SPECIAL FEATURES

Highlights of This Issue 251

CCR Translations

253 Targeting CDH17 in Cancer: When Blocking theLigand Beats Blocking the Receptor?John F. MarshallSee related article, p. 433

256 Drug Repositioning Meets Precision inGlioblastomaWolfgang Wick and Tobias KesslerSee related article, p. 295

Reviews

259 Toward Precision Radiotherapy for Use withImmune Checkpoint BlockersClaire Vanpouille-Box, Silvia C. Formenti, andSandra Demaria

266 Tumor-Treating Fields: A Fourth Modality inCancer TreatmentElijah J. Mun, Hani M. Babiker, Uri Weinberg,Eilon D. Kirson, and Daniel D. Von Hoff

CANCER THERAPY: CLINICAL

276 Clinical and Immunologic Biomarkers forHistologic Regression of High-Grade CervicalDysplasia and Clearance of HPV16 and HPV18after ImmunotherapyMatthew P. Morrow, Kimberly A. Kraynyak,Albert J. Sylvester, Michael Dallas, Dawson Knoblock,Jean D. Boyer, Jian Yan, Russell Vang, Amir S. Khan,Laurent Humeau, Niranjan Y. Sardesai, J. Joseph Kim,Stanley Plotkin, David B. Weiner, Cornelia L. Trimble, andMark L. Bagarazzi

295 Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and ProgressiveGlioblastomaSara A. Byron, Nhan L. Tran, Rebecca F. Halperin,Joanna J. Phillips, John G. Kuhn, John F. de Groot,Howard Colman, Keith L. Ligon, Patrick Y. Wen,Timothy F. Cloughesy, Ingo K. Mellinghoff,Nicholas A. Butowski, Jennie W. Taylor, Jennifer L. Clarke,Susan M. Chang, Mitchel S. Berger, Annette M. Molinaro,Gerald M. Maggiora, Sen Peng, Sara Nasser,Winnie S. Liang, Jeffrey M. Trent, Michael E. Berens,John D. Carpten, David W. Craig, and Michael D. PradosSee related commentary, p. 256

306 Muscadine Grape Skin Extract (MPX) in Men withBiochemically Recurrent Prostate Cancer: ARandomized, Multicenter, Placebo-ControlledClinical TrialChanning J. Paller, Xian C. Zhou, Elisabeth I. Heath,Mary-Ellen Taplin, Tina Mayer, Mark N. Stein,Glenn J. Bubley, Roberto Pili, Tamaro Hudson,Radhika Kakarla, Muneer M. Abbas, Nicole M. Anders,Donna Dowling, Serina King, Ashley B. Bruns,William D. Wagner, Charles G. Drake,Emmanuel S. Antonarakis, Mario A. Eisenberger,Samuel R. Denmeade, Michelle A. Rudek, Gary L. Rosner,and Michael A. Carducci

316 A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy andSafety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients withChemorefractory Metastatic Colorectal CancerAxel Grothey, Jonathan R. Strosberg, Lindsay A. Renfro,Herbert I. Hurwitz, John L. Marshall, Howard Safran,Michael J. Guarino, George P. Kim, J.R. Hecht,Susan C. Weil, John Heyburn, Wenquan Wang,Charles Schweizer, Daniel J. O'Shannessy, andLuis Alberto Diaz Jr

PERSONALIZED MEDICINE AND IMAGING

326 Location of Mutation in BRCA2 Gene andSurvival in Patients with Ovarian CancerS. Intidhar Labidi-Galy, Timoth�ee Olivier,Manuel Rodrigues, Domenico Ferraioli, Olfa Derbel,Alexandre Bodmer, Patrick Petignat, Beata Rak,Nicolas Chopin, Olivier Tredan, Pierre-Etienne Heudel,Sarah Stuckelberger, Pierre Meeus, Patrick Meraldi,Valeria Viassolo, Aur�elie Ayme, Pierre O. Chappuis,Marc-Henri Stern, Claude Houdayer,Dominique Stoppa-Lyonnet, Adrien Buisson,Lisa Golmard, Val�erie Bonadona, andIsabelle Ray-Coquard

