Citocinas Hormonas y Factores de Crecimiento

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    -(50(0$/=$&

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    Hormones

    Cytokines

    neuropeptidesGrowtH faCtors

    APPENDIX

    HomeopatHic materia medicaof clinical immunology

    The vision of

    Physiological Regulating Medicine

    on the use of physiological low doses of

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    All rights reserved.

    Reproduction under any form are prohibited without written permission of pubblisher

    2010 J mlzc cgh

    2010 nv i e l, h

    .v. - -l: @v.

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    1

    Hormones

    Cytokines

    neuropeptides

    GrowtH faCtors

    APPENDIX

    The vision of

    Physiological Regulating Medicine

    on the use of physiological low doses of

    is based on a revolutionary ideain the medical field: restoring the initial physiological conditions of a sick body by usingthe same biological molecules that are usually present in the body and which control and

    guide its functions in healthy conditions.

    To be precise, these molecules are very well known and extensively studied in MolecularBiology, and it is no mere chance that they are called messenger molecules- substances that

    can convey the right instructions for correct function to the various cells of the body.These molecules include

    (Ner-vous System messen-gers),(Endocrine System mes-sengers),(Immune System mes-

    sengers).There are also

    ,which are essential tissueregulating and stimulatingmolecules.

    It has been acknowledged that these substances play a decisive role in determining eitherhealth or disease, and today it has been ascertained that every disease is the expression of

    changes in concentrations either of an increase or of a reduction of these substances.All international medical research is focusing on the study of messenger molecules; thepositive (healing) or negative (disease) fate of several pathological conditions depends onthem and on the possibility of using them for therapeutic purposes

    PSYCHE

    SOMAPSYCHE

    P.N.E.I. NETWORKP.N.E.I. NETWORK

    AND MESSENGER MOLECULESAND MESSENGER MOLECULES

    INTERLEUKINS

    HORMONES

    NEUROPEPTIDES

    HORMONES

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    For instance, correcting Immune System alterations through the use of cytokines and en-docrine diseases with hormones is one of the most fascinating and innovative objectives ofresearch centered on applying Molecular Biology to Medicine. But the clinical applicationof this know-how has always come to a standstill when faced with the side effects caused

    by the high doses of these substances that have been routinely used until today.

    The pharmaceutical technique known as enablesthe administration of OF HORMONES, NEUROPEPTIDES,CYTOKINES AND GROWTH FACTORS to achieve the same therapeutic results ashigh doses but without any side effects.

    In November 2009 the prestigious international scientific

    reviewpublished the article Low dose oral administration

    of cytokines for treatment of allergic asthma. The paperenlarged on the effects of low doses of SKA-activated cytokinesin the treatment of allergic asthma, proving in a clear, evidentand especially reproducible manner that the low dosesadministered during the study produced the same effects ashigh doses in changing a series of clinical and laboratory

    parameters typical of the allergic condition.

    The opens a new era in options for the clinical use of messenger moleculesand concretises the scientific dream of using biological molecules, such as cytokines,hormones and neuropeptides, in low doses (the only doses that can avoid side effects).

    A new frontier has most likely been set for pharmaceutical industries and in the field ofMolecular Biology, and both Italian researchers and the Italian industry are paving the wayin this sector.

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    Low physiological doses of cytokines activated with the SKA procedure are marketed in ahydroalcoholic solution in 30 ml bottles. The drug concentration is in picograms/ml, whichcorresponds to a homeopathic dilution of 4CH1.

    The standard posology is 20 drops twice a day.Sublingual administration is recommended.

    The duration of therapy differs depending on the clinical condition and on the gravity ofthe disease.Chronic diseases usually require the administration of treatment cycles with minimum du-ration of 2 months. They can be repeated, preferably after a 15-day suspension.In acute diseases therapy is continued until remission of symptoms. At times a massive dosetherapy can be applied with 10 drops every 20 minutes for maximum 2 hours.

    Cytokines can be prescribed following two trends.

    if the pathological condition is the expression of a ofa certain cytokine, the same cytokine will be used;

    if the pathological condition is the expression of an of a certaincytokine, the so-called opposing cytokine will be used.

    the cytokine is prescribed to suit the symptoms of the patient.

    1 Single cytokines are also available in dilutions of 15CH and 30CH, which are at times

    used as maintenance treatment to stabilize therapeutic results achieved with the use of di-lution 4CH.

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    Anti IL-1 alpha Anti IL-1 alpha 4 CH IL-1 4CH

    Anti IL-1 beta Anti IL-1 beta 4 CH IL-1 4CH

    GCSF GCSF 4CH IL-10 4CH / IL-4 4CH

    IL-1 IL-1 4CH

    Anti IL-1 alpha 4CH

    Anti IL-1 beta / IL-10 4CHIL-2 IL-2 4CH IL-11 4CH

    IL-3 IL-3 4CH IL-10 4CH

    IL-4 IL-4 4CH INF-gamma 4CH / IL-12 4CH

    IL-5 IL-5 4CH TGF-beta 4CH

    IL-6 IL-6 4CH

    Acute inflammation:

    IL-4 4CH/INF- 4CHChronic inflammation:TNF Alpha 4CH

    IL-7 IL-7 4CH IL-10 4CH / TGF-b 1 4CH

    IL-8 IL-8 4CH IL-10 4CH / TGF-b 1 4CH

    IL-9 IL-9 4CH IL-10 4CH

    IL-10 IL-10 4CH IL-1 4CH / TNF 4CH

    IL-6 4CHIL-11 IL-11 4CH IL-2 4CH

    IL-12 IL-12 4CH IL-4 4CH/IL-10 4CH

    INF alpha INF alpha 4CH IL-4 4CH

    INF gamma INF gamma 4CH IL-4 4CH

    TGF-beta 1 TGF-beta 4CH IL-12 4CH

    TNF TNF-alpha 4CH Anti IL-1 4CH+IL-10 4CH

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    Pain syndromes Acute inflammatory diseases Fever

    Pain syndromes Acute inflammatory diseases Fever

    Asthenia Sleep disorders Appetite disorders (excessive appetite)

    Immunodeficiencies General sickness Subacute pain syndromes Localised inflammations Aging Complementary treatment for tumours Weariness, adynamia Burning sensation in the mouth Sensitivity to viral infections

    Haemopoiesis disorders Side effects associated with chemotherapy, radio-

    therapy and antiviral treatments Early aging Memory loss Digestive disorders Vertigo with vomiting Skin eruptions Erratic pains

    Basic treatment for autoimmune diseases Chronic inflammatory diseases Spastic cramp-like pain Mental fatigue

    Intestinal parasitosis Bruise-induced pain Constipation and flatulence Abdominal pains (cramp-like) RRI with IgA deficiency

    General sickness Complementary therapy for tumours Appetite disorders (excessive appetite)

    Recurrent infections Asthenia Growth and development disorders

    Pulsating pain Nervous breakdown and tiredness

    Activation of chemotaxis Productive cough Catarrh Acute and chronic stress

    Asthenia and drowsiness Erythroid proliferation disorders (synergywith erythropoietin)

    Neuralgic pain Chronic catarrh Water retention

    Chronic inflammatory diseases Itching with a burning sensation Reddened mucous tissue Chronic pain syndromes Vomiting/loss of appetite

    Pyrosis and gastric acid hypersecretion Memory disorders Haemopoiesis disorders Psoriasis Abdominal bloating Basic regulation of patients undergoing immunotherapy Growth and development disorders Pulsating pain Nervous breakdown and tiredness

    Allergies Food intolerances Complementary therapy for tumours Recurrent nighttime cough Nasal obstruction and nose itch Paroxysmal sneezing Allergy-induced hyperlacrimation Swollen and reddened skin

    Recurrent viral infections Articular pain Asthenia Sudden pain with numbing Painful muscle spasms

    Chronic viral infections Allergic syndromes Complementary therapy for tumours Asthenia Spastic muscle pain

    Complementary therapy for tumours

    Chronic bacterial infections Confusion at night with sleep disorders Myalgia and stiffness especially in the morning

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    2 For single hormones or single neuropeptides marketed in dilutions of 4CH, dilutions of15CH/30CH are also available. They are at times used as maintenance therapy to stabilisetherapeutic results achieved with the use of the 4CH dilution.

    3 Single hormones are also available in a 30DH dilution, which is at times used as maintenancetreatment to stabilise therapeutic results achieved with the use of dilution 6DH.

    Low physiological doses of hormones activated with the SKA procedure are marketed in ahydroalcoholic solution in 30 ml bottles. The drug concentration is in picograms/ml, whichcorresponds to the homeopathic dilution of 4CH for some (Beta-Endorphin, Melatonin,Somatostatin)2, and in nanograms/ml, corresponding to the homeopathic dilution of 6DHfor others3.

    The standard posology is 20 drops twice a day.Sublingual administration is recommended.

