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Chromeleon 7 Operational Simplicity for the Laboratory
• Introducing Chromeleon 7 • User Interface • Peak Detection Tools • eWorkflows™ • Interactive Charting • Reporting • Support for Third Party Instrumentation • Summary
Topics
Introducing Chromeleon® 7
• New-generation Chromatography Data System
• “Simply Intelligent”
• Intelligent Functionality - it does everything you need!
• Operational Simplicity™ - everything is fast and easy!
• Simplifies all chromatography processes
Chromeleon® 7 - Operational Simplicity
• Operational Simplicity™ was the core design principle
• Major design rules:
• Minimize number of steps needed to perform any task
• Make all steps easy to understand and easy to use
• Minimize time needed to perform any task
• Major features for Operational Simplicity:
• Modern user interface
• Peak detection and integration tools
• eWorkflows
• Data visualization tools
• Enterprise functionality
USER INTERFACE
User Interface
The Chromeleon User Interface consists of two major parts: • Chromeleon Console • Chromatography Studio
Chromeleon Console
• Designed to provide easy navigation through your data
• Provides quick access to:
• Instruments • Data • eWorkflows
Console – Quick Access to Information
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Navigation Pane
Category Bars
Thumbnails – Quick Access to Data
• Quick check to see if chromatogram ran properly
• Check for presence / absence of peaks
• Check quality of separations
Instruments - ePanels
Provides access to all instruments on the network
Direct Control of Instrument through controls on ePanel
Chromatography Studio
• Used for All Data Evaluation • Provides access to every object in the sequence:
• Injection List • Instrument Method • Processing Method • Results • Report Template • Spectral Library
• Opens in separate window on task bar – makes working with multiple sequences easy
• Uses new “Ribbon” technology introduced in Microsoft Office 2007
Chromatography Studio
Category Bars
Navigation Pane
Ribbon
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New Ribbon Interface
• Provides contextual access to commands and options in the Studio
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PEAK DETECTION COBRA™ Detection Algorithm / SmartPeaks™
Peak Detection
• Most time consuming and tedious task in chromatography process:
• Chromatogram Integration
• Chromeleon 7 introduces two new tools to simplify this process:
• Cobra Peak Detection Algorithm / Wizard
• SmartPeaks Integration Assistant
Peak Detection – Cobra
• Cobra is a new algorithm that:
• Finds peak start and end times accurately and consistently
• Requires minimum number of parameters to reach integration goals
• Cobra Wizard provides:
• Fast, guided way to determine initial detection parameters
Peak Detection – Cobra Wizard
Peak Detection – Cobra Wizard
Start Cobra Wizard
Define the integration range
Select the narrowest peak to be integrated
Select the smallest peak to be integrated
Peak Detection – Cobra Wizard
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And your integration is done!
Peak Detection - SmartPeaks
• Unique tool for easily reaching your integration goals for unresolved peaks
• Requires no training
• Great example of Operational Simplicity • Process is clear and understandable • Requires only a few steps • Correctly integrates all unresolved peaks in seconds
Peak Detection – SmartPeaks
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Activate SmartPeaks Wizard
Select area of interest
Select the integration you want
Peak Detection – SmartPeaks
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And your integration is done!
eWORKFLOWS™
The Ultimate in Operational Simplicity
eWorkflows
• eWorkflows automate all chromatography processes
• Applies to all laboratories, for example: • QA/QC laboratories • Method development laboratories • Research & Development laboratories • Walk-up instrument workflows
• Takes you from Samples to Results in only a few steps
eWorkflows
• An eWorkflow brings together all aspects of a chromatography run: • Instruments which are allowed to run this application • All associated files:
• Instrument Methods • Processing Methods • Reports • Spectral Libraries • Documents with description of method
• Template for sequence name and storage location • Custom Variables • Rules for sequence layout
eWorkflows – A Regulated USP/EP Method
Choose eWorkflow, select instrument, and click “Start”
Enter number of samples, and start position
Sequence is created and can be immediately run
eWorkflows – A Regulated USP/EP Method
• This eWorkflow also:
• Processes all data
• Calculates all results
eWorkflows – From Samples to Results
• eWorkflows take you from Sample to Results in the minimum number of steps
• Fully customizable for any application
• Minimum amount of training required
• Reduces errors and produces results faster
• A new framework for Operational Simplicity
INTERACTIVE CHARTING
Data Visualization
• Interactive Charts for Data Visualization
• Fully customizeable • Templates for the most
common tasks • Available for both on-screen
and printed/exported reports.
Interactive Charting
● Various Chart types
Pie Chart 2D / 3D
Stacked Column 2D / 3D
Scatter Plot
Interactive Charting: Examples
Product Stability
Active Rel.Area % vs. Impurity Rel.Area %.
Query performed on SQL Server database on all data (including historical)
Interactive Charting: Examples
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Instrument Utilization
Interactive Charting: Examples
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Column Performance
REPORTING
Spreadsheet Based Reporting • The Excel-like report
environment is both familiar and intuitive.
• If Excel is used for additional calculations they can be included in Chromeleon.
• No data transcription or export to Excel is required.
• Results are generated instantly.
Spreadsheet Based Reporting
Excel-like formulae can be included for custom
calculations
In this case the operator has configured a report to flag out of specification results.
Report Designer - Functions
Many Excel-like functions available – use identical syntax
AVERAGE IF / AND / OR STDEV COUNT SUM LOOKUP etc……
Report Designer – Export Options
1. TXT
2. PDF
3. XLS
SUPPORT FOR THIRD PARTY INSTRUMENTS
Instrument Control
• Chromeleon 7 can control Thermo Scientific LC, GC and IC.
• Chromeleon 7 can control 3rd Party LCs and GCs
• Agilent 1100, 1200, 1260, 1290, G1888, 6850, 6890, 7890
• Waters Acquity, Alliance • Shimadzu LC10, LC2010, LC20
• Chromeleon 6.8 controls over 330 different
modules from 30 different manufacturers. • These drivers are being converted to CM7
Interfacing with 3rd Party Instruments
● Formal Code Exchange agreements with major manufacturers: ● Waters ● Agilent ● CTC ● Shimadzu
● For other manufacturers we rely on openly published codes ● e.g. GSIOC codes for Gilson systems
● For some manufacturers we provide a Driver Development Kit ● Merck Hitachi
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SUMMARY
Chromeleon 7 – Simply Intelligent
• Contains the Intelligent Functionality needed to generate the result!
• Uses Operational Simplicity™ to minimize the steps and time needed to generate the result!
• Offers state-of-the-art technology: • User Interface with “Ribbon” • COBRA Peak Detection Algorithm & Wizard • SmartPeaks Integration Assistant • eWorkflows – THE framework for Operational Simplicity • Advanced Interactive Charting • Advanced Reporting
• Permits control of multiple vendors equipment from one application.
Chromeleon 7 – Simply Intelligent
Questions?