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PROBLEMS OF PATERNITY IN A CASE OF BOMBAY TYPE

U. Baecker and G. Gathof (Blood Transfusion Service of the Bavarian Red Cross, Munich, F.R.G.)

During the examinations of different families the following case with two children was detected:

child I: B ccddee child II: A1 CcD.ee mother: 0 CcD.ee with an irregular antibody father: A, CcD.ee.

Without an exact specification of the antibodies of the mother, the father would have been excluded from paternity of child I. Antibody testing re- vealed an anti-H of the rare Bombay-type and further testing confirmed this result. Further studies of the family showed that all five brothers and sisters of the mother of the child’s mother had blood group B.

The family study included 22 systems and the HLA-system. Besides the problems in the ABO-systems no exclusion of paternity could be found for the father. From the biostatistics (without ABO-system) the following values were obtained:

plausibility of maternity: 99.967% plausibility of parentage: 99.99996% plausibility of paternity: 99.993%.

Based on these studies the child’s mother must have 0,” and therefore no exclusions of paternity can be stated. Biostatistical examinations also support these results.

CHROMOSOME 6 GENETICS

K. Bender (Institut fur Humangenetik, Albertstrasse 11, D-7800 Freiburg, F.R.G.)

Linkage disequilibrium data for the linkage group HLA-A, B, Bf, GLO are presented and family analyses are given concerning whether the Gm and Pi loci might be situated on chromosome 6.

POLYMORPHIC ENZYME SYSTEMS IN HUMAN HAIR SHEATH CELLS

C. Bosley, R. Burgess, J. G. Sutton and P. H. Whitehead (Central Research Establishment, Aldermaston, Berks., U.K.)