    The duration of treatment differs depending on the clinical condition and on the gravity ofthe disease.Chronic diseases usually require the administration of treatment cycles with minimum du-ration of 2 months. They can be repeated, preferably after a 15-day suspension.In acute diseases therapy is continued until remission of symptoms. At times a massive dosetherapy can be applied with 10 drops every 20 minutes for maximum 2 hours.

    Hormones and neuropeptides can be prescribed following two trends.

    if the pathological condition is the expression of a ofa certain hormone or neuropetide, the same hormone will be used;

    If the pathological condition is the expression of an of a certain

    hormone, the so-called opposing hormone will be used consistently with the physiologyof negative feedback.

    the hormone is prescribed to suit the symptoms of the patient.

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    ACTH ACTH 6DH TSH 6DH

    Beta-ENDORPHIN Beta-ENDORPHIN 4CH no opposing hormone

    Beta-ESTRADIOL beta-ESTRADIOL 6DH PROGESTERON 6DH

    CALCITONIN CALCITONIN 6DH PARATHYROIDHORMONE 6DH

    DOPAMIN DOPAMIN 6DH

    SEROTONIN 6DH

    MELATONIN 4CH

    PROLACTIN 6DH

    FSH FSH 6DH beta-ESTRADIOL 6DH

    GH IGF-1 6DH SOMATOSTATIN 4CH

    LH LH 6DH PROGESTERON 6DH

    MELATONIN MELATONIN 4CH PROLACTIN 6DH

    OXYTOCIN OXYTOCIN 6DHPROGESTERONE 6DH

    Beta-ESTRADIOL 6DH

    PARATHYROID

    HORMONE

    PARATHYROID

    HORMONE 6DHCALCITONIN 6DH

    PROGESTERONE PROGESTERONE 6DH Beta-ESTRADIOL 6DH

    PROLACTIN PROLACTIN 6DH MELATONIN 4CH

    SOMATOSTATIN SOMATOSTATIN 4CHIGF-1 6DH

    PROLACTIN 6DH

    T3 T3 6DH SOMATOSTATIN 4CH

    T4 T4 6DH SOMATOSTATIN 4CH

    TSH TSH 6DH ACTH 6DHSOMATOSTATIN 4CH

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    Asthenia Aging Chronic stress Loss of appetite Hypervagotonia

    Pain of diverse origins

    Female hormone cycle disorders and infertility Aging Hot flushes Sagging skin Stress

    Osteoporosis Bone pain

    Chronic Fatigue Syndrome Mental Strain Mood disorders Lack of attentiveness Lack of sexual desire Decreased sexual arousal Supportive therapy of Parkinson's disease

    Female hormone cycle disorders and infertility Aging Ovarian polycystosis Low female libido

    Aging Female hormone cycle disorders and infertility Low male libido

    Sleep disorders Circadian rhythm and organ function alterations Stress Mood disorders with unstable mood Complementary therapy for tumours Hypersympathicotonia

    Jet lag

    Mood disorders Social phobya Decreased sexual satisfaction Supportive treatment during delivery Supportive treatment of Autism

    Cramp-like pains Asthenia

    Premenstrual syndrome Female hormone cycle disorders and infertility Menstrual pain Intermenstrual spotting Ovarian polycystosis

    Mood disorders with unstable mood Muscle weakness

    Mood disorders with unstable mood Headache Diet disorders

    Oncological diseases Hyperthyroidism

    Hypothyroidism Tendency toward overweight

    Growth disorders Physical asthenia Neurasthenia

    Sleep disorders Mood disorders and unstable mood

    Neurasthenia Water retention

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    Low physiological doses of growth factors activated with the SKA procedure are marketedin a hydroalcoholic solution of 30 ml bottles. The drug concentration is in picograms/ml,which corresponds to a homeopathic dilution of 4CH4.

    The standard posology is 20 drops twice a day.Sublingual administration is recommended.

    The duration of therapy differs depending on the clinical condition and on the gravity ofthe disease.Chronic diseases usually require the administration of treatment cycles with minimum du-ration of 2 months. They can be repeated, preferably after a 15-day suspension.In acute diseases therapy is continued until remission of symptoms. At times a massivedose therapy can be applied with 10 drops every 20 minutes for maximum 2 hours.

    Growth factors can be prescribed following two trends.

    if the pathological condition is the expression of a ofa certain growth factor, the same growth factor will be used.

    the growth factor is prescribed to suit the symptoms of the patient.

    4 Single growth factors are also available in dilutions 15C and 30C, which are at times used

    as maintenance therapy to stabilise therapeutic results achieved with the use of dilution4CH.

