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Clinical Practice Guideline

Chul Kim , MD, PhD1, Jidong Sung , MD, PhD2, Jong Hwa Lee , MD, PhD3, Won-Seok Kim , MD, PhD4,5, Goo Joo Lee , MD6, Sungju Jee , MD, PhD7, Il-Young Jung , MD7, Ueon Woo Rah , MD, PhD8, Byung Ok Kim , MD, PhD9, Kyoung Hyo Choi , MD, PhD10, Bum Sun Kwon , MD, PhD11, Seung Don Yoo , MD, PhD12, Heui Je Bang , MD6, Hyung-Ik Shin , MD, PhD13, Yong Wook Kim , MD, PhD14, Heeyoune Jung , MD15, Eung Ju Kim , MD, PhD16, Jung Hwan Lee , MD, PhD17, In Hyun Jung , MD, PhD9, Jae-Seung Jung , MD, PhD18, Jong-Young Lee , MD, PhD19, Jae-Young Han , MD, PhD20, Eun Young Han , MD, PhD21, Yu Hui Won , MD, PhD22, Woosik Han , MD23, Sora Baek , MD, PhD24, Kyung-Lim Joa , MD, PhD25, Sook Joung Lee , MD, PhD26, Ae Ryoung Kim , MD27, So Young Lee , MD21, Jihee Kim , MD28, Hee Eun Choi , MD29, Byeong-Ju Lee , MD30, and Soon Kim , PhD31

1 Department of Rehabilitation Medicine, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, Korea2 Division of Cardiology, Department of Medicine, Sungkyunkwan University School of Medicine–Heart Vascular Stroke Institute, Samsung Medical Center, Seoul, Korea

3 Department of Physical Medicine and Rehabilitation, Dong-A University College of Medicine–Regional Cardiocerebrovascular Center, Dong-A Medical Center, Busan, Korea

4 Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea

5Gyeonggi Regional Cardiocerebrovascular Center, Seongnam, Korea6 Department of Rehabilitation Medicine, Chungbuk National University Hospital, Chungbuk Regional Cardiocerebrovascular Center, Chungbuk National University College of Medicine, Cheongju, Korea

7 Department of Rehabilitation Medicine, Chungnam National University College of Medicine–Daejeon Chungcheong Regional Cardiocerebrovascular Center, Chugnam National University Hospital, Daejeon, Korea

8Department of Physical Medicine and Rehabilitation, Ajou University School of Medicine, Suwon, Korea9Department of Internal Medicine, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, Korea10 Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine,

Seoul, Korea11Department of Rehabilitation Medicine, Dongguk University School of Medicine, Goyang, Korea12Department of Rehabilitation Medicine, Kyung Hee University College of Medicine, Seoul, Korea13 Department of Rehabilitation Medicine, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea

14Department and Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea15National Traffic Injury Rehabilitation Hospital, Yangpyeong, Korea16 Division of Cardiology, Department of Medicine, Korea University Guro Hospital, Korea University College

of Medicine, Seoul, Korea17Namdarun Rehabilitation Clinic, Yongin, Korea18 Department of Thoracic and Cardiovascular Surgery, Anam Hospital, Korea University Medical Center,

Seoul, Korea19 Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan

University School of Medicine, Seoul, Korea20 Department of Rehabilitation Medicine, Gwangju-Jeonnam Regional Cardiocerebrovascular Center,

Chonnam National University Medical School & Hospital, Gwangju, Korea

Clinical Practice Guideline for Cardiac Rehabilitation in Korea: Recommendations for Cardiac Rehabilitation and Secondary Prevention after Acute Coronary Syndrome

Received: Jun 24, 2019Accepted: Aug 23, 2019

Correspondence toGoo Joo Lee, MDDepartment of Rehabilitation Medicine, Chungbuk National University Hospital, Chungbuk Regional Cardiocerebrovascular Center, Chungbuk National University College of Medicine, 776, 1Shunhwan-ro, Seowon-gu, Cheongju 28644, Korea.E-mail: rmdr29@cbnuh.or.kr

Copyright © 2019. The Korean Society of CardiologyThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

ORCID iDsChul Kim https://orcid.org/0000-0001-8223-2945Jidong Sung https://orcid.org/0000-0002-1006-5727Jong Hwa Lee https://orcid.org/0000-0003-2489-358XWon-Seok Kim https://orcid.org/0000-0002-1199-5707Goo Joo Lee https://orcid.org/0000-0002-8436-4463Sungju Jee https://orcid.org/0000-0002-9400-9609Il-Young Jung https://orcid.org/0000-0001-8204-8195Ueon Woo Rah https://orcid.org/0000-0002-5667-160XByung Ok Kim https://orcid.org/0000-0002-7920-2750

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Kyoung Hyo Choi https://orcid.org/0000-0001-9137-3889Bum Sun Kwon https://orcid.org/0000-0001-7755-435XSeung Don Yoo https://orcid.org/0000-0003-4513-2560Heui Je Bang https://orcid.org/0000-0001-5280-122XHyung-Ik Shin https://orcid.org/0000-0001-8805-3104Yong Wook Kim https://orcid.org/0000-0002-5234-2454Heeyoune Jung https://orcid.org/0000-0002-4649-3053Eung Ju Kim https://orcid.org/0000-0003-2322-6267Jung Hwan Lee https://orcid.org/0000-0003-2680-6953In Hyun Jung https://orcid.org/0000-0002-1793-215XJae-Seung Jung https://orcid.org/0000-0002-8848-4112Jong-Young Lee https://orcid.org/0000-0001-5737-4968Jae-Young Han https://orcid.org/0000-0003-1672-8875Eun Young Han https://orcid.org/0000-0002-4780-8862Yu Hui Won https://orcid.org/0000-0003-2007-9652Woosik Han https://orcid.org/0000-0003-4002-3154Sora Baek https://orcid.org/0000-0003-3404-6202Kyung-Lim Joa https://orcid.org/0000-0002-3747-9831Sook Joung Lee https://orcid.org/0000-0002-6894-445XAe Ryoung Kim https://orcid.org/0000-0003-3765-3024So Young Lee https://orcid.org/0000-0002-0433-4548Jihee Kim https://orcid.org/0000-0003-2758-124XHee Eun Choi https://orcid.org/0000-0002-8753-929XByeong-Ju Lee https://orcid.org/0000-0002-7250-8909Soon Kim https://orcid.org/0000-0001-7154-2809

This secondary publication is based on a study first reported in the Annals of Rehabilitation Medicine (Kim C, Sung J, Lee JH, et al. Clinical practice guideline for cardiac rehabilitation in Korea. Ann Rehabil Med 2019;43:355-443).

ABSTRACT

Though clinical practice guidelines (CPGs) for cardiac rehabilitation (CR) are an effective and widely used treatment method worldwide, they are as yet not widely accepted in Korea. Given that cardiovascular (CV) disease is the second leading cause of death in Korea, it is urgent that CR programs be developed. In 2008, the Government of Korea implemented CR programs at 11 university hospitals as part of its Regional Cardio-Cerebrovascular Center Project, and 3 additional medical facilities will be added in 2019. In addition, owing to the promotion of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have begun CR programs even as a growing number of medical institutions are preparing to offer CR. The purpose of this research was to develop evidence-based CPGs to support CR implementation in Korea. This study is based on an analysis of CPGs elsewhere in the world, an extensive literature search, a systematic analysis of multiple randomized control trials, and a CPG management, development, and assessment committee comprised of thirty-three authors—primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and 2 general hospitals. Twelve consultants, primarily rehabilitation, sports medicine, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts participated in the research and development of these CPGs. After the draft guidelines were developed, 3 rounds of public hearings were held with staff members from relevant academic societies and stakeholders, after which the guidelines were further reviewed and modified. CR involves a more cost-effective use of healthcare resources relative to that of general treatments, and the exercise component of CR lowers CV mortality and readmission rates, regardless of the type of coronary heart disease and type and setting of CR. Individualized CR programs should be considered together with various factors, including differences in heart function and lifestyle, and doing so will boost participation and adherence with the CR program, ultimately meeting the final goals of the program, namely reducing the recurrence of myocardial infarction and mortality rates.

Keywords: Acute coronary syndrome; Cardiac rehabilitation; Mortality; Clinical practice guideline; Secondary prevention

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Clinical Practice Guideline for Cardiac Rehabilitation in Korea

21 Department of Rehabilitation Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea

22 Department of Physical Medicine and Rehabilitation, Research Institute of Clinical Medicine of Chonbuk National University–Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea

23Department of Thoracic Surgery, Chungnam National University Hospital, Daejeon, Korea24 Department of Rehabilitation Medicine, Kangwon National University School of Medicine–Kangwon

Regional Cardiocerebrovascular Center, Kangwon National University Hospital, Chuncheon, Korea25Department of Rehabilitation Medicine, Inha University Hospital, Incheon, Korea26Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea27Department of Rehabilitation Medicine, Kyungpook National University School of Medicine, Daegu, Korea28 Department of Rehabilitation Medicine, Institute of Wonkwang Medical Science, Wonkwang University

School of Medicine, Iksan, Korea29 Department of Physical Medicine and Rehabilitation, Inje University Haeundae Paik Hospital, Inje

University College of Medicine, Busan, Korea30Department of Rehabilitation Medicine, Pusan National University Hospital, Busan, Korea31Research Institute for Social Science, Ewha Woman's University, Seoul, Korea

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FundingThis study was funded by the Ministry of Health and Welfare (MOHW) as part of the Health and Medical Technology Research and Development Project of the Korea Health Industry Development Institute (KHIDI) (Project number: HC17C0063, study period: November 1,2018 to October 31, 2018). There has not been any influence from the KHIDI and National Evidence-Based Healthcare Collaborating Agency throughout the entire process of the CPGs development, and no funding has been received from other academic societies, organizations, and interest groups. The authors express their gratitude to Kyung Pyo Hong, Samsung Medical Center, Yun-Hee Kim, Department of Physical and Rehabilitation Medicine, Sungkyunkwan University School of Medicine, Sung-Bo Sim, Department of Thoracic and Cardiovascular Surgery, The Catholic University of Korea College of Medicine, Won-Hah Park, Department of Sports Medicine Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kun-Sei Lee, Department of Preventive Medicine, School of Medicine, Konkuk University, Soo Young Kim, Department of Family Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Woong Ju, School of Medicine, Ewha Womans University, Sae Young Jae, Department of Sport Science, Graduate School of Urban Public Health, University of Seoul, Mi Ja Jang, Samsung Medical Center, Hye Jeong Kim, Inje University Sanggye Paik Hospital, Jung-Ho Youn, Mediplex Sejong Hospital, Song Mi Lee, Severance Hospital, Seungmin Lee, Department of Food and Nutrition, Sungshin Women's University, Jeong Ju Lee, Kyunghee University Hospital at Gangdong for their effort in expert's advices. All researchers involved in the development of these CPGs declare no conflict of interest while participating in the development process.

Conflict of InterestThe authors have no financial conflicts of interest.

Author ContributionsConceptualization: Kim C, Lee GJ, Jee S; Data curation: Kim C, Sung J, Lee JH, Kim WS, Lee GJ, Jung IY, Kim BO, Bang HJ, Jung H, Kim EJ, Jung IH, Jung JS, Lee JY, Han JY, Han EY, Won YH, Han W, Baek S, Joa KL, Lee SJ, Kim AR, Lee SY, Kim J, Choi HE, Lee BJ, Kim S; Formal analysis: Sung J, Lee JH, Kim WS, Lee

INTRODUCTION

Cardiovascular (CV) mortality rose by 42.8% over a 10-year period in South Korea, to become the second leading cause of death in 2014. According to a 2016 report by Statistics Korea, of 100,000 people, 58.2 died from CV disease (CVD), and of these 52% died from ischemic heart disease, namely acute myocardial infarction (AMI).1-3) The high mortality rate is influenced by deaths at the time of onset as well as deaths from recurrence and complications in the short-term and long-term after onset. The disease is accompanied by multiple problems, such as reduced exercise capacity and poorer quality of life (QOL).

Acute coronary syndrome (ACS) clinically manifests as an acute condition, but is actually an acute onset of chronic systemic vascular disease (atherosclerosis) that has been progressing slowly over a long period. Further, despite receiving appropriate treatment in the acute phase, patients are left with a chronic vascular condition, so lifelong treatment and management is essential following discharge.4) Moreover, even after being treated for acute CVD, patients with tachycardia, frequent arrhythmia, reduced cardiac output, orthostatic hypotension, and exercise-induced hypertension have difficulty exercising, and older patients and those with complications face a permanent and marked reduction in their capacity to exercise at an appropriate fitness level. When this state persists, atherosclerosis progresses further, thereby causing adverse outcomes in the long-term—5 to 10 years after onset (e.g., QOL, recurrence, readmission, and death). Therefore, patients should be put on a cardiac rehabilitation (CR) program as soon as they are stabilized following acute phase treatment. This program includes individualized exercise training, optimal medical treatment, and education for self-care of risk factors (e.g., smoking cessation, diet therapy, physical activities, diabetes and hypertension management, and stress management).

CR is actively performed in many Western countries, where its effectiveness and safety have already been established, and clinical practice guidelines (CPGs) for CR have been developed in consideration of each country's circumstances, and medical and scientific evidence documenting CR has been systematically organized to inform medical professionals' decision-making.4-9)

In Korea, on the other hand, CVD treatment is still focused on acute phase treatment and lacks a sound understanding of CR. As a result, only a handful of hospitals nationwide offer CR. The purpose of this research is to develop CPGs that will promote CR in Korea. The CPGs proposed here are based on medical and scientific evidence, and are intended to inform medical decision-making. These guidelines should not be uniformly applied to all patients, and medical professionals must make final decisions in consideration of a patient's medical state and other circumstances. These CPGs do not limit a physician's practice, and neither can they be used to assess or review a physician's practice.

These CPGs address CR and secondary prevention programs for male and female adult patients who have been admitted and treated for ACS and survived the acute phase treatment. They do not deal with primary prevention of CVD or CR among pediatric patients. Moreover, due to limited time and resources, this first edition does not cover heart failure, valvular heart diseases, congenital heart diseases, arrhythmia, or other heart and peripheral vascular deformities, as such contents will be developed in future revisions and updates. ACS includes AMI and unstable angina, and acute phase treatment includes intensive treatment at the coronary care unit, medical drug therapy, percutaneous coronary interventions (PCIs), and coronary artery bypass grafting (CABG) surgery.

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GJ, Jung IY, Kim BO, Bang HJ, Jung H, Kim EJ, Jung IH, Jung JS; Funding acquisition: Kim C; Investigation: Kim C, Sung J, Lee JH, Kim WS, Lee GJ, Jung IY, Kim BO, Bang HJ, Jung H, Kim EJ, Jung IH, Jung JS, Lee JY, Han JY, Han EY, Won YH, Han W, Baek S, Joa KL, Lee SJ, Kim AR, Lee SY, Kim J, Choi HE, Lee BJ, Kim S; Methodology: Kim C, Sung J, Lee JH, Kim WS, Lee GJ, Jung IY, Kim BO, Bang HJ, Jung H, Kim EJ, Lee JH, Jung IH, Jung JS, Lee JY, Han JY, Han EY, Won YH, Han W, Baek S, Joa KL, Lee SJ, Kim AR, Lee SY, Kim J, Choi HE, Lee BJ; Supervision: Rah UW, Choi KH, Yoo SD, Lee JH, Shin HI; Validation: Kwon BS; Writing - original draft: Kim C, Sung J, Lee JH, Kim WS, Lee GJ, Jung IY, Kim BO, Bang HJ, Jung H, Kim EJ, Jung IH, Jung JS, Lee JY, Han JY, Han EY, Won YH, Han W, Baek S, Joa KL, Lee SJ, Kim AR, Lee SY, Kim J, Choi HE, Lee BJ; Writing - review & editing: Kim C, Sung J, Lee JH, Kim WS, Lee GJ, Jung IY.

More specifically, the purpose of these CPGs is to provide best practice guidelines for CR after ACS based on objective, scientific evidence, for physicians and other medical professionals (e.g., nurses, physical therapists, and clinical nutritionists) responsible for CR of patients with ACS. Furthermore, these guidelines were developed in an attempt to minimize gaps between medical and scientific evidence and actual clinical practice, as well as gaps in CR treatments across hospitals and physicians, thereby ultimately contributing to the development of a universal, evidence-based CR program. These CPGs discuss the health benefits and risks of each individual patient requiring CR. Their ultimate objective is to improve patients' QOL by restoring their cardiopulmonary functions, reducing recurrence and readmission, and lowering mortality rates.

These are the first CPGs for CR to be developed in Korea. Some contents of the Scottish (2017)5) guidelines for CR were adapted with additional references to other foreign CPGs for CR,4-9) and based on studies published between January 1, 2009 and April 30, 2018. However, these CPGs only deal with patients experiencing ACS, so in future they will have to be supplemented by including content for other heart diseases. We aim to revise these guidelines every 3 to 4 years, when a consensus is reached on the need for revisions in light of new knowledge.

METHODS

Research frameworkThe group that developed these CPGs was comprised of writers and consultants. Thirty-three authors, primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and 2 general hospitals, were involved in the CPG management, development, and assessment committees. During the research and development process, opinions were garnered from 12 consultants including rehabilitation, sports, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts.

This research was based on an extensive literature review of CR, the assessment of CR outcomes, exercise therapies appropriate for CR, and educational components for secondary prevention. The key questions related to each of these aspects were selected during a process that involved all members of the CPG management and development committees, and finalized with reference to the latest foreign CPGs,4-9) in consultation with the CPG consultation committee. Individual guidelines were then developed in relation to circumstances in Korea. Key questions that had not been adequately analyzed in existing guidelines were developed de novo, and finalized in consultation with the CPG consultation committee in consideration of the circumstances in Korea.

To select foreign CPGs for adaptation, the Scottish (2017),5) British (2013),6) American (2011),7) Canadian (2009),4) and Japanese (2012)8) CPGs for CR published within the past 10 years were evaluated using accepted appraisal guidelines for research and evaluation II (AGREE II).10) Two investigators appraised one set of CPGs, and guidelines assigned an average “total score for each domain” of 80 or greater (out of a score of 161) by 2 investigators, and a “rigor of development” score of 70% or greater for each domain (out of a score of 56).

As summarized in Table 1, the Scottish (2017)5) and British (2013)6) CPGs were selected after being reviewed by the CPG management committees, and the Scottish Intercollegiate

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Guidelines Network (SIGN) CPGs,5) which had been published more recently, were chosen as the major guidelines for adaptation in this study. References regarding specific key questions and topics were taken from all 5 foreign CPGs.4-9)

The key questions were used to inform the CPGs were primarily selected during a process that involved all members of the CPG management and development committees. The Scottish CPGs (SIGN) (2017)5) were used as the primary reference, but the English (National Institute for Health and Care Excellence) (2013),6) American (American Heart Association [AHA]) (2011),7) Canadian (Canadian Association of Cardiac Rehabilitation [CACR]) (2009),4) and Japanese (Japanese Circulation Society [JCS]) (2012)8) CPGs were also used for reference in relation to key questions not adequately addressed in the SIGN (2017) guidelines. Those developed de novo due to the lack of available references were as follows: “Is a submaximal exercise test, such as a 6-minute walk test useful for CR?” “Is high-intensity interval training (HIT) more effective than continuous moderate-intensity training as an aerobic exercise?” “Should policosanol be recommended as a food supplement?” (Table 2).

Data sourcesTo gather evidence to inform the development of the CPGs, PubMed was searched using the following key terms and search strategies: Search “cardiac rehabilitation” [TIAB] OR “cardiac rehabilitation” [MeSH] Filters: Consensus Development Conference; Guideline; NIH; Practice Guidelines. In addition, PubMed was searched for guidelines using key words such as myocardial infarction (MI) as follows: Search (rehabilitation or “secondary prevention”) and (“myocardial infarction” or “acute coronary syndrome”) Filters: Consensus Development Conference; NIH; Guidelines; Practice Guidelines.

Studies published after publication of the latest foreign CPGs were primarily found in the following 3 databases: Cochrane Library (https://www.cochranelibrary.com), PubMed (https://www.ncbi.nlm.nih.gov/pubmed), and Embase (https://www.embase.com).

MeSH terms were used (cardiac rehabilitation) in the Cochrane Library and PubMed, and Emtree terms (heart rehabilitation) were used when searching Embase. Based on the search strategies used in SIGN 2017, CR-related search strategies for each study question were developed, and the specific search terms for each were entered using AND or OR operators.

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∗ Percentage score for each domain (%) =Total score for each domain − minimum score for each domain

Maximum score for each domain − minimum score for each domain× 100 (%)

Table 1. Appraisal of foreign clinical practice guidelines for cardiac rehabilitation with AGREE IIGuideline Reviewer Rigor of development Rigor percentage Total score for each domain Overall appraisal ResultScotland (SIGN 2107) 1 50 83% 130 6 Selected

2 46 125 6England (NICE 2013) 3 50 89% 121 6 Partial selection

4 56 135 6United States (AHA 2011) 5 37 67% 90 5 Partial selection

6 30 89 4Canada (CACR 2009) 7 20 44% 71 3 Partial reference

8 38 99 4Japan (JCS 2012) 7 26 34% 70 3 Partial reference

8 23 75 4AGREE II = appraisal guidelines for research and evaluation II; AHA = American Heart Association; CACR = Canadian Association of Cardiac Rehabilitation; JCS = Japanese Circulation Society; NICE = National Institute for Health and Care Excellence; SIGN = Scottish Intercollegiate Guidelines Network.

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Operators and synonyms were taken from the search strategies published in Cochrane Review articles found in the Cochrane Library using the MESH term “cardiac rehabilitation.” After conducting a search in the Cochrane Library, the search strategy was saved, and the same search strategy used in the Embase. The Cochrane Library and Embase use the same search strategies, such as proximity operators, and the search strategy for PubMed was also nearly identical, with the exception of different proximity operators. Therefore, due to space limitations, we present only the search strategy used for the Cochrane Library in this report (Supplementary Data). When making revisions with reference to existing guidelines, we limited the searches to systematic review articles, and the year of publication was set to the year following the publication of the existing guidelines. Korean articles were searched in RISS, KMbase, and KoreaMed using terms “cardiac rehabilitation” and “심장재활” (cardiac rehabilitation). After the duplicate removal, the 2 researchers selected the first, second, and third document selection for the same documents. In case of disagreement during the article selection process, the consensus was reached after the discussion or the final decision was made by the third researcher's arbitration.

For assessing the methodological quality of article, AMSTAR 2.0, GRADE system used for systematic review, Cochrane risk of bias (RoB) used for randomized controlled trials (RCTs), and the RoB Assessment tool for Non-randomized Studies used for non-RCTs. Two researchers evaluated the quality of one article. In case of disagreement during the assessing the methodological quality of article, the consensus was reached after the discussion or the final decision was made by the third researcher's arbitration. Data obtained in the search were accepted as evidence of the studies' populations (human cases of ACS), designs, and methods (sample size, blinding, and data analysis), results (objectivity of results and consistency throughout studies), language (Korean and English), and applicability to Korea.

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Table 2. Key questions for clinical practice guidelines for cardiac rehabilitationQuestion DescriptionKQ1 Must cardiac rehabilitation be included in the treatment of ACS?KQ2 Does cardiac rehabilitation influence the outcome of patients with CVD?KQ3 Does cardiac rehabilitation improve the quality of life of patients with CVD?KQ4 When should cardiac rehabilitation be begun? (timing of cardiac rehabilitation)KQ5 How should cardiac rehabilitation programs be structured?KQ6 Can cardiac rehabilitation programs lower health management costs for patients with ACS?KQ7 Are individualized cardiac rehabilitation programs more effective than the existing fixed cardiac rehabilitation program?KQ8 Should psychological interventions concerning anxiety, depression, and stress be included in the cardiac rehabilitation program?KQ9 Is a cardiopulmonary exercise test necessary for cardiac rehabilitation?KQ10 Is a submaximal exercise test, such as a 6-minute walk test, useful for cardiac rehabilitation?KQ11 What are the effective measures for promoting participation in cardiac rehabilitation?KQ12 What are the effective measures for increasing physical activity compliance rates?KQ13 When should patients begin cardiac rehabilitation following coronary artery bypass grafting?KQ14 Should aerobic exercises be included in the cardiac rehabilitation program?KQ15 Should resistance (muscle training) exercises be included in the cardiac rehabilitation program?KQ16 How can the safety of cardiac rehabilitation exercises be enhanced?KQ17 Can a home-based cardiac rehabilitation program replace a hospital-based cardiac rehabilitation program?KQ18 Should cardiac rehabilitation programs be recommended to elderly patients?KQ19 Is patient education a necessary part of cardiac rehabilitation?KQ20 What contents should be included in patient education?KQ21 What interventions are needed to improve patients' adherence to taking their medications?KQ22 What is an effective intervention for patients who need to stop smoking?KQ23 What diet therapies are recommended for patients undergoing cardiac rehabilitation?KQ24 Should a specific food supplement be recommended?KQ25 Would an ICT-based modality be helpful in maintaining the effects of education in the long-term?ACS = acute coronary syndrome; CVD = cardiovascular disease; ICT = information and communication technology.

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Both adaptation and de novo methods were used. For the former, all available evidence cited in foreign guidelines was reviewed, as the level of evidence and recommendations presented by each country used different evidence appraisal methods, and an evidence chart was developed based on all the subsequent evidence published after the publication of the latest foreign CPGs. After drafting the CPGs, the levels of evidence (LOE) and strength of recommendations (SOR) were determined based on the evidence chart and with reference to the method used in the SIGN (2017)5) (Tables 3 and 4). LOE ranged from 1++ (highest quality) to 4 (lowest quality) (Table 3).5) The SOR was determined in consideration of the LOE, reliability and consistency of the LOE, impact on patients, applicability in Korea, and balance between harm and benefits, but instead of following the GRADE classification of ABCD, recommendations were classified as either strong or conditional and good-practice points (GPPs) were given according to the method used in the SIGN (2017) (Table 3). The SIGN stopped using the ABCD classification in 2013 due difficulties associated with its practical application, and has been classifying recommendations into strong, conditional, and GPPs since then.5)

Process followed to develop clinical practice guidelinesExpert panels consisting of 11 rehabilitation specialists, cardiologists, and thoracic surgeons achieved formal consensus using the nominal group technique. Authors of the draft guidelines first reviewed the evidence collected with these panels, and then conducted a question and answer session, after which the final recommendations and the LOEs and SORs were determined through a vote. Participants gave their opinions using a 9-point scale (1, 2, 3 “inappropriate”/4, 5, 6 “uncertain”/7, 8, 9 “appropriate”). If the ratings given by more than 70% of the panel (8 out of 11) were within a single 3-point band, and there were no objections with the phrasing of the recommendation, a consensus was deemed to have been reached.

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Table 3. Levels of evidence5)

Levels Evidence1++ High-quality meta-analyses, systematic reviews of randomized control trials, or randomized control trials with a very low RoB1+ Well-conducted meta-analyses, systematic reviews, or randomized control trials with a low RoB1− Meta-analyses, systematic reviews, or randomized control trials with a high RoB2++ High-quality systematic reviews of case-control or cohort studies

High-quality case-control or cohort studies with a very low-risk of confounding or bias and a high probability that the relationship is causal2+ Well-conducted case-control or cohort studies with a low-risk of confounding or bias and a moderate probability that the relationship is causal2− Case-control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal3 Non-analytic studies, e.g., case reports, case series4 Expert opinionROB = risk of bias.

Table 4. Recommendations5)

Some recommendations can be made with more certainty than others. The wording used in the recommendations in this guideline denotes the certainty with which the recommendation is made (the ‘strength’ of the recommendation).The ‘strength’ of a recommendation takes into account the quality (level) of the evidence. Although higher-quality evidence is more likely to be associated with strong recommendations than lower-quality evidence, a particular level of quality does not automatically lead to a particular strength of recommendation.Other factors that are taken into account when forming recommendations include: relevance to the National Health Service in Scotland; applicability of published evidence to the target population; consistency of the body of evidence, and the balance of benefits and harms of the options.R For “strong” recommendations on interventions that “should” be used, the guideline development group is confident that, for the vast majority of people,

the intervention (or interventions) will do more good than harm. For ‘strong’ recommendations on interventions that ‘should not’ be used, the guideline development group is confident that, for the vast majority of people, the intervention (or interventions) will do more harm than good.

R For “conditional” recommendations on interventions that should be “considered,” the guideline development group is confident that the intervention will do more good than harm for most patients. The choice of intervention is therefore more likely to vary depending on a person's values and preferences, and so the healthcare professional should spend more time discussing the options with the patient.

