advancement of the

candidate during the period of the K

award.

47

Institution’s Commitment

Page 48: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Description of Institutional Environment

• This section is limited to 1 page.• Evaluation criteria:

– Adequacy of research facilities and the availability of appropriate educational opportunities.

– Quality and relevance of the environment for scientific and professional development of the candidate.

Page 49: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Description of Institutional Environment

• Describe the research facilities and educational opportunities of the sponsoring institution that are related to the candidate’s career development training and research plans.– Include relevance of each component to your

career development plan.

• Describe resources outside UD, as needed.

Page 50: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Institutional Commitment to Candidate’s Research Career

Development• This section is limited to 1 page.• Evaluation criteria

– Applicant institution’s commitment to the scientific development of the candidate and assurances that the institution intends the candidate to be “an integral part of its research program.”

– Applicant institution’s commitment to protect at least 75% of the candidate’s effort for proposed career development activities.

Page 51: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Institutional Commitment to Candidate’s Research Career

Development (Cont’d)

– These assurances are stated in a letter from your department chair or division chief (see Example 4).

• Note: For fellows, this letter must state that you will be promoted from your current position to a “higher” position (ideally, to a full-time faculty position) during the K award period.

Page 52: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Overall Impact: This score reflects the reviewers assessment of the likelihood for the candidate to become/remain an independent investigator. An application does not need to be strong in all categories to have a major impact.

Scored Review Criteria: Determination of scientific, technical, and career merit. Each gets a separate score:

→ Candidate→ Career Development Plan/Career Goals

& Objectives→ Research Plan→ Mentor(s), Consultants(s),

Collaborator(s).→ Environment and Institutional

Commitment to the Candidate

Career Award Review Criteria

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Page 53: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Candidate: Quality of research, academic and/or clinical

record Potential to develop as an independent and

productive researcher Commitment to a research career Quality of the letters of referenceCareer Development Plan/Career Goals &

Objectives: Likelihood that plan will contribute

substantially to the scientific development of candidate – Added Value

Content, scope, phasing, and duration of the plan in the context of prior experience and stated career objectives

Career Award Review Criteria

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Page 54: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Research Plan:

Scientific and technical merit of the research question, design and methodology

Relevance of the proposed research to the candidate‘s career objectives

Appropriateness of the research plan to the stage of research development and as a vehicle for developing the research skills described in the career development plan

Career Award Review Criteria

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Page 55: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Mentor(s), Consultants(s), Collaborator(s):

Qualifications and statement by Mentor and collaborators/Consultants

Environment and Institutional Commitment to the Candidate:

Commitment of institution to ensure that the candidate's effort will be devoted to research (Minimum 75%)

Adequacy of research facilities and training opportunities, including capable faculty

Assurance that institution intends for the candidate to be an integral part of its research program

Career Award Review Criteria

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Page 56: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Additional Review Criteria: Protection of Human Subjects from Research

Risk Inclusion of Women, Minorities, and Children in

Research Care and Use of Vertebrate Animals in

Research Biohazards Resubmission Applications Renewal Applications (as applicable)

Additional Review Considerations: Training in the Responsible Conduct of

Research Select Agents Resource Sharing Plans Budget and Period of Support

Career Award Review Criteria

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Page 57: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Expectations of a Mentor

Stephen B. Trippel et al

Page 58: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

DefinitionsGreek History:

• Mentor was a close friend and counselor for Odysseus. When Odysseus left for the Trojan War, he placed Mentor in charge of his

son and his palace.

NIH:

• “A mentor is a person who has achieved career success and counsels and guides another for the purpose of helping him or her achieve like success. Research supervisors should always be mentors; they have the responsibility to discuss with and advise a trainee on aspects of his or her work and professional development.”

Page 59: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Picking a Mentor

Selection is based on a variety ofattributes:

ExpertiseRecord of mentorshipPersonal rapportCommitment to your development

Picking a mentor requires you toknow yourself and your researchenvironment

May have more than one mentor fordifferent facets of your career

No “one size fits all” mentality

Page 60: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Roles of Mentor

Finding a good mentor may be asimportant as skillful grantsmanship

InfrastructureLab management adviceCollaborationHonest evaluationAdvocacy University Scientific Community

Page 61: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

What About Infrastructure

Basic research is a complicated enterprise

Core facilities/equipment

Methodologies

Administrative support

Start-up Funds

Page 62: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

The Transition to LabManagement

Lots of training, but … you need help!

How to become a leader Managing technicians

Mentoring students/fellows

Navigating human resources Evaluations

Conflicts

Page 63: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Your Best/WorstCollaborator

The best mentor is in your field - Better yet ifspecific interests overlap

Access to reagents/data/expertise

Familiarity with allies/competition

Pulse of the study section

Co-investigator status More grant writing!!

1 Risk: Exploitation

Page 64: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

The Person that EmbodiesThese Characteristics: Has a relationship with you that is both

personal and professional

Views his/her success as linked to yoursuccess

Is empathetic yet pragmatic

Page 65: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Honest Evaluation:Friend, Critic or Both? Regular evaluations

Individual programs Papers

Grants Unfunded research

Mentoring activity

Promotions/tenure

Page 66: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Advocacy

Your mentor should be your advocate At Home

Academic departments/studentsDepartmental and university committeesProtected research timePromotions/tenure

On The Road Meet and Greet Access to the “Inner Circle”

Journal reviewer Grant reviewer

Page 67: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

The Impact of OutstandingMentorship Immediate productivity

Access to lab personnel

Involvement in mature programs

Co-investigatorship A window into the world of grant writing

Open dialog about your own developingprogram Use of funds

People management Overall research direction

Page 68: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Immediate Productivity

Main objective: get your own programrolling

Also: During the start-up phase

Getting early publications Learn the bureaucratic ropes early

Research Affairs office IACUC, IRB Pursuit of intramural pilot money

Page 69: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Co-investigatorship Main objective: get your own grant

fundedAlso:

Becoming a Co-I has perks Early evidence of support Forging effective collaborations Involvement in areas outside your focus

Critical to have multiple directions Bring new perspective to your own program

Learn grant writing first hand

Page 70: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Open Dialog About YourProgram

Advice on the use of start-up funds

Preserve for the futureEquipment vs. supplies vs. personnelSmall grants make a big differenceGetting the best bang for the $

Who can help the most right away? How to manage staff successfully

Research direction Morphing hypotheses into proposals

Roadmap to promotion

Page 71: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Despite All The Mentoring …

There are still no guarantees Set limits on time spent away from your main goal

Always be in the process of paper and proposalwriting

Never fear critiques Friends

Study section

Always be responsive, not argumentative

Don’t focus solely on the NIH for funding

Marshall your ‘big idea’ with smaller, sure-fireprojects

NOT

Page 72: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

Develop a Plan for Long TermProductivity & Funding

Create a strategic vision for research thatincludes: Creation of a research focus Stepwise plan to publish results and obtain

commensurate funding Overall career development

Effectively manage research time vis-à-vis other activities: clinical, educationaland administrative

Page 73: COBRE Grant Writing Workshop Writing Successful NIH Mentored Career Development Awards (K and F Series), Mentorship Plan and Role of a Mentor Lynn Snyder-Mackler

MotivateEmpowerNurture confidence and competenceTeach by exampleOffer sound counselRaise the performance barShine in reflected light

SummaryMentor’s Role