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Therapy Cisapride helps kids keep food down Reflu x is common in infants, and so cisapride was assessed openly or compared with placebo for symptomatic outcome in 137 infants aged < 12 months with chronic postprandial regurgitation or vomiting. Cisapride 0.1 and 0.2 mg/kg tid gave dose-dependent reductions in the frequency and severity of regurgitation for up to 4 weeks. Relapse seemed to be more frequent in infants who were treated for less than 4 weeks; diarrhoea and abdominal cramps occurred in 9 cisapride recipients. With doses of 0.2 mg/kg, only about 20% of infants had moderate or severe symptoms after 4 weeks. ' ... Cisapride may be a valuable pharmacologic aid in infants refractory to positional therapy and dietary measures.' Van E ygen M, Van Ravensteyn H . Effect of cisapride on excessive regurgitation in infant s. Cli nical T hera peutics 11 : 669-677, Sep-Oct 1989 1729 o INPHARMA ® 9 Dec 1989 0156-2703/ 89/ 1209-0006/ 0$01 .00/ 0 © ADIS Press

Cisapride helps kids keep food down

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Page 1: Cisapride helps kids keep food down

Therapy Cisapride helps kids keep food down

Reflux is common in infants, and so cisapride was assessed openly or compared with placebo for symptomatic outcome in 137 infants aged < 12 months with chronic postprandial regurgitation or vomiting . Cisapride 0.1 and 0.2 mg/kg tid gave dose-dependent reductions in the frequency and severity of regurgitation for up to 4 weeks . Relapse seemed to be more frequent in infants who were treated for less than 4 weeks; diarrhoea and abdominal cramps occurred in 9 cisapride recipients . With doses of 0.2 mg/kg, only about 20% of infants had moderate or severe symptoms after 4 weeks .

' ... Cisapride may be a valuable pharmacologic aid in infants refractory to positional therapy and dietary measures.' Van E ygen M, Van Ravensteyn H . Effect of cisapride on excessive regurgitation in infants. Clinical T herapeutics 11 : 669-677, Sep-Oct 1989

1729

o INPHARMA® 9 Dec 1989 0156-2703/ 89/ 1209-0006/ 0$01 .00/ 0 © ADIS Press