Good-practice points√ Recommended best practice based on the clinical experience of the guideline development group.

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The SORs were indicated as strong, conditional, or GPPs, in consideration of the LOE, likely impacts on patients, their applicability in Korea, and the balance that would be achieved between benefits and harm. “Strong” recommendations were used when it was deemed that the benefits of the recommendation would outweigh the harm for a vast majority of people. If recommended, it was phrased as “must be performed,” “should be performed,” or “should be strongly recommended.” If it was not recommended, the possible phrases used were “must not be performed,” “should not be performed,” and “should not be recommended.” The word “conditional” was used when the benefits of the recommendation would outweigh its harms on most people. If recommended, it was phrased as “recommend” or “is recommended,” and if it was not recommended, it was phrased as “should not be performed” and “is not recommended.” Therefore, for interventions that were conditionally recommended, performance should be determined on the basis of an individual's values and preferences, and after discussing the intervention with the patient and ensuring the decision is based on a thorough understanding of the intervention's importance. Finally, GPPs were used when the SORs could not be determined due to a low LOE in the literature but the practice was deemed to be a recommended practice based on the guideline development group's clinical experience. It was phrased as “is considered” and “should be referred to.”

Staff from relevant academic societies and other persons concerned were invited to attend 3 rounds of public hearings on the draft guidelines (Korean Academy of Rehabilitation Medicine, Korean Society of Cardiology, and Korean Society for Thoracic and Cardiovascular Surgery), following which they were reviewed and modified.

The CPG management committee designated one investigator responsible for each topic. These individuals then finalized the guidelines together with the CPG writing committee. The process of identifying key questions and preparing evidence summaries and meeting transcripts was used to reference the writing process. Internal revisions were made after the first review by the investigator in charge, and the CPG management committee then performed a final review. The CPG Committee at the Korean Academy of Medical Sciences was also asked to appraise the draft guidelines, and those comments will be taken into consideration in a future second revision.

Academic societies and associations for physicians caring for patients in CR will use the 2018 CPGs for CR in their professional development, as will health professionals in their consultations with patients and caregivers, and they will be used to inform various medical institutions' decisions related to convalescence. Following their distribution, the authors will continue to respond to questions and obtain opinions from health professionals using the CPGs. A second edition will be developed once consensus has been reached on the need for further revisions based on foreign CPGs and new evidence.

LITERATURE REVIEW AND RESULTS

This section reviews CR and secondary prevention programs for male and female adult patients admitted for ACS who survived after the acute phase treatment (e.g., ICU management, medical drug therapy, PCI, and CABG). It considers in-hospital CR, the post-discharge CR process, and continuous risk factor management. It describes the rationale, timing, basic principles, and flow of CR, before reviewing the various methods used to assess CR. Exercise therapy, the core component of CR, and the self-care of CVD risk factors needed for secondary prevention of CVD conclude this section (Table 5).

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Introduction of cardiac rehabilitationAlthough patients with ACS risk death while being transferred to a hospital and during treatment after onset of the disease, many patients make dramatic recoveries from the condition after treatment in the acute phase. Consequently, many patients, and even medical professionals, are excessively optimistic about the long-term prognosis and outcomes of this disease, and once the symptoms have abated after the acute phase treatment, many patients revert to the lifestyles they had adopted prior to disease onset, with a total disregard for risk factor management.

As reflected in their CPGs, many other countries have already accepted CR as an essential component of comprehensive treatment for ACS (LOE of 1++), including Scottish, British, and American guidelines.7)11-13) Until recently, many studies analyzed the efficacy of CR in relation to CVD and patients' mortality, recurrence, admission risk, and QOL. Scotland's CPGs state that patients should be offered a CR program that includes an exercise component to reduce CV mortality, hospital readmissions, and improve patients' QOL (SIGN 2017) (SOR: strong/LOE: 1++).5) England's guidelines are that all patients (regardless of age) should be informed about and offered a CR program that includes an exercise component (NICE 2013).6) US guidelines state that all eligible patients with ACS, or patients' whose status is immediately post CABG surgery or post-PCI, should be referred to a comprehensive outpatient CR program, either prior to hospital discharge or during the first follow-up office visit (AHA 2011) (SOR: I/LOE: A).7)

The Cochrane Review (2016) summarized the findings of a systematic literature review and meta-analysis of patients with AMI, patients who underwent revascularization, such as CABG and PCI, patients with angina, and patients diagnosed with coronary heart disease (CHD) based on angiography. Exercise-based CR lowered CV mortality (relative risk [RR], 0.74; 95% confidence interval [CI], 0.64, 0.86) and risk for readmission (RR, 0.82; 95% CI, 0.70, 0.96), but did not significantly reduce the risk of re-infarction (RR, 0.90; 95% CI, 0.79, 1.04) or all-cause mortality (RR, 0.96; 95% CI, 0.88, 1.04) (LOE of 1−).14) In a systematic review of 8 observational studies on the effects of CR published after the year 2000, CR lowered the all-cause mortality (adjusted odds ratio [OR], 0.47; 95% CI, 0.38, 0.59) and CV mortality

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Table 5. Key recommendations of CR1. Introduction of CR

• CR programs must be included in the treatment of ACS (SOR: strong/LOE: 1++)• CR exercise should be initiated as early as possible following acute phase treatment (SOR: strong/LOE: 1−)

2. Assessments of CR• Cardiopulmonary exercise testing should be performed to assess patients' cardiopulmonary exercise functions, prescribe exercise, and predict outcomes

(SOR: strong/LOE: 2++)• Interventions to increase self-efficacy and awareness of the need for CR are needed to increase CR participation (SOR: strong/LOE: 1++)• Systematized automatic referrals and liaison systems should be considered to increase CR referral rates. (SOR: GPP/LOE: 2−)

3. Exercise therapy for CR• CR should be initiated early after surgery, as an inpatient program for patients who undergo CABG (SOR: strong/LOE: 1++)• Risk assessment and appropriate monitoring based on the risk assessment results should be performed to ensure patient safety during CR exercise

programs (SOR: strong/LOE: 2++)• CR programs should also be administered to patients aged 65 years and older (SOR: strong/LOE: 1++)

4. Education for secondary prevention• CR programs should include patient education (SOR: strong/LOE: 1++)• Smoking cessation interventions should be provided for patients who smoke, and continuous interventions of more than 4 weeks should be considered

(SOR: strong/LOE: 1++)• ICT-based modalities should be considered to maintain the effects of education (SOR: conditional/LOE: 1−)

ACS = acute coronary syndrome; CABG = coronary artery bypass grafting; CR = cardiac rehabilitation; GPP = good-practice point; ICT = information and communication technology; LOE = levels of evidence; SOR = strength of recommendations.

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(adjusted OR, 0.43; 95% CI, 0.23, 0.79) of patients with acute MI (LOE of 1+).15) CR was initially focused on exercise therapy, but has since transitioned to become a comprehensive program that includes mental support, risk factor corrections, and education for lifestyle transformations. Behavioral change techniques (BCTs) include providing information about the outcomes of a behavior, educating patients on how to behave, encouraging outcome-related goal-setting, providing information about specific behaviors to be performed at specific times and places, providing feedback, and training patients how to manage stress and control their emotions. Compared to the control group, which only received the usual care, BCT interventions demonstrated better outcomes in smoking cessation (RR, 0.89; 95% CI, 0.81, 0.97), with significantly lower mortality risk (RR, 0.82; 95% CI, 0.69, 0.97), and 3.13 mmHg lower SBP (95% CI, −5.11, −1.15). However, the CHD risk was not significantly reduced with BCTs (LOE of 1+).16)

A Korean study also reported that a CR group had significantly lower recurrence rates (AMIs, readmission rates, need for reperfusion, mortality rates) (10%, 7 of 69 patients), and significantly longer disease-free days (354±38.34 days vs. 316±99.96 days), compared to the control group (24%, 17 of 72 patients).17)

Whether CR lowers mortality rates from heart disease is a critical question in relation to the need for CR. Although the results of recent studies on the effects of CR have been partially inconsistent, multiple studies have reported that the exercise component of CR lowers CV mortality and readmission rates, regardless of the type of CHD and type and setting of CR.14)18)19)

Scotland's CPGs state that patients should be offered a CR program that includes an exercise component to reduce CV mortality, hospital readmissions, and improve their QOL, and note that the exercise component of CR reduces CV mortality and hospital admissions, and improves health-related QOL, regardless of the type of CHD, the type of CR, or its setting (SIGN 2017) (LOE: 1++).5)

The 2016 Cochrane Review—an online collection of 6 databases that summarize high-quality, independent evidence to inform healthcare decision-making—summarized the results of a systematic literature review and meta-analysis of RCTs involving patients with AMI, patients who underwent revascularization, such as CABG and PCI, patients with angina, and patients diagnosed with CHD based on angiography. Exercise-based CR lowered CV mortality (RR, 0.74; 95% CI, 0.64, 0.86) and risk for readmission (RR, 0.82; 95% CI, 0.70, 0.96), but did not significantly reduce the risk of all-cause mortality (RR, 0.96; 95% CI, 0.88, 1.04) (LOE of 1−).14) In another systematic literature review and meta-analysis of 31 studies of 6,926 patients published in 2017, over a 10-year follow-up, the comprehensive CR group had significantly lower CV mortality compared to that of the usual care group (RR, 0.74; 95% CI, 0.65, 0.86; p<0.0001) (LOE of 1+).20) In a meta-analysis of 18 studies including 7,691 patients who underwent CABG or reperfusion after MI or were diagnosed with coronary stenosis based on coronary angiography, the CR group had similar all-cause mortality (RR, 1.00; 95% CI, 0.88, 1.13), but significantly lower CV mortality compared to that of the control group (RR, 0.42; 95% CI, 0.21, 0.88) (LOE of 1+).21)

Verifying whether CR improves patients' QOL following the onset of heart disease is key to patients' abilities to return to their daily lives. Recent studies on the effects of CR found that the exercise component of CR improves these individuals' QOL, regardless of the type

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of coronary syndrome and type and setting of CR,14)18)19) and benefits the cardiopulmonary health and QOL of patients with heart failure with preserved ejection fraction.22)23)

Scotland's CPGs state that patients should be offered a CR program that includes an exercise component to reduce CV mortality and hospital readmissions and improve patients' QOL. These benefits are known to occur regardless of the type of CHD, the type of CR, or the setting (SIGN 2017) (LOE: 1++).5)

Meta-analysis could not be performed in a systematic literature review of 63 RCTs that examined exercise-based CR in patients with coronary syndrome due to the heterogeneity of outcome measurement methods and reporting methods in 20 studies that assessed health-related QOL using verified general or disease-specific outcome measurement methods. Nonetheless, most of these studies found an improvement in the QOL of those in the CR group. Further, 14 studies reported a higher QOL in one or more domains in the exercise-based CR group compared to the control group, and 5 studies reported a significantly higher QOL in more than 50% of domains in the CR group compared to those in the control group (LOE of 1−).14)

Recommendation• CR programs must be included in the treatment of ACS (SOR: strong/LOE: 1++).

Timing of cardiac rehabilitationThe Scottish CPGs (SIGN 2017) state that “all patients must be referred to CR to undergo individualized intervention and treatment plans based on individualized assessment,”5) regardless of the type of treatment they undergo after the onset of ACS, and notes that their treatment should be comprehensive and individualized at the initiation of the rehabilitation program. There is not enough clinical evidence, however, to document the optimum timing of exercise, a critical component of CR, and early exercise is often determined passively. We therefore reviewed evidence regarding the timing of CR exercise in existing guidelines and additional studies.

US guidelines are that all eligible patients with ACS or patients' whose status is immediately post CABG surgery or post-PCI should be referred to a comprehensive outpatient CR program either prior to hospital discharge or during the first follow-up office visit. Further, all eligible outpatients with the diagnosis of ACS, CAB surgery or PCI, chronic angina and/or peripheral artery disease in the past year should be referred to a comprehensive outpatient CR program (AHA 2011) (SOR: I/LOE: A).7) England's guidelines are that CR should be initiated as soon as possible after admission and before discharge from hospital. Patients should be invited to a CR session within 10 days of their discharge from hospital (NICE 2013).6)

Haykowsky et al.24) reported that commencing and maintaining exercise training early after the onset of MI (within 1 week of onset) leads to benefits in left ventricular (LV) remodeling (LOE of 1+). Most studies examining the timing of CR analyzed the effects of exercise training on LV remodeling, and found that exercise training in the acute phase or early phases since onset produces positive outcomes. These studies describe the timing of the exercise component of CR, as opposed to the timing of the CR per se. The RoB was low in clinical trials included in a 2016 meta-analysis that analyzed the impacts of the timing of exercise training on LV functions. These studies classified the timing of exercise training into an acute phase (6 hours to 7 days), a recovery phase (7 to 28 days), and a maintenance

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phase (≥29 days), and examined differences in the left ventricle ejection fraction (LVEF), LV end-systolic diameter, and peak VO2 of patients with reduced LV function after MI. Although results on the changes of LVEF and end-systolic diameter varied widely, exercise training in the acute phase led to significant improvements (more than moderate improvements) in LV end-systolic diameter, and peak VO2 that were also greater than those produced by exercise training begun in the recovery phase and the maintenance phase. In conclusion, exercise training had positive effects on LV remodeling and recovery of cardiopulmonary functions, with the greatest effects achieved when exercise training was initiated in the acute phase (LOE of 1−).25) In this context, we determined that it is more appropriate to provide recommendations for the timing of exercise training as opposed to the timing of CR.

Recommendation• It is more appropriate to provide recommendations for the timing of exercise training

than the timing of CR.• CR exercise should be initiated as early as possible following acute phase treatment (SOR:

strong/LOE: 1−).

