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9990 Park Meadows Drive Lone Tree, CO 80124 USA (Phone) +1.303.703.4906 (Fax) +1.303.867.3927 [email protected] www.zynexmedinternational.com NeuroMove Clinical Study Conclusions Clinical documentation for the effectiveness of the NeuroMove technology (EMG-triggered stim): These clinical studies have all been published in peer-reviewed journals, such as “Archives of Physical Medicine and Rehabilitation” and “Stroke” by the American Heart Association. 1. Patients using this technology improved 42% compared to no treatment, while basic muscle stimulation improved 25% and traditional physical therapy (PNF) improved 18%. In comparison this technology was 233% more effective than traditional physical therapy for improving function in arm and hand for stroke patients between 6 months and 6 years post-stroke. The same study also followed up on the patients nine months after and they had all maintained the improvements gained. Study was conducted at the University of Washington. Source: “Techniques to Improve Function of the Arm and Hand in Chronic Hemiplegia” , Kraft G., Fitts S., Hammond M., Archives of Physi- cal Medicine and Rehabilitation, Vol 73, 1992, 220-7. 2. Patients between 1 and 4 years post-stroke experienced a 129% gain in functional improvement over the control group. Study was conducted at the University of Florida. Source:“Chronic Motor Dysfunction After Stroke” , Cauraugh H., Light K., Kim S., Thigpen M., Behrman A., Stroke American Heart Association, Vol 31, 2000 1360-4. 3. Patients between 7 months and 6 years post-stroke experi- enced significant functional gains. This study also involved fMRI scans of the patient’s brain activity and patients receiving the real treatment (and thus improved significantly) also show a significant increase in brain voxel intensity. The study was conducted at the University of Minnesota. Source: “Electrical Stimulation driving functional improvements and cortical changes in subjects with stroke” , Kimberley T., Lewis S., Auerbach E., Dorsey L., Lojovich J., Carey J., Experimental Brain Research, Springer-Verlag, November 2003. 4. Patients between 4 months and 14 years post-stroke achieved significant improvements in wrist extension and/or ankle dorsiflexion. The results were equally good regardless of age, time since the stroke, side of stroke and the nature of stroke. The study was conducted at the Oregon Health Sciences University. Source; “Electromyographically Triggered Electric Muscle Stimulation for Chronic Hemiplegia” , Fields W., Archives of Physical Medicine and Rehabilitation, Vol 68, 1987, 407-14. 5. Patients achieved improvements 7 times better than the control group in carrying out functional tasks such as moving blocks from one box to another. The study was conducted at the University of Florida. Source: “Two coupled Motor Recovery Protocols Are Better Than One” , Cauraugh J., Kim S., Stroke American Heart Associa- tion, Vol 33, 2002, 1589-94. 6. 90% of patients in the experimental group gained significant improvements after 4 months of use and significant functional use after 6 months of use. The study was conducted in Gera, Germany. Source: “Treatment of hemiplegia by means of imagination- dependent EMG-triggered muscle stimulation” , Danz J., Gutierrez-Lopez S., Physikalische Medizin, Vol 4, 1994. 5-9. 7. Patients within 6 weeks of their stroke experienced a significant functional independence and upper body dressing score compared to the control group. The study was conducted at the New Jersey Medical School and the Kessler Institute in New Jersey. Source: “Electromyogram-triggered Neuromuscular Stimula- tion for Improving the Arm Function of Acute Stroke Survivors” , Francisco G., Chae J., Chawla H., Kirschblum S., Zorowitz R., Lewis G., Pang S., Archives of Physical Medicine and Rehabilita- tion, Vol 79, 1998, 570-4.

Clinical Study Summary NeurMove

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Page 1: Clinical Study Summary NeurMove

9990 Park Meadows DriveLone Tree, CO 80124 USA(Phone) +1.303.703.4906

(Fax) [email protected]

www.zynexmedinternational.com

NeuroMoveClinical Study Conclusions

Clinical documentation for the effectiveness of the NeuroMove technology (EMG-triggered stim): These clinical studies have all been published in peer-reviewed journals, such as “Archives of Physical Medicine and Rehabilitation” and “Stroke” by the American Heart Association.

1. Patients using this technology improved 42% compared to no treatment, while basic muscle stimulation improved 25% and traditional physical therapy (PNF) improved 18%. In comparison this technology was 233% more effective than traditional physical therapy for improving function in arm and hand for stroke patients between 6 months and 6 years post-stroke. The same study also followed up on the patients nine months after and they had all maintained the improvements gained. Study was conducted at the University of Washington.Source: “Techniques to Improve Function of the Arm and Hand in Chronic Hemiplegia”, Kraft G., Fitts S., Hammond M., Archives of Physi-cal Medicine and Rehabilitation, Vol 73, 1992, 220-7.

2. Patients between 1 and 4 years post-stroke experienced a 129% gain in functional improvement over the control group. Study was conducted at the University of Florida.Source: “Chronic Motor Dysfunction After Stroke”, Cauraugh H., Light K., Kim S., Thigpen M., Behrman A., Stroke American Heart Association, Vol 31, 2000 1360-4.

3. Patients between 7 months and 6 years post-stroke experi-enced significant functional gains. This study also involved fMRI scans of the patient’s brain activity and patients receiving the real treatment (and thus improved significantly) also show a significant increase in brain voxel intensity. The study was conducted at the University of Minnesota.Source: “Electrical Stimulation driving functional improvements and cortical changes in subjects with stroke”, Kimberley T., Lewis S., Auerbach E., Dorsey L., Lojovich J., Carey J., Experimental Brain Research, Springer-Verlag, November 2003.

4. Patients between 4 months and 14 years post-stroke achieved significant improvements in wrist extension and/or ankle dorsiflexion. The results were equally good regardless of age, time since the stroke, side of stroke and the nature of stroke. The study was conducted at the Oregon Health Sciences University.Source; “Electromyographically Triggered Electric Muscle Stimulation for Chronic Hemiplegia”, Fields W., Archives of Physical Medicine and Rehabilitation, Vol 68, 1987, 407-14.

5. Patients achieved improvements 7 times better than the control group in carrying out functional tasks such as moving blocks from one box to another. The study was conducted at the University of Florida.Source: “Two coupled Motor Recovery Protocols Are Better Than One”, Cauraugh J., Kim S., Stroke American Heart Associa-tion, Vol 33, 2002, 1589-94.

6. 90% of patients in the experimental group gained significant improvements after 4 months of use and significant functional use after 6 months of use. The study was conducted in Gera, Germany.Source: “Treatment of hemiplegia by means of imagination-dependent EMG-triggered muscle stimulation”, Danz J., Gutierrez-Lopez S., Physikalische Medizin, Vol 4, 1994. 5-9.

7. Patients within 6 weeks of their stroke experienced a significant functional independence and upper body dressing score compared to the control group. The study was conducted at the New Jersey Medical School and the Kessler Institute in New Jersey.Source: “Electromyogram-triggered Neuromuscular Stimula-tion for Improving the Arm Function of Acute Stroke Survivors”, Francisco G., Chae J., Chawla H., Kirschblum S., Zorowitz R., Lewis G., Pang S., Archives of Physical Medicine and Rehabilita-tion, Vol 79, 1998, 570-4.