An American HeartAssociation Journal

January 17, 2017Volume 135Number 3

CirculationFRAME OF REFERENCEOn My MindA Surgeon’s View on the Pathogenesis of Atherosclerosis 205Axel Haverich, MD

ORIGINAL RESEARCH ARTICLESWide Variation in Reported Rates of Stroke Across Cohorts of Patients With Atrial Fibrillation 208Gene R. Quinn, MD, MS; Olivia N. Severdija, MD; Yuchiao Chang, PhD; Daniel E. Singer, MD

EditorialAdding Rigor to Stroke Rate Investigations in Patients With Atrial Fibrillation 220

Peter Brønnum Nielsen, PhD; Gregory Y. H. Lip, MD

Heart Failure Stages Among Older Adults in the Community: The Atherosclerosis Risk in Communities Study

224

Amil M. Shah, MD, MPH; Brian Claggett, PhD; Laura R. Loehr, MD, PhD; Patricia P. Chang, MD, MHS; Kunihiro Matsushita, MD, PhD; Dalane Kitzman, MD; Suma Konety, MD; Anna Kucharska-Newton, PhD, MPH; Carla A. Sueta, MD, PhD; Thomas H. Mosley, PhD; Jacqueline D. Wright, DrPH; Joseph Coresh, MD, PhD; Gerardo Heiss, MD, PhD; Aaron R. Folsom, MD, MPH; Scott D. Solomon, MD

Ticagrelor Compared With Clopidogrel in Patients With Prior Lower Extremity Revascularization for Peripheral Artery Disease

241

W. Schuyler Jones, MD; Iris Baumgartner, MD; William R. Hiatt, MD; Gretchen Heizer, MS; Michael S. Conte, MD; Christopher J. White, MD; Jeffrey S. Berger, MD, MS; Peter Held, MD, PhD; Brian G. Katona, PharmD; Kenneth W. Mahaffey, MD; Lars Norgren, MD, PhD; Juuso Blomster, MD; Marcus Millegård, MSc; Craig Reist, PhD; Manesh R. Patel, MD; F. Gerry R. Fowkes, MD; On behalf of the International Steering Committee and Investigators of the EUCLID Trial

LPA Gene, Ethnicity, and Cardiovascular Events 251Sang-Rok Lee, MD, PhD; Anand Prasad, MD; Yun-Seok Choi, MD, PhD; Chao Xing, PhD; Paul Clopton, MS; Joseph L. Witztum, MD; Sotirios Tsimikas, MD

Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide, Troponin-T, and Growth-Differentiation Factor 15 in Adult Congenital Heart Disease

264

Vivan J.M. Baggen, MD; Annemien E. van den Bosch, MD, PhD; Jannet A. Eindhoven, MD, PhD; Anne-Rose W. Schut, BSc; Judith A.A.E. Cuypers, MD, PhD; Maarten Witsenburg, MD, PhD; Monique de Waart; Ron H.N. van Schaik, PhD; Felix Zijlstra, MD, PhD; Eric Boersma, MSc, PhD; Jolien W. Roos-Hesselink, MD, PhD

Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways

280

Malak Abbas, PhD; Laurence Jesel, MD, PhD; Cyril Auger, PhD; Lamia Amoura; Nathan Messas, MD; Guillaume Manin, MD; Cordula Rumig, PhD; Antonio J. León-González, PhD; Thais P. Ribeiro, PhD; Grazielle C. Silva, PhD; Raghida Abou-Merhi, PhD; Eva Hamade, PhD; Markus Hecker, PhD; Yannick Georg, MD; Nabil Chakfe, MD, PhD; Patrick Ohlmann, MD, PhD; Valérie B. Schini-Kerth, PhD; Florence Toti, PhD; Olivier Morel, MD, PhD

PODCAST

CME

OPEN ACCESS

On the Cover: Circulation Doodle

Happy New Year and Best Wishes for 2017 from Circulation.