The organization of cardiac rehabilitationBecause staff numbers, equipment, and facilities vary according to the size, capital, number of relevant medical professionals, and number of eligible patients in each institution, CR programs should be structured on basic concepts in consideration of organizational circumstances. The structure of a multidisciplinary team, and particularly the number of people on the team and the type of health care professionals, is directly dependent on the number of patients and contents of the program, the complexity of the patients being treated, the organization's human resources policies, and the community resources available to deliver the program.4)

Scotland's guidelines state that CR services should offer individualized exercise assessments, tailor the exercise components to individuals' choices, and deliver them in a range of settings (SIGN 2017) (SOR: strong).5) Canada's guidelines state that all CR programs must address site-specific facilities' equipment in conjunction with safety requirements and considerations, and all CR programs must have policies and procedures to address the management of environmental and medical emergency situations (CACR 2009).4)

In a systematic literature review of 8 observational studies that compared patients participating in a CR program with those not participating in a CR program, CR reduced all-cause and cardiac-related mortality rates, and significantly improved patients' health-related QOL.26) More than half of these studies adopted a multidisciplinary team approach, and structured their teams to provide interventions regarding exercise education, health-related information and education, lifestyle modifications, mental health support, and social support (LOE of 1−). A meta-analysis of 71 RCTs that reported the effects of comprehensive CR in coronary artery diseases (CADs) found a reduction of all-cause and cardiac-related mortality, noncritical re-infarction and readmission rates, and also found that many types of professionals were involved in providing exercise and psychological treatments, risk factor education and counseling (LOE of 1−).15) In a systematic literature review analyzing 63 studies investigating the effects of exercise-based CR on CHD, CR lowered CV mortality rates and risk of hospital admission, and the rehabilitation programs included strategies for exercise and risk factor education, behavior change, psychological support, and traditional risk factor management (LOE of 1−).14)

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In 2010, the Korean Society of Cardiac Rehabilitation discussed and adapted various Korean and foreign CR guidelines, including the American Association of Cardiovascular and Pulmonary Rehabilitation guidelines, and relevant studies that provided recommendations for the basic facilities, equipment, and personnel required in Korea's CR centers.27)

Recommendation• CR programs should be comprehensive and multidisciplinary (SOR: GPP/LOE: 1−).

Cost-effectiveness of cardiac rehabilitationThe cost-effectiveness of CR has been reported in multiple studies.14) These authors consistently concluded that CR involves a more cost-effective use of healthcare resources relative to that of general treatments. This conclusion is based on foreign literature however, so high quality Korean studies are needed to assess the cost-effectiveness of CR in Korea, based on the total cost of healthcare and the cost per quality-adjusted life year (QALY) analysis.

Scotland's guidelines state that interventions are considered to be cost effective if they fall below the commonly accepted UK threshold of £20,000 per QALY. However, no evidence of the cost-effectiveness of CR was identified in the UK, and additional higher-quality trials are needed to assess the cost-effectiveness of CR (SIGN 2017) (SOR: conditional).5)

According to a systematic literature review analyzing 63 RCTs involving exercise-based CR in patients with coronary syndrome, it was difficult to compare 7 studies on the cost of CR and overall health management costs due to differences in their currencies and study periods, and given that 4 studies used a QALY that ranged from $42,535 higher to $650 lower per QALY gained in the CR group compared to the control group (LOE of 1−).14)

Recommendation• Though CR programs are reported to lower health management costs in patients with

CVD, high-quality Korean studies are needed to substantiate this, considering the differences of insurance systems and healthcare environments across countries (SOR: GPP/LOE: 1−).

Assessments of cardiac rehabilitationUse individualized assessments to develop care plans and interventionsPatients referred to CR following MI are in diverse medical, social, and financial situations. Therefore, individualized CR programs should be considered together with various factors, including differences of heart function such as cardiac output, comorbidities that hinder exercise, such as lung disease, arthritis, and low back pain, differences in lifestyle such as smoking and drinking status, and patients' ability to visit the hospital for CR according to employment status and distance from home. This is crucial to boosting participation and adherence with the CR program and ultimately achieving its goal, namely reducing the recurrence of MI and mortality rates. For this reason, the British Association for CR describes an individualized assessment of patient needs as an important component in the early phase of CR.28)

Scotland's guidelines state that all patients referred to CR should undergo an individualized assessment that is used to create to a care plan and identify interventions specific to their needs. In addition, CR services should offer individualized exercise assessments, tailor the exercise components of their programs to individual choice, and deliver them in a range of settings (strong) (SIGN 2017) (SOR: GPP, strong/LOE: 1+).5)

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In a prospective cohort study that compared a general CR and an individualized CR program, participation was about 30% higher in the individualized CR program (p<0.001), and the risk for admission was significantly lower with the individualized CR program (RR, 0.664; 95% CI, 0.554, 0.797) (LOE of 2+).29) A Cochrane review of 19 RCTs (n=10.856) examined the effects of programs that consisted of goal setting and action planning based on individualized assessments of various chronic diseases, such as heart failure, kidney failure, and diabetes, and found that individualized programs were more effective than those of the control group in lowering glycated hemoglobin (−0.24%, 95% CI, −0.35, −0.14) and systolic blood pressure (BP, −2.64 mm/Hg; 95% CI, −4.47, −0.82), and improving depression (standardized mean differences [SMD], −0.36; 95% CI, −0.52, −0.20) and self-efficacy (SMD, 0.25; 95% CI, 0.07−0.43) (LOE of 1+).30) In a RCT of 132 patients admitted for a heart disease such as CAD, a higher percentage of patients agreed to be referred to a lifestyle adjustment program in the individualized assessment group than in the conventional assessment group (27% vs. 5%) (LOE of 1+).31) In a RCT of 40 patients with ACS, the intervention group, members of which received educational components according to their needs at an early stage, showed significantly higher self-efficacy compared to those in the control group, and a higher percentage of the intervention group participated in more than 90% of outpatient CR sessions (47% vs. 21%) (LOE of 1+).32) In a RCT of patients with ACS, providing individualized goals and plans (n=78) led to a high improvement in outcome indices that included self-efficacy, return to work or the recovery of pre-onset functions, readmission, and mortality, compared to the conventional method (n=105) (21.8%, n=17 vs. 10.5%, n=11; p=0.039).33)

Recommendation• Individualized CR plans should be tailored to individual needs and be developed through

individual assessments of patients referred to CR (SOR: strong/LOE: 1+).

Psychological evaluations and interventionsPsychological symptoms such as depression, anxiety, and stress are common among patients with MI, and these symptoms can lead to recurrence, increased mortality, and reduced QOL. At about 15–20%, the prevalence of depression among patients with MI is about 3 times higher than that of the general population,34)35) and similar prevalence rates are observed among patients who have undergone PCI or CABG.36) Depression undermines secondary prevention by lowering adherence with treatment plans, such as drug therapies, lifestyle adjustments, and CR participation,37-39) and may increase medical costs40) for patients with heart disease. Anxiety and stress have been associated with recurrence and mortality rates among patients with CAD.41)42) For this reason, psychological assessments and interventions have recently been recognized as essential components of CR programs.

Scotland's guidelines are that all patients should be offered a psychological care package, based on a cognitive behavioral model (e.g., stress management, cognitive restructuring, and communication skills) as an integral part of CR (SIGN 2017) (SOR: strong/LOE: 1++).5) US guidelines are that patients with recent CABG surgery or MI should be screened for depression, in collaboration with their primary care physicians and a mental health specialist (AHA 2011) (LOE: B).7) Canada's guidelines are that all CR patients should undergo screening for active and historical depression and anxiety at their intake assessment, and a qualified professional such as a psychologist or psychiatrist should refer individuals who screen positive for depression or anxiety for assessment or treatment (CACR 2009).4) Japan observes that because the prevalence of depression and depressed states is high among patients with CAD, and depression has been reported to relate to increased morbidity and mortality

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from CD, so specialists should screen for and treat depression in this patient population. Screening for depressed moods or other psychological symptoms, as well as conducting psychological interventions for the prevention and treatment of depression, are expected to alleviate psychological symptoms, improve QOL, enhance adherence to treatment, and reduce the mortality and incidence of CV events (JCS 2012) (LOE: B, C).8)

A 2017 Cochrane meta-analysis reviewed 35 (n=10,703) RCTs with regard to the psychological interventions conducted for CAD, and found that they did not reduce all-cause mortality, revascularization, or incidence of nonfatal MI compared to conventional treatment, but they did significantly lower heart disease-related mortality rates (RR, 0.79; 95% CI, 0.63, 0.98), and improved perceived depression (SMD, −0.27; 95% CI, −0.39, 0.15), anxiety (SMD, −0.24; 95% CI, −0.38, −0.09), and stress levels (SMD, −0.56; 95% CI, −0.88, −0.24) (LOE of 1++).43) In a meta-analysis of 13 studies of the outcomes of psychological interventions in CVD patients, they were effective in reducing stress (Hedge's g effect size, 0.34; 95% CI, −0.19, 0.87), anxiety (1.04; 95% CI, 0.53, 1.54), and depression (0.67; 95% CI, 0.41, 0.92) (LOE of 1+).44) A RCT that compared early counseling focused on psychological trauma and conventional stress counseling in 190 patients with ACS, found no significant differences in psychological symptoms, mortality rates, or CVD-related readmission rates between the 2 groups (LOE of 1−).45)

Recommendation• Patients referred to CR should be assessed for psychological problems, such as anxiety,

depression, and stress, and should be provided with psychological interventions if abnormal findings are observed (SOR: strong/LOE: 1++).

Symptom-limited cardiopulmonary exercise testThe symptom-limited cardiopulmonary exercise test that provides useful information related to exercise prescriptions can be obtained by monitoring heart rate (HR), BP, symptoms, electrocardiography (ECG), and gas analysis, while gradually increasing exercise load.46) Assessing the risk of participation in exercise-induced CR programs based on changes in HRs, abnormal ECGs, changes in BP, and the onset of symptoms as a result of increasing exercise load can be used to develop safe and effective exercise prescriptions.47) Aerobic exercise capacity, as measured with VO2max, was associated with CVD patients' prognosis, and the effectiveness of CR can also be evaluated on the basis of its improvement after CR. Thus, in the absence of contraindications, the symptom-limited cardiopulmonary test is recommended for CR.7)8)47)

US guidelines recommend a risk assessment with a physical activity history and/or an exercise test for all patients, to guide their prognosis and prescription (AHA 2011) (SOR: I/LOE: B).7) Canada recommends that a directly supervised graded exercise test (GXT) be part of the initial CR assessment prior to the initiation of therapy (CACR 2009).4) Japan recommends using a symptom-limited exercise stress test on day 14–21 after onset to predict prognosis, prescribe exercise training programs, and assess the treatment efficacy of CR (JCS 2012) (LOE: B).8)

Symptom-limited cardiopulmonary exercise testing is currently accepted as a standard in CR programs for patients after ACS, so it is difficult to conduct a new RCT to directly compare the clinical outcomes of patients who undergo this testing and those who do not. Consequently, we could not find such clinical trials in our search. However, large cohort

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studies on CVD patients found that VO2max measured with cardiopulmonary exercise testing or exercise testing-based risk score are strongly correlated with all-cause mortality or heart disease-related mortality with consistent dose-response correlations. This suggests that maximal cardiopulmonary exercise testing is a useful tool for predicting the outcomes and risks during exercise for patients with ACS (LOE of 2++).44) In a study of 100 patients who underwent coronary angioplasty due to MI, patients were randomly divided into an exercise testing group (n=50) and a non-exercise testing group (n=50); physicians permitted 7 out of 11 activities, including the return to work, earlier for the exercise testing group than for the non-exercise testing group (LOE of 1−).48)

Recommendation• Cardiopulmonary exercise testing should be performed to assess patients'

cardiopulmonary exercise functions, prescribe exercise, and predict outcomes (SOR: strong/LOE: 2++).

Submaximal exercise test (6-minute walk test)The symptom-limited exercise test is recommended to assess exercise capacity and risk, prescribe exercise, and predict outcomes for patients undergoing CR.7)8)46) However, exercise, ECG, gas analysis equipment, and adequate space are needed to conduct this standard cardiopulmonary exercise testing, and the associated costs hinder the universal application of this testing across all medical institutions.49) Where maximal exercise testing is difficult, a submaximal exercise test, such as a 6-minute walk test, is commonly recommended,50)51) and a 6-minute walk distance is used to set exercise intensity and evaluate the effectiveness of CR.52)53) In Korea, the 6-minute walk test is generally used as a submaximal exercise test, so recommendations in consideration of the validity, reliability, and responsiveness of the 6-minute walk test are needed.

Japan's guidelines state that a submaximal exercise test conducted on day 4 after onset or thereafter should be used to predict prognosis, prescribe exercise-training programs, and assess treatment efficacy (JCS 2012) (LOE: B).8)

A 2012 systematic review of studies of the 6-minute walk test included 6 studies on validity, one study on reliability, and 11 studies on responsiveness.54) The maximum metabolic equivalents obtained from the 6-minute walk test and symptom-limited exercise test were more than moderately correlated, and the maximum HR obtained from the 6-minute walk test and symptom-limited exercise test were also more than moderately correlated. Changes in reliability ranged from 2 to 8%, but the intraclass correlation coefficient (ICC) was 0.97, based on which level of evidence was evaluated to be moderate. In a meta-analysis of studies on the responsiveness of the 6-minute walk test in CR, the mean difference (MD) of a 6-minute walk distance before and after treatment was 60.43 m (95% CI, 54.57, 66.30; p<0.001), indicating a high responsiveness (LOE of 2+). In a subsequent study, a repeated 6-minute walk test within one week after onset of MI had high reliability (ICC, 0.879; 95% CI, 0.785, 0.939), and the ICC for HR, rate of perceived exertion, measured using the Borg scale, and BP ranged from 0.880 to 0.934, also showing high reliability (LOE of 2+).55) Hanson et al.56) found a high reliability for the 6-minute walk test (ICC, 0.94), but the 6-minute walk distance tended to increase with subsequent tests, suggesting the need to consider this fact when assessing treatment responsiveness (LOE of 2+). A moderate correlation between 6-minute walk distance and VO2max was found in a recent study of 49 patients referred to CR (r=0.56; p<0.01) (LOE of 2++).57)

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Recommendation• A submaximal exercise test, such as a 6-minute walk test, should be considered when

symptom-limited exercise testing is difficult (SOR: conditional/LOE: 2+).