    9

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    Neurological damage (duringdevelopment or subsequent to injuries)

    Outcome of psychic shock Mental tiredness Stress Autism Cerebral aging Tingling and numbing of hands

    and feet

    Muscle stiffness

    Neurological damage (duringdevelopment or subsequent to injuries) Sight disorders Cerebral aging Appetite control Cerebral aging

    Skin rashes Skin aging Itching Chapped skin Gastric acid hypersecretion Feeling of heaviness in the epigastrium

    with soreness Blurred vision with scintillating scotomas Hypersensitivity to pain

    Aging Cicatrisation difficulty Articular symptoms with limited movement

    Skin aging

    Mental tiredness Muscle weakness Damaged myelin sheath

    Sensitivity to infectious diseases Immune response triggered in chronic

    and autoimmune diseases.

    Growth disorders Aging Memory disorders (stimulates

    hippocampus function)

    Neuralgic pain Memory disorders Mood disorders

    Skin thinning and ulcers Loss of strength in limbs, easy tiredness Sadness and loss of interest

    Muscle weakness Mood disorders CNS and PNS diseasesNeurological damage (during

    development and subsequent to injuries)

    Muscle weakness Mood disorders CNS and PNS disorders Neurological damage (during

    development and subsequent to injuries) Pain syndromes

    Aging Wrinkles Mytogenic activity

    Chronic pain syndromes Autoimmune diseases Chronic inflammations

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    INTERLEUKIN-5 4CH

    INTERLEUKIN-11 4CH

    INTERLEUKIN-8 4CH

    Anti INTERLEUKIN-1alpha 4CH/Anti INTERLEUKIN-1beta 4CH

    INTERLEUKIN-2 4CH / FGF 4CH / IGF-1 4CH / PDGF 4CH /ACTH 6DH / Beta-ESTRADIOL 6DH / FSH 6DH / LH 6DH

    INF-gamma 4CH+INTERLEUKIN-12 4CH

    INTERLEUKIN-12 4CH + INTERFERON-gamma 4CH /INTERLEUKIN-13 4CH

    INTERLEUKIN-12 4CH

    CNTF 4CHINTERLEUKIN-1 beta 4CH /

    INTERLEUKIN-6 4CH

    INF-alpha 4CH

    FGF 4CH

    INTERLEUKIN-1 beta 4CH / INTERLEUKIN-7 4CH /INF-alpha 4CH / INF-gamma 4CH / ACTH 6DH /

