Cm chapter 5

1. Leaving a reagent strip in the specimen for too long will:

A. Cause runover between reagent padsB. Alter the color of the specimenC. Cause reagents to leach from the padsD. Not affect the chemical reactions

2. Failure to mix a specimen prior to inserting thereagent strip will primarily affect the:

A. Glucose reading B. Blood readingC. Nitrite reading D. Ph reading

3. Testing a refrigerated specimen that has not warmed to room temperature will adversely affect:

A. Enzymatic reactionsB. Dye-binding reactionsC. The sodium nitroprusside reactionD. Diazo reactions

4. The reagent strip reaction that requires the longest reaction time is the:

A. Bilirubin B. pHC. Leukocyte esterase D. Glucose

5. Quality control of reagent strips is performed:

A. Using positive and negative controlsB. When results are questionableC. At least once every 24 hoursD. All of the above

6. All of the following are important to protect theintegrity of reagent strips except:

A. Removing the desiccant from the bottleB. Storing in an opaque bottleC. Storing at room temperature

D. Resealing the bottle after removing a strip

7. The principle of the reagent strip test for pH is the:

A. Protein error of indicatorsB. Greiss reactionC. Dissociation of a polyelectrolyteD. Double indicator reaction

8. A urine specimen with a pH of 9.0:

A. Is indicative of metabolic acidosisB. Should be recollectedC. May contain calcium oxalate crystalsD. Is seen after drinking cranberry juice

9. In the laboratory, a primary consideration associated with pH is:

A. Identification of urinary crystalsB. Monitoring of vegetarian dietsC. Determination of specimen acceptabilityD. Both A and C

10. Indicate the source of the following proteinurias by placing a 1 for prerenal, 2 for renal, or 3 for postrenal in front of the condition.

A. ____MicroalbuminuriaB. ____Acute phase reactantsC. ____Pre-eclampsiaD. ____Vaginal inflammationE. ____Multiple myelomaF. ____Orthostatic proteinuriaG. ____Prostatitis

11. The principle of the protein error of indicators reaction is that:

A. Protein changes the pH of the urineB. Albumin accepts hydrogen ions from the indicatorC. The indicator accepts ions for albuminD. Albumin changes the pH of the urine

12. All of the following will cause false-positive protein reagent strip values except:

A. Proteins other than albuminB. Highly buffered alkaline urinesC. Delay in removing the reagent strip from the specimenD. Contamination by quartenary ammonium compounds

13. A patient with a 1_ protein reading in the afternoon is asked to submit a first morning specimen. The second specimen also has a 1_ protein. This patient is:

A. Positive for orthostatic proteinuriaB. Negative for orthostatic proteinuriaC. Positive for Bence Jones proteinD. Negative for clinical proteinuria

14. Testing for microalbuminuria is valuable for monitoring patients with:

A. HypertensionB. Diabetes mellitusC. Cardiovascular disease riskD. All of the above

15. All of the following are true for the Micral-Test for microalbumin except:

A. It is run on first morning specimensB. It contains an antibody-enzyme conjugateC. Two blue bands are formed on the stripD. Unbound antibody attaches to immobilizedAlbumin

16. All of the following are true for the Immunodip test for microalbumin except:

A. Unbound antibody migrates farther than boundantibodyB. Blue latex particles are coated with antibodyC. Bound antibody migrates further than unboundantibody

D. It utilizes an immumochromographic principle

17. The principle of the protein-low reagent pad on theMultistix Pro is the:

A. Binding of albumin to sulphonphtalein dyeB. Immunologic binding of albumin to antibodyC. Reverse protein error of indicators reactionD. Enzymatic reaction between albumin and dye

18. The principle of the creatinine reagent pad onmicroalbumin reagent strips is the:

A. Double indicator reactionB. Diazo reactionC. Pseudoperoxidase reactionD. Reduction of a chromogen

19. The purpose of performing an albumin:creatinineratio is to:

A. Estimate the glomerular filtration rateB. Correct for hydration in random specimensC. Avoid interference for alkaline urinesD. Correct for abnormally colored urines

20. A patient with a normal blood glucose and a positiveurine glucose should be further checked for:

A. Diabetes mellitusB. Renal diseaseC. Gestational diabetesD. Pancreatitis

21. The principle of the reagent strip tests for glucose isthe:

A. Peroxidase activity of glucoseB. Glucose oxidase reactionC. Double sequential enzyme reactionD. Dye-binding of glucose and chromogen

22. All of the following may produce false-negative glucose reactions except:

A. Detergent contaminationB. Ascorbic acidC. Unpreserved specimensD. Low urine temperature

23. A positive Clinitest and a negative reagent strip glucose are indicative of:

A. Low levels of glucoseB. Nonglucose reducing substancesC. High levels of glucoseD. Both A and B

24. The primary reason for performing a Clinitest is to:

A. Check for high ascorbic acid levelsB. Confirm a positive reagent strip glucoseC. Check for newborn galactosuriaD. Confirm a negative glucose reading