Strategies to improve cardiac rehabilitation participationDespite the effectiveness of CR in patients with ACS, the problem of low CR participation lingers. In the US, CR participation among patients with MI is about 35%, and 20% to 30% in Europe, while that in Japan is low, at about 4% to 8%.58) A recent Korean study also found a hospital-based CR participation rate of about 30% among patients with ACS in 3 university hospitals, and various factors that included distance, cost, time, comorbidity, and perceptions of CR were identified as hindering factors.59) Therefore, effective strategies that could increase early uptake or participation in and adherence to CR are essential. In the US, the Million Heart Project has been undertaken to lower recurrence, readmission, mortality, and medical costs among patients with ACS by increasing their CR participation based on grounds for effective strategies.60)

Scotland's guidelines are that interventions to improve self-efficacy should be considered for inclusion in a CR program. Further, the strategies associated with increased uptake in at least one trial were: 1) structured telephone calls/visits by a nurse/therapist after hospital discharge; 2) early appointments to CR; 3) motivational letters based on the theory of planned behavior; 4) CR programs tailored for women; and 5) intermediate phase programs (self-management, instruction, and exercise monitoring) for older patients (SIGN 2017) (SOR: conditional/LOE: 1++).5) Canada recommends maximizing the number of patients who may benefit from CR programs by developing systematized, preferably automated, referral mechanisms that are sensitive to socioeconomic and ethno-cultural diversity with key patient care partners and other CVD stakeholders. An automated referral process should be used to significantly increase referrals from acute care to CR and subsequent enrollment (CACR 2009).4)

A 2014 Cochrane Review of RCTs on CR participation among CVD patients included 10 studies on early CR participation (n=1,338) and 8 studies on CR maintenance (n=1,167), but a meta-analysis could not be performed due to the varying types of treatment involved.61) Eight out of ten studies and 3 out of 8 studies, however, found a significant increase in CR participation and maintenance, respectively. Strategies that increased CR participation included structured phone interviews or house visits after discharge,62-65) early visits to rehabilitation programs,66) and letters that recommended CR participation.67) Three studies that observed an increase in CR maintenance rates used physical monitoring based on daily journals, goal setting, and execution plans as strategies (LOE of 1++).68-70) In a RCT of 141 patients with ACS, physical activity rates increased in the intervention group that received motivating counseling compared to the control group (LOE of 1+).71) In a RCT that compared a female-only CR program and a mixed-gender CR program, there were no significant differences in participation rates between the 2 groups (LOE of 1++).72) In a RCT of 825 patients with ischemic heart disease or heart failure, participants were divided into 2 groups, one of which received instructions on learning and coping strategies and another that participated in conventional CR program strategies. The results showed that a higher percentage of the former group participated in more than 75% of the CR sessions (80% vs. 73%; OR, 1.48; 95% CI, 1.07, 2.05) (LOE of 1+).73)

In a systematic literature review of 14 observational or intervention studies on the use of systematized automatic referrals and a liaison system to boost CR participation, meta-

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analysis revealed that the CR participation rate was highest when both systematized automatic referrals and a liaison system were applied (66%; 95% CI, 54%, 77%), as opposed to using only the conventional CR referral system (24%; 95% CI, 18%, 32%), only the systematized automatic referral system (45%; 95% CI, 33%, 57%), or only the liaison system (44%; 95% CI, 35%, 53%) (LOE of 2−).74)

Recommendation• Interventions to increase self-efficacy and awareness of the need for CR are needed to

increase CR participation (SOR: strong/LOE: 1++).• Systematized automatic referrals and liaison systems should be considered to increase CR

referral rates. (SOR: GPP/LOE: 2−).

Strategies to maintain long-term physical activitiesMaintaining physical activities is important to reducing CVD recurrence rates and improving patients' QOL in the long-term, after undergoing exercise-based CR. Although fitness is improved and maintained for a certain amount of time after participating in a CR program,75) these effects are often not translated into maintaining physical activities in the long-term.76)77) In a Korean study administering physical activity surveys before and after the onset of MI, 37% of the patients who were active prior to MI became inactive after onset, and 11% of the patients who were inactive prior to MI maintained physical activities after onset, thereby suggesting the need for strategies to promote the maintenance of physical activities in the long-term.78)

Scotland's guidelines are that psychoeducation (goal setting, self-monitoring) should be considered for patients in CR to facilitate adherence to physical activities, and noted that the interventions reported to be of benefit were: 1) goal setting, 2) action planning, and 3) using daily diary entries to monitor activities (SIGN 2017) (SOR: conditional/LOE: 1++).5)

In a meta-analysis of 209 patients in 4 studies, psychological education (using strategies such as goal setting, problem solving, and self-monitoring) led to greater long-term physical activities compared to those promoted by simple education about exercise and risk factors (SMD, 0.62; 95% CI, 0.30, 0.94) (LOE: 1++).79) In a systematic literature review of strategies used to maintain physical activities in the long-term, one study examined the effects of a problem-based learning strategy, but the study failed to find any significant effects (LOE of 1+).80) Further, a study on improving self-efficacy also did not find significant differences,81) while one RCT that used self-monitoring observed significant effects.82) In a recent RCT of 47 patients with CVD, no significant differences in the maintenance of physical activities one year after the program were found between a voluntary, incremental physical activity program and the existing supervised exercise program (LOE of 1+).83) However, the addition of group education regarding exercise based on the use of a pedometer and face-to-face counseling to the conventional CR program significantly increased the duration of patients' continuous moderate to vigorous exercise one year after the program (LOE of 1+).84)

Recommendation• Psychological education strategies (including goal setting and self-monitoring) should be

used to increase CR maintenance rates (SOR: strong/LOE: 1++).

Exercise therapy for cardiac rehabilitationTiming of cardiac rehabilitation in the case of coronary artery bypass surgeryEarly CR is usually recommended if PCI is performed for ACS. In cases of CABG, CR may be

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delayed due to concerns about general deconditioning and the recovery of the sutured site after sternotomy. Thus, we propose appropriate timing for CR in cases involving CABG for ACS.

US guidelines recommend CR for all patients after CABG, with the referral ideally performed early postoperatively during the surgical hospital stay (AHA 2015) (SOR: I/LOE: A),85) and all eligible patients with ACS, or those whose status is immediate post CAB surgery or post-PCI should be referred to a comprehensive outpatient CR program either prior to hospital discharge or during the first follow-up office visit (AHA 2011) (SOR: I/LOE: A).7)

Patients with ACS who underwent CABG and participated in CR showed significantly reduced mortality rates, CVD incidence, readmission rates, and length of hospital stays, compared to those in the control group.86)87) According to AHA recommendations in 2015, CR is recommended for all patients who undergo CABG, and being referred to CR as an inpatient early after surgery is ideal.85) Furthermore, according to AHA recommendations made in 2011, all patients who undergo CABG should begin CR while hospitalized, and must be referred immediately after discharge or at the first outpatient visit for a more comprehensive outpatient-based CR program.7)

A systematic review of 9 randomized controlled studies on the effects of CR after CABG on patients with ACS found that the CR group showed improved QOL and reduced CV risk factors.88) However, this study could not systematically analyze the effects of specific rehabilitation regimens, since the type, intensity, and frequency of exercise varied in different CR programs across the studies, and diverse assessment parameters were used to analyze the effects of CR (LOE of 1−). It has been reported in Korea that beginning CR in the hospital after CABG leads to lower resting HRs and increased 6-minute walking distances at the time of discharge and one month after surgery.89)

Recommendation• CR should be initiated early after surgery, as an inpatient program for patients who

undergo CABG (SOR: strong/LOE: 1++).

Aerobic exercise programCR programs encompass the management of various risk factors that increase the risk of CVD. In particular, interventions for physical activities are a major component of CR programs.90) Among various interventions for physical activities, we presented published evidence from aerobic exercise programs, and reviewed the different effects of CR according to the types of aerobic exercise involved.

Scotland's guidelines are that aerobic and resistance exercises should be considered part of the exercise prescription for patients attending CR (SIGN 2017) (SOR: conditional/LOE: 1++).5) Canada recommends that patients in CR engage in aerobic and resistance exercise 3 to 5 times per week, at 40% to 85% of their HR reserve, for 20–40 minutes per session. Each exercise session should include an appropriate warm-up and cool-down period. These guidelines further note that regardless of the form of interval training, there is compelling evidence that interval training can lead to improvements in peak VO2, functional status, and overall QOL. Accordingly, CR programs have increasingly used interval training as an alternative to traditional continuous aerobic training (CACR 2009).4)

The exercise component of CR lowers CV mortality and readmission rates while increasing QOL.91) Though the methods, frequencies, durations, and intensities of exercise vary widely

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across the studies conducted, nonetheless, studies have reported that CR is effective, regardless of specific frequency, duration, intensity, and place of exercise (LOE of 1++).18)19)92) The SIGN (2017) recommends that aerobic exercise should be included in exercise prescriptions for patients participating in CR.5)

In 18 RCTs that compared aerobic exercise-based CR and control groups among patients who underwent PCI or CABG for ACS,93) the aerobic exercise group showed reduced systolic BP (95% CI, −6.67, −0.91), increased high-density lipoprotein (HDL) (95% CI, 1.24, 6.43), and reduced low-density lipoprotein (LDL) (95% CI, −10.35, −0.73) compared to the control group. Furthermore, peak VO2 (95% CI, 2.41, 4.53) and LVEF (95% CI, 0.26, 4.93) were improved when aerobic exercise was performed. However, there were no significant differences in diastolic BP, total cholesterol, and triglycerides between the 2 groups. Regarding the effects of aerobic exercise according to duration, exercise for 8 to 12 weeks led to lower systolic BP at rest and significantly higher peak VO2 compared to the conventional treatment group, and exercise for more than 12 weeks led to positive effects on HDL, LDL, triglycerides, peak VO2, and LVEF. Regarding the amount of exercise per week, 60 to 90 minutes of exercise per week had positive effects on systolic BP, HDL, triglycerides, peak VO2, and LVEF, and there were no additional effects, even when exercise was performed more than 90 minutes per week (LOE of 1−).

In a systematic literature review comparing the effects of CR with HIT and that with moderate-intensity continuous training (MCT),94) HIT led to greater changes of peak VO2 than did MCT (MD, 1.78; 95% CI, 0.45, 3.11), while MCT led to lower resting HRs (MD, −1.80/min; 95% CI, 0.71, 2.89) and body weight (MD, −0.48 kg; 95% CI, 0.15, 0.81) than did HIT. There were no differences in changes to blood glucose, triglycerides, and HDL after exercise between the 2 exercise groups (LOE of 1+). A Korean study also reported that HIT (1–2 times a week for 9–10 weeks) led to a greater increase in peak VO2, and a 6-minute walking distance led to a greater reduction in perceived depression and fatigue in patients with low to moderate-risk stratification for exercise-related CV adverse events.95)96)

Recommendation• CR exercise programs should include aerobic exercise (SOR: strong/LOE: 1++).• HIT may obtain better results than aerobic exercise (SOR: conditional/LOE: 1+).

Resistance exercise programCR programs encompass the management of various risk factors that increase the risk of CVD. In particular, interventions for physical activities are a key component of CR.90) Among different types of physical activities, we presented evidence of resistance training for CR, and reviewed the different effects of CR according to types of resistance exercise.

Scotland recommends that aerobic and resistance exercises be considered part of the exercise prescriptions for patients attending CR (SIGN 2017) (SOR: conditional/LOE: 1++).5) US guidelines are that it is reasonable for a clinician to recommend complementary resistance training at least 2 days per week5) (AHA 2011) (SOR: IIa/LOE: C).7) Canada in turn comments that patients in CR may safely derive fitness benefits from a supervised program of resistance training, and resistance training should be offered to all eligible CR participants (CACR 2009).4)

The exercise component of CR lowers CV mortality and readmission rates while increasing patients' QOL.91) The methods, frequencies, durations, and intensities of exercise vary widely

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across studies, however, it has been reported that CR is effective, regardless of the specific frequency, duration, intensity, and place of exercise (LOE of 1++).18)19)92)

The SIGN (2017) recommends the inclusion of resistance training in exercise prescriptions for CR,5) and the American Heart Association (AHA) (2011) reports that resistance exercise improves muscle strength, endurance, fitness, independence, and QOL, regardless of the presence of CVD.7) One limitation of these studies on the reported effects of resistance training, however, was that they were generally small-scale studies involving low-risk groups for exercise-related adverse CV events. Thus, the AHA (2011) presents the absolute and relative contraindications of resistance exercise (Table 6).97)

In a systematic review analyzing the effects of progressive resistance exercise in CR programs, both progressive resistance exercise and aerobic exercise led to increased peak VO2 and fitness, with no significant differences between the 2 types of exercise. Although the improvement of peak VO2 did not differ between the aerobic exercise plus resistance exercise group and the aerobic exercise only group, the aerobic exercise plus resistance exercise group had greater improvements in maximal exercise capacity. When progressive resistance exercise was performed, there was a significant increase in upper and lower limb muscle strength compared to the control group. When both resistance and aerobic exercises were performed, there was a significant improvement in lower limb muscle strength compared to aerobic exercise alone. Regarding types of exercise, the combined exercise group showed significant improvements when isotonic exercise was performed, but the combined exercise group and the aerobic exercise group did not significantly differ in muscle strength improvements when isokinetic and isometric exercises were used. For lower limb muscles, combining isotonic resistance with aerobic exercises led to significantly better improvements in lower limb muscle strength compared to the effects of using only aerobic exercise (LOE of 1−).98)

In a systematic review of 3 clinical trials that compared the effects of eccentric and concentric exercises in patients with acute MI, there were no significant differences in peak VO2 and 6-minute walk test results between the 2 groups (LOE of 1−).99)

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Table 6. Absolute and relative contraindications to resistance trainingAbsolute

Unstable coronary heart diseaseDecompensated heart failureUncontrolled arrhythmiasSevere pulmonary hypertension (mean pulmonary arterial pressure>55 mmHg)Severe and symptomatic aortic stenosisAcute myocarditis, endocarditis, or pericarditisUncontrolled hypertension (>180/110 mmHg)Aortic dissectionMarfan syndromeHigh-intensity RT (80–100% of 1-RM) in patients with active proliferative retinopathy or moderate or worse non-proliferative diabetic retinopathy

Relative (should consult a physician before participation)Major risk factors for coronary heart diseaseDiabetes at any ageUncontrolled hypertension (>160/100 mmHg)Low functional capacity (<4 metabolic equivalents of task)Musculoskeletal limitationsIndividuals with implanted pacemakers or defibrillators

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In a systematic literature review of studies analyzing the effects of CR according to the intensity of resistance exercise, the amount of VO2max increase was greater when low-moderate-intensity resistance exercise (<70% 1RM or ≥12 repetition/set) and aerobic exercise were combined, than when aerobic exercise was performed alone. When performed for less than 12 weeks, combined exercise led to a greater increase in VO2max than did aerobic exercise alone, but when performed for more than 12 weeks, studies could not find significant differences in the increases in VO2max between the 2 groups. One study that examined high-intensity exercise (≥70% 1RM or <12 repetition/set) did not find differences between the 2 exercise methods. Combined exercise led to superior enhancements in muscle strength compared to those with aerobic exercise, regardless of the intensity and duration of exercise (LOE of 1+).100)

Recommendation• CR programs should include resistance (strengthening) exercises (SOR: conditional/LOE: 1++).

