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Coagulation Pathways (All Components) www.ecat.nl
Coagulation Pathways (All Components)
Symbol Name
HK High molecular weight Kininogen
FXII Factor XII
FXIIa Activated Factor XII
FXI Factor XI
FXIa Activated Factor XI
FIX Factor IX
FIXa Activated Factor IX
FVIIIa Activated Factor VIII
FX Factor X
FXa Activated Factor X
FVIIa Activated Factor VII
FVa Activated Factor V
TFPI Tissue Factor Pathway Inhibitor
Symbol Name
TAFI Thrombin-Activatable Fibrinolysis
Inhibitor
TAFIa Activated Thrombin-Activatable
Fibrinolysis Inhibitor
PC Protein C
APC Activated Protein C
TM Thrombomodulin
Inhibits
Inhibited by APC
Extrinsic Pathway
“converts”, “gives rise to”, “yields”
Intrinsic Pathway
“converts”, “gives rise to”, “yields”
Different roles of Thrombin
“converts”, “gives rise to”, “yields”
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
VIIIa
TFPI
IX
XIa
XI
Vessel Injury
X
XIIa
XII
Prothrombin
Thrombin
Platelet Activated Platelet
Thrombin
Thrombin
Thrombin
Fibrinogen FIBRIN
TAFIa
TAFI
Fibrinolysis
TM
PC APC
TM
Adapted from Broze, Semin Hematol 1992;29:159-69
Coagulation Pathways (All Components) www.ecat.nl
FVIIa
TF
Vessel Injury
XIIa
XII
Coagulation Pathways (All Components) www.ecat.nl
FVIIa
TF
X
Xa
IX
IXa
Vessel Injury
XIIa
XII
Coagulation Pathways (All Components) www.ecat.nl
FVIIa
TF
X
Xa
Va
IX
IXa
Vessel Injury
XIIa
XII
Prothrombin
Thrombin
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
XIa
XI
Vessel Injury
XIIa
XII
Prothrombin
Thrombin
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
TFPI
XIa
XI
Vessel Injury
XIIa
XII
Prothrombin
Thrombin
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
TFPI
IX
XIa
XI
Vessel Injury
XIIa
XII
Prothrombin
Thrombin
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
VIIIa
TFPI
IX
XIa
XI
Vessel Injury
X
XIIa
XII
Prothrombin
Thrombin
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
VIIIa
TFPI
IX
XIa
XI
Vessel Injury
X
XIIa
XII
Prothrombin
Thrombin
Fibrinogen FIBRIN
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
VIIIa
TFPI
IX
XIa
XI
Vessel Injury
X
XIIa
XII
Prothrombin
Thrombin
Platelet Activated Platelet
Thrombin
Fibrinogen FIBRIN
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
VIIIa
TFPI
IX
XIa
XI
Vessel Injury
X
XIIa
XII
Prothrombin
Thrombin
Platelet Activated Platelet
Thrombin
Thrombin
Fibrinogen FIBRIN
TAFIa
TAFI
Fibrinolysis
TM
Coagulation Pathways (All Components) www.ecat.nl
Thrombin
FVIIa
TF
X
Xa
Va
IX
IXa
VIIIa
TFPI
IX
XIa
XI
Vessel Injury
X
XIIa
XII
Prothrombin
Thrombin
Platelet Activated Platelet
Thrombin
Thrombin
Thrombin
Fibrinogen FIBRIN
TAFIa
TAFI
Fibrinolysis
TM
PC APC
TM
Adapted from Broze, Semin Hematol 1992;29:159-69