For more information about the doodle, go to http://circ.ahajournals.org/content/circulation-cover-doodle.

by guest on May 6, 2018

http://circ.ahajournals.org/D

ownloaded from

PODCAST

CME

OPEN ACCESS

STATE OF THE ARTIn DepthExercise Dynamics in Secondary Mitral Regurgitation: Pathophysiology and Therapeutic Implications

297

Philippe B. Bertrand, MD, MSc, PhD; Ehud Schwammenthal, MD, PhD; Robert A. Levine, MD; Pieter M. Vandervoort, MD

CORRESPONDENCEResearch LetterEffect of Clopidogrel by Smoking Status on Secondary Stroke Prevention 315Bruce Ovbiagele, MD; Jing Wang, MD; S. Claiborne Johnston, MD, PhD; Anxin Wang, MS; David Wang, DO; Yongjun Wang, MD; Xingquan Zhao, MD, PhD; Yilong Wang, MD, PhD

CorrespondenceLetter by Colli and Gerosa Regarding Article, “Transapical Beating-Heart Mitral Valve Repair With an Expanded Polytetrafluoroethylene Cordal Implantation Device: Initial Clinical Experience”

e16

Andrea Colli, MD, PhD; Gino Gerosa, MD

Response by Gammie et al to Letter Regarding Article, “Transapical Beating-Heart Mitral Valve Repair With an Expanded Polytetrafluoroethylene Cordal Implantation Device: Initial Clinical Experience”

e18

James S. Gammie, MD; Peter Wilson, BSMET; Krzysztof Bartus, MD, PhD; Andrzej Gackowski, MD, PhD; Judy Hung, MD; Michael N. D’Ambra, MD; Piotr Kolsut, MD, PhD; Gregory J. Bittle, MD; Piotr Szymanski, MD, PhD; Jerzy Sadowski, MD, PhD; Boguslaw Kapelak, MD, PhD; Agata Bilewska, MD, PhD; Mariusz Kusmierczyk, MD; Mehrdad Ghoreishi, MD

Letter by Dhruva and Redberg Regarding Article, “Sex and Race/Ethnicity Differences in Implantable Cardioverter-Defibrillator Counseling and Use Among Patients Hospitalized With Heart Failure: Findings From the Get With The Guidelines-Heart Failure Program”

e20

Sanket S. Dhruva, MD; Rita F. Redberg, MD, MSc

Response by Hess et al to Letter Regarding Article, “Sex and Race/Ethnicity Differences in Implantable Cardioverter-Defibrillator Counseling and Use Among Patients Hospitalized With Heart Failure: Findings From the Get With The Guidelines-Heart Failure Program”

e22

Paul L. Hess, MD, MHS; Adrian F. Hernandez, MD, MHS; Deepak L. Bhatt, MD, MPH; Anne S. Hellkamp, MS; Clyde W. Yancy, MD, MSc; Lee H. Schwamm, MD; Eric D. Peterson, MD, MPH; Phillip J. Schulte, PhD; Gregg C. Fonarow, MD; Sana M. Al-Khatib, MD, MHS

CIRCULATION (ISSN 0009-7322) is published weekly except June and December by Wolters Kluwer Health, Inc. at 14700 Citicorp Drive, Bldg 3, Hagerstown, MD 21742. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. Individuals may subscribe for their personal use at the following rates for print subscriptions: $225 for AHA/ASA Domestic and International Members (excluding General Membership level), or $657 for domestic non-members and $1,006 for international non-members. AHA membership information can be found online at professional.heart.org. Periodicals postage paid at Hagerstown, MD, and additional mailing offices. POSTMASTER: Send address changes to CIRCULATION, American Heart Association, Wolters Kluwer Health, Inc., PO Box 1610, Hagerstown, MD 21740.

by guest on May 6, 2018

http://circ.ahajournals.org/D

ownloaded from

135 (3)

Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2017 American Heart Association, Inc. All rights reserved.

is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231Circulation 2017;135:e20-316Circulation. 

http://circ.ahajournals.org/content/135/3.citationWorld Wide Web at:

The online version of this article, along with updated information and services, is located on the

  http://circ.ahajournals.org//subscriptions/

is online at: Circulation Information about subscribing to Subscriptions: 

http://www.lww.com/reprints Information about reprints can be found online at: Reprints:

  document. Permissions and Rights Question and Answer this process is available in the

click Request Permissions in the middle column of the Web page under Services. Further information aboutOffice. Once the online version of the published article for which permission is being requested is located,

can be obtained via RightsLink, a service of the Copyright Clearance Center, not the EditorialCirculationin Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions:

by guest on May 6, 2018

http://circ.ahajournals.org/D

ownloaded from