Safety issues of exercise training in cardiac rehabilitationThe safety of patients who have experienced ACS must be ensured during CR. To this end, it is universal practice to assess patients' cardiac states after ACS, stratify risk for exercise-related CV adverse events through cardiopulmonary exercise testing, and have patients perform ECG-monitored exercise at the hospital for a certain period early after onset.

With regard to safety issues related to CR and exercise, US recommendations are that all patients receive a risk assessment with a physical activity history and/or an exercise test to guide prognoses and prescriptions, and the clinician should counsel patients to report and be evaluated for symptoms related to exercise (AHA 2011) (SOR: I/LOE: B, C).7) Canada advises that risk stratification is the key to safe and effective exercise prescriptions, and all patients entering CR programs must have a medical assessment and undergo determination of their cardio-metabolic fitness prior to the initiation of therapy. A directly supervised GXT is recommended as part of the initial CR assessment prior to the initiation of therapy, and the provision of continuous EKG telemetry should be at the discretion of the CR program Medical Director. Patients in CR are encouraged to wear a HR monitor during physical activity and exercise, and follow the target HRs prescribed for them (CACR 2009).4)

Findings such as VO2max, duration of exercise testing, presence of angina symptoms, and ECG abnormalities from cardiopulmonary exercise testing are helpful for predicting long-term outcomes such as mortality for patients who underwent PCI or CABG for ACS.101-105) Furthermore, demographic factors and CVD history, such as sex, age, body mass index (BMI), smoking, systolic BP, total cholesterol, HDL, hypertension, diabetes, and drug history are known to be predictors of CVD recurrence and mortality.4)106)

Therefore, risk stratification for exercise related CV adverse events based on history and cardiopulmonary exercise testing is important for patients who undergo PCI or CABG.7) Risk stratification is critical for ensuring the effectiveness and safety of exercise prescriptions, and therefore, cardiopulmonary exercise testing is recommended prior to beginning an initial CR exercise program.4) The incidence of heart attacks when conducting exercises such as jogging, swimming, playing tennis, and engaging in cross country skiing is reported to be higher in the heart disease population than in the population without heart disease, with one case per 12,000 to 121,955 hours, and one case per 375,000 to 888,000 hours, respectively.107) However, appropriate exercise programs significantly lower the disease-related mortality

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of patients with heart disease, so recommending aggressive CR exercise training to these patients is a reasonable decision in which the benefits far outweigh the harms. The type and intensity of exercise and monitoring during exercise are known to have a serious impact on exercise-related deaths, and continuous ECG monitoring markedly lowers the incidence of heart attacks during exercise.107)

According to one Korean report, there were 17 cases of angina symptoms without ECG anomalies, 31 cases of ECG anomalies without angina symptoms, 10 cases of ECG anomalies with angina symptoms, and 10 cases of temporary BP instability during 13,934 hours of CR by 975 patients over a 10-year period, but during this time there was not a single major adverse cardiac event, such as a death or AMI.108)

Recommendation• Risk assessment and appropriate monitoring based on the risk assessment results should be

performed to ensure patient safety during CR exercise programs (SOR: strong/LOE: 2++).

Home-based cardiac rehabilitationHome-based CR does not refer to an exercise performed alone by the patient at home; it is a form of exercise performed at home after medical professionals have assessed the patient's cardiac functions at the hospital through exercise testing, and the patient has been given an exercise prescription and education about risk factor management. Effective home-based CR is based on continuous bidirectional communication with the medical team, and continuous follow-up assessments. Owing to recent advances in information and communication technologies (ICTs) and medical technologies, studies are continuing to examine new approaches to home-based CR and their effects. Hence, we reviewed relevant evidence and prepared a recommendation tailored to the circumstances in Korea.

Scotland's guidelines state that an exercise component in CR reduces CV mortality and hospital admissions, and improves health related QOL regardless of the type of CHD, type of CR, or setting. Benefits appear to be independent of a specific frequency, duration, or intensity of exercise, or whether it takes place in a hospital, home, or community setting. Further, in home-based CR programs, BCTs such as social supports and goal setting were shown to be effective in reducing CVD risk factors, with results comparable to those of hospital- or center-based programs. It concluded that there is little difference between home- and center-based CR in terms of the number of program withdrawals (SIGN 2017) (LOE: 1++).5) US guidelines are that a home-based CR program can be substituted for a supervised, center-based program for low-risk patients (AHA 2011) (SOR: I/LOE: A).7) Canada advises that CR programs should follow comprehensive program models, both home-based and institution-based, and integrate the core program components presented within its guidelines (CACR 2009).4)

Previous studies have proposed several methods of home-based CR, including one in which patients perform CR at home by themselves after undergoing a cardiac function assessment at the hospital and being given an exercise prescription, with periodic visits from a therapist to provide further instructions on CR. Another approach involves teaching patients to exercise using a brochure or phone, and monitoring their adherence.109)

A systematic literature review that analyzed the effects of home-based CR and hospital-based CR found no differences between the 2 groups in total mortality at 12 months after

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onset (RR, 1.19; 95% CI, 0.65, 2.16), fitness at 12 months after onset (MD, −0.13; 95% CI, −0.28, 0.02), fitness at 12 to 24 months after onset, QOL parameters at 24 months, CR completion rates, and total cholesterol, LDL, triglycerides, systolic BP, diastolic BP, and smoking cessation rates at 3 months and 12 months (LOE of 1+).110)111) Furthermore, home-based CR and hospital-based CR had equal effects on maximum HR and weight loss (LOE of 1−).111) Similarly, both CR programs had equal effects on physical and emotional components of QOL as well as on depression (LOE of 1−).111) Regarding anxiety, one study reported that home-based CR and hospital-based CR had similar levels of effectiveness,111) and another study reported that home-based CR was slightly more effective (LOE of 1−).112) Regarding blood HDL, 1 study found increased blood HDL after hospital-based CR,110) while another study found hospital-based CR to be more effective, though the statistical significance of the difference was unclear,111) thus calling for additional analysis (LOE of 1+). BCTs such as social supports and goal setting during home-based CR programs are effective in decreasing CV risk factors, and the levels of effects were similar to those of hospital-based CR programs (LOE of 1++).113)

A report conducted in Korea suggested that home-based CR programs using a mobile ECG data transmission device (HeartCallTM) led to improvements in the participants' fitness and QOL.114) Owing to recent advances in ICTs, researchers in Korea are attempting to study CR equipment based on smart devices and sensors, and additional studies are needed to investigate the clinical effects of home-based CR programs using these technologies.115)116)

Recommendation• Home-based CR programs may replace hospital-based CR programs for low-risk patients

(SOR: conditional/LOE: 1++).

Cardiac rehabilitation for elderly patientsThe need for CR is also growing due to aging and the subsequent rise of coronary syndromes among those aged 65 years and older. In many cases, however, the elderly engage in fewer daily physical activities, and have a low level of participation in CR exercise programs due to other comorbidities. Based on our review of the relevant literature, we developed recommendations for CR for the elderly.

Canada's guidelines state that elderly patients with CAD will benefit from and should participate in CR programs that include both aerobic and resistance training (CACR 2009).4)

One-year survival rates for acute MIs is known to decline with advancing age.117) There is also a report that those aged 65 years or older who have had MIs show lower VO2max, exercise testing durations, depression indexes, and grip strength compared to those with other heart diseases.118) According to an article that reviewed various studies observing the effects of CR by age, CR improves aerobic fitness and physical functioning scores equally, and lowers body fat percentages and LDL/HDL ratios in patients 65 years and older similarly to its effects on patients under the age of 65.119) Even among the superaged over 75, CR can lead to functional improvements, and for this group it is important to initiate CR aggressively in the acute phase, immediately after being admitted for heart disease, and continuing into hospital-centered outpatient CR after discharge.120) Therefore, elderly patients with CAD must also be provided with and be motivated to participate in CR that is comprised of aerobic and resistance exercise.4) A systematic literature review that analyzed the effects of resistance training on elderly (≥65 years) patients and mid-aged patients with CAD also found that

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resistance training improves upper and lower limb muscle strength, exercise capacity, and mobility equally in both patient groups (LOE of 1++).121)

Although no Korean study has analyzed the effects of CR in those aged 65 years and older, it has been reported that CR improves VO2max and anaerobic thresholds in MI in patients aged 60 years and older.122)

Recommendation• CR programs should also be administered to patients aged 65 years and older (SOR:

strong/LOE: 1++).

Education for secondary preventionNeed for educational components in cardiac rehabilitationThe British Association for Cardiovascular Prevention and Rehabilitation defines CR as the collection of all behaviors aiming to delay or reverse disease progress by rectifying health behaviors and returning to an ideal social life or preserving social functions.123) Other CR guidelines use similar definitions, and thereby confirm that existing CR programs are oriented to providing a comprehensive program that consists of secondary prevention and improvements in patients' QOL, as opposed to simply focusing on their rehabilitation with reduced motor functions.

Behavioral interventions that focus on directing patients' health behaviors in a desirable direction are needed with regard to various aspects such as physical activities, diet, smoking cessation, body weight management, stress management, and psychological problems, and there is high demand for CR programs that encompass these factors, though they are not adequately addressed in conventional clinical practices. Furthermore, although maintaining various drug therapies such as statins, antiplatelets, and beta-blockers is well supported by evidence and plays an important role, the issue of whether patients are actually adhering to these drug therapies is influenced by diverse factors that involve the patients, medical teams, prescriptions, and healthcare systems. There is evidence suggesting that the ideal state has not yet been reached, and CR programs must also address this shortcoming.

Providing knowledge about a patient's disease, subsequent treatments, the expected effects and needs, precautions and self-care efforts is important for assessing their effects on patient outcomes, but also has ethical implications in terms of ensuring patients' rights to know.

Scotland's guidelines reviewed the evidence for what was at that time called “comprehensive rehabilitation.” This term was used to define the prevalent model of CR, which consisted of 2 components, exercise and education. They concluded that when helping patients make lifestyle changes, CR programs should place comparable emphasis on each of the lifestyle risk factors (SIGN 2017) (SOR: strong).5) England's guidelines observed that comprehensive CR programs should include health education and stress management components (NICE 2013) (SOR: I).6) Japan has recommended that CR programs include patient education sessions (JCS 2012) (SOR: I/LOE: A).8)

In a review of 6 RCTs that compared exercise-only groups and exercise and education groups of patients with CAD, exercise and education about risk factors increased patients' levels of physical activities over 6 to 12 months, but their effects on smoking and diet were not clear; the strategies employed here included goal setting, problem solving, self-monitoring, and

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role-modeling (LOE of 1++).79) Other results indicated that similar strategies were effective after participating in a CR program (limited to exercise training), and even when not participating in a CR program (LOE of 2−).124)

In a systematic review of patients with ACS, only one RCT examined the effects of an intervention aimed to increase self-efficacy. This trial reported that there were no significant differences in the levels of physical activities between the intervention and conventional treatment groups at 6 months (LOE of 1+).77) However, when the results of all qualitative studies on patients with heart failure were combined, patients' responses to their bodily changes and the extent of encouragement to exercise received from friends and family members were associated with their levels of physical activity, suggesting that enhancing self-efficacy and helping patients have positive expectations of their results may be important factors for inducing behavioral change (LOE of 1+).125) In a systematic literature review of studies that analyzed the effects of home-based CR programs, 10 out of 11 RCTs found that behavior change techniques were useful in lowering controllable CVD risk factors, and the techniques used included social support, goal setting, and self-monitoring (LOE of 1++).113)

When articles published after the publication of existing CPGs were searched, of 22 clinical trials, one study found that the effects of educational interventions were appropriate to answering the key question (LOE of 1+).126) Most clinical trials included in this study had low RoB, and educational interventions varied widely, from 40-minute interviews with 15-minute phone follow-ups, to 4-week programs with 11 months of follow-up sessions. Most studies reported only all-cause mortality, and few studies compared mortality rates by cause of death. There were significant differences in CVD mortality rates according to educational levels, suggesting that educational interventions may be effective, but there were only 2 relevant studies, and the level of evidence is low. The 2 groups did not significantly differ in all-cause mortality, MI, revascularization rates, and admission rates, and the educational intervention group tended to show higher QOL indices, though they were not consistently high across all indices.

Because the effects of educational interventions are more indirect—as in altering patient behaviors—as opposed to influencing the outcomes of CVD directly, they may vary greatly according to the patient population's characteristics, the method/intensity/duration of an intervention, and whether patients accepted the interventions. It is difficult to conclude that simply summing the results alone could describe the effects of educational interventions in their entirety. Furthermore, there are cases in which the control group may alter its behaviors independently, thereby diluting the effects of interventions. When interpreting the results, therefore, the effects of educational interventions are much more difficult to substantiate than those of drug therapies or procedures. Given this background, we strongly recommend that patient education be included in CR programs, despite the low evidence level supporting the effects of educational interventions, and the low effects these interventions are documented to have in the literature.

Recommendation• CR programs should include patient education (SOR: strong/LOE: 1++).

Contents of patient educational programsExisting CPGs for CR make recommendations about the information that should be provided

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to patients, that is, the contents to be included in patient education. Supporting evidence is thin, however, and there is a lack of adequate evidence to support each specific item.

With regard to the content of patient education materials, one study reported that many patients voluntarily stopped taking prescribed medicines, and even those who continued to take them often took them irregularly, with adherence rates merely reaching an average of 50% in the long-term.127) Several drugs such as statins and antiplatelets provide firm evidence of improved outcomes from ACS. Helping patients adhere to these drug therapies is crucial for secondary prevention, and CR programs may serve as an opportunity to achieve this end.