    PARATHYROID HORMONE 6DHINTERLEUKIN-9 4CH

    BDNF 4CH

    TGF-beta 1 4CH

    INTERLEUKIN-11 4CH

    INTERLEUKIN-4 4CH

    EGF 4CH

    CALCITONIN 6DHINTERLEUKIN-5 4CH

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    INTERLEUKIN-2 4CH

    INTERLEUKIN-8 4CH

    BDNF 4CH / CNTF 4CH

    EGF 4CH

    INTERLEUKIN-8 4CH

    TNF-alpha 4CH

    INTERLEUKIN-9 4CH

    DOPAMIN 6DH

    TGF-beta 1 4CH

    INTERLEUKIN-4 4CH /

    INTERLEUKIN-10 4CHInterleuchina-10 4CH / Beta-ENDORFINA 4CH /TGF-beta 1 4CH

    INF-gamma 4CH

    ACTH 6DH

    FGF 4CH

    MELATONIN 4CH

    NT3 4CH/NT4 4CH

    SOMATOSTATIN 4CH /INTERLEUKIN-12 4CH / INTERFERON-gamma 4CH /INTERLEUKIN-2 4CH / MELATONIN 4CH / TNF-alpha 4CH

    TNF-alpha 4CH

    INTERLEUKIN-5 4CH

    PARATHYROID HORMONE 6DH

    INTERLEUKIN-10 4CH + Anti IL-1

    G1 4CH

    DOPAMIN 6DH

    OXYTOCIN 6DH

    SEROTONIN 6DH

    INTERLEUKIN-3 4CH

    DOPAMIN 6DH

    INTERLEUKIN-3 4CHINTERLEUKIN-3 4CH

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    INTERLEUKIN-9 4CH

    EGF 4CH

    Beta-ESTRADIOL 6DH /

    FSH 6DH / LH 6DH / PROGESTERON 6DHAnti IL-1 4CH

    INTERLEUKIN-12 4CH

    EGF 4CH

    INTERLEUKIN-2 4CH / INTERLEUKIN-6 4CH

    INTERLEUKIN-7 4CH /INTERLEUKIN-11 4CH

    IGF-1 4CH / T4 6DHSEROTONIN 6DH

    INTERLEUKIN-3 4CH / INTERLEUKIN-11 4CH

    EGF 4CH

    ACTH 6DH

    MELATONIN 4CH

    SOMATOSTATIN 4CH

    T3 6DHBeta-ESTRADIOL 6DH

    GCSF 4CH

    INTERLEUKIN-2 4CH

    PROGESTERON 6DH

    INTERLEUKIN-5 4CH

    EGF 4CH

    INTERLEUKIN-10 4CH

    MELATONIN 4CH

    DOPAMIN 6DH

    DOPAMIN 6DH

    INTERLEUKIN-2 4CH

    ACTH 6DH

    NGF 4CHFSH 6DH / OXYTOCIN6DH / DOPAMIN 6DH

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    LH 6DH / DOPAMIN 6DH

    NGF 4CH / IGF-1 4CH (stimulates hippocampusfunction) / INTERLEUKIN-11 4CH

    INTERLEUKIN-3 4CH

    PROGESTERON 6DH

    INTERLEUKIN-4 4CH

    DOPAMIN 6DH

    BDNF 4CH / G1 4CH

    NGF 4CH / NT3 4CH / NT4 4CH /OXYTOCIN 6DH / DOPAMIN 6DH

    MELATONIN 4CH /SEROTONIN 6DH / TRYPTOPHAN 6DH

    G1 4CH / NT3 4CH / NT4 4CH / PROLACTIN 6DH

    TNF-alpha 4CH

    PDGF 4CH

    INTERLEUKIN-12 4CH

    INTERLEUKIN-7 4CH /INTERLEUKIN-11 4CH

    NGF 4CH / INTERLEUKIN-9 4CHT4 6DH / TSH 6DH

    BDNF 4CH / CNTF 4CH / NT3 4CH / NT4 4CH

    CALCITONIN 6DH

    BDNF 4CH

    FSH 6DH / PROGESTERON 6DH

    Beta-ENDORPHIN 4CHBeta-ENDORPHIN 4CH / Anti INTERLEUKIN-1 4CH /

    NT4 4CH

    INF-alpha 4CH

    INTERLEUKIN-12 4CH

    T4 6DH

    INTERLEUKIN-7 4CH / INTERLEUKIN-11 4CH

    PROGESTERON 6DH / Beta-ENDORPHIN 4CHINTERLEUKIN-8 4CH

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    INTERLEUKIN-11 4CH / INTERLEUKIN-4 4CH /INTERLEUKIN-10 4CH

    INTERLEUKIN-11 4CH

    INTERLEUKIN-7 4CH

    INTERLEUKIN-12 4CH

    INF-alpha 4CH

    INTERLEUKIN-10 4CH

    INTERLEUKIN-5 4CH

    NGF 4CH

    Beta-ESTRADIOL 6DH

    GCSF 4CH

    INTERLEUKIN-2 4CH

    INTERLEUKIN-3 4CH

    CNTF 4CH

    EGF 4CH / FGF 4CH

    INTERLEUKIN-3 4CH

    EGF 4CH

    NGF 4CH

    MELATONIN 4CH / TRIPTOPHAN 6DH /INTERLEUKIN-1 beta 4CH

    OXYTOCIN 6DH

    INTERLEUKIN-4 4CH

    INF-gamma 4CH

    BDNF 4CH

    BDNF 4CH / Beta-ESTRADIOL 6DH / MELATONIN 4CH

    INTERLEUKIN-2 4CH / Beta-ENDORPHIN 4CH

    INF-alpha 4CH

    OXYTOCIN 6DH

    OXYTOCIN 6DH

    DOPAMIN 6DH

    INTERLEUKIN-12 4CHT3 6DH

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    BDNF 4CH

    INTERLEUKIN-3 4CH

    INTERLEUKIN-10 4CH

    INTERLEUKIN-9 4CH / TSH 6DH

    INTERLEUKIN-2 4CH

    PDGF 4CH

    16

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    -(50(0$/=$&

    0$7(5,$0(',&$20(23$7,&$',,00812/2*,$&/,1,&$

    1829$,36$(',725(

    Hormones

    Cytokines

    neuropeptides

    GrowtH faCtors

    APPENDIX

    HomeopatHic materia medica

    of clinical immunology

    The vision of

    Physiological Regulating Medicine

    on the use of physiological low doses of