CLOUD-BASED MULTIPHASE FLOW SIMULATION OF A … · 2016-06-28 · calculation time, e.g. 25 variants in one week (no investment costs). Variant simulation (e.g. DoE) is not direct

CLOUD-BASED MULTIPHASE FLOW

SIMULATION OF A BIOREACTOR

PROJECT: CLOUDFLOW

23rd and 24th of June – Amsterdam

USE-CASE: BIOREACTOR

I4MS 2016: FOSTERING DIGITAL INDUSTRIAL INNOVATION IN EUROPE · 23rd and 24th of June · Amsterdam

Bioreactor is a device, which supports a

biologically active environment

It is used for the production of different

organisms, which are used in pharmaceutical,

chemical and food industries

Pharma companies: Bayer, Pfizer, etc.

Food & drink manufactures: Nestle, Paulaner

Brewery, etc.

Manufacturer of the bioreactors are

equipment manufacturer: ZETA, VTU, Vogel-

Busch Biopharma, Eppendorf etc.

Source: http://www.sanisure.com/

What is the problem and for whom?

Long calculation time (about a week - caused by the need to run transient simulations up to 20

seconds) without a highly optimized workflow and huge computational resources

Industry requires a calculation time not longer than one week

These computational resources are often not affordable for SME

Why simulation?

Product improvement (e.g. higher cell density, number of viable cells etc.)

Process understanding (e.g. scale up, new impeller design or number of impellers etc.)

Improvement of process criteria (kLa, shear rate, homogenization etc.)

Why Cloud computing for a bioreactor simulation?

Peak demands can be covered

Huge number of CPUs are available on demand

Possibility to perform DoE analysis (e.g. up to 25 parallel variants)

Full cost control

Already developed and proven workflow

ACTUAL PROBLEM AND WHY

CAN CLOUD COMPUTING HELP?


SES-Tec OG, Austria

Leading partner and End-User

Simulation technology consulter and service

provider

SME*

AVL LIST GmbH, Austria

Software vendor

Large enterprise**

Arctur računalniški inženiring d.o.o., Slovenia

HPC Provider

SME*

* fewer than 250 employees** more than 250 employees

EXPERIMENT CONSORTIUM


EXPERIMENT DESIGN AND

TECHNICAL APPROACH


Simulation model

Vessel

Impeller

Baffles

Sparger

Rotor cell

selection

Stator cell

selection

Fill level

CURRENT PROCESS WITHOUT

USING CLOUD COMPUTATION


MISSING

COMPUTATIONAL

RESOURCES

EXPERIMENT DESIGN AND

TECHNICAL APPROACH


Implementation

Solution

Access to computational resources via Cloud - thus full cost control,

shorter calculation time and affordable for SME

Highly optimized workflow for this kind of application

WEB BROWSER AND CLOUDFLOW PORTAL

3D RESULTS POST-

PROCESSING IN CLOUD


2D and 3D data post-processing in

Cloud

Full integrated 2D/3D post-

processing application in

Cloud

No data transfer through

network

Simulation and residuals

monitoring

ECONOMIC IMPACT AND

BUSINESS OPPORTUNITIES


In house costs

45.000€ (12-16CPUs + License for

a year)

Utilization: about 80% per year

Cloud costs: 1,2 [€ / CPU h]

Real advantage of Cloud for an

end-user

Huge number of variants in short

calculation time, e.g. 25 variants in

one week (no investment costs).

Variant simulation (e.g. DoE) is

not direct comparable with in-

house calculation, due to very high

investment costs (e.g. 25*45.000€,

practically not possible for SMEs)

0

20000

40000

60000

80000

100000

120000

0 20 40 60 80 100

Co

sts

[€]

Nr. of Variants

Cloud costs

In house costs

Cost saving

ECONOMIC IMPACT AND

BUSINESS OPPORTUNITIES


Time saving

Actual impact for SES-Tec

In the next three years SES-Tec is planning to increase the actual turnover by 15% of the actual turnover only due to Cloud computing. SES-Tec

We will contact potential customers (e.g. Vision Pharma (2016) and CPHI (2016)) and increase the market in the are of pharma and bio technology

Furthermore, SES-Tec is planning to hire a new employee, which deals exclusively with cloud computation.

CONCLUSION AND

FURTHER PLANS


Cloud computing advantages

No investment and service costs

Available 24/7

Benefits from CloudFlow project

Cloud computing knowledge and integration of a workflow

Results of a DoE analysis in Cloud

Experience and basis knowledge for other applications and integrations

New services offer new application areas and new job positions

How I4MS helped SES-Tec

With the help of I4MS it was possible to create a new tested application – in order to keep up also as an SME

Provided a large network

A SME is forced to economize differently as a large enterprise and therefore it is pretty tough to develop a

cloud-based platform for a CFD simulation during the daily work

Dissemination and exploitation activities

Contact with potential customers

Usability test with SES-Tec customers (live demonstrations for potential new applications)

THANK YOUANY QUESTIONS?

Documents

CLOUD-BASED MULTIPHASE FLOW SIMULATION OF A … · 2016-06-28 · calculation time, e.g. 25 variants in one week (no investment costs). Variant simulation (e.g. DoE) is not direct