Scotland's guidelines recommend discussing the impacts of a cardiac event/CHD on emotional well-being throughout CR, advising patients about the purpose and use of secondary prevention medication and encourage concordance, while linking patients to other information sources, peer support, and support groups. Prior to hospital discharge following a cardiac event, verbal and written information on diagnosis, chest pain management—including how to use the glyceryl trinitrate (GTN) spray—advice on driving, returning to work, and appropriate daily activities should be provided, including information such as booklets from the British Heart Foundation or Chest, Heart & Stroke Scotland. Future treatments, interventions, and appointments should be discussed, along with the purpose of CR, and a contact number for the CR unit should be provided. The benefits of smoking cessation should be discussed if appropriate. At the CR assessment, information appropriate to the needs and choices of the patient with regard to activities, exercise, smoking cessation, weight management, diet, and common emotional adjustment reactions to ill health should be provided, and the patient should be advised of the benefits of continuing to exercise long term, and assured that it can be undertaken safely and effectively in any setting. The patient should also be given a contact number for ongoing person-centered advice (SIGN 2017).5)8)

Japan encourages 1) teaching the patient how to manage chest pain, and providing contact information in the event unmanageable chest pain occurs, 2) instructing the patient on the use of nitroglycerin sublingual tablets or sprays, 3) encouraging the patient and his/her family members to learn how to perform cardiopulmonary resuscitation, 4) explaining the patient's coronary risk factors, 5) motivating the patient to participate in CR and improving their lifestyle, and 6) encouraging the patient to stop smoking and maintain a tobacco-free lifestyle (JCS 2012).8)

The authors did not review the level of evidence for specific educational content, but did review evidence concerning adherence to drug therapies by reviewing the published literature. SIGN 2017 found that most studies with high LOE and high effects used multifaceted and complex interventions, including intensive education and counseling by various medical and non-medical experts, continuous treatment support, as well as family and coworker support, and given that the heterogeneity across studies was high, concluded that it was difficult to present specific recommendations (LOE of 1++).127)

Other evidence showed that early interventions by a nurse and those in which the physician in charge was provided with information about a patient's adherence to drug therapy were effective, albeit to a small extent.128) Multiple recent studies, as well as new studies, are continuing to investigate the effectiveness of mobile health (mHealth) using cell phone messages or smartphone applications, and systematic reviews of completed studies found that these techniques are effective to some degree (LOE of 1−).129-132) Even so, there is

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significant heterogeneity regarding the methods involved, so it is difficult to make specific recommendations about the interventions that should be used to improve adherence.

Medication adherence remains a crucial issue that cannot be neglected, necessitating that CR teams confirm and evaluate whether patients are adhering to their prescribed medications. CR programs have great potential to provide a tool for checking and improving patients' adherence, but additional studies are needed to confirm which interventions should to be integrated in CR programs to effect this outcome.

Recommendation• The recommendations in SIGN 2017 should be largely accepted regarding educational

contents (Table 7) (SOR: GPP/LOE: 2+).

Education for smoking cessationThe importance of smoking cessation by patients with ACS and the general population is undoubtable. However, there is currently inadequate evidence documenting the specific benefits of smoking cessation interventions in CR programs, and existing structures and intensities of such interventions are inadequate. These interventions require additional staff resources, and because the availability of these resources varies across hospitals in Korea, each organization's circumstances must be considered when including this intervention. In general, an adequate intensity of intervention is most likely to determine the effects of a behavioral therapy, so we recommend an appropriate follow-up period. Nonetheless, programs should be designed on the basis of the human resources available, the extent to which these resources could be dedicated to CR programs or educational efforts that include smoking cessation, and the expected outcomes.

Scotland's guidelines recommend that CR patients who smoke should be offered smoking cessation interventions that extend over more than 4 weeks. These interventions should include telephone contact, behavioral support, and self-help materials (SIGN 2017) (SOR: strong/LOE: 1++).5) US recommendations are that tobacco users should be advised to stop smoking at every visit, patients should receive counseling and help developing a plan to stop smoking that may include pharmacotherapy and/or referral to a smoking cessation program (AHA 2011) (SOR: I/LOE: A), and all patients should be advised at every office visit to avoid exposure to environmental tobacco smoke at work, home, and in public places (LOE: B).7)

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Table 7. Education contents for CR in SIGN 20175)

Throughout entire CR program- Education about the effects of cardiovascular events/coronary artery disease, such as myocardial infarction, on psychological/emotional state- To promote secondary prevention, explain the purpose and need for the prescribed medications and encourage patients to adhere to prescription- guide

patients to additionally obtain appropriate informationBefore discharge

- Provide information about disease and other precautions: name of diagnosis, how to respond to chest pain (including nitroglycerin sublingual tablet or spray), recommendations about appropriate daily activities and driving, return to work

- Provide additional relevant educational materials- Inform about upcoming treatments, interventions, and appointments- Purpose and need for CR program. How to contact the CR team- (For smokers) Importance of smoking cessation

When assessing CR- Additional education according to patient needs: physical activity, exercise, smoking cessation, weight management, nutritional education, psychological/

emotional response to disease- Needs for and benefits of maintaining exercise habits in the long-term; can perform exercise safely and effectively at the appropriate intensity- Ways to contact the CR team when in need of advice or support

CR = cardiac rehabilitation; SIGN = Scottish Intercollegiate Guidelines Network.

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A systematic review of published studies found that psychosocial interventions were effective in achieving smoking cessation.133) It is known that behavioral therapies, phone support, and self-help have similar effects, but most programs combined 2 or more approaches. The effects are closely associated with the duration of interventions, but programs that lasted for more than a month after initial contact (RR, 1.28; 95% CI, 1.17, 1.40), were more effective than those that lasted for less than a month (RR, 1.01; 95% CI, 0.91, 1.12) (LOE of 1++). Phone support interventions were also found to be very effective in promoting smoking cessation (RR, 1.32; 95% CI, 1.07, 1.62). The current review includes both CR programs that included phone support interventions and those that did not (LOE of 1−).134)

In a systematic review of studies that assessed interventions begun during patients' hospital stays and continued during outpatient visits, only those that extended over more than one month were effective. Diverse CVD patients were studied, and some were offered nicotine replacement therapies (LOE of 1++).135) A review of studies based on interventions delivered by nurses found them to be effective. These interventions included counseling sessions where patients' were encouraged to stop smoking, benefits and factors that hindered smoking cessation were reviewed along with coping strategies, and follow-up visits were incorporated. This review noted that 5 studies found significant effects associated with CR programs that had an educational component (RR, 1.35; 95% CI, 1.14, 1.59). Interventions led by a nurse responsible for CR and health education components delivered over several sessions were more effective than interventions led by a nurse who was also involved in other tasks (LOE of 1+).136) Combining therapy with face-to-face or phone behavioral interventions increased the success rates of patients undergoing nicotine replacement therapy by 10–25% (LOE of 1++).137)

Regarding evidence published after the publication of CPGs, Franck et al.'s138) conducted a systematic review of 7 studies with a patient population similar to that in this study. It included 3 intervention studies focused on counseling, and 4 studies that combined drug therapy with counseling.138) Of the studies that used drug therapy, only the one that used varenicline found a significant increase in the smoking abstinence rate, and 3 behavioral intervention studies that significantly improved the rate of smoking abstinence at 6 months and 12 months were assessed as having problems with generalizability. All-cause mortality was not reduced, and there were no significant differences in the recurrence of MI, revascularization, and readmission. Two studies documented a significant decrease in CV events. Though there was a tendency to improve QOL, this improvement was not consistent across all indices. If limited to the additional evidence, smoking cessation interventions do seem useful for ACS, but there is not a high level of evidence supporting this supposition (LOE of 1−).

Recommendation• Smoking cessation interventions should be provided for patients who smoke, and continuous

interventions of more than 4 weeks should be considered (SOR: strong/LOE: 1++).

Diet program for patients with cardiovascular disease (proposal by the Korean Society of Clinical Nutrition)The diet program for CR patients proposed by the Korean Society of Clinical Nutrition aims to help these individuals maintain a healthy weight, appropriate blood lipid levels, and BP. Since diet programs must consider a country's general meal patterns and cultural backgrounds, it is inappropriate to follow existing American or European recommendations, and it is unrealistic

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to review the LOE for each specific item, as is the case with educational contents. We therefore present GPPs in collaboration the Korean Society of Clinical Nutrition.

These guidelines were developed on the basis of recently revised major dietary guidelines related to CVD prevention and rehabilitation in Korea and abroad.4-6)9)139-142) The Mediterranean diet, one of the most widely accepted healthy dietary patterns, has been reported to lower CVD risks in 5-year meta-analyses of RCTs and cohort studies,143)144) and has also been reported to significantly lower morbidity and mortality in CVD secondary prevention intervention studies that include comprehensive nutritional interventions.145-147) More systematic studies are needed, however, since there are few relevant Korean data that can be used to propose LOE and assess the strengths of recommendations for each item in this dietary guideline.

Recommendation• Diet programs should be designed with reference to the following guidelines (Table 8)

(SOR: GPP/LOE: 2+).

Recommendations for food supplementsAs is true among patients with other acute or chronic diseases, many patients with CVD take food supplements and are interested in them. Often they also consult their physicians about them, and physicians must respond appropriately, thereby necessitating a review of evidence regarding the use of food supplements. Patients are interested in or take diverse types of food supplements, but it is impossible to address all of them in detail. For this reason, we developed a recommendation for the food supplements most commonly encountered in practice: omega-3 fatty acids, polycosanol, and antioxidants. Although the available evidence is inadequate, by carefully generalizing these recommendations, it was possible to give levels of recommendations for food supplements (LOE of 4).

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Table 8. Diet program for cardiac rehabilitation programItem Contents NotesDiet pattern Diversify food groups within the appropriate total

energy consumption to maintain a healthy weight, including whole grains, vegetables, fruits, fish (blue-backed fish), poultry, beans, and nuts.

Major foreign guidelines prioritize a guideline for overall diet patterns. Korean guidelines do not provide instructions about diet patterns, but it would be desirable to include one, owing to the nature of the diet culture. However, considering Koreans' food culture, we did not mention dairies (low fat).

Fat141) Limit total fat intake to 30% of total energy intake. Limit saturated fat intake to 7% of total energy intake. Replace saturated fats with MUFA and PUFA, and limit omega-6 PUFA to 10% of total energy intake. Limit trans-fat intake to 1% of total energy intake.

Generally, accept the recommendations of the KSLA guideline (However, to increase the emphasis on MUFA, we revised the guideline to separately mention MUFA and PUFA).

Cholesterol141)175) Limit daily cholesterol intake to 300 mg. Recently, multiple foreign guidelines tend to delete a guideline for cholesterol. However, we included this, as some foreign guidelines still limit daily cholesterol intake to 200–300 mg, and the Korean nutrient standard and KSLA guideline limits daily cholesterol intake to 300 mg.

Salt176)177) Limit daily salt intake to 5 g (daily sodium intake to 2 g) Daily salt intake ranges from 4–6 g in foreign guidelines. To remain consistent with the Korean nutrient standard, we set daily salt intake to 5 g.

Fibers178)179) Eat enough whole grains and vegetables to keep daily fiber intake above 25 g.

European guidelines set daily fiber intake to 30–45 g, but Canadian, American, and Korean guidelines set the cutoff to 25 g.

Sugars Limit added sugar (sugars added during cooking or processing) intake to 10% of total energy intake

Most foreign major guidelines include a phrase about limiting sugar-sweetened beverages in their diet pattern guideline. Because sugar intake is on the rise recently, it is valid to include sugar intake in the guideline. As with the added sugar standard in the Korean nutrient standard, added sugars are limited to 10% of total energy intake.

Alcohol142) It is desirable to avoid drinking. In unavoidable cases, alcohol should be limited to 2 shots a day for men (20 mg) and 1 shot a day for women (10 mg). Alcohol intake should be minimized to control blood pressure and body weight.

KSLA = Korean Society of Lipid and Atherosclerosis; MUFA = monounsaturated fatty acid; PUFA = polyunsaturated fatty acid.

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Omega-3 fatty acids. England advises physicians not to offer or advise people to use the following to prevent another MI: omega-3-fatty acid capsules and/or foods supplemented with omega-3 fatty acid. There is, however, no evidence of harm if people choose to take these capsules or foods. It further advises people not to take supplements containing beta-carotene, and does not recommend antioxidant supplements (vitamins E and/or C) or folic acid to reduce CV risk (NICE 2013).6)

Patients who had MIs and take omega-3 supplements or increase the α-Linoenic acid (ALA) content in their diet for secondary prevention will not experience negative consequences. Further, omega-3 or ALA does not have a harmful effect on lipid metabolism, and may also reduce triglycerides.148) However, there is no clear evidence suggesting that they influence CV events or all-cause mortality (LOE of 1++).149)

There have been reports of relatively mild adverse events, such as diarrhea, nausea, delayed hemostasis, and allergies after taking omega-3 as food supplements, but omega-3 lowers triglycerides and increases HDL-cholesterol. Several clinical trials and meta-analyses, however, found little evidence suggesting that taking omega-3 lowers all-cause mortality, CV events, or CV mortality, the incidence of CAD, cerebrovascular disease, or arrhythmia.149-152) An ALA-rich diet did not lower all-cause mortality or CV mortality, and its effects on the incidence of stroke were not clear. It did, however, slightly reduce deaths from CAD and the incidence of arrhythmia.149)

Polycosanol: In a study that assessed the effects of policosanol in patients with hyperlipidemia, polycosanol lowered total cholesterol and LDL-cholesterol and increased HDL-cholesterol with no significant effects on triglycerides or body weight.153) Patients with a history of CAD must take high-dose statins for secondary prevention purposes, however, in cases where side effects included poor drug adherence and necessitated the use of low-dose statins, combining low-dose statins with Armolipid Plus (red yeast rice, policosanol, berberine, folic acid, coenzyme Q10, and astaxanthin complex) led to a greater reduction of LDL-cholesterol and higher achievement of targeted LDL-cholesterol rates without differences in adverse events (LOE of 1−).154)

Another study that assessed the safety and effects of adding polycosanol for patients receiving antiplatelets after drug eluting stent insertions found that adding polycosanol did not significantly elevate CV events, deaths, or bleeding tendencies (LOE of 1−).155) However, findings on the association of polycosanol and improvements in dyslipidemia are inconsistent,156) and there have been no clinical trials on the long-term clinical outcomes or secondary prevention outcomes related to polycosanol intake in patients with CAD.

Antioxidants: Vitamin E, beta-carotene, and vitamin C are antioxidants widely used as food supplements. Vitamin C has been found to delay the progression of early atherosclerosis, with no benefits for atherosclerosis in later stages in vitro. A meta-analysis of the effects of these antioxidants on major CV events found that there were no significant differences between these antioxidants and placebos in major CV events, that is, MI, stroke, all-cause mortality, heart disease-related mortality, revascularization rates, CAD, and heart failure.157) Further, antioxidants did not prevent CV events in women (LOE of 1++).158)159)

It has been reported that vitamin E lowers the incidence of MI and stroke in patients aged 65 years or older,160) but this was only observed in a RCT that involved supplements

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manufactured by a pharmaceutical company, and there is a lack of evidence suggesting that it has preventive effects against CVD (LOE of 1++).157)161) Given published findings and the results of the analyses conducted in developing these CPGs, there is not sufficient evidence to conclude definitively that omega-3, polycosanol, and antioxidants have benefits for the secondary prevention of CAD.