25. The three intermediate products of fat metabolisminclude all of the following except:

A. Acetoacetic acidB. Ketoacetic acidC. Beta-hydroxybutyric acidD. Acetone

26. The most significant reagent strip test that is associated with a positive ketone result is:

A. GlucoseB. ProteinC. pHD. Specific gravity27. The primary reagent in the reagent strip test forketones is:

A. GlycineB. Lactose

C. Sodium hydroxideD. Sodium nitroprusside

28. Ketonuria may be caused by all of the followingexcept:

A. Bacterial infectionsB. Diabetic acidosisC. StarvationD. Vomiting

29. Urinalysis on a patient with severe back and abdominal pain is frequently performed to check for:

A. GlucosuriaB. ProteinuriaC. HematuriaD. Hemoglobinuria

30. Place the appropriate number or numbers in front ofeach of the following statements. Use both numbersfor an answer if needed.

1. Hemoglobinuria2. Myoglobinuria

A. ____Associated with transfusion reactionsB. ____Clear, red urine and pale yellow plasmaC. ____Clear, red urine and red plasmaD. ____Associated with rhabdomylosisE. ____Precipitated by ammonium sulfateF. ____Not precipitated by ammonium sulfateG. ____Produced hemosiderin granules in urinary sedimentsH. ____Associated with acute renal failure

31. The principle of the reagent strip test for blood isbased on the:

A. Binding of heme and a chromogenic dyeB. Peroxidase activity of hemeC. Reaction of peroxide and chromogenD. Diazo activity of heme

32. A speckled pattern on the blood pad of the reagentstrip indicates:

A. HematuriaB. HemoglobinuriaC. MyoglobinuriaD. All of the above33. List the following products of hemoglobin degradationin the corrct order by placing numbers 1–4 infront of them.

A. ___Conjugated bilirubinB. ___Urobilinogen and stercobiligenC. ___UrobilinD. ___Unconjugated bilirubin

34. The principle of the reagent strip test for bilirubin isthe:

A. Diazo reactionB. Ehrlich reactionC. Greiss reactionD. Peroxidase reaction

35. An elevated urine bilirubin with a normal urobilinogenis indicative of:

A. Cirrhosis of the liverB. Hemolytic diseaseC. HepatitisD. Biliary obstruction

36. The primary cause of a false-negative bilirubin reaction is:

A. Highly pigmented urineB. Specimen contaminationC. Specimen exposure to lightD. Excess conjugated bilirubin

37. The purpose of the special mat supplied with theIctotest tablets is that:

A. Bilirubin remains on the surface of the mat.B. It contains the dye needed to produce color.C. It removes interfering substances.D. Bilirubin is absorbed into the mat.

38. The reagent in the Multistix reaction for urobilinogenis:

A. A diazonium saltB. TetramethylbenzidineC. p-dimethylaminobenzaldehydeD. Hoesch reagent

39. The primary problem with urobilinogen tests usingEhrlich reagent is:

A. Positive reactions with porphobilinogenB. Lack of sensitivityC. Positive reactions with Ehrlich reactive substancesD. Both A and C40. In the Watson-Schwartz differentiation test, the substance(s) not extracted into butanol is/are:

A. UrobilinogenB. PorphobilinogenC. Ehrlich reactive substancesD. All of the above

41. The Hoesch test is used to monitor or screen patientsfor the presence of:

A. UrobilinogenB. NitriteC. PorphobilinogenD. Leukocyte esterase

42. The reagent strip test for nitrite used the:

A. Greiss reactionB. Hoesch reactionC. Peroxidase reactionD. Pseudoperoxidase reaction

43. All of the following can cause a negative nitrite reading except:

A. Gram-positive bacteriaB. Gram-negative bacteriaC. Random urine specimensD. Heavy bacterial infections

44. A positive nitrite test and a negative leukocyte

esterase test is an indication of a:

A. Dilute random specimenB. Specimen with lyzed leukocytesC. Vaginal yeast infectionD. Specimen older than 2 hours

45. All of the following can be detected by the leukocyteesterase reaction except:

A. NeutrophilsB. EosinophilsC. LymphocytesD. Basophils

46. Screening tests for urinary infection combine theleukocyte esterase test with the test for:

A. pHB. NitriteC. ProteinD. Blood47. The principle of the leukocyte esterase reagent striptest uses a:

A. Peroxidase reactionB. Double indicator reactionC. Diazo reactionD. Dye-binding technique

48. The principle of the reagent strip test for specificgravity uses the dissociation constant of a/an:

A. Diazonium saltB. Indicator dyeC. PolyelectrolyteD. Enzyme substrate

49. A specific gravity of 1.030 would produce the reagentstrip color:

A. BlueB. GreenC. YellowD. Red

50. Reagent strip–specific gravity readings are affected by:

A. GlucoseB. Radiographic dyeC. Alkaline urineD. All of the above