334 Effects of Co-occurring Genomic Alterations onOutcomes in Patients with KRAS-Mutant Non–Small Cell Lung CancerKathryn C. Arbour, Emmett Jordan, Hyunjae Ryan Kim,Jordan Dienstag, Helena A. Yu, Francisco Sanchez-Vega,Piro Lito, Michael Berger, David B. Solit,MatthewHellmann, Mark G. Kris, Charles M. Rudin, Ai Ni,Maria Arcila, Marc Ladanyi, and Gregory J. Riely

January 15, 2018 � Volume 24 � Number 2

Clinical Cancer Research

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341 RAD50 Expression Is Associated with PoorClinical Outcomes after Radiotherapy forResected Non–small Cell Lung CancerYifan Wang, Jayanthi Gudikote, Uma Giri, Jun Yan,Weiye Deng, Rui Ye, Wen Jiang, Nan Li, Brian P. Hobbs,Jing Wang, Stephen G. Swisher, Junya Fujimoto,Ignacio I. Wistuba, Ritsuko Komaki, John V. Heymach,and Steven H. Lin

351 Pancreatic Ductal Adenocarcinoma SubtypingUsing the Biomarkers Hepatocyte NuclearFactor-1A and Cytokeratin-81 Correlates withOutcome and Treatment ResponseAlexander Muckenhuber, Anne Katrin Berger,Anna Melissa Schlitter, Katja Steiger, Bj€orn Konukiewitz,Andreas Trumpp, Roland Eils, Jens Werner,Helmut Friess, Irene Esposito, G€unter Kl€oppel,G€uralp O. Ceyhan, Moritz Jesinghaus, Carsten Denkert,Marcus Bahra, Albrecht Stenzinger, Martin R. Sprick,Dirk J€ager, Christoph Springfeld, and Wilko Weichert

CANCER THERAPY: PRECLINICAL

360 Venetoclax Is Effective in Small-Cell LungCancers with High BCL-2 ExpressionTimothy L. Lochmann, Konstantinos V. Floros,Mitra Naseri, KristaM. Powell, Wade Cook, Ryan J.March,Giovanna T. Stein, Patricia Greninger, Yuki Kato Maves,Laura R. Saunders, Scott J. Dylla, Carlotta Costa,Sosipatros A. Boikos, Joel D. Leverson, Andrew J. Souers,Geoffrey W. Krystal, Hisashi Harada, Cyril H. Benes, andAnthony C. Faber

370 Allogeneic Human Double Negative T Cells as aNovel Immunotherapy for Acute MyeloidLeukemia and Its Underlying MechanismsJongBok Lee, Mark D. Minden, Weihsu C. Chen,Elena Streck, Branson Chen, Hyeonjeong Kang,Andrea Arruda, Dalam Ly, Sandy D. Der, Sohyeong Kang,Paulina Achita, Cheryl D'Souza, Yueyang Li,Richard W. Childs, John E. Dick, and Li Zhang

383 Inhibition of ID1–BMPR2 Intrinsic SignalingSensitizes Glioma Stem Cells to DifferentiationTherapyXiong Jin, Xun Jin, Leo J.Y. Kim, Deobrat Dixit,Hee-Young Jeon, Eun-Jung Kim, Jun-Kyum Kim,Seon Yong Lee, Jinlong Yin, Jeremy N. Rich, andHyunggee Kim

395 Dual mTOR Kinase Inhibitor MLN0128Sensitizes HRþ/HER2þ Breast Cancer Patient-Derived Xenografts to Trastuzumab orFulvestrantPei-Yin Hsu, Victoria Shang Wu, Noriko Kanaya,Karineh Petrossian, Hang-Kai Hsu, Duc Nguyen,Daniel Schmolze, Masaya Kai, Chun-Yu Liu, Hannah Lu,Peiguo Chu, Courtney A. Vito, Laura Kruper,Joanne Mortimer, and Shiuan Chen

BIOLOGY OF HUMAN TUMORS

407 Low PD-1 Expression in Cytotoxic CD8þ

Tumor-Infiltrating Lymphocytes Confers anImmune-Privileged Tissue Microenvironmentin NSCLC with a Prognostic and PredictiveValueGiulia Mazzaschi, Denise Madeddu, Angela Falco,Giovanni Bocchialini, Matteo Goldoni, Francesco Sogni,Giovanna Armani, Costanza Annamaria Lagrasta,Bruno Lorusso, Chiara Mangiaracina, Rocchina Vilella,Caterina Frati, Roberta Alfieri, Luca Ampollini,Michele Veneziani, EnricoMaria Silini, Andrea Ardizzoni,Konrad Urbanek, Franco Aversa, Federico Quaini, andMarcello Tiseo

420 Vimentin Is Required for Lung AdenocarcinomaMetastasis via Heterotypic Tumor Cell–Cancer-Associated Fibroblast Interactions duringCollective InvasionAlessandra M. Richardson, Lauren S. Havel,Allyson E. Koyen, Jessica M. Konen, John Shupe,W.G. Wiles, IV W. David Martin, Hans E. Grossniklaus,Gabriel Sica, Melissa Gilbert-Ross, and Adam I. Marcus

433 Monoclonal Antibodies Directed againstCadherin RGD Exhibit Therapeutic Activityagainst Melanoma and Colorectal CancerMetastasisRub�en A. Bartolom�e, Carmen Aizpurua, Marta Ja�en,Sofía Torres, Eva Calvi~no, Juan I. Imbaud, andJ. Ignacio CasalSee related commentary, p. 253

445 Inhibition of REDD1 Sensitizes BladderUrothelial Carcinoma to Paclitaxel byInhibiting AutophagyQinghai Zeng, Jianye Liu, Peiguo Cao, Jingjing Li,Xiaoming Liu, Xiaojun Fan, Ling Liu, Yan Cheng,Wei Xiong, Jigang Li, Hao Bo, Yuxing Zhu, Fei Yang,Jun Hu, Ming Zhou, Yanhong Zhou, Qiong Zou,Jianda Zhou, and Ke Cao

460 CD31 Expression Determines Redox Statusand Chemoresistance in Human AngiosarcomasVivek Venkataramani, Stefan K€uffer,Kenneth C.P. Cheung, Xuejun Jiang, Lorenz Tr€umper,Gerald G. Wulf, and Philipp Str€obel

474 Global Metabolic Profiling Identifies a PivotalRole of Proline and Hydroxyproline Metabolismin Supporting Hypoxic Response inHepatocellular CarcinomaLing Tang, Jun Zeng, Pengyu Geng, Chengnan Fang,Yang Wang, Mingju Sun, Changsong Wang, Jiao Wang,Peiyuan Yin, Chunxiu Hu, Lei Guo, Jane Yu, Peng Gao,Enyou Li, Zhengping Zhuang, Guowang Xu, andYang Liu

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486 Functional Role of a Novel Long NoncodingRNA TTN-AS1 in Esophageal Squamous CellCarcinoma Progression and MetastasisChenyu Lin, Shengnan Zhang, Ying Wang,Yuanshu Wang, Edouard Nice, Changying Guo,Erhao Zhang, Liting Yu, Mengwei Li, Chen Liu,Lirong Hu, Jingchao Hao, Weiyan Qi, andHanmei Xu

CORRECTIONS

499 Correction: Prevention of Colitis and Colitis-Associated Colorectal Cancer by a NovelPolypharmacological Histone DeacetylaseInhibitor

500 Correction: Phase Ib/II Study of the Safety andEfficacy of Combination TherapywithMultikinaseVEGF Inhibitor Pazopanib and MEK InhibitorTrametinib In Advanced Soft Tissue Sarcoma

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ABOUT THE COVER

The cover shows a section of the lung from a patient affected by adenocarcinoma. Doubleimmunofluorescence staining illustrating cytotoxic tumor-infiltrating lymphocytes (TIL)carrying granzyme B (green) to hinder the invasion of the bronchial lumen by cytokeratinpositive (red) cancer cells. For details, see the article by Mazzaschi and colleagues onpage 407 of this issue.

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2018;24:251-501. Clin Cancer Res     24 (2)

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