It would clearly be harmful if patients overestimated the effects of these food supplements and deluded themselves into thinking they were undergoing adequate treatment, and so paid less attention to adhering to other established measures for secondary prevention, that is, taking prescribed medicines, exercising, and giving up smoking. Therefore, healthcare professionals must intervene aggressively in this matter (LOE of 4).

Recommendation• Food supplements are not recommended for secondary prevention of CAD (SOR:

conditional)

Information and communication technology-based modality for patient educationICTs (e.g., phones, cell phones/smartphones, mobile apps, tablet computers, the Internet, and biosensors) are now widely used in healthcare. The World Health Organization defines medical and public health practice using mobile devices (e.g., cell phones, patient monitoring devices, personal digital devices, and other wireless devices) as mHealth,162) though its definition is still vague, and it is often confused with electronic health and telehealth. This technology can, however, help overcome factors that limit participation in CR, such as distance, traveling, scheduling, access to caregivers, and costs. These technologies can increase access to home-based CR, enable 2-way communications with experts and monitoring by experts, and is also helpful for hospital-based programs. In particular, mHealth is very useful for managing chronic diseases such as CVD, by increasing a patient's knowledge and awareness of their disease, and providing appropriate education to induce and maintain good self-care.

As of 2015, Internet usage rates and smartphone penetration rates among adults in advanced countries worldwide were 87% and 68%, respectively. At 94% and 88%, respectively, these rates are highest in South Korea. Although there is a great gap in developing countries, which have rates of about 54% and 37% respectively, rates in these countries are rising sharply.163) As of 2017, 50% of global Internet traffic was on mobile devices (smartphones or tablet computers),164) and mHeatlh apps were estimated to have been downloaded 3.7 billion times.165) In other words, the internet and mobile digital devices based on ICTs that are already a routine part of our daily lives are widely used for health-related purposes.

Scotland's guidelines are that technology-based interventions should be considered for patients participating in CR, and psychoeducation (goal setting, self-monitoring) should be considered for patients in CR to facilitate adherence to engaging in physical activities (SIGN 2017) (SOR: conditional/LOE: 1++).5)

The results of ICT-based interventions intended to promote exercise are not consistent.111)166) An Australian patient-centered program that consisted of a one-hour initial consultation followed by 3 months of repeated phone follow-ups significantly reduced total cholesterol (mean 154.7±3.9 vs. 181.8±3.9 mg/dL, p<0.001), systolic BP (mean 131.6±1.8 vs. 143.9±2.3 mmHg, p<0.001) and BMI (mean 28.9±0.7 vs. 31.2±0.7 kg/m2; p=0.025).166) In another multicenter

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RCT in Australia, goal setting with 6 months of phone follow-ups led to a greater reduction in total cholesterol (MD, 21 mg/dL; 95% CI, 16, 25 mg/dL vs. MD, 7 mg/dL; 95% CI, 3, 11 mg/dL), body weight, BMI, dietary fat intake, saturated fat intake, and anxiety.166) These interventions, which had efficacies similar to those of traditional CR, may serve as alternatives for patients who cannot participate in hospital-based CR, or those who simply prefer this method (LOE of 2+).111)166) In a RCT that used exercise prescriptions and behavior support over the Internet and text messages (4 to 6/week for 24 weeks) for patients with ischemic heart disease (mean age 60 years), this intervention did not improve exercise capacity (VO2max), but significantly increased leisure activities (MD, 110.2 min/week; 95% CI, −0.8, 221.3; p=0.05) and walking time (MD, 151.4 min/week; 95% CI, 27.6, 275.2; p=0.02). In addition, patients' self-efficacy and QOL were significantly improved (LOE of 1++).167) The use of digital pedometers in a small-scale RCT significantly increased the total number of physical activities, walking time, and walking frequency of patients undergoing CR (LOE of 1+).168)

Combining physical activities with video games increased involvement in physical activities and improved QOL, well-being, and symptoms of depression in patients with stroke or heart failure aged 50 years or older. These attempts were evaluated to be safe and fun (LOE of 2+).169) Internet-based interventions, such as websites that provided individual instructions, also improved the number of steps and exercise capacity of patients in distant locations, or those who had decided not to participate in hospital-based CR (LOE of 1++).71)170)171) In a home-based RCT that provided a web-based rehabilitation program for patients with angina, at the 6-week follow-up the intervention group showed an average increase of 497 steps daily, while the control group showed an average decrease of 861 steps daily (LOE of 1+).170) Patients who were provided with 6 months of online personal instruction called CardioFit, an Internet-based system developed to promote physical activities in patients with CAD, increased the amount of physical activities they engaged in and their QOL at 6 months and 12 months (LOE of 1++).172) In addition, the intervention group, which used an Internet-based virtual CR program for 4 months, showed a significant increase in maximum treadmill duration (45.7 seconds; 95% CI, 1.04, 90.48) at 16 months, compared to that of the control group. The intervention group also had decreased total cholesterol, LDL-cholesterol, and dietary saturated fat intake (LOE of 1++).171) Home-based multilateral CR models using ICT were associated with improvements in CVD risk factors comparable to those of traditional hospital-based CR programs.166) Thus, these CR models may be integrated into traditional treatment models, and increase the number of options available to patients (LOE of 2+).

A recent study reviewed and meta-analyzed 10 clinical trials of 607 patients in 5 countries about the utility, acceptance, and usefulness of mobile apps for self-care of CVD and management of risk factors.173) The mobile app group showed improvements in readmission rates, disease knowledge, psychosocial well-being, BMI, waist circumference, cholesterol and fitness, physical activities, drug adherence, and smoking cessation rates.173) However, many of these studies were small-scale, had a short study period, had no blinding due to the nature of the intervention, and used biased data, thereby necessitating additional studies to address these shortcomings. Nevertheless, these studies confirmed the potential mobile apps had for inducing behavioral changes and ameliorating CVD risk factors. These findings allude to the usefulness of mHealth as a healthcare delivery system that improves access to CR for patients who have difficulty participating in traditional hospital-based CR (LOE of 1−).

Maintaining medication adherence is critical for the secondary prevention of CVD, and is associated with readmission, disease onset, mortality, and increased medical costs.174) Hence,

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behavioral interventions such as education and counseling intended to enhance medication adherence are essential components of CR. In this context, study findings that ICT-based interventions are useful in improving medication adherence for patients with CVD, as with other chronic diseases are mounting. A recent meta-analysis of RCTs used mHealth devices for CVD patients had medication adherence as its primary outcome. According to this meta-analysis of 10 clinical trials (1 to 18 months of follow-up), using text messages, Bluetooth-electronic pillboxes, online messaging platforms, and conversational voice calls all enhanced drug adherence, though the degrees of improvement varied.130) This meta-analysis was also limited because it analyzed mostly small-scale studies with short-term follow-ups and self-reported results, but the results nevertheless suggest that mHealth tools may be useful for improving drug adherence among CVD patients (LOE of 1−).

Recommendation• ICT-based modalities should be considered to maintain the effects of education (SOR:

conditional/LOE: 1−)

DISCUSSION AND CONCLUSIONS

According to a 2016 Statistics Korea report,3) CVD is the second leading cause of death in Korea, and most of these events involve ACS.1)2) This high mortality rate encompasses not only deaths at the time of onset, but also deaths from recurrence and complications over a short- or long-term following initial onset, but unfortunately, relevant statistics are lacking in Korea. ACS clinically manifests as an acute condition, but pathologically, it is actually an onset of chronic atherosclerotic vascular disease that has been slowly progressing over a long period. Therefore, even following appropriate treatment in the acute phase, patients are left with a chronic atherosclerotic vascular condition, so lifelong treatment and management is essential after discharge.4) Many patients, moreover, have difficulty managing risk factors on their own, and continuing with appropriate levels of physical activity after discharge due to tachycardia, angina, arrhythmia, orthostatic hypotension, and reduced fitness. In particular, older patients and those with complications are faced with markedly reduced exercise capacity, which, if it persists, will allow the CAD to progress, and lead to adverse outcomes in the long-term—5 years and ten years after onset (e.g., QOL, recurrence, readmission, and death).

A widely used treatment method worldwide, the effects, safety, and recommendations associated with CR are well established. Several countries have developed their own CPGs in consideration of their circumstances,4-9) but CR is still largely an unknown in Korea, due to a lack of awareness among patients and medical professionals, as well as a lack of relevant experts and facilities. On a positive note, in 2008, CR programs were implemented at 11 university hospitals as part of the government-led Regional Cardio-Cerebrovascular Center Project; 3 additional medical facilities will be added in 2019, after which 14 CR hubs will be fully operational. In addition, with the growing acceptance of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have established CR programs, and a growing number of medical institutions are preparing to offer CR. Large gaps remain among Korean medical facilities administrating CR, however, due to the lack of a standardized concept, purpose, and application. Furthermore, CPGs that document standards, principles, and methods are needed to direct medical facilities that aim to establish new CR programs, even as demands for CPGs are growing in the field.

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The purpose of the CPGs proposed in this paper—the first in Korea—is to present published evidence of the need for and rationale of CR, and the SOR that medical professionals treating CVD could make with regard to CR to their patients, with strong confidence and a sense of duty. We hope that this goal has been achieved, and that the following CPGs will be used to promote CR in Korea, ultimately enriching people's health and enhancing medical-economic efficiencies by markedly improving the short- and long-term outcomes of ACS (e.g., QOL, recurrence, readmission rates, reoperations, and mortality).

Recommendations for Korea's clinical practice guidelinesIntroduction of cardiac rehabilitation

• CR programs must be included in the treatment of ACS (SOR: strong/LOE: 1++)• It is more appropriate to provide recommendations for the timing of exercise training

than the timing of CR• CR exercise should be initiated as early as possible following acute phase treatment (SOR:

strong/LOE: 1−)• CR programs should be comprehensive and multidisciplinary (SOR: GPP/LOE: 1−)• Though CR programs are reported to lower health management costs in patients with

CVD, high-quality Korean studies are needed to substantiate this, considering the differences of insurance systems and healthcare environments across countries (SOR: GPP/LOE: 1−).

Assessments of cardiac rehabilitation• Individualized CR plans should be tailored to individual needs and be developed through

individual assessments of patients referred to CR (SOR: strong/LOE: 1+)• Patients referred to CR should be assessed for psychological problems, such as anxiety,

depression, and stress, and should be provided with psychological interventions if abnormal findings are observed (SOR: strong/LOE: 1++)

• Cardiopulmonary exercise testing should be performed to assess patients' cardiopulmonary exercise functions, prescribe exercise, and predict outcomes (SOR: strong/LOE: 2++)

• A submaximal exercise test, such as a 6-minute walk test, should be considered when symptom-limited exercise testing is difficult (SOR: conditional/LOE: 2+)

• Interventions to increase self-efficacy and awareness of the need for CR are needed to increase CR participation (SOR: strong/LOE: 1++)

• Systematized automatic referrals and liaison systems should be considered to increase CR referral rates. (SOR: GPP/LOE: 2-)

• Psychological education strategies (including goal setting and self-monitoring) should be used to increase CR maintenance rates (SOR: strong/LOE: 1++)

Exercise therapy for cardiac rehabilitation• CR should be initiated early after surgery, as an inpatient program for patients who

undergo CABG (SOR: strong/LOE: 1++)• CR exercise programs should include aerobic exercise (SOR: strong/LOE: 1++)• HIT may obtain better results than aerobic exercise (SOR: conditional/LOE: 1+)• CR programs should include resistance (strengthening) exercises (SOR: conditional/LOE: 1++)• Risk assessment and appropriate monitoring based on the risk assessment results should be

performed to ensure patient safety during CR exercise programs (SOR: strong/LOE: 2++)• Home-based CR programs may replace hospital-based CR programs for low-risk patients

(SOR: conditional/LOE: 1++)

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• CR programs should also be administered to patients aged 65 years and older (SOR: strong/LOE: 1++)

Education for secondary prevention• CR programs should include patient education (SOR: strong/LOE: 1++)• The recommendations in SIGN 2017 should be largely accepted regarding educational

contents (Table 7). (SOR: GPP/LOE: 2+)• Smoking cessation interventions should be provided for patients who smoke, and continuous

interventions of more than 4 weeks should be considered (SOR: strong/LOE: 1++)• Diet programs should be designed with reference to the following guidelines (Table 8).

(SOR: GPP/LOE: 2+)• Food supplements are not recommended for secondary prevention of CAD (SOR:

conditional)• ICT-based modalities should be considered to maintain the effects of education (SOR:

conditional/LOE: 1−)

Despite their clinical importance and benefits, it is practically difficult to design high-quality RCTs for CR, which requires a long-term behavioral correction. These CPGs were developed with reference to foreign CPGs in consideration of the latest medical technologies and circumstances in Korea, and will suffice to present standards for CR programs in Korea for the next 3 to 4 years. Furthermore, they will contribute to improving people's health, as well as advancing national health policies, by optimizing fitness, improving the QOL, and bettering outcomes after the discharge of patients with ACS. In the future, CR experts in relevant academic associations should continue to develop CPGs for CR in relation to heart failure, heart valve disease, congenital heart disease, arrhythmic disease, and other heart and peripheral vascular deformities.

CONCLUSION

These Korean CPGs for CR present LOE and assess the relative strengths of the various recommendations made for the fundamental components of CR, which should no longer be treated as alternative medicine with insufficient efficacy and evidence. We expect that CR will become an essential prescription whose benefits far outweigh its possibility for inflicting harm, and must be recommended and encouraged by physicians for most patients. Promoting CR is difficult when it is solely based on the efforts of medical institutions. Government-led strategies and support are crucial to ensuring that patients who are treated in the acute phase maintain healthy lifestyles, engage in appropriate physical activities, and adequately care for themselves. This is the fundamental purpose and direction of Korea's Act on the Prevention and Management of Cardio-Cerebrovascular Diseases.

SUPPLEMENTARY MATERIAL

Supplementary DataSearch strategy

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REFERENCES

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