Chromatin Remodeling

Review:

Crystal structure of a nucleosomal core particle

Race between transcription factors and histones:

In vitro transcription and reconstituted chromatin:

Model of Transcriptional Activation

DNase Hypersensitive Regions

Histone post-translational modifications:

*acetylation *deactylation

Activation and Repression:

Chromatin Immunoprecipitation:

Post-translational modifications:

*phosphorylation

*methlyation

*others

Outcomes of Remodeling:

Remodeler Families:

Model of DNA Movement: