CASE WESTERN RESERVE UNIVERSITY CASE SCHOOL OF ENGINEERING CLARE M. RIMNAC EMAE ASSOCIATE PROFESSOR OF MECHANICAL & AEROSPACE ENGINEERING and Director, Musculosketeal Mechanics and Materials Laboratories 620 GLENNAN BUILDING [email protected]; 216-368-6442; 216-368-3007 (fax) RESEARCH AREAS AND APPLICATIONS •Mechanical performance and modeling of musculoskeletal tissues •Mechanical performance and modeling of inert and resorbable orthopaedic implant materials •Implant retrieval/failure analysis of total joint replacements APPROACH •Static and cyclic mechanical testing measurements of materials; constitutive modeling of materials; finite element analyses of structures •Microstructural and ultrastructural damage identification and microstructural and ultrastructural characterization of materials using light, scanning and transmission electron microscopy; fourier transform infrared microspectroscopy COLLABORATIONS •Departments of Orthopaedics and Neurosurgery, CWRU Medical School •Rush Presbyterian Medical School, Chicago, IL •Exponent Failure Analysis, Philadelphia, PA •Drexel University, Philadelphia, PA •Mt. Sinai Medical School, New York, NY RESEARCH SPONSORS •NIH, OREF, Orthopaedic Industries RECENT ACCOMPLISHMENTS Developed physically-based constitutive models of conventional and new crosslinked ultra high molecular weight polyethylene formulations to predict wear and damage of total joint replacement components. Characterized the kinetics of fatigue crack growth of microcracks and of macrocracks in human cortical bone. Microcracks decelerate and arrest at microstructural barriers. Fatigue crack propagation resistance of macrocracks are reduced by age-related changes in bone tissue. Figure 2 K ,M Pa(m ) 1/2 0.1 1.0 10.0 da/dN,m/cycle 10 -9 10 -8 10 -7 10 -6 10 -5 10 -4 10 -3 10 -2 Y ounger Fem ale (E),n=5 C= 1.51e-8 m = 5.90 r²= 0.58 O lderFem ale(J),n=4 C= 2.45e-7 m = 5.60 r²= 0.38 Fatigue crack growth of older female bone tissue is less than younger female bone tissue. Damage retrieved PE total knee and total hip replacement components

CLARE M. RIMNACEMAE ASSOCIATE PROFESSOR OF MECHANICAL & AEROSPACE ENGINEERING and Director, Musculosketeal Mechanics and Materials Laboratories

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CASE WESTERN RESERVE UNIVERSITYCASE SCHOOL OF ENGINEERING

CLARE M. RIMNAC EMAE

ASSOCIATE PROFESSOR OF MECHANICAL & AEROSPACE ENGINEERING and Director, Musculosketeal Mechanics and Materials Laboratories620 GLENNAN [email protected]; 216-368-6442; 216-368-3007 (fax)

RESEARCH AREAS AND APPLICATIONS•Mechanical performance and modeling of musculoskeletal tissues •Mechanical performance and modeling of inert and resorbable orthopaedic implant materials•Implant retrieval/failure analysis of total joint replacements

APPROACH•Static and cyclic mechanical testing measurements of materials; constitutive modeling of materials; finite element analyses of structures•Microstructural and ultrastructural damage identification and microstructural and ultrastructural characterization of materials using light, scanning and transmission electron microscopy; fourier transform infrared microspectroscopy

COLLABORATIONS•Departments of Orthopaedics and Neurosurgery, CWRU Medical School•Rush Presbyterian Medical School, Chicago, IL •Exponent Failure Analysis, Philadelphia, PA•Drexel University, Philadelphia, PA•Mt. Sinai Medical School, New York, NY

RESEARCH SPONSORS•NIH, OREF, Orthopaedic Industries

RECENT ACCOMPLISHMENTSDeveloped physically-based constitutive models of conventional and new crosslinked ultra high molecular weight polyethylene formulations to predict wear and damage of total joint replacement components.

Characterized the kinetics of fatigue crack growth of microcracks and of macrocracks in human cortical bone. Microcracks decelerateand arrest at microstructural barriers. Fatigue crack propagation resistance of macrocracks are reduced by age-relatedchanges in bonetissue.

Figure 2

K, MPa(m)1/20.1 1.0 10.0

da/d

N, m

/cyc

10-9

10-8

10-7

10-6

10-5

10-4

10-3