POSTER PRESENTATION Open Access Clinical study of cardiac autonomic dysfunction in HIV patients Pradheep C Mathew * , Shishir Nagesh Duble From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. 30 January - 1 February 2014 Background Cardiovascular autonomic nervous dysfunction has been demonstrated to severely debilitate HIV infected patients, namely by postural hypotension and syncopes. It has important implication in health care of HIV patients. Presence of autonomic neuropathy signals the need for added precautions when invasive procedures are performed on HIV patients. Methods Fifty patients (25 HIV +ve without AIDS and 25 HIV+ with AIDS) who fulfilled the inclusion and exclusion criteria and 50 healthy matched controls were enrolled in the study. All HIV positive/AIDS patients were evalu- ated according to a detailed proforma with elicitation of history, symptoms, signs and routine and specialized investigations. Results In the present study, 16% of HIV +ve with the AIDS had abnormal autonomic dysfunction and 4% of HIV positive without AIDS had abnormal autonomic dysfunction. Reduced heart rate variability is the commonest manifestation of autonomic dysfunction noted in both HIV positive without AIDS and HIV positive with AIDS groups. Diastolic BP response to sustained handgrip has a limited role in discriminating autonomic function in HIV infected patients. There is no statistically significant corre- lation with the CD4 level and the presence of autonomic nervous system dysfunction in both the groups. Conclusion Cardiac autonomic nervous dysfunction is a common and relevant clinical problem affecting both HIV positive without AIDS and HIV positive with AIDS groups. It may provide an alternative explanation for symptoms commonly observed in HIV infected indivi- duals such as bowel and bladder dysfunction, impotence, syncope and sweating abnormalities. Published: 27 May 2014 doi:10.1186/1471-2334-14-S3-P35 Cite this article as: Mathew and Duble: Clinical study of cardiac autonomic dysfunction in HIV patients. BMC Infectious Diseases 2014 14(Suppl 3):P35. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit * Correspondence: [email protected] Department of General Medicine, Rajiv Gandhi University, AJ Institute of Medical Sciences, Mangalore, Karnataka, India Mathew and Duble BMC Infectious Diseases 2014, 14(Suppl 3):P35 http://www.biomedcentral.com/1471-2334/14/S3/P35 © 2014 Mathew and Duble; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Clinical study of cardiac autonomic dysfunction in HIV patients

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Page 1: Clinical study of cardiac autonomic dysfunction in HIV patients

POSTER PRESENTATION Open Access

Clinical study of cardiac autonomic dysfunctionin HIV patientsPradheep C Mathew*, Shishir Nagesh Duble

From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014)Chennai, India. 30 January - 1 February 2014

BackgroundCardiovascular autonomic nervous dysfunction has beendemonstrated to severely debilitate HIV infected patients,namely by postural hypotension and syncopes. It hasimportant implication in health care of HIV patients.Presence of autonomic neuropathy signals the needfor added precautions when invasive procedures areperformed on HIV patients.

MethodsFifty patients (25 HIV +ve without AIDS and 25 HIV+with AIDS) who fulfilled the inclusion and exclusioncriteria and 50 healthy matched controls were enrolledin the study. All HIV positive/AIDS patients were evalu-ated according to a detailed proforma with elicitation ofhistory, symptoms, signs and routine and specializedinvestigations.

ResultsIn the present study, 16% of HIV +ve with the AIDShad abnormal autonomic dysfunction and 4% of HIVpositive without AIDS had abnormal autonomic dys-function. Reduced heart rate variability is the commonestmanifestation of autonomic dysfunction noted in bothHIV positive without AIDS and HIV positive with AIDSgroups. Diastolic BP response to sustained handgrip has alimited role in discriminating autonomic function in HIVinfected patients. There is no statistically significant corre-lation with the CD4 level and the presence of autonomicnervous system dysfunction in both the groups.

ConclusionCardiac autonomic nervous dysfunction is a commonand relevant clinical problem affecting both HIV

positive without AIDS and HIV positive with AIDSgroups. It may provide an alternative explanation forsymptoms commonly observed in HIV infected indivi-duals such as bowel and bladder dysfunction, impotence,syncope and sweating abnormalities.

Published: 27 May 2014

doi:10.1186/1471-2334-14-S3-P35Cite this article as: Mathew and Duble: Clinical study of cardiacautonomic dysfunction in HIV patients. BMC Infectious Diseases 201414(Suppl 3):P35.

Submit your next manuscript to BioMed Centraland take full advantage of:

• Convenient online submission

• Thorough peer review

• No space constraints or color figure charges

• Immediate publication on acceptance

• Inclusion in PubMed, CAS, Scopus and Google Scholar

• Research which is freely available for redistribution

Submit your manuscript at www.biomedcentral.com/submit

* Correspondence: [email protected] of General Medicine, Rajiv Gandhi University, AJ Institute ofMedical Sciences, Mangalore, Karnataka, India

Mathew and Duble BMC Infectious Diseases 2014, 14(Suppl 3):P35http://www.biomedcentral.com/1471-2334/14/S3/P35

© 2014 Mathew and Duble; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the CreativeCommons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

mailto:[email protected]

http://creativecommons.org/licenses/by/4.0

http://creativecommons.org/publicdomain/zero/1.0/