FASTER GC-MS ANALYSIS WITH A SHORT NARROW BORE COLUMN AND METHOD TRANSLATION

Christopher Rattray, Matt Lininger, Linx Waclaski, Mark Badger; Restek Corporation, 110 Benner Circle, 16823 Bellefonte, United States

Designed with GC-MS users in mind, the GC Accelerator kit provides a simple way to speed up sample analysis. By reducing oven volume, these inserts allow faster ramp rates to be attained, which reduces oven cycle time and allows for increased sample throughput and more capacity to process rush samples. When faster ramp rates are used, existing methods can be accurately scaled down to smaller, high-efficiency, narrow-bore columns using Restek’s EZGC method translator. With a scaled-down column, a properly translated method, and a GC Accelerator kit, you can obtain the same chromatographic separation—often with greater sensitivity—in a fraction of the time without making a capital investment.

50-70 70-115 115-175 175-300 300-350MFG no oven pillow (⁰C/min) 120 95 65 45 35MSD experimental (⁰C/min) 120 120 110 70 65

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208v Fast ramping oven

Use the EZGC method translator to move from a traditional column format to a scaled-down column for faster semivolatiles analysis: (a) Fields to input original method conditions; (b) field to input new column dimensions; (c) calculated scaled method conditions, with ramp rates that pose a problem for certain GCs but that can be resolved with the GC Accelerator kit; (d) calculated analysis time changes.

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Translated 20 m x 0.15 mm x 0.15 µm 120V oven ramp profile (blue) with the GC Accelerator kit installed compared to the standard 30 m x 0.25 mm x 0.25 µm application oven profile (orange), with example chromatograms below. The third gray trace shows the semivolatiles application oven profile possible in a 208V oven with the GC Accelerator installed. Refer to GC_EV1475 at www.restek.com and for the 208V analytical parameters.

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