CHOLESTAGELHealth Economics Study

México March 7, 2008

Health Economics Perspectives

– No treatment (Davidson et al., Insull et al.)

– Statin + placebo (Hunninghake et al., Knapp et al.)

– Ezetimibe + placebo (Bays et al., Zema et al.)

– Statin + EZE + placebo (no data available)

Cholestagel monotherapyCholestagel monotherapy

Statin + CholestagelStatin + Cholestagel

Ezetimibe + CholestagelEzetimibe + Cholestagel

Statin + EZE + CholestagelStatin + EZE + Cholestagel

VS

Feb Mar Apr May Jun

2009

Run DataRegulatory Affairs

Time Line Health Economic Study

Jan

Inputs to K.Brito

GuiamarkRegulatory Affairs

New Prod Especial.

New Input:Statin + Cholestagel vs Statin + Placebo

Dec

Run DataRegulatory Affairs

Finaly Report

Conference Call (Mar 12,’08)

To Define:

- Ezetimibe + Cholestagel

- Statin + Cholestagel

2008