Cite as: J. Mateus et al., Science

10.1126/science.abd3871 (2020).

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http://www.sciencemag.org/http://dx.doi.org/10.1016/S1473-3099(20)30120-1http://dx.doi.org/10.1016/S1473-3099(20)30120-1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32087114&dopt=Abstracthttp://dx.doi.org/10.1016/S0140-6736(20)30183-5http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31986264&dopt=Abstracthttp://dx.doi.org/10.1038/s41586-020-2550-zhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32668444&dopt=Abstracthttp://dx.doi.org/10.1016/j.cell.2020.05.015http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32473127&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32587963&dopt=Abstracthttp://dx.doi.org/10.1126/sciimmunol.abd2071http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32591408&dopt=Abstracthttps://doi.org/10.1101/2020.04.17.20061440http://science.sciencemag.org/

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http://www.sciencemag.org/http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32577665&dopt=Abstracthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32511394&dopt=Abstracthttp://dx.doi.org/10.1038/s41591-020-0819-2http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32284614&dopt=Abstracthttps://doi.org/10.1101/2020.06.03.20121582http://dx.doi.org/10.1016/j.ebiom.2020.102763http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32361250&dopt=Abstracthttp://dx.doi.org/10.1126/science.abc8511http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32669297&dopt=Abstracthttp://dx.doi.org/10.1016/j.jcv.2018.01.019http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29427907&dopt=Abstracthttp://dx.doi.org/10.1128/CVI.00278-10http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20943876&dopt=Abstracthttp://dx.doi.org/10.1093/infdis/jit393http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23922367&dopt=Abstracthttp://dx.doi.org/10.1093/infdis/jiaa185http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32296837&dopt=Abstracthttp://dx.doi.org/10.1126/science.abb5793http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32291278&dopt=Abstracthttp://dx.doi.org/10.1093/infdis/jiw309http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27443615&dopt=Abstracthttp://dx.doi.org/10.4049/jimmunol.1000405http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20554959&dopt=Abstracthttp://dx.doi.org/10.1093/infdis/jiv289http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25980035&dopt=Abstracthttps://doi.org/10.1101/2020.07.29.227082http://dx.doi.org/10.1146/annurev.iy.13.040195.003103http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7612235&dopt=Abstracthttp://dx.doi.org/10.1016/S1074-7613(00)80360-Xhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9324359&dopt=Abstracthttp://dx.doi.org/10.4049/jimmunol.1600318http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27342848&dopt=Abstracthttp://dx.doi.org/10.4049/jimmunol.1600320http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27335502&dopt=Abstracthttp://dx.doi.org/10.1371/journal.pone.0186998http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29065175&dopt=Abstracthttp://dx.doi.org/10.1016/j.jaut.2017.04.008http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28479213&dopt=Abstracthttp://dx.doi.org/10.1128/mSphere.00344-20http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32321823&dopt=Abstracthttp://dx.doi.org/10.1007/978-3-642-57276-0_21http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11036772&dopt=Abstracthttp://dx.doi.org/10.1128/JVI.00089-20http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32132233&dopt=Abstracthttp://dx.doi.org/10.1038/277223a0http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=551249&dopt=Abstracthttp://dx.doi.org/10.1126/sciimmunol.abc8413http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32527802&dopt=Abstracthttp://dx.doi.org/10.1126/science.abb7269http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32245784&dopt=Abstracthttp://science.sciencemag.org/

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Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Silva, Bjoern Peters, Shane Crotty, Alessandro Sette and Daniela WeiskopfDawen Yu, Ricardo da Silva Antunes, Jason Greenbaum, April Frazier, Alena J. Markmann, Lakshmanane Premkumar, Aravinda deDavey M. Smith, Elizabeth Phillips, Simon Mallal, Marshall Lammers, Paul Rubiro, Lorenzo Quiambao, Aaron Sutherland, Esther Jose Mateus, Alba Grifoni, Alison Tarke, John Sidney, Sydney I. Ramirez, Jennifer M. Dan, Zoe C. Burger, Stephen A. Rawlings,

published online August 4, 2020

ARTICLE TOOLS http://science.sciencemag.org/content/early/2020/08/03/science.abd3871

MATERIALSSUPPLEMENTARY http://science.sciencemag.org/content/suppl/2020/08/03/science.abd3871.DC1

CONTENTRELATED

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REFERENCES

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