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Case 9 Clinical History: 28 yo female with an atypical pigmented lesion on the back.

Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

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Page 1: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

Case 9

Clinical History:

• 28 yo female with an atypical pigmented lesion on the back.

Page 2: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 3: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 4: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 5: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 6: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 7: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 8: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 9: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 10: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 11: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 12: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

Case 9

Diagnosis:

• A: Superficial spreading melanoma with regression

• B: Melanoma with in invasive spindle cell component

• C: Recurrent naevus

• D: Lentiginous compound dysplastic naevus

• E: Invasive extramammary Paget’s disease

Page 13: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

Case 9

Additional Clinical History:

• Histological impression concerning for SSMM

• Additional clinical information at MDM: Previous removal of a pigmented lesion at this site by GP

• Specimen discarded and not sent to Pathology

Page 14: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

Case 9

Diagnosis:

• A: Superficial spreading melanoma with regression

• B: Melanoma with in invasive spindle cell component

• C: Recurrent naevus

• D: Lentiginous compound dysplastic naevus

• E: Invasive extramammaryPaget’s disease

Page 15: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

Recurrent Naevus -Introduction-

• Repigmentation within a scar due to regrowth of melanocytes following incomplete removal of benign naevus

• Most frequently following shave biopsy of common acquired naevi but also congenital and dysplastic naevi

• Time course: weeks to few months (<6 months)

Page 16: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

Recurrent Naevus -Clinical-

• Wide age range

• Most commonly before age 40 years

• F>M

• Predilection for back

Page 17: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 18: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 19: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 20: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 21: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 22: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 23: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 24: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 25: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 26: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 27: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 28: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 29: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma
Page 30: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

Recurrent Naevus -Diagnosis-

• Prior history of trauma/surgery

• Time course

• Review of previous Pathology

Page 31: Clinical History: 28 yo female with an atypical pigmented ... 9.pdfsite by GP •Specimen discarded and not sent to Pathology . Case 9 Diagnosis: •A: Superficial spreading melanoma

Recurrent Naevus -Differential Diagnosis-

Superficial spreading melanoma:

• Reliable separation possible only in the context of appropriate